JP2004500380A5 - - Google Patents
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- Publication number
- JP2004500380A5 JP2004500380A5 JP2001559460A JP2001559460A JP2004500380A5 JP 2004500380 A5 JP2004500380 A5 JP 2004500380A5 JP 2001559460 A JP2001559460 A JP 2001559460A JP 2001559460 A JP2001559460 A JP 2001559460A JP 2004500380 A5 JP2004500380 A5 JP 2004500380A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cell proliferation
- rheumatoid arthritis
- treating rheumatoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18263500P | 2000-02-15 | 2000-02-15 | |
| PCT/US2001/004095 WO2001060363A1 (en) | 2000-02-15 | 2001-02-08 | A method for synthesizing leflunomide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004500380A JP2004500380A (ja) | 2004-01-08 |
| JP2004500380A5 true JP2004500380A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
Family
ID=22669359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559460A Pending JP2004500380A (ja) | 2000-02-15 | 2001-02-08 | レフルノミドの合成方法 |
Country Status (18)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2150808T3 (es) * | 1997-08-08 | 2000-12-01 | Aventis Pharma Gmbh | Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico. |
| AU779931B2 (en) * | 1999-12-16 | 2005-02-17 | Teva Pharmaceutical Industries Ltd. | Novel processes for making- and a new crystalline form of- leflunomide |
| GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US20030139606A1 (en) * | 2001-11-09 | 2003-07-24 | Ray Anup Kumar | Process for preparing 5-methylisoxazole-4-carboxylic- (4'-trifluoromethyl)-anilide |
| RU2365373C2 (ru) * | 2003-05-27 | 2009-08-27 | Роберт Пер Хэгерквист | Применение ингибитора тирозинкиназы для лечения диабета |
| AU2003300692A1 (en) * | 2003-10-30 | 2005-05-19 | Lupin Ltd. | Stable formulations of ace inhibitors and methods for preparation thereof |
| US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
| DE102005017592A1 (de) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
| WO2007086076A2 (en) * | 2006-01-24 | 2007-08-02 | Unichem Laboratories Limited | An improved process for preparation of leflunomide |
| CN101817797B (zh) * | 2009-02-26 | 2013-04-10 | 江苏亚邦爱普森药业有限公司 | 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法 |
| KR101547880B1 (ko) | 2009-09-18 | 2015-08-27 | 사노피 | 향상된 안정성을 갖는 (ｚ)-2-시아노-3-하이드록시-부트-2-엔산-(4''-트리플루오로메틸페닐)-아미드 정제 제형 |
| CN102002009B (zh) * | 2010-10-18 | 2012-11-07 | 齐鲁制药有限公司 | 一种5-甲基异恶唑-4-甲酰氯的制备方法 |
| RU2722316C2 (ru) * | 2015-06-17 | 2020-05-29 | Биокон Лимитед | Новый способ получения терифлуномида |
| JOP20190207A1 (ar) * | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854439A1 (de) | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| GB8619432D0 (en) | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| JP2995086B2 (ja) * | 1990-05-18 | 1999-12-27 | ヘキスト・アクチエンゲゼルシヤフト | イソオキサゾール−４−カルボキサミド類およびヒドロキシアルキリデンシアノアセトアミド類を含有する製剤 |
| ATE174218T1 (de) | 1993-01-08 | 1998-12-15 | Hoechst Ag | Verwendung von leflunomid zur hemmung von interleukin 1 beta |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| ES2150808T3 (es) * | 1997-08-08 | 2000-12-01 | Aventis Pharma Gmbh | Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico. |
| DE19908527C2 (de) * | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| AU779931B2 (en) * | 1999-12-16 | 2005-02-17 | Teva Pharmaceutical Industries Ltd. | Novel processes for making- and a new crystalline form of- leflunomide |
-
2001
- 2001-02-08 AU AU2001234943A patent/AU2001234943A1/en not_active Abandoned
- 2001-02-08 AT AT01907127T patent/ATE292966T1/de not_active IP Right Cessation
- 2001-02-08 HU HU0301865A patent/HUP0301865A3/hu unknown
- 2001-02-08 US US09/779,928 patent/US6723855B2/en not_active Expired - Fee Related
- 2001-02-08 IL IL15119601A patent/IL151196A0/xx unknown
- 2001-02-08 KR KR1020027010595A patent/KR20020072312A/ko not_active Ceased
- 2001-02-08 ES ES01907127T patent/ES2237553T3/es not_active Expired - Lifetime
- 2001-02-08 EP EP01907127A patent/EP1257270B1/en not_active Expired - Lifetime
- 2001-02-08 HR HRP20020671 patent/HRP20020671A2/hr not_active Application Discontinuation
- 2001-02-08 YU YU61602A patent/YU61602A/sh unknown
- 2001-02-08 CZ CZ20023024A patent/CZ20023024A3/cs unknown
- 2001-02-08 JP JP2001559460A patent/JP2004500380A/ja active Pending
- 2001-02-08 PL PL01366088A patent/PL366088A1/xx not_active Application Discontinuation
- 2001-02-08 DE DE60110043T patent/DE60110043T2/de not_active Expired - Fee Related
- 2001-02-08 SK SK1299-2002A patent/SK12992002A3/sk unknown
- 2001-02-08 WO PCT/US2001/004095 patent/WO2001060363A1/en not_active Ceased
- 2001-02-08 CA CA002400290A patent/CA2400290A1/en not_active Abandoned
-
2002
- 2002-08-14 ZA ZA200206494A patent/ZA200206494B/en unknown
-
2003
- 2003-12-10 US US10/730,949 patent/US20040127532A1/en not_active Abandoned
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