JP2004510772A5 - - Google Patents
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- Publication number
- JP2004510772A5 JP2004510772A5 JP2002532439A JP2002532439A JP2004510772A5 JP 2004510772 A5 JP2004510772 A5 JP 2004510772A5 JP 2002532439 A JP2002532439 A JP 2002532439A JP 2002532439 A JP2002532439 A JP 2002532439A JP 2004510772 A5 JP2004510772 A5 JP 2004510772A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- pyrrolo
- thienyl
- formula
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000001420 pyrrolonyl group Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000003857 carboxamides Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00810886A EP1193267A1 (en) | 2000-09-27 | 2000-09-27 | Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases |
| EP00810886.2 | 2000-09-27 | ||
| PCT/IB2001/001771 WO2002028856A1 (en) | 2000-09-27 | 2001-09-27 | Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein junkinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510772A JP2004510772A (ja) | 2004-04-08 |
| JP2004510772A5 true JP2004510772A5 (https=) | 2012-01-19 |
| JP4927306B2 JP4927306B2 (ja) | 2012-05-09 |
Family
ID=8174936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532439A Expired - Fee Related JP4927306B2 (ja) | 2000-09-27 | 2001-09-27 | タンパク質Ｊｕｎ−キナーゼのインヒビターとしての医薬的活性親水性スルホンアミド誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040077632A1 (https=) |
| EP (2) | EP1193267A1 (https=) |
| JP (1) | JP4927306B2 (https=) |
| AU (2) | AU8799001A (https=) |
| CA (1) | CA2421417A1 (https=) |
| ES (1) | ES2392039T3 (https=) |
| IL (1) | IL154966A0 (https=) |
| WO (1) | WO2002028856A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1193268A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases |
| EP1193256A1 (en) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| ES2318041T3 (es) * | 2001-07-23 | 2009-05-01 | Laboratoires Serono Sa | Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales. |
| AU2004271741A1 (en) * | 2003-09-12 | 2005-03-24 | Laboratoires Serono Sa | Sulfonamide derivatives for the treatment of diabetes |
| JP5080241B2 (ja) * | 2004-04-08 | 2012-11-21 | メルク セローノ ソシエテ アノニム | Ｊｎｋ阻害剤およびスクロスポリンを含んでなる組成物 |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| WO2007141224A2 (en) * | 2006-06-02 | 2007-12-13 | Laboratoires Serono Sa | Jnk inhibitors for treatment of skin diseases |
| US20100240720A1 (en) * | 2009-03-20 | 2010-09-23 | Burnham Institute For Medical Research | Allosteric jnk inhibitors |
| WO2011060321A1 (en) | 2009-11-16 | 2011-05-19 | Chdi, Inc. | Transglutaminase tg2 inhibitors, pharmaceutical compositions, and methods of use thereof |
| US8889716B2 (en) | 2011-05-10 | 2014-11-18 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
| CN112663077B (zh) * | 2021-01-11 | 2022-07-01 | 陕西师范大学 | 一种苯并磺内酰胺类化合物的电化学制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2553414B1 (fr) * | 1983-10-18 | 1986-08-14 | Choay Sa | Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques |
| WO1991013872A1 (en) | 1990-03-15 | 1991-09-19 | The Upjohn Company | Therapeutically useful heterocyclic indole compounds |
| US5106983A (en) | 1990-04-30 | 1992-04-21 | The United States Of America As Represented By The Secretary Of The Army | Process of making carfentanil and related analgesics |
| US5238950A (en) * | 1991-12-17 | 1993-08-24 | Schering Corporation | Inhibitors of platelet-derived growth factor |
| US5576313A (en) | 1994-08-29 | 1996-11-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5744320A (en) * | 1995-06-07 | 1998-04-28 | Promega Corporation | Quenching reagents and assays for enzyme-mediated luminescence |
| EP1001764A4 (en) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| AR019322A1 (es) * | 1998-06-18 | 2002-02-13 | Smithkline Beecham Corp | Derivados de sulfonilo sustituido por heterociclo-etanodionanilina sustituida por heterociclo, composicion farmaceutica que los contiene y su uso para lamanufactura de un medicamento |
| CN1332943C (zh) * | 1998-07-08 | 2007-08-22 | 萨诺费－阿文蒂斯德国有限公司 | 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂 |
| EP1088821A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
| EP1193256A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| EP1193268A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases |
-
2000
- 2000-09-27 EP EP00810886A patent/EP1193267A1/en not_active Withdrawn
-
2001
- 2001-09-27 IL IL15496601A patent/IL154966A0/xx unknown
- 2001-09-27 JP JP2002532439A patent/JP4927306B2/ja not_active Expired - Fee Related
- 2001-09-27 AU AU8799001A patent/AU8799001A/xx active Pending
- 2001-09-27 CA CA002421417A patent/CA2421417A1/en not_active Abandoned
- 2001-09-27 AU AU2001287990A patent/AU2001287990B2/en not_active Ceased
- 2001-09-27 US US10/381,200 patent/US20040077632A1/en not_active Abandoned
- 2001-09-27 ES ES01967621T patent/ES2392039T3/es not_active Expired - Lifetime
- 2001-09-27 EP EP01967621A patent/EP1322641B1/en not_active Expired - Lifetime
- 2001-09-27 WO PCT/IB2001/001771 patent/WO2002028856A1/en not_active Ceased
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