EP1166102A4 - HEART ERRORS OF VEGF-DEFICIENT ANIMALS AND RELATED METHODS - Google Patents

HEART ERRORS OF VEGF-DEFICIENT ANIMALS AND RELATED METHODS

Info

Publication number
EP1166102A4
EP1166102A4 EP00914803A EP00914803A EP1166102A4 EP 1166102 A4 EP1166102 A4 EP 1166102A4 EP 00914803 A EP00914803 A EP 00914803A EP 00914803 A EP00914803 A EP 00914803A EP 1166102 A4 EP1166102 A4 EP 1166102A4
Authority
EP
European Patent Office
Prior art keywords
cardiac
vegf
endothelial
animals
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00914803A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1166102A1 (en
Inventor
Karin Aase
Peter Thoren
Ulf Eriksson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Cancer Research
Original Assignee
Ludwig Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Cancer Research filed Critical Ludwig Cancer Research
Publication of EP1166102A1 publication Critical patent/EP1166102A1/en
Publication of EP1166102A4 publication Critical patent/EP1166102A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0375—Animal model for cardiovascular diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP00914803A 1999-03-03 2000-03-03 HEART ERRORS OF VEGF-DEFICIENT ANIMALS AND RELATED METHODS Withdrawn EP1166102A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16008399P 1999-03-03 1999-03-03
US160083P 1999-03-03
PCT/US2000/005465 WO2000052462A1 (en) 1999-03-03 2000-03-03 Heart abnormalities in vascular endothelial growth factor b (vegf-b) deficient animals and methods relating to these heart abnormalities

Publications (2)

Publication Number Publication Date
EP1166102A1 EP1166102A1 (en) 2002-01-02
EP1166102A4 true EP1166102A4 (en) 2002-08-21

Family

ID=22575449

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00914803A Withdrawn EP1166102A4 (en) 1999-03-03 2000-03-03 HEART ERRORS OF VEGF-DEFICIENT ANIMALS AND RELATED METHODS

Country Status (7)

Country Link
EP (1) EP1166102A4 (enExample)
JP (1) JP2004513328A (enExample)
CN (1) CN1342264A (enExample)
AU (1) AU3614700A (enExample)
CA (1) CA2363488A1 (enExample)
NZ (1) NZ513780A (enExample)
WO (1) WO2000052462A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ529915A (en) * 2001-06-20 2007-07-27 Ludwig Inst Cancer Res Stimulation of vascularization of ischemic tissue by angiogenesis with VEGF-B186
CN102203606A (zh) * 2008-10-30 2011-09-28 公共健康研究中心 生物标记物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026736A1 (en) * 1995-03-01 1996-09-06 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b
WO1998036052A1 (en) * 1997-02-18 1998-08-20 Ludwig Institute For Cancer Research Transgenic animal with recombinant vascular endothelial growth factor b (vegf-b) dna and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026736A1 (en) * 1995-03-01 1996-09-06 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b
WO1998036052A1 (en) * 1997-02-18 1998-08-20 Ludwig Institute For Cancer Research Transgenic animal with recombinant vascular endothelial growth factor b (vegf-b) dna and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAWATA HIROYUKI ET AL: "Upregulation of VEGF-B mRNA in the rat heart following acute myocardial infarction (AMI).", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 30, no. 6, June 1998 (1998-06-01), XVI World Congress of the International Society for Heart Research: Cardiovascular Biology and Medicine into the 21st Century, pages A43, XP008003746, ISSN: 0022-2828 *
See also references of WO0052462A1 *

Also Published As

Publication number Publication date
NZ513780A (en) 2001-09-28
CN1342264A (zh) 2002-03-27
CA2363488A1 (en) 2000-09-08
AU3614700A (en) 2000-09-21
JP2004513328A (ja) 2004-04-30
WO2000052462A1 (en) 2000-09-08
EP1166102A1 (en) 2002-01-02

Similar Documents

Publication Publication Date Title
DE60043005D1 (de) Prothese implantierbar in einem lumen
GB2355190B (en) Improvements in or relating to sterilising preparations
ID26882A (id) Metode diagnosa kondisi nutrisi hasil panen di ladang tanaman
EP1072256A4 (en) QUICKLY DEGRADING TABLETS IN THE MOUTH AND THEIR PRODUCTION METHOD
DE60111184D1 (de) Künstiche herzklappe
NO20004133L (no) Antistoffer mot human CD40
FI972524A0 (fi) Fungisideja kasvien mustatyvitaudin säätelemiseksi
EE05067B1 (et) Aminoproplfosfiinhapped ning nende kasutamine meditsiinis
IT1289114B1 (it) Impianto automatico per la pulizia igienica post funzioni fisiologiche
EP1097199A4 (en) 71 HUMAN SECRETED PROTEINS
FI980114L (fi) Puunkorjuumenetelmä ja harvesteripää sen toteuttamiseksi
AU6539000A (en) Composition and method for treating disease by increasing activated alpha2 macroglobulin in the blood and extravascular tissue
EP1244443A4 (en) METHOD FOR INCREASING THE CONCENTRATION OF ASCORBIC ACID IN THE BRAIN TISSUE OF A SUBJECT
EP1323425A4 (en) CONNECTION TO REDUCE NEUTRAL FATS IN BLUR
NO20014848D0 (no) Fremgangsmåte for anvendelse av Emamectin ved behandling av fiskeparasitter
NO20020207L (no) Biologiske materialer og fremgangsmåter som er nyttige ved diagnostisering og behandling av sykdom
FI963947L (fi) Täydellisesti liuennut luukudos ja menetelmä sen valmistamiseksi
PT1226837E (pt) Coracao artificial ortotopico total
NZ513780A (en) Heart abnormalities in vascular endothelial growth factor B (VEGF-B) deficient animals and methods relating to these heart abnormalities
PT1228031E (pt) Derivados do acido 15-hidroxieicosatetraenoico modificados na cadeia omega e sua utilizacao no tratamento da secura ocular
EP1228082A4 (en) HUMAN SECRETED PROTEINS 29
ITMO20000182A0 (it) Organo bioartificiale per ospitare cellule animali e-o umane
DE69525903D1 (de) Ballenpresse und Verfahren um das Halmgut zu bearbeiten
AU7686400A (en) Ribozymes to growth factor originating in human platelet
GB2348134B (en) Improvements in or relating to sphygmomanometers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010917

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20020705

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020924