JP2004520041A5 - - Google Patents

Info

Publication number

JP2004520041A5

JP2004520041A5 JP2002558535A JP2002558535A JP2004520041A5 JP 2004520041 A5 JP2004520041 A5 JP 2004520041A5 JP 2002558535 A JP2002558535 A JP 2002558535A JP 2002558535 A JP2002558535 A JP 2002558535A JP 2004520041 A5 JP2004520041 A5 JP 2004520041A5

Authority

JP

Japan

Prior art keywords

bace

polypeptide

nogo

modulator

activity

Prior art date

2002-01-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 102100021257 Beta-secretase 1 Human genes 0.000 claims 22
• 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 22
• 229920001184 polypeptide Polymers 0.000 claims 16
• 102000004196 processed proteins & peptides Human genes 0.000 claims 16
• 108090000765 processed proteins & peptides Proteins 0.000 claims 16
• 238000000034 method Methods 0.000 claims 15
• 102000010410 Nogo Proteins Human genes 0.000 claims 12
• 108010077641 Nogo Proteins Proteins 0.000 claims 12
• 230000000694 effects Effects 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 8
• 239000012634 fragment Substances 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 208000035475 disorder Diseases 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 208000028389 Nerve injury Diseases 0.000 claims 3
• 108091005804 Peptidases Proteins 0.000 claims 3
• 239000004365 Protease Substances 0.000 claims 3
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
• 230000001154 acute effect Effects 0.000 claims 3
• 238000012544 monitoring process Methods 0.000 claims 3
• 230000008764 nerve damage Effects 0.000 claims 3
• 210000003169 central nervous system Anatomy 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 230000003463 hyperproliferative effect Effects 0.000 claims 2
• 230000001613 neoplastic effect Effects 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 1
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 1
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 1
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 1
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
• 206010019196 Head injury Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000009826 neoplastic cell growth Effects 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 208000020431 spinal cord injury Diseases 0.000 claims 1