JP2004500878A - Clk−2、cex−7およびcoq−4遺伝子ならびにその使用 - Google Patents

Clk−2、cex−7およびcoq−4遺伝子ならびにその使用 Download PDF

Info

Publication number
JP2004500878A
JP2004500878A JP2002504626A JP2002504626A JP2004500878A JP 2004500878 A JP2004500878 A JP 2004500878A JP 2002504626 A JP2002504626 A JP 2002504626A JP 2002504626 A JP2002504626 A JP 2002504626A JP 2004500878 A JP2004500878 A JP 2004500878A
Authority
JP
Japan
Prior art keywords
clk
gene
protein
coq
physiological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002504626A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004500878A5 (https=
Inventor
ヘキミ,ジークフリード
ベナルド,クレア
マックライト,ブレント
ラコウスキー,ベルナルド
ハン,ドン
ラビー,ジャン−クラウド
Original Assignee
マックギル ユニヴァーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マックギル ユニヴァーシティー filed Critical マックギル ユニヴァーシティー
Publication of JP2004500878A publication Critical patent/JP2004500878A/ja
Publication of JP2004500878A5 publication Critical patent/JP2004500878A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
JP2002504626A 2000-06-22 2001-06-20 Clk−2、cex−7およびcoq−4遺伝子ならびにその使用 Pending JP2004500878A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21317400P 2000-06-22 2000-06-22
US25493200P 2000-12-13 2000-12-13
PCT/CA2001/000913 WO2001098478A2 (en) 2000-06-22 2001-06-20 Clk-2, cex-7 and coq-4 genes, and uses thereof

Publications (2)

Publication Number Publication Date
JP2004500878A true JP2004500878A (ja) 2004-01-15
JP2004500878A5 JP2004500878A5 (https=) 2005-02-17

Family

ID=26907831

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002504626A Pending JP2004500878A (ja) 2000-06-22 2001-06-20 Clk−2、cex−7およびcoq−4遺伝子ならびにその使用

Country Status (7)

Country Link
US (2) US20030162291A1 (https=)
EP (1) EP1325124A2 (https=)
JP (1) JP2004500878A (https=)
AU (1) AU2001272238A1 (https=)
CA (1) CA2413452A1 (https=)
IL (1) IL153573A0 (https=)
WO (1) WO2001098478A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1325124A2 (en) * 2000-06-22 2003-07-09 McGILL UNIVERSITY Clk-2, cex-7 and coq-4 genes, and uses thereof
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
US7329495B2 (en) 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
US8361976B2 (en) 2004-07-09 2013-01-29 University Of Massachusetts Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
WO2006037224A1 (en) * 2004-10-06 2006-04-13 Mcgill University Isolated clk-1 -i- cells from clk-1 heterozygous animals and their use in treating oxidative stress disorders
ATE544071T1 (de) * 2005-03-03 2012-02-15 Sirtris Pharmaceuticals Inc Fluoreszenzpolarisationstests für die acetyltransferase-deacetylase-aktivität
JP5514401B2 (ja) 2005-09-21 2014-06-04 国立大学法人広島大学 Gテイル配列の長さ測定方法及びそれに用いるキット
AU2006339607A1 (en) * 2005-12-02 2007-09-13 Sirtris Pharmaceuticals, Inc. Modulators of Cdc2-like kinases (Clks) and methods of use thereof
EP1955077B1 (en) * 2005-12-02 2012-06-13 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase/deacetylase activity
TW201803890A (zh) 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0932701A1 (en) * 1996-10-21 1999-08-04 McGILL UNIVERSITY STRUCTURAL AND FUNCTIONAL CONSERVATION OF THE C. ELEGANS CLOCK GENE clk-1
EP1325124A2 (en) * 2000-06-22 2003-07-09 McGILL UNIVERSITY Clk-2, cex-7 and coq-4 genes, and uses thereof

Also Published As

Publication number Publication date
EP1325124A2 (en) 2003-07-09
US20030199002A1 (en) 2003-10-23
US20030162291A1 (en) 2003-08-28
IL153573A0 (en) 2003-07-06
WO2001098478A3 (en) 2003-05-01
CA2413452A1 (en) 2001-12-27
AU2001272238A1 (en) 2002-01-02
WO2001098478A2 (en) 2001-12-27

Similar Documents

Publication Publication Date Title
Bénard et al. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
Inoue et al. Targets of TGF-β signaling in Caenorhabditis elegans dauer formation
Sieburth et al. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans
de Nooij et al. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
Feng et al. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans
Wang et al. The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
van der Linden et al. The G-protein β-subunit GPB-2 in Caenorhabditis elegans regulates the Goα-Gqα signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16
Calgaro et al. The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus
Graw et al. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse
Kuroyanagi et al. SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development
JP2004500878A (ja) Clk−2、cex−7およびcoq−4遺伝子ならびにその使用
Charroux et al. The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells
JPWO2003004637A1 (ja) 体重または摂食量の調節に関与するヒスタミン受容体h3遺伝子の利用
Rushforth et al. Functions of the Caenorhabditis elegans regulatory myosin light chain genes mlc-1 and mlc-2
Hayashizaki et al. Characterization of the C. elegans gap‐2 gene encoding a novel Ras‐GTPase activating protein and its possible role in larval development
WO2001018549A1 (en) Method for identifying modulators of daf-16
WO1999054436A2 (en) Nucleic acids and proteins of c. elegans insulin-like genes and uses thereof
Yoo et al. Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis
Kasravi et al. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster
JP2004522408A (ja) プレセニリンエンハンサー
Althoff et al. Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions
Ji et al. Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans
Kwon et al. The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans
US20040127444A1 (en) Poly-(ADP) ribose polymerase enzyme and uses thereof
US20050054592A1 (en) Identification of ses-1 and the uses of the same