JP2004525618A5 - - Google Patents
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- Publication number
- JP2004525618A5 JP2004525618A5 JP2002555104A JP2002555104A JP2004525618A5 JP 2004525618 A5 JP2004525618 A5 JP 2004525618A5 JP 2002555104 A JP2002555104 A JP 2002555104A JP 2002555104 A JP2002555104 A JP 2002555104A JP 2004525618 A5 JP2004525618 A5 JP 2004525618A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- cell
- mrna
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 155
- 102000039446 nucleic acids Human genes 0.000 claims 155
- 150000007523 nucleic acids Chemical class 0.000 claims 155
- 210000004027 cell Anatomy 0.000 claims 105
- 108020004999 messenger RNA Proteins 0.000 claims 94
- 239000002773 nucleotide Substances 0.000 claims 83
- 125000003729 nucleotide group Chemical group 0.000 claims 83
- 230000027455 binding Effects 0.000 claims 71
- 108020005067 RNA Splice Sites Proteins 0.000 claims 63
- 238000000034 method Methods 0.000 claims 28
- 125000006850 spacer group Chemical group 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 201000003883 Cystic fibrosis Diseases 0.000 claims 18
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 18
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 18
- 230000000295 complement effect Effects 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 15
- 108091092236 Chimeric RNA Proteins 0.000 claims 14
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 13
- 239000013598 vector Substances 0.000 claims 10
- 238000003259 recombinant expression Methods 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000003053 toxin Substances 0.000 claims 7
- 231100000765 toxin Toxicity 0.000 claims 7
- 108020004705 Codon Proteins 0.000 claims 6
- 108700024394 Exon Proteins 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000013507 mapping Methods 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
Images
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/756,096 US20030077754A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/756,097 US20060088938A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
| US09/756,095 US20020115207A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/838,858 US20030148937A1 (en) | 1995-12-15 | 2001-04-20 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/941,492 US20030027250A1 (en) | 1995-12-15 | 2001-08-29 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| PCT/US2002/000416 WO2002053581A2 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005003076A Division JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
| JP2005003107A Division JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525618A JP2004525618A (ja) | 2004-08-26 |
| JP2004525618A5 true JP2004525618A5 (enExample) | 2006-01-05 |
Family
ID=27542170
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002555104A Pending JP2004525618A (ja) | 2001-01-08 | 2002-01-08 | スプライセオソームにより媒介されるrnaトランススプライシング |
| JP2005003076A Pending JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
| JP2005003107A Pending JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005003076A Pending JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
| JP2005003107A Pending JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるrnaトランススプライシング |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1358203A4 (enExample) |
| JP (3) | JP2004525618A (enExample) |
| AU (1) | AU2002246959B2 (enExample) |
| CA (1) | CA2434118A1 (enExample) |
| IL (3) | IL165056A0 (enExample) |
| WO (1) | WO2002053581A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10139492B4 (de) * | 2001-08-13 | 2004-06-09 | Eul, Joachim, Dr. | Verfahren zur Reparatur einer mutierten RNA aus einer gendefekten DNA und zum gezielten Abtöten von Tumorzellen durch RNA-Transspleißen sowie Verfahren zum Nachweis von natürlich-transgespleißter zellulärer RNA |
| WO2003104412A2 (en) | 2002-06-05 | 2003-12-18 | Intronn, Inc. | Spliceosome mediated rna trans-splicing and correction of factor viii genetic defects using spliceosome mediated rna trans spling |
| CA2553828A1 (en) * | 2004-01-23 | 2005-08-04 | Intronn, Inc. | Expression of apoa-1 and variants thereof using spliceosome mediated rna trans-splicing |
| US7879321B2 (en) * | 2004-10-08 | 2011-02-01 | Virxsys Corporation | Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production |
| JP5017118B2 (ja) * | 2004-10-08 | 2012-09-05 | バークシス コーポレーション | 組換えタンパク質をインビボ生産するための、非常に豊富な転写産物の標的化トランススプライシング |
| JP5081462B2 (ja) * | 2007-02-02 | 2012-11-28 | 富士フイルム株式会社 | トランススプライシング法による融合タンパク質作製方法 |
| HK1199285A1 (en) * | 2011-08-12 | 2015-06-26 | Virxsys Corporation | Compositions and methods for inducing apoptosis |
| PL3164492T3 (pl) * | 2014-07-03 | 2020-04-30 | F. Hoffmann-La Roche Ag | Układy ekspresji polipeptydu |
| EP4217010A4 (en) * | 2020-09-28 | 2025-01-08 | Tacit Therapeutics, Inc. | TRANS-SPLICING SYSTEM FOR TISSUE-SPECIFIC REPLACEMENT OF RNA SEQUENCES |
| WO2022220968A1 (en) * | 2021-04-15 | 2022-10-20 | U1 Bio, Inc. | High efficiency trans-splicing for replacement of targeted rna sequences in human cells |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0883344B2 (en) * | 1995-12-15 | 2010-06-09 | VIRxSYS Corporation | Therapeutic molecules generated by trans-splicing |
| US6280978B1 (en) * | 1995-12-15 | 2001-08-28 | Intronn Holdings, Llc | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
-
2002
- 2002-01-08 EP EP02714709A patent/EP1358203A4/en not_active Withdrawn
- 2002-01-08 AU AU2002246959A patent/AU2002246959B2/en not_active Ceased
- 2002-01-08 IL IL16505602A patent/IL165056A0/xx unknown
- 2002-01-08 JP JP2002555104A patent/JP2004525618A/ja active Pending
- 2002-01-08 CA CA002434118A patent/CA2434118A1/en not_active Abandoned
- 2002-01-08 WO PCT/US2002/000416 patent/WO2002053581A2/en not_active Ceased
- 2002-01-08 IL IL15666502A patent/IL156665A0/xx unknown
-
2004
- 2004-11-04 IL IL16505704A patent/IL165057A0/xx unknown
-
2005
- 2005-01-07 JP JP2005003076A patent/JP2005176849A/ja active Pending
- 2005-01-07 JP JP2005003107A patent/JP2005168509A/ja active Pending
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