JP2004519488A5 - - Google Patents
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- Publication number
- JP2004519488A5 JP2004519488A5 JP2002571051A JP2002571051A JP2004519488A5 JP 2004519488 A5 JP2004519488 A5 JP 2004519488A5 JP 2002571051 A JP2002571051 A JP 2002571051A JP 2002571051 A JP2002571051 A JP 2002571051A JP 2004519488 A5 JP2004519488 A5 JP 2004519488A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- nicotinic acid
- acid ester
- subject
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 16
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 11
- 229960003512 nicotinic acid Drugs 0.000 claims 8
- 235000001968 nicotinic acid Nutrition 0.000 claims 8
- 239000011664 nicotinic acid Substances 0.000 claims 8
- -1 nicotinic acid ester Chemical class 0.000 claims 6
- 102000016267 Leptin Human genes 0.000 claims 3
- 108010092277 Leptin Proteins 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 3
- 229940039781 leptin Drugs 0.000 claims 3
- 206010072170 Skin wound Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27434901P | 2001-03-08 | 2001-03-08 | |
| US60/274,349 | 2001-03-08 | ||
| PCT/US2002/007256 WO2002072092A1 (en) | 2001-03-08 | 2002-03-08 | Method for increasing leptin levels using nicotinic acid compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004519488A JP2004519488A (ja) | 2004-07-02 |
| JP2004519488A5 true JP2004519488A5 (https=) | 2005-12-22 |
| JP5057353B2 JP5057353B2 (ja) | 2012-10-24 |
Family
ID=23047813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571051A Expired - Fee Related JP5057353B2 (ja) | 2001-03-08 | 2002-03-08 | ニコチン酸化合物を使用するレプチンレベル増大のための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6750234B2 (https=) |
| EP (1) | EP1365762B1 (https=) |
| JP (1) | JP5057353B2 (https=) |
| CN (1) | CN1265792C (https=) |
| AT (1) | ATE409037T1 (https=) |
| CA (1) | CA2437844C (https=) |
| DE (1) | DE60229041D1 (https=) |
| DK (1) | DK1365762T3 (https=) |
| ES (1) | ES2315358T3 (https=) |
| MX (1) | MXPA03008096A (https=) |
| PT (1) | PT1365762E (https=) |
| WO (1) | WO2002072092A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| WO2002009639A2 (en) | 2000-07-31 | 2002-02-07 | Bar Ilan University | Methods and pharmaceutical compositions for healing wounds |
| WO2002072092A1 (en) * | 2001-03-08 | 2002-09-19 | University Of Kentucky | Method for increasing leptin levels using nicotinic acid compounds |
| JP5204947B2 (ja) * | 2002-11-27 | 2013-06-05 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | リン酸受容体化合物の使用、ならびにリン酸受容体化合物を含んでいる、薬学的組成物、スキンケア用の組成物、およびキット |
| US7736636B2 (en) * | 2003-02-12 | 2010-06-15 | Shaker Mousa | Method for treating occlusive vascular diseases & wound healing |
| US7218948B2 (en) | 2003-02-24 | 2007-05-15 | Qualcomm Incorporated | Method of transmitting pilot tones in a multi-sector cell, including null pilot tones, for generating channel quality indicators |
| US8811348B2 (en) | 2003-02-24 | 2014-08-19 | Qualcomm Incorporated | Methods and apparatus for generating, communicating, and/or using information relating to self-noise |
| US9544860B2 (en) | 2003-02-24 | 2017-01-10 | Qualcomm Incorporated | Pilot signals for use in multi-sector cells |
| WO2005013885A2 (en) | 2003-08-07 | 2005-02-17 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| US8969291B2 (en) | 2004-10-08 | 2015-03-03 | Enzo Therapeutics, Inc. | Methods for decreasing leptin levels or activity for treating inflammation |
| WO2006044718A2 (en) | 2004-10-14 | 2006-04-27 | Flarion Technologies, Inc. | Methods and apparatus for determining, communicating and using information which can be used for interference control purposes |
| US8503938B2 (en) | 2004-10-14 | 2013-08-06 | Qualcomm Incorporated | Methods and apparatus for determining, communicating and using information including loading factors which can be used for interference control purposes |
| JP2006253769A (ja) * | 2005-03-08 | 2006-09-21 | National Institute Of Advanced Industrial & Technology | 情報処理システムおよび方法 |
| CN103127111B (zh) * | 2005-06-24 | 2016-02-10 | 代表亚利桑那大学的亚利桑那校董会 | 用于治疗头发生长病症比如女性型脱发的方法及可用于此的组合物 |
| EP2462944A3 (en) | 2005-08-29 | 2012-09-12 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| US20070066512A1 (en) * | 2005-09-12 | 2007-03-22 | Dominique Verhelle | Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels |
| US8989084B2 (en) | 2005-10-14 | 2015-03-24 | Qualcomm Incorporated | Methods and apparatus for broadcasting loading information corresponding to neighboring base stations |
| US9191840B2 (en) | 2005-10-14 | 2015-11-17 | Qualcomm Incorporated | Methods and apparatus for determining, communicating and using information which can be used for interference control |
| US8437251B2 (en) | 2005-12-22 | 2013-05-07 | Qualcomm Incorporated | Methods and apparatus for communicating transmission backlog information |
| US7801589B2 (en) | 2005-12-22 | 2010-09-21 | Olympus Corporation | In-vivo examination method and in-vivo examination apparatus |
| US9119220B2 (en) | 2005-12-22 | 2015-08-25 | Qualcomm Incorporated | Methods and apparatus for communicating backlog related information |
| US9125093B2 (en) | 2005-12-22 | 2015-09-01 | Qualcomm Incorporated | Methods and apparatus related to custom control channel reporting formats |
| US9148795B2 (en) | 2005-12-22 | 2015-09-29 | Qualcomm Incorporated | Methods and apparatus for flexible reporting of control information |
| US9451491B2 (en) | 2005-12-22 | 2016-09-20 | Qualcomm Incorporated | Methods and apparatus relating to generating and transmitting initial and additional control information report sets in a wireless system |
| US9125092B2 (en) | 2005-12-22 | 2015-09-01 | Qualcomm Incorporated | Methods and apparatus for reporting and/or using control information |
| US9572179B2 (en) | 2005-12-22 | 2017-02-14 | Qualcomm Incorporated | Methods and apparatus for communicating transmission backlog information |
| US9137072B2 (en) | 2005-12-22 | 2015-09-15 | Qualcomm Incorporated | Methods and apparatus for communicating control information |
| US9338767B2 (en) | 2005-12-22 | 2016-05-10 | Qualcomm Incorporated | Methods and apparatus of implementing and/or using a dedicated control channel |
| US8514771B2 (en) | 2005-12-22 | 2013-08-20 | Qualcomm Incorporated | Methods and apparatus for communicating and/or using transmission power information |
| US20070253449A1 (en) | 2005-12-22 | 2007-11-01 | Arnab Das | Methods and apparatus related to determining, communicating, and/or using delay information |
| US9473265B2 (en) | 2005-12-22 | 2016-10-18 | Qualcomm Incorporated | Methods and apparatus for communicating information utilizing a plurality of dictionaries |
| US20070243882A1 (en) | 2006-04-12 | 2007-10-18 | Qualcomm Incorporated | Method and apparatus for locating a wireless local area network associated with a wireless wide area network |
| WO2008026349A1 (fr) * | 2006-08-31 | 2008-03-06 | Juridical Foundation Osaka Industrial Promotion Organization | Agent thérapeutique destiné au traitement de l'effluvium télogène |
| PL2120917T3 (pl) * | 2007-02-28 | 2014-09-30 | Univ Kentucky Res Found | Sposób na łagodzenie działań niepożądanych terapii kwasem retinowym i/lub ulepszanie skuteczności bez zakłócania skuteczności |
| JP2013516500A (ja) | 2010-01-11 | 2013-05-13 | ヒールオア・リミテッド | 炎症性疾患および障害を治療するための方法 |
| EP3446689B1 (en) * | 2016-04-22 | 2025-01-08 | JC (Wuxi) COMPANY, Inc. | Isothiocyanate compound for use in the treatment of hyperbilirubinemia |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| DE3110611A1 (de) * | 1981-03-18 | 1982-10-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | "mitogene der leukozyten und des entzuendungsgewebes:natuerliche leukopoetine zur selektiven anregung der teilung und differenzierung von leukozyten" |
| GB8330969D0 (en) * | 1983-11-21 | 1983-12-29 | Wellcome Found | Promoting healing |
| DE3570598D1 (en) * | 1984-11-15 | 1989-07-06 | Nitto Denko Corp | Composition for percutaneous administration |
| US4965252A (en) * | 1988-06-28 | 1990-10-23 | Hauser-Kuhrts, Inc. | Cholesterol-lowering combination compositions of guar gum and niacin |
| JP2657583B2 (ja) * | 1991-03-01 | 1997-09-24 | ユニバーシテイ オブ フロリダ リサーチ ファンデーション インコーポレイテッド | 神経系変性疾患の治療に対するニコチン類似体の利用 |
| US5240945A (en) * | 1992-02-18 | 1993-08-31 | Warshaw Thelma G | Method and compositions for treating acne |
| US5496827A (en) * | 1994-07-15 | 1996-03-05 | Patrick; Jay | Compositions for the transdermal delivery of nutrients |
| US5612382A (en) * | 1994-07-15 | 1997-03-18 | Frances B. Fike | Composition for percutaneous absorption of pharmaceutically active ingredients |
| EP0815230A2 (en) * | 1995-03-20 | 1998-01-07 | Ligand Pharmaceuticals, Inc. | MODULATORS OF ob GENE AND SCREENING METHODS THEREFOR |
| US6015821A (en) * | 1995-05-01 | 2000-01-18 | Horrobin; David Frederick | Nicotinic acid esters and pharmaceutical compositions containing them |
| US20040102358A1 (en) * | 1997-05-19 | 2004-05-27 | Scivoletto Rosemarie | Composition for treating skin conditions |
| AU4672199A (en) * | 1998-05-20 | 1999-12-06 | Yale University | Modulation of angiogenesis and wound healing |
| DE69919403T2 (de) * | 1998-12-01 | 2005-09-08 | The University Of Kentucky Research Foundation | Verwendung von nikotinsäurederivate zur behandlung von dna-schäden bei hautzellen |
| IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
| US6326034B1 (en) * | 1999-12-22 | 2001-12-04 | Natural Compounds Ltd | Natural extracted and synthetic antioxidant compositions |
| WO2002072092A1 (en) * | 2001-03-08 | 2002-09-19 | University Of Kentucky | Method for increasing leptin levels using nicotinic acid compounds |
-
2002
- 2002-03-08 WO PCT/US2002/007256 patent/WO2002072092A1/en not_active Ceased
- 2002-03-08 CA CA002437844A patent/CA2437844C/en not_active Expired - Lifetime
- 2002-03-08 MX MXPA03008096A patent/MXPA03008096A/es active IP Right Grant
- 2002-03-08 AT AT02721337T patent/ATE409037T1/de active
- 2002-03-08 ES ES02721337T patent/ES2315358T3/es not_active Expired - Lifetime
- 2002-03-08 JP JP2002571051A patent/JP5057353B2/ja not_active Expired - Fee Related
- 2002-03-08 DK DK02721337T patent/DK1365762T3/da active
- 2002-03-08 EP EP02721337A patent/EP1365762B1/en not_active Expired - Lifetime
- 2002-03-08 DE DE60229041T patent/DE60229041D1/de not_active Expired - Lifetime
- 2002-03-08 US US10/094,063 patent/US6750234B2/en not_active Expired - Lifetime
- 2002-03-08 CN CNB028061209A patent/CN1265792C/zh not_active Expired - Fee Related
- 2002-03-08 PT PT02721337T patent/PT1365762E/pt unknown
-
2004
- 2004-04-14 US US10/825,405 patent/US20040198776A1/en not_active Abandoned
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