JP2004509845A - 治療剤及び診断剤としての新規ポリアミン類似体 - Google Patents
治療剤及び診断剤としての新規ポリアミン類似体 Download PDFInfo
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- JP2004509845A JP2004509845A JP2002500833A JP2002500833A JP2004509845A JP 2004509845 A JP2004509845 A JP 2004509845A JP 2002500833 A JP2002500833 A JP 2002500833A JP 2002500833 A JP2002500833 A JP 2002500833A JP 2004509845 A JP2004509845 A JP 2004509845A
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
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- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
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- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
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- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
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- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
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- C07C2603/58—Ring systems containing bridged rings containing three rings
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Applications Claiming Priority (2)
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US09/584,175 US6646149B1 (en) | 1997-07-15 | 2000-05-31 | Polyamine analogues as therapeutic and diagnostic agents |
PCT/US2001/017795 WO2001092218A2 (en) | 2000-05-31 | 2001-05-31 | Polyamine analogues as therapeutic and diagnostic agents |
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JP2004509845A true JP2004509845A (ja) | 2004-04-02 |
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JP2002500833A Pending JP2004509845A (ja) | 2000-05-31 | 2001-05-31 | 治療剤及び診断剤としての新規ポリアミン類似体 |
Country Status (8)
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004529082A (ja) * | 2001-01-08 | 2004-09-24 | メディクエスト セラピューティックス インク | 疎水性ポリアミン類似体及びそれらの使用方法 |
WO2008105441A1 (ja) * | 2007-02-27 | 2008-09-04 | Ajinomoto Co., Inc. | リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 |
JP2019509349A (ja) * | 2016-03-24 | 2019-04-04 | オーバス セラピューティクス インコーポレイテッド | 神経膠腫を含むがんを処置するためのエフロルニチンおよびその誘導体および類似体の組成物ならびにそれらの使用方法 |
US11439612B2 (en) | 2016-10-06 | 2022-09-13 | Orbus Therapeutics, Inc. | Formulations for administration of eflornithine |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1088815A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
AU2002235126A1 (en) * | 2000-11-08 | 2002-05-21 | Slil Biomedical Corporation | Novel polyamine analog-amino acid conjugates useful as anticancer agents |
US7144920B2 (en) | 2002-09-23 | 2006-12-05 | Mediquest Therapeutics, Inc. | Polyamine analogs that activate antizyme frameshifting |
US20070088081A1 (en) * | 2002-09-27 | 2007-04-19 | Research Foundation Of The University Of Central Florida Incorporated | Polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs |
GB0223563D0 (en) * | 2002-10-10 | 2002-11-20 | Secr Defence | Detection system |
AU2005214149A1 (en) * | 2004-02-19 | 2005-09-01 | F2G Ltd | 2031 oxidoreductase |
GB2414477A (en) * | 2004-05-25 | 2005-11-30 | Hunter Fleming Ltd | Novel polyamines and their therapeutic use |
JP2008502618A (ja) * | 2004-06-14 | 2008-01-31 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 皮脂産生および毛穴サイズを低下させる方法 |
US7199267B1 (en) * | 2005-10-21 | 2007-04-03 | Mediquest Therapeutics, Inc. | Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases |
US7411002B2 (en) * | 2006-06-07 | 2008-08-12 | The University Of Kansas | Polycationic sulfonamides and use thereof |
JP5327669B2 (ja) * | 2006-11-15 | 2013-10-30 | 学校法人日本大学 | 新規ポリアミン誘導体化合物 |
CN104892449B (zh) * | 2014-03-06 | 2017-06-13 | 天津红日药业股份有限公司 | 一种精胺类似物及其药用盐的制备方法和用途 |
KR102454783B1 (ko) | 2016-03-25 | 2022-10-13 | 아미넥스 테라퓨틱스, 인크. | 생체이용가능한 폴리아민 |
EP4221698A1 (en) | 2020-09-30 | 2023-08-09 | Aminex Therapeutics, Inc. | Combination drug substance of polyamine transport inhibitor and dfmo |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999003823A2 (en) * | 1997-07-15 | 1999-01-28 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
WO1999054283A1 (en) * | 1998-04-21 | 1999-10-28 | Universite Laval | Polyamine transport inhibitors |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4309442A (en) | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
US4590288A (en) * | 1983-06-29 | 1986-05-20 | Exxon Research And Engineering Co. | Bi- or polymetallic coordination complex |
HU200093B (en) | 1983-12-20 | 1990-04-28 | Adam Kovacs | Process for production of medical compositions against tumour |
DE3568063D1 (en) * | 1985-01-10 | 1989-03-09 | Molecular Diagnostics Inc | Photochemical method of labelling nucleic acids for detection in hybridization assays |
US4818770A (en) | 1986-10-22 | 1989-04-04 | Boyce Thompson Institute For Plant Research | Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis |
US5342945A (en) | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
US5312928A (en) | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
DE69434889D1 (de) | 1994-02-08 | 2007-01-11 | Nps Pharma Inc | An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen |
WO1996022962A1 (en) | 1995-01-23 | 1996-08-01 | The Trustees Of Columbia University In The City Of New York | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same |
US5583239A (en) | 1995-05-30 | 1996-12-10 | Lehigh University | Antimicrobial sterol conjugates |
CA2318004A1 (en) * | 1999-09-15 | 2001-03-15 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
-
2000
- 2000-05-31 US US09/584,175 patent/US6646149B1/en not_active Expired - Fee Related
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2001
- 2001-05-31 KR KR1020027016255A patent/KR100851452B1/ko not_active IP Right Cessation
- 2001-05-31 WO PCT/US2001/017795 patent/WO2001092218A2/en not_active Application Discontinuation
- 2001-05-31 JP JP2002500833A patent/JP2004509845A/ja active Pending
- 2001-05-31 CN CNA018105106A patent/CN1512982A/zh active Pending
- 2001-05-31 AU AU2001268139A patent/AU2001268139A1/en not_active Abandoned
- 2001-05-31 CA CA002410935A patent/CA2410935A1/en not_active Abandoned
- 2001-05-31 EP EP01946044A patent/EP1317424A2/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999003823A2 (en) * | 1997-07-15 | 1999-01-28 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
WO1999054283A1 (en) * | 1998-04-21 | 1999-10-28 | Universite Laval | Polyamine transport inhibitors |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004529082A (ja) * | 2001-01-08 | 2004-09-24 | メディクエスト セラピューティックス インク | 疎水性ポリアミン類似体及びそれらの使用方法 |
WO2008105441A1 (ja) * | 2007-02-27 | 2008-09-04 | Ajinomoto Co., Inc. | リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 |
JP2019509349A (ja) * | 2016-03-24 | 2019-04-04 | オーバス セラピューティクス インコーポレイテッド | 神経膠腫を含むがんを処置するためのエフロルニチンおよびその誘導体および類似体の組成物ならびにそれらの使用方法 |
US11439612B2 (en) | 2016-10-06 | 2022-09-13 | Orbus Therapeutics, Inc. | Formulations for administration of eflornithine |
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KR20030007768A (ko) | 2003-01-23 |
EP1317424A2 (en) | 2003-06-11 |
WO2001092218A2 (en) | 2001-12-06 |
CA2410935A1 (en) | 2001-12-06 |
KR100851452B1 (ko) | 2008-08-08 |
CN1512982A (zh) | 2004-07-14 |
WO2001092218A3 (en) | 2003-03-27 |
US6646149B1 (en) | 2003-11-11 |
AU2001268139A1 (en) | 2001-12-11 |
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