JP2004529943A5 - - Google Patents
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- Publication number
- JP2004529943A5 JP2004529943A5 JP2002588757A JP2002588757A JP2004529943A5 JP 2004529943 A5 JP2004529943 A5 JP 2004529943A5 JP 2002588757 A JP2002588757 A JP 2002588757A JP 2002588757 A JP2002588757 A JP 2002588757A JP 2004529943 A5 JP2004529943 A5 JP 2004529943A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkoxycarbonyl
- optionally
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 22
- 125000001424 substituent group Chemical group 0.000 claims description 22
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims description 19
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 14
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 14
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 14
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 12
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 claims description 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 6
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 6
- 239000000417 fungicide Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 150000001204 N-oxides Chemical class 0.000 claims description 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 4
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- 229930182558 Sterol Natural products 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 4
- 230000000855 fungicidal effect Effects 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 235000003702 sterols Nutrition 0.000 claims description 4
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 claims description 3
- 239000005756 Cymoxanil Substances 0.000 claims description 3
- AIPRFCIQHCXFQY-UHFFFAOYSA-N 2,6-dichloro-n-(3-methyl-5,6,7,8-tetrahydroquinolin-8-yl)benzamide Chemical compound C1CCC2=CC(C)=CN=C2C1NC(=O)C1=C(Cl)C=CC=C1Cl AIPRFCIQHCXFQY-UHFFFAOYSA-N 0.000 claims description 2
- VCMYXUVETJZCIH-UHFFFAOYSA-N 2-chloro-6-methoxy-n-(3-methyl-5,6,7,8-tetrahydroquinolin-8-yl)pyridine-4-carboxamide Chemical compound ClC1=NC(OC)=CC(C(=O)NC2C3=NC=C(C)C=C3CCC2)=C1 VCMYXUVETJZCIH-UHFFFAOYSA-N 0.000 claims description 2
- YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims description 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 claims description 2
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000012990 dithiocarbamate Substances 0.000 claims description 2
- 244000053095 fungal pathogen Species 0.000 claims description 2
- 244000000004 fungal plant pathogen Species 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000002438 mitochondrial effect Effects 0.000 claims description 2
- 125000005543 phthalimide group Chemical class 0.000 claims description 2
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 150000003053 piperidines Chemical class 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 125000004438 haloalkoxy group Chemical group 0.000 description 4
- 125000001188 haloalkyl group Chemical group 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 description 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 description 2
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29088401P | 2001-05-15 | 2001-05-15 | |
| PCT/US2002/018394 WO2002091830A1 (en) | 2001-05-15 | 2002-05-14 | Pyridinyl fused bicyclic amide as fungicides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529943A JP2004529943A (ja) | 2004-09-30 |
| JP2004529943A5 true JP2004529943A5 (enExample) | 2006-01-05 |
Family
ID=23117917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002588757A Withdrawn JP2004529943A (ja) | 2001-05-15 | 2002-05-14 | 殺菌・殺カビ剤としてのピリジニル縮合二環式アミド |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1387612A1 (enExample) |
| JP (1) | JP2004529943A (enExample) |
| CN (1) | CN1509140A (enExample) |
| AR (1) | AR033893A1 (enExample) |
| BR (1) | BR0209687A (enExample) |
| IL (1) | IL158009A0 (enExample) |
| MX (1) | MXPA03010436A (enExample) |
| PL (1) | PL367200A1 (enExample) |
| RU (1) | RU2003136089A (enExample) |
| WO (1) | WO2002091830A1 (enExample) |
| ZA (1) | ZA200307375B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| JP5034293B2 (ja) * | 2005-07-14 | 2012-09-26 | 住友化学株式会社 | カルボキサミド化合物及びこれを含有する植物病害防除剤 |
| US8044043B2 (en) * | 2008-04-11 | 2011-10-25 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| JP5685203B2 (ja) | 2009-05-29 | 2015-03-18 | ラクオリア創薬株式会社 | カルシウムチャネル遮断薬またはナトリウムチャネル遮断薬としてのアリール置換カルボキサミド誘導体 |
| DK3174868T3 (da) | 2014-08-01 | 2021-11-08 | Nuevolution As | Forbindelser, der er aktive mod bromodomæner |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| CN114097792A (zh) * | 2021-11-25 | 2022-03-01 | 兰州大学 | 一种2，8-三氟甲基喹唑啉酮类化合物在防治农业植物病害中的用途 |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE136543T1 (de) * | 1989-01-11 | 1996-04-15 | Agrevo Uk Ltd | Acrylat-fungizide |
| WO1996037473A1 (de) * | 1995-05-23 | 1996-11-28 | Hoechst Schering Agrevo Gmbh | Substituierte 2,3-cycloalkenopyridine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung als schädlingsbekämpfungsmittel und fungizide |
| TW575562B (en) * | 1998-02-19 | 2004-02-11 | Agrevo Uk Ltd | Fungicides |
-
2002
- 2002-05-14 BR BR0209687-0A patent/BR0209687A/pt not_active IP Right Cessation
- 2002-05-14 EP EP02744275A patent/EP1387612A1/en not_active Withdrawn
- 2002-05-14 RU RU2003136089/04A patent/RU2003136089A/ru not_active Application Discontinuation
- 2002-05-14 CN CNA028100646A patent/CN1509140A/zh active Pending
- 2002-05-14 PL PL02367200A patent/PL367200A1/xx not_active Application Discontinuation
- 2002-05-14 IL IL15800902A patent/IL158009A0/xx unknown
- 2002-05-14 WO PCT/US2002/018394 patent/WO2002091830A1/en not_active Ceased
- 2002-05-14 JP JP2002588757A patent/JP2004529943A/ja not_active Withdrawn
- 2002-05-14 MX MXPA03010436A patent/MXPA03010436A/es unknown
- 2002-05-15 AR ARP020101792A patent/AR033893A1/es not_active Application Discontinuation
-
2003
- 2003-09-22 ZA ZA200307375A patent/ZA200307375B/en unknown
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