JP2004526412A5 - - Google Patents
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- Publication number
- JP2004526412A5 JP2004526412A5 JP2002529483A JP2002529483A JP2004526412A5 JP 2004526412 A5 JP2004526412 A5 JP 2004526412A5 JP 2002529483 A JP2002529483 A JP 2002529483A JP 2002529483 A JP2002529483 A JP 2002529483A JP 2004526412 A5 JP2004526412 A5 JP 2004526412A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- polypeptide
- amino acid
- normal control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 208000029742 colonic neoplasm Diseases 0.000 claims description 45
- 229920001184 polypeptide Polymers 0.000 claims description 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 208000020816 lung neoplasm Diseases 0.000 claims description 21
- 208000037841 lung tumor Diseases 0.000 claims description 21
- 150000007523 nucleic acids Chemical class 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 239000000523 sample Substances 0.000 claims description 17
- 206010006187 Breast cancer Diseases 0.000 claims description 16
- 208000026310 Breast neoplasm Diseases 0.000 claims description 16
- 108020004707 nucleic acids Proteins 0.000 claims description 15
- 102000039446 nucleic acids Human genes 0.000 claims description 15
- 239000002773 nucleotide Substances 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 8
- 208000013718 rectal benign neoplasm Diseases 0.000 claims description 8
- 206010019695 Hepatic neoplasm Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 230000014509 gene expression Effects 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 4
- 208000023958 prostate neoplasm Diseases 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 230000035755 proliferation Effects 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 210000004924 lung microvascular endothelial cell Anatomy 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 102100026188 3-hydroxybutyrate dehydrogenase type 2 Human genes 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101000764864 Homo sapiens 3-hydroxybutyrate dehydrogenase type 2 Proteins 0.000 claims 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002751 oligonucleotide probe Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 description 14
- 101000828971 Homo sapiens Signal peptidase complex subunit 3 Proteins 0.000 description 3
- 102100023789 Signal peptidase complex subunit 3 Human genes 0.000 description 3
- 101000841325 Homo sapiens Urotensin-2 Proteins 0.000 description 2
- 102100029097 Urotensin-2 Human genes 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000000439 tumor marker Substances 0.000 description 2
- 102100034299 Germ cell-specific gene 1-like protein Human genes 0.000 description 1
- 101001069989 Homo sapiens Germ cell-specific gene 1-like protein Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22989600P | 2000-09-01 | 2000-09-01 | |
| US23062100P | 2000-09-05 | 2000-09-05 | |
| US23514700P | 2000-09-22 | 2000-09-22 | |
| PCT/US2000/030873 WO2001040465A2 (en) | 1999-11-30 | 2000-11-10 | Compositions and methods for the treatment of immune related diseases |
| US26187801P | 2001-01-12 | 2001-01-12 | |
| US26193901P | 2001-01-16 | 2001-01-16 | |
| US26191001P | 2001-01-16 | 2001-01-16 | |
| US26215001P | 2001-01-16 | 2001-01-16 | |
| US26439501P | 2001-01-25 | 2001-01-25 | |
| US26642101P | 2001-02-02 | 2001-02-02 | |
| US26762301P | 2001-02-09 | 2001-02-09 | |
| PCT/US2001/006520 WO2001068848A2 (en) | 2000-03-01 | 2001-02-28 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US27439901P | 2001-03-09 | 2001-03-09 | |
| US28098201P | 2001-04-03 | 2001-04-03 | |
| US28219901P | 2001-04-04 | 2001-04-04 | |
| US28212901P | 2001-04-04 | 2001-04-04 | |
| US29058901P | 2001-05-09 | 2001-05-09 | |
| PCT/US2001/017092 WO2001092331A2 (en) | 2000-05-30 | 2001-05-25 | Compositions and methods for the treatment of immune related diseases |
| PCT/US2001/017800 WO2001093983A1 (en) | 2000-06-02 | 2001-06-01 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2001/019692 WO2002000690A2 (en) | 2000-06-23 | 2001-06-20 | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| PCT/US2001/021066 WO2002008288A2 (en) | 2000-07-20 | 2001-06-29 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2001/021735 WO2002008284A2 (en) | 2000-07-20 | 2001-07-09 | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| PCT/US2001/027099 WO2002024888A2 (en) | 2000-09-01 | 2001-08-29 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006024604A Division JP2006223304A (ja) | 2000-09-01 | 2006-02-01 | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526412A JP2004526412A (ja) | 2004-09-02 |
| JP2004526412A5 true JP2004526412A5 (enrdf_load_stackoverflow) | 2010-01-28 |
| JP4451059B2 JP4451059B2 (ja) | 2010-04-14 |
Family
ID=27585542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002529483A Expired - Lifetime JP4451059B2 (ja) | 2000-09-01 | 2001-08-29 | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
| JP2006024604A Pending JP2006223304A (ja) | 2000-09-01 | 2006-02-01 | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006024604A Pending JP2006223304A (ja) | 2000-09-01 | 2006-02-01 | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1341814A2 (enrdf_load_stackoverflow) |
| JP (2) | JP4451059B2 (enrdf_load_stackoverflow) |
| AU (2) | AU2002216610A1 (enrdf_load_stackoverflow) |
| CA (2) | CA2632702A1 (enrdf_load_stackoverflow) |
| WO (1) | WO2002024888A2 (enrdf_load_stackoverflow) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| US6395511B1 (en) | 1998-11-27 | 2002-05-28 | Darwin Discovery, Ltd. | Nucleic acids encoding a novel family of TGF-β binding proteins from humans |
| EP1661996A1 (en) * | 1999-12-01 | 2006-05-31 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2001272482A1 (en) * | 2000-06-19 | 2002-01-02 | F.Hoffmann-La Roche Ag | Osteolevin gene polymorphisms |
| US7268223B2 (en) | 2000-09-22 | 2007-09-11 | Wyeth | Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof |
| US7094570B2 (en) | 2003-03-11 | 2006-08-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules which encode a soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof |
| NZ527087A (en) | 2001-01-12 | 2008-09-26 | Genetics Inst Llc | Type 2 cytokine receptor and nucleic acids encoding same |
| EP1406928B1 (en) * | 2001-07-19 | 2010-04-14 | Innate Pharma | Ntb-a, a surface molecule involved in natural killer cells activity |
| WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
| US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
| US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
| FR2844713A1 (fr) * | 2002-09-25 | 2004-03-26 | Exonhit Therapeutics Sa | Nouvelle cible de l'angiogenese et utilisations |
| WO2004035789A1 (en) * | 2002-10-18 | 2004-04-29 | Lg Life Sciences Ltd. | Gene families associated with cancers |
| CN1835974A (zh) | 2003-06-16 | 2006-09-20 | 细胞技术研究与发展公司 | 对硬化素特异的抗体和用于增加骨矿化的方法 |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| WO2011051280A1 (en) | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Ovary tumor markers and methods of use thereof |
| EP2494362B1 (en) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Prostate tumor markers and methods of use thereof |
| EP2383578A1 (en) * | 2010-04-30 | 2011-11-02 | Externautics S.p.A. | Tumor marker and methods of use thereof |
| SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
| WO2012118903A2 (en) | 2011-03-01 | 2012-09-07 | Amgen Inc. | Bispecific binding agents |
| AU2012236962B2 (en) | 2011-03-25 | 2017-05-11 | Amgen Inc. | Anti-sclerostin antibody crystals and formulations thereof |
| PT2739311T (pt) | 2011-08-04 | 2018-03-26 | Amgen Inc | Método para tratamento de defeitos de lacunas ósseas |
| IN2014CN04634A (enrdf_load_stackoverflow) | 2011-12-28 | 2015-09-18 | Amgen Inc | |
| EP3626267A1 (en) | 2012-07-05 | 2020-03-25 | UCB Pharma, S.A. | Treatment for bone diseases |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| JP6449777B2 (ja) | 2012-12-21 | 2019-01-09 | シアトル ジェネティックス， インコーポレイテッド | 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法 |
| MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
| GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
| CA3093457A1 (en) | 2018-03-30 | 2019-10-03 | Amgen Inc. | C-terminal antibody variants |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707829A (en) * | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
| US5824504A (en) * | 1996-09-26 | 1998-10-20 | Elshourbagy; Nabil A. | Human 7-transmembrane receptor and DNA |
| CA2283299A1 (en) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| CA2285554A1 (en) * | 1997-03-25 | 1998-10-01 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| DE19817557A1 (de) * | 1998-04-09 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Ovartumorgewebe |
| IL139686A0 (en) * | 1998-06-02 | 2002-02-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| ATE478145T1 (de) * | 1999-06-02 | 2010-09-15 | Genentech Inc | Sekretierte und transmembran polypeptide und dafür kodierende nukleinsäuren |
-
2001
- 2001-08-29 CA CA002632702A patent/CA2632702A1/en not_active Abandoned
- 2001-08-29 EP EP01985272A patent/EP1341814A2/en not_active Ceased
- 2001-08-29 CA CA002421056A patent/CA2421056A1/en not_active Abandoned
- 2001-08-29 WO PCT/US2001/027099 patent/WO2002024888A2/en active Application Filing
- 2001-08-29 JP JP2002529483A patent/JP4451059B2/ja not_active Expired - Lifetime
- 2001-08-29 AU AU2002216610A patent/AU2002216610A1/en not_active Abandoned
- 2001-09-19 AU AU1661002A patent/AU1661002A/xx active Pending
-
2006
- 2006-02-01 JP JP2006024604A patent/JP2006223304A/ja active Pending
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