JP2004500008A - ストレプトマイセス属のサブチリシンの変異体と融合したプロテアーゼ - Google Patents

ストレプトマイセス属のサブチリシンの変異体と融合したプロテアーゼ Download PDF

Info

Publication number
JP2004500008A
JP2004500008A JP2000558221A JP2000558221A JP2004500008A JP 2004500008 A JP2004500008 A JP 2004500008A JP 2000558221 A JP2000558221 A JP 2000558221A JP 2000558221 A JP2000558221 A JP 2000558221A JP 2004500008 A JP2004500008 A JP 2004500008A
Authority
JP
Japan
Prior art keywords
ssi
protease
amino acid
fusion protein
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000558221A
Other languages
English (en)
Japanese (ja)
Inventor
ソーンダーズ，チャールズ　ウィンストン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of JP2004500008A publication Critical patent/JP2004500008A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
JP2000558221A 1998-07-07 1999-07-07 ストレプトマイセス属のサブチリシンの変異体と融合したプロテアーゼ Pending JP2004500008A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9190498P 1998-07-07 1998-07-07
PCT/US1999/015247 WO2000001831A2 (fr) 1998-07-07 1999-07-07 Proteases fusionnees avec des variants d'inhibiteur de subtilisine de streptomyces

Publications (1)

Publication Number Publication Date
JP2004500008A true JP2004500008A (ja) 2004-01-08

Family

ID=22230236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000558221A Pending JP2004500008A (ja) 1998-07-07 1999-07-07 ストレプトマイセス属のサブチリシンの変異体と融合したプロテアーゼ

Country Status (8)

Country Link
EP (1) EP1093522A2 (fr)
JP (1) JP2004500008A (fr)
CN (1) CN1317052A (fr)
AR (1) AR020105A1 (fr)
AU (1) AU4862499A (fr)
BR (1) BR9911891A (fr)
CA (1) CA2332177A1 (fr)
WO (1) WO2000001831A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019182914A (ja) * 2018-04-02 2019-10-24 花王株式会社 食器及び／又は台所周りの硬質物品用液体洗浄剤組成物
US11275075B2 (en) 2018-04-27 2022-03-15 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03000793A (es) 2000-07-28 2003-06-04 Henkel Kgaa Enzima amilolitica novedosa, extraida de bacilo sp a 7-7 (dsm 12368) y agentes de lavado y limpiadores que contienen esta enzima amilolitica novedosa.
JP4557108B2 (ja) * 2000-08-11 2010-10-06 ライオン株式会社 キメラ酵素及び洗浄剤組成物
AU2001272366A1 (en) * 2000-08-21 2002-03-04 Novozymes A/S Method for production of a protease-inhibitor complex
WO2002044350A2 (fr) 2000-11-28 2002-06-06 Henkel Kommanditgesellschaft Auf Aktien Nouvelle cyclodextrine-glucanotransferase (cgtase) issue de bacillus agaradherens (dsm 9948) et produits detergents et de nettoyage comprenant cette nouvelle cyclodextrine-glucanotransferase
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10343375A1 (de) * 2003-09-17 2005-04-28 Axaron Bioscience Ag Verfahren zur Detektion und Analyse von Protein-Protein-Interaktionen
DE102007032111B4 (de) 2007-07-09 2017-07-20 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen
DE102007036756A1 (de) 2007-08-03 2009-02-05 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen
CN106047892B (zh) * 2016-07-14 2019-05-10 西南交通大学 川芎α-淀粉酶/枯草杆菌蛋白酶抑制剂基因及表达产物的纯化方法
KR102641645B1 (ko) 2017-05-31 2024-02-27 비.알.에이.아이.엔. 바이오테그놀로지 리서치 앤드 인포메이션 네크워크 아게 숙주 세포에서의 세린 프로테아제 발현의 최적화
CN113166231A (zh) 2018-10-10 2021-07-23 诺维信公司 胰凝乳蛋白酶抑制剂变体及其用途
EP3875591A4 (fr) * 2018-10-31 2022-09-21 Qingdao Vland Biotech Group Co. Ltd. Procédé de production d'une enzyme pour détergent ayant une résistance aux protéases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506393A (ja) * 1996-09-24 2000-05-30 ザ、プロクター、エンド、ギャンブル、カンパニー プロテアーゼ、及びペプチドプロテアーゼインヒビターを融合したそれらの変種
JP2000506394A (ja) * 1996-09-24 2000-05-30 ザ、プロクター、エンド、ギャンブル、カンパニー 安定化されたタンパク質性プロテアーゼインヒビターおよびその変種

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019182914A (ja) * 2018-04-02 2019-10-24 花王株式会社 食器及び／又は台所周りの硬質物品用液体洗浄剤組成物
JP7073170B2 (ja) 2018-04-02 2022-05-23 花王株式会社 食器及び／又は台所周りの硬質物品用液体洗浄剤組成物
US11275075B2 (en) 2018-04-27 2022-03-15 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same

Also Published As

Publication number Publication date
CN1317052A (zh) 2001-10-10
AU4862499A (en) 2000-01-24
BR9911891A (pt) 2001-03-27
EP1093522A2 (fr) 2001-04-25
CA2332177A1 (fr) 2000-01-13
WO2000001831A3 (fr) 2000-04-13
AR020105A1 (es) 2002-04-10
WO2000001831A2 (fr) 2000-01-13

Similar Documents

Publication Publication Date Title
JP3642735B2 (ja) プロテアーゼ複合体
JP2002507426A (ja) アミノ酸置換を有するセリンプロテアーゼ変異体
JPH09510363A (ja) 非タンパク質プロテアーゼ抑制剤を使用するプロテアーゼ酵素の製造
JP2004500008A (ja) ストレプトマイセス属のサブチリシンの変異体と融合したプロテアーゼ
CA2376045A1 (fr) Proteases variantes de la subtilisine par substitutions acide amine dans des regions definies de l'epitope
JP2004500007A (ja) ストレプトマイセス属のサブチリシンインヒビターの安定化変異体
CA2379712A1 (fr) Variants de protease subtilisine possedant des suppressions et des substitutions d'acides amines dans certaines regions de sites antigeniques
JP2002518993A (ja) アミノ酸欠失および置換を有するセリンプロテアーゼ変異体
JP2003516116A (ja) 立体的に保護されたクリップ部位を有するプロテアーゼ抱合体
JP2000506394A (ja) 安定化されたタンパク質性プロテアーゼインヒビターおよびその変種
CA2379723A1 (fr) Conjugues de protease comprenant des regions epitope protegees steriquement
MXPA01000304A (en) Proteases fused with variants of streptomyces subtilisin inhibitor
MXPA01000302A (en) Stabilized variants of streptomyces
CA2379718A1 (fr) Proteases de subtisiline a reticulation intermoleculaire a antigenicite reduite
MXPA00009385A (en) Protease conjugates
CZ20003397A3 (cs) Varianta serinové proteázy; prostředek pro osobní hygienu, čistící prostředek, mutovaný gen
CZ20003396A3 (cs) Proteázový konjugát a prostředek osobní hygieny
CZ20003394A3 (cs) Varianta serinové proteázy, mutovaný gen, prostředek pro osobní hygienu

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20040727

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20041027

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20041119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20050322