JP2004519488A5 - - Google Patents
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- Publication number
- JP2004519488A5 JP2004519488A5 JP2002571051A JP2002571051A JP2004519488A5 JP 2004519488 A5 JP2004519488 A5 JP 2004519488A5 JP 2002571051 A JP2002571051 A JP 2002571051A JP 2002571051 A JP2002571051 A JP 2002571051A JP 2004519488 A5 JP2004519488 A5 JP 2004519488A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- nicotinic acid
- acid ester
- subject
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 16
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 11
- 229960003512 nicotinic acid Drugs 0.000 claims 8
- 235000001968 nicotinic acid Nutrition 0.000 claims 8
- 239000011664 nicotinic acid Substances 0.000 claims 8
- -1 nicotinic acid ester Chemical class 0.000 claims 6
- 102000016267 Leptin Human genes 0.000 claims 3
- 108010092277 Leptin Proteins 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 3
- 229940039781 leptin Drugs 0.000 claims 3
- 206010072170 Skin wound Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27434901P | 2001-03-08 | 2001-03-08 | |
| US60/274,349 | 2001-03-08 | ||
| PCT/US2002/007256 WO2002072092A1 (en) | 2001-03-08 | 2002-03-08 | Method for increasing leptin levels using nicotinic acid compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004519488A JP2004519488A (ja) | 2004-07-02 |
| JP2004519488A5 true JP2004519488A5 (https=) | 2005-12-22 |
| JP5057353B2 JP5057353B2 (ja) | 2012-10-24 |
Family
ID=23047813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571051A Expired - Fee Related JP5057353B2 (ja) | 2001-03-08 | 2002-03-08 | ニコチン酸化合物を使用するレプチンレベル増大のための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6750234B2 (https=) |
| EP (1) | EP1365762B1 (https=) |
| JP (1) | JP5057353B2 (https=) |
| CN (1) | CN1265792C (https=) |
| AT (1) | ATE409037T1 (https=) |
| CA (1) | CA2437844C (https=) |
| DE (1) | DE60229041D1 (https=) |
| DK (1) | DK1365762T3 (https=) |
| ES (1) | ES2315358T3 (https=) |
| MX (1) | MXPA03008096A (https=) |
| PT (1) | PT1365762E (https=) |
| WO (1) | WO2002072092A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416788A1 (en) | 2000-07-31 | 2002-02-07 | Tamar Tennenbaum | Methods and pharmaceutical compositions comprising protein kinase c isoforms for healing wounds |
| US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| US6750234B2 (en) * | 2001-03-08 | 2004-06-15 | University Of Kentucky Research Foundation | Methods for increasing leptin levels using nicotinic acid compounds |
| BR0315942A (pt) * | 2002-11-27 | 2005-10-04 | Dmi Biosciences Inc | Tratamento de doenças e condições mediadas pelo aumento de fosforilação |
| US7736636B2 (en) * | 2003-02-12 | 2010-06-15 | Shaker Mousa | Method for treating occlusive vascular diseases & wound healing |
| US9544860B2 (en) | 2003-02-24 | 2017-01-10 | Qualcomm Incorporated | Pilot signals for use in multi-sector cells |
| US7218948B2 (en) | 2003-02-24 | 2007-05-15 | Qualcomm Incorporated | Method of transmitting pilot tones in a multi-sector cell, including null pilot tones, for generating channel quality indicators |
| US8811348B2 (en) | 2003-02-24 | 2014-08-19 | Qualcomm Incorporated | Methods and apparatus for generating, communicating, and/or using information relating to self-noise |
| WO2005013885A2 (en) | 2003-08-07 | 2005-02-17 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| US8969291B2 (en) | 2004-10-08 | 2015-03-03 | Enzo Therapeutics, Inc. | Methods for decreasing leptin levels or activity for treating inflammation |
| NZ555079A (en) | 2004-10-14 | 2010-04-30 | Qualcomm Inc | Methods and apparatus for determining, communicating and using information which can be used for interference control purposes |
| US8503938B2 (en) | 2004-10-14 | 2013-08-06 | Qualcomm Incorporated | Methods and apparatus for determining, communicating and using information including loading factors which can be used for interference control purposes |
| JP2006253769A (ja) * | 2005-03-08 | 2006-09-21 | National Institute Of Advanced Industrial & Technology | 情報処理システムおよび方法 |
| EP1898867B1 (en) | 2005-06-24 | 2017-08-09 | Arizona Board of Regents, acting on behalf of the University of Arizona | Method for treating hair growth disorders, such as female pattern alopecia, and compositions useful therefore |
| EP2452686A3 (en) | 2005-08-29 | 2012-09-05 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| US20070066512A1 (en) * | 2005-09-12 | 2007-03-22 | Dominique Verhelle | Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels |
| US9191840B2 (en) | 2005-10-14 | 2015-11-17 | Qualcomm Incorporated | Methods and apparatus for determining, communicating and using information which can be used for interference control |
| US8694042B2 (en) | 2005-10-14 | 2014-04-08 | Qualcomm Incorporated | Method and apparatus for determining a base station's transmission power budget |
| US9572179B2 (en) | 2005-12-22 | 2017-02-14 | Qualcomm Incorporated | Methods and apparatus for communicating transmission backlog information |
| US9451491B2 (en) | 2005-12-22 | 2016-09-20 | Qualcomm Incorporated | Methods and apparatus relating to generating and transmitting initial and additional control information report sets in a wireless system |
| US9148795B2 (en) | 2005-12-22 | 2015-09-29 | Qualcomm Incorporated | Methods and apparatus for flexible reporting of control information |
| US9125092B2 (en) | 2005-12-22 | 2015-09-01 | Qualcomm Incorporated | Methods and apparatus for reporting and/or using control information |
| US7801589B2 (en) | 2005-12-22 | 2010-09-21 | Olympus Corporation | In-vivo examination method and in-vivo examination apparatus |
| US9125093B2 (en) | 2005-12-22 | 2015-09-01 | Qualcomm Incorporated | Methods and apparatus related to custom control channel reporting formats |
| US8514771B2 (en) | 2005-12-22 | 2013-08-20 | Qualcomm Incorporated | Methods and apparatus for communicating and/or using transmission power information |
| US9137072B2 (en) | 2005-12-22 | 2015-09-15 | Qualcomm Incorporated | Methods and apparatus for communicating control information |
| US9338767B2 (en) | 2005-12-22 | 2016-05-10 | Qualcomm Incorporated | Methods and apparatus of implementing and/or using a dedicated control channel |
| US8437251B2 (en) | 2005-12-22 | 2013-05-07 | Qualcomm Incorporated | Methods and apparatus for communicating transmission backlog information |
| US9473265B2 (en) | 2005-12-22 | 2016-10-18 | Qualcomm Incorporated | Methods and apparatus for communicating information utilizing a plurality of dictionaries |
| US9119220B2 (en) | 2005-12-22 | 2015-08-25 | Qualcomm Incorporated | Methods and apparatus for communicating backlog related information |
| US20070249360A1 (en) | 2005-12-22 | 2007-10-25 | Arnab Das | Methods and aparatus related to determining, communicating, and/or using delay information in a wireless communications system |
| US20070243882A1 (en) | 2006-04-12 | 2007-10-18 | Qualcomm Incorporated | Method and apparatus for locating a wireless local area network associated with a wireless wide area network |
| WO2008026349A1 (fr) * | 2006-08-31 | 2008-03-06 | Juridical Foundation Osaka Industrial Promotion Organization | Agent thérapeutique destiné au traitement de l'effluvium télogène |
| JP5699414B2 (ja) * | 2007-02-28 | 2015-04-08 | ユニバーシティー オブ ケンタッキー リサーチ ファウンデイション | レチノイン酸療法の効力を妨げることなくレチノイン酸療法の副作用を軽減する方法、および／又は、その効力を改善する方法 |
| EP2523677A2 (en) | 2010-01-11 | 2012-11-21 | Healor Ltd. | Method for treatment of inflammatory disease and disorder |
| CN109414424A (zh) * | 2016-04-22 | 2019-03-01 | 无锡杰西医药股份有限公司 | 异硫氰酸酯类化合物的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| DE3110611A1 (de) * | 1981-03-18 | 1982-10-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | "mitogene der leukozyten und des entzuendungsgewebes:natuerliche leukopoetine zur selektiven anregung der teilung und differenzierung von leukozyten" |
| GB8330969D0 (en) * | 1983-11-21 | 1983-12-29 | Wellcome Found | Promoting healing |
| DE3570598D1 (en) * | 1984-11-15 | 1989-07-06 | Nitto Denko Corp | Composition for percutaneous administration |
| US4965252A (en) * | 1988-06-28 | 1990-10-23 | Hauser-Kuhrts, Inc. | Cholesterol-lowering combination compositions of guar gum and niacin |
| EP0573568B1 (en) * | 1991-03-01 | 2001-01-24 | University Of Florida Research Foundation, Inc. | Use of nicotinic analogs for treatment of degenerative diseases of the nervous system |
| US5240945A (en) * | 1992-02-18 | 1993-08-31 | Warshaw Thelma G | Method and compositions for treating acne |
| US5612382A (en) * | 1994-07-15 | 1997-03-18 | Frances B. Fike | Composition for percutaneous absorption of pharmaceutically active ingredients |
| US5496827A (en) * | 1994-07-15 | 1996-03-05 | Patrick; Jay | Compositions for the transdermal delivery of nutrients |
| AU5524896A (en) * | 1995-03-20 | 1996-10-08 | Institut Pasteur De Lille | Modulators of ob gene and screening methods therefor |
| DK0823897T3 (da) * | 1995-05-01 | 2004-12-06 | Scarista Ltd | Nicotinsyreestere og farmaceutiske præparater indeholdende disse |
| WO1998052927A1 (en) * | 1997-05-19 | 1998-11-26 | Rosemarie Scivoletto | Composition for treating skin conditions |
| WO1999059614A1 (en) * | 1998-05-20 | 1999-11-25 | Yale University | Modulation of angiogenesis and wound healing |
| PT1143954E (pt) * | 1998-12-01 | 2004-12-31 | Univ Kentucky Res Found | Utilizacao de derivados de acido nocotinico para o tratamento de danos no adn em celulas da pele |
| IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
| US6326034B1 (en) * | 1999-12-22 | 2001-12-04 | Natural Compounds Ltd | Natural extracted and synthetic antioxidant compositions |
| US6750234B2 (en) * | 2001-03-08 | 2004-06-15 | University Of Kentucky Research Foundation | Methods for increasing leptin levels using nicotinic acid compounds |
-
2002
- 2002-03-08 US US10/094,063 patent/US6750234B2/en not_active Expired - Lifetime
- 2002-03-08 CN CNB028061209A patent/CN1265792C/zh not_active Expired - Fee Related
- 2002-03-08 CA CA002437844A patent/CA2437844C/en not_active Expired - Lifetime
- 2002-03-08 AT AT02721337T patent/ATE409037T1/de active
- 2002-03-08 EP EP02721337A patent/EP1365762B1/en not_active Expired - Lifetime
- 2002-03-08 DK DK02721337T patent/DK1365762T3/da active
- 2002-03-08 DE DE60229041T patent/DE60229041D1/de not_active Expired - Lifetime
- 2002-03-08 JP JP2002571051A patent/JP5057353B2/ja not_active Expired - Fee Related
- 2002-03-08 PT PT02721337T patent/PT1365762E/pt unknown
- 2002-03-08 ES ES02721337T patent/ES2315358T3/es not_active Expired - Lifetime
- 2002-03-08 MX MXPA03008096A patent/MXPA03008096A/es active IP Right Grant
- 2002-03-08 WO PCT/US2002/007256 patent/WO2002072092A1/en not_active Ceased
-
2004
- 2004-04-14 US US10/825,405 patent/US20040198776A1/en not_active Abandoned
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