JP2004513328A - 血管内皮増殖因子(vegf−b)欠損動物の心臓異常及びこれら心臓異常に関する方法 - Google Patents

血管内皮増殖因子(vegf−b)欠損動物の心臓異常及びこれら心臓異常に関する方法 Download PDF

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JP2004513328A
JP2004513328A JP2000602624A JP2000602624A JP2004513328A JP 2004513328 A JP2004513328 A JP 2004513328A JP 2000602624 A JP2000602624 A JP 2000602624A JP 2000602624 A JP2000602624 A JP 2000602624A JP 2004513328 A JP2004513328 A JP 2004513328A
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vegf
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ischemia
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JP2004513328A5 (enExample
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アーセ,カリン
トーレン,ペーター
エリクソン,ウルフ
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ルードヴィッヒ インスティテュート フォー キャンサー リサーチ
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0375Animal model for cardiovascular diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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JP2000602624A 1999-03-03 2000-03-03 血管内皮増殖因子(vegf−b)欠損動物の心臓異常及びこれら心臓異常に関する方法 Pending JP2004513328A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16008399P 1999-03-03 1999-03-03
PCT/US2000/005465 WO2000052462A1 (en) 1999-03-03 2000-03-03 Heart abnormalities in vascular endothelial growth factor b (vegf-b) deficient animals and methods relating to these heart abnormalities

Publications (2)

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JP2004513328A true JP2004513328A (ja) 2004-04-30
JP2004513328A5 JP2004513328A5 (enExample) 2004-12-24

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JP2000602624A Pending JP2004513328A (ja) 1999-03-03 2000-03-03 血管内皮増殖因子(vegf−b)欠損動物の心臓異常及びこれら心臓異常に関する方法

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EP (1) EP1166102A4 (enExample)
JP (1) JP2004513328A (enExample)
CN (1) CN1342264A (enExample)
AU (1) AU3614700A (enExample)
CA (1) CA2363488A1 (enExample)
NZ (1) NZ513780A (enExample)
WO (1) WO2000052462A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507026A (ja) * 2008-10-30 2012-03-22 セントレ・ドゥ・レシェルシェ・パブリック・ドゥ・ラ・サン バイオマーカー

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709450B2 (en) 2001-06-20 2010-05-04 Ludwig Institute For Cancer Research Stimulation of vascularization with VEGF-B-186

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928939A (en) * 1995-03-01 1999-07-27 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b and dna coding therefor
US6262337B1 (en) * 1997-02-18 2001-07-17 Ludwig Institute For Cancer Research Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B DNA) and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507026A (ja) * 2008-10-30 2012-03-22 セントレ・ドゥ・レシェルシェ・パブリック・ドゥ・ラ・サン バイオマーカー

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CN1342264A (zh) 2002-03-27
AU3614700A (en) 2000-09-21
EP1166102A4 (en) 2002-08-21
WO2000052462A1 (en) 2000-09-08
EP1166102A1 (en) 2002-01-02
CA2363488A1 (en) 2000-09-08
NZ513780A (en) 2001-09-28

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