JP2004521951A5 - - Google Patents
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- Publication number
- JP2004521951A5 JP2004521951A5 JP2003511833A JP2003511833A JP2004521951A5 JP 2004521951 A5 JP2004521951 A5 JP 2004521951A5 JP 2003511833 A JP2003511833 A JP 2003511833A JP 2003511833 A JP2003511833 A JP 2003511833A JP 2004521951 A5 JP2004521951 A5 JP 2004521951A5
- Authority
- JP
- Japan
- Prior art keywords
- sulfamate
- dosage unit
- unit according
- dose
- estrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940011871 estrogen Drugs 0.000 claims 9
- 239000000262 estrogen Substances 0.000 claims 9
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 claims 8
- OEFRKKWTZSUQCT-LPNAZMDGSA-N C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2(NS(=O)(=O)O)O)CCC4=C3C=CC(=C4)O Chemical class C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2(NS(=O)(=O)O)O)CCC4=C3C=CC(=C4)O OEFRKKWTZSUQCT-LPNAZMDGSA-N 0.000 claims 5
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims 4
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 4
- 229960004845 drospirenone Drugs 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010013496 Disturbance in attention Diseases 0.000 claims 1
- 206010016825 Flushing Diseases 0.000 claims 1
- 206010022998 Irritability Diseases 0.000 claims 1
- 206010027951 Mood swings Diseases 0.000 claims 1
- VGHIBOFCBWMZNZ-ZXXIGWHRSA-N NS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 Chemical compound NS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 VGHIBOFCBWMZNZ-ZXXIGWHRSA-N 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010037180 Psychiatric symptoms Diseases 0.000 claims 1
- YXYXCSOJKUAPJI-ZBRFXRBCSA-N [(8r,9s,13s,14s,17s)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate Chemical compound NS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 YXYXCSOJKUAPJI-ZBRFXRBCSA-N 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30476001P | 2001-07-13 | 2001-07-13 | |
| DKPA200101109 | 2001-07-13 | ||
| PCT/IB2002/003354 WO2003006027A1 (en) | 2001-07-13 | 2002-07-12 | Combination of drospirenone and an estrogen sulphamate for hrt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521951A JP2004521951A (ja) | 2004-07-22 |
| JP2004521951A5 true JP2004521951A5 (https=) | 2006-01-05 |
Family
ID=26069054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511833A Pending JP2004521951A (ja) | 2001-07-13 | 2002-07-12 | Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6869941B2 (https=) |
| EP (1) | EP1406634A1 (https=) |
| JP (1) | JP2004521951A (https=) |
| WO (1) | WO2003006027A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| EP1535618A1 (en) * | 2003-11-26 | 2005-06-01 | Schering Aktiengesellschaft | Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions |
| US8475838B2 (en) * | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
| US20070254036A1 (en) * | 2006-04-13 | 2007-11-01 | Besins Healthcare Sa | Treatment of menopause associated symptoms |
| CA2662956A1 (en) * | 2006-09-16 | 2008-03-20 | Bayer Schering Pharma Aktiengesellschaft | Oral modified release formulations |
| EP1902711A1 (en) * | 2006-09-20 | 2008-03-26 | KAIROSmed GmbH | Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT) |
| CN100396693C (zh) * | 2006-11-08 | 2008-06-25 | 浙江大学 | 1,4-孕二烯-16β-甲基-17α,21-二羟基物的制备方法 |
| US20100204146A1 (en) * | 2007-09-17 | 2010-08-12 | Preglem S.A. | Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| JP2012502988A (ja) * | 2008-09-16 | 2012-02-02 | プレイテックス プロダクツ エルエルシー | 月経抑制、避妊、およびホルモン補充療法のための製剤、ならびにその投与方法 |
| CN102985070A (zh) | 2010-04-15 | 2013-03-20 | 拜耳知识产权有限责任公司 | 用于hrt的极低剂量的固体口服剂型 |
| EP2558076B1 (en) * | 2010-04-15 | 2014-12-24 | Bayer Intellectual Property GmbH | Low-dosed solid oral dosage forms for hrt |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3942641A (en) * | 1972-05-05 | 1976-03-09 | Syntex Corporation | Dispensing packages containing novel cyclic progestogen-interrupted estrogen oral contraceptive regimens |
| DE2652761C2 (de) | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4826831A (en) * | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| NL9301562A (nl) | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| DE4344462C2 (de) * | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
| DE4447715C2 (de) * | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen |
| DE19633685C1 (de) | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| DE19651000A1 (de) | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
| DE19654609A1 (de) | 1996-12-20 | 1998-06-25 | Schering Ag | Therapeutische Gestagene zur Behandlung von Premenstrual Dysphoric Disorder |
| DE19834931A1 (de) * | 1998-07-28 | 2000-02-24 | Jenapharm Gmbh | Verwendung von biogenen Estrogenen zur Hormonsubstitutionstherapie |
| AU6795000A (en) | 1999-08-18 | 2001-03-13 | Curagen Corporation | Defense-related signaling genes and methods of use |
| KR100913910B1 (ko) | 2000-01-18 | 2009-08-26 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 호르몬 보충 요법용 드로스피렌온 |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
-
2002
- 2002-07-12 JP JP2003511833A patent/JP2004521951A/ja active Pending
- 2002-07-12 WO PCT/IB2002/003354 patent/WO2003006027A1/en not_active Ceased
- 2002-07-12 EP EP02755534A patent/EP1406634A1/en not_active Withdrawn
- 2002-07-15 US US10/194,970 patent/US6869941B2/en not_active Expired - Fee Related
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