JP2004532213A5 - - Google Patents

Info

Publication number

JP2004532213A5

JP2004532213A5 JP2002578888A JP2002578888A JP2004532213A5 JP 2004532213 A5 JP2004532213 A5 JP 2004532213A5 JP 2002578888 A JP2002578888 A JP 2002578888A JP 2002578888 A JP2002578888 A JP 2002578888A JP 2004532213 A5 JP2004532213 A5 JP 2004532213A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

egr

promoter

therapeutic protein

expression

Prior art date

2002-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 206010028980 Neoplasm Diseases 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 16
• 101100444898 Mus musculus Egr1 gene Proteins 0.000 claims 13
• 108090000623 proteins and genes Proteins 0.000 claims 13
• 102000004169 proteins and genes Human genes 0.000 claims 13
• 230000001225 therapeutic effect Effects 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 11
• 230000001939 inductive effect Effects 0.000 claims 10
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical group OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical group ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 229960004397 cyclophosphamide Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 229960002949 fluorouracil Drugs 0.000 claims 1
• 230000002601 intratumoral effect Effects 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 210000005166 vasculature Anatomy 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1