JP2004249087A - Blood processing filter system and filter thereof - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood processing filter system with a shorter bypass flow passage allowing good operation and enabling, for example, air or the like to be easily and surely exhausted from a second container. <P>SOLUTION: The blood processing filter system 1 includes a blood sampling bag 2, a filter 4 and a bag 3 to store the blood filtered by the filter 4. A first inlet 45 of the filter 4 is connected with one end of a tube 8 and the other end is closed. One end of a tube 9 is connected with an outlet 47 of the filter 4, and the other end is connected with the bag 3. To a branch connecter 12 mounted on the halfway of the tube 9, one end of a tube 11 is connected and the other end is connected to a second inlet 46 of the filter 4. On the halfway of the tube 11, a check valve 14 is provided. The first inlet 45, the second inlet 46 and the outlet 47 are formed with tubular projections respectively. The projections of the second inlet 46 and the outlet 47 have different outer diameters in order to avoid misconnection. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

  The present invention relates to a blood processing filter system and a filter.

  In a blood processing filter system for processing blood, for example, a blood processing filter system in which a leukocyte removal filter and bags are connected in advance, the blood in the first container is filtered by a filter (white blood cells are separated) and the second blood is filtered. And the blood in the second container is separated into components by means such as centrifugation.

  In this blood processing filter system, when blood in the first container is filtered by the filter and stored in the second container, unnecessary components (for example, air) previously contained in the filter or the like are removed from the second container. Means for discharging (removing) unnecessary components in the second container is provided in order to prevent the components contained in the container from adversely affecting the separation operation.

  As a blood processing filter system provided with such a means for discharging unnecessary components in the second container, a bypass circuit (bypass flow path) for bypassing the filter is provided, and the second circuit is provided via the bypass circuit. In some cases, unnecessary components in the container are discharged to the first container.

  As a typical example, one having a bypass circuit in which one end is connected to an inlet channel between a first container and a filter inlet side and the other end is directly connected to a second container (for example, see Patent Document 1) 1) or a bypass circuit having one end connected to the inlet channel between the first container and the filter inlet and the other end connected to the outlet channel between the filter outlet and the second container. (For example, see Patent Document 2).

  However, the conventional blood processing filter system has a drawback that the length of the bypass circuit is long, so that blood remaining in the bypass circuit increases and operability is poor.

  Further, in such a blood processing filter system, at the time of assembling, a tube constituting a corresponding flow path is connected to each port of the filter to form the entire circuit, but the connected tubes have no apparent distinction. In some cases, erroneous connection of a flow path, that is, connection of a tube to a different port by mistake, may occur.

Japanese Patent Publication No. Hei 8-500532 Japanese Patent Publication No. Hei 8-500509

  An object of the present invention is to provide a blood processing filter system in which the length of a bypass flow path is short, operability is good, and, for example, air or the like can be easily and reliably discharged from a second container.

  Another object of the present invention is to provide a blood processing filter system and a filter that can prevent erroneous connection of flow paths during assembly.

Such an object is achieved by the present invention described in the following (1) to (18).
(1) A blood processing filter system for processing blood,
A filter having a housing, a filter medium for partitioning the housing into an inflow chamber and an outflow chamber, a first inflow port and a second inflow port communicating with the inflow chamber, and an outflow port communicating with the outflow chamber; ,
A first flow path having one end communicating with the first inflow port and the other end communicating with a first container for storing blood;
A second container for storing the blood that has passed through the filter medium of the filter,
A second flow path having one end communicating with the outlet and the other end communicating with the second container;
A blood processing filter system comprising: a third flow path having one end communicating with the second flow path and the other end communicating with the second inflow port.

  (2) The air in the second container is filled with the second flow path, the third flow path, the second inlet, the inflow chamber, the first inlet, and the first flow. The blood processing filter system according to (1), wherein the blood processing filter system is delivered to the first container via a path in this order.

  (3) a second flow path regulating means for regulating the flow of the fluid flowing through the second flow path located on the filter side from the junction of the second flow path and the third flow path. The blood processing filter system according to the above (1) or (2).

(4) a blood processing filter system for processing blood,
A filter having a housing, a filter medium for partitioning the housing into an inflow chamber and an outflow chamber, a first inflow port and a second inflow port communicating with the inflow chamber, and an outflow port communicating with the outflow chamber; ,
A first flow path having one end communicating with the first inflow port and the other end communicating with a first container for storing blood;
A second container for storing the blood that has passed through the filter medium of the filter,
A second flow path having one end communicating with the outlet and the other end communicating with the second container;
A blood processing filter system comprising: a third flow path having one end communicating with the second container and the other end communicating with the second inlet.

  (5) The air in the second container passes through the third channel, the second inlet, the inflow chamber, the first inlet, and the first channel in this order. The blood processing filter system according to the above (4), wherein the blood processing filter system is sent to the first container.

  (6) The blood processing filter system according to the above (4) or (5), further comprising a second flow path regulating means for regulating a flow of a fluid flowing through the second flow path.

  (7) The blood processing filter system according to any one of (1) to (6), further including a third flow path regulating unit that regulates a flow of a fluid flowing through the third flow path.

  (8) The third flow path regulating means is a backflow preventing means that allows a fluid to flow from the second container side to the filter side and prevents a fluid from flowing in the opposite direction. The blood processing filter system according to the above (7).

  (9) The device according to any one of (1) to (8), further including the first container, wherein the first container communicates with the other end of the first flow path. Blood processing filter system.

(10) a blood collection needle for collecting blood from a donor,
The blood processing filter system according to (9), further including a fourth channel having one end communicating with the first container and the other end communicating with the blood collection needle.

  (11) In the filter, the first inlet is provided at one end of the housing, and the second inlet and the outlet are provided side by side at the other end of the housing. The blood processing filter system according to any one of (1) to (10).

  (12) An erroneous connection preventing means for preventing the erroneous connection of the second flow path and the third flow path to the outflow port and the second inflow port when assembling the blood processing filter system. The blood processing filter system according to the above (11), comprising:

  (13) The second inflow port and the outflow port are each formed of a protrusion projecting in a tubular shape, and the outer diameters of the second inflow port and the outflow port are different from each other. The blood processing filter system according to the above (11) or (12), wherein

  (14) Each of the second inflow port and the outflow port has a protrusion protruding in a tubular shape, and the inner diameters of the second inflow port and the outflow port are different from each other. The blood processing filter system according to the above (11) or (12).

  (15) The second flow path and the third flow path are connected to the outflow port and the second inflow port via an adapter, and the adapter is connected to the outflow port and the second outflow port. The blood processing filter system according to the above (11) or (12), wherein the blood processing filter system is configured so that the mounting direction with respect to the inlet can be mounted only in an appropriate direction.

(16) A housing, and a filter medium for partitioning the inside of the housing into an inflow chamber and an outflow chamber, wherein the housing has a first inflow port and a second inflow port communicating with the inflow chamber, and the outflow chamber. And an outlet communicating with the filter,
The first inflow port is provided on one end side of the housing, the second inflow port and the outflow port are provided side by side on the other end side of the housing, and the first inflow port and the first inflow port are provided. The two inlets and the outlets are each constituted by a protruding portion projecting in a tubular shape,
A filter wherein the outer diameter and / or inner diameter of the protrusion of the second inlet and the protrusion of the outlet are different from each other.

(17) Used in the blood treatment filter system according to any one of (1) to (10) above, comprising a housing, and a filter medium for partitioning the inside of the housing into an inflow chamber and an outflow chamber. A filter provided with a first inflow port and a second inflow port communicating with the inflow chamber, and an outflow port communicating with the outflow chamber,
The first inflow port is provided on one end side of the housing, the second inflow port and the outflow port are provided side by side on the other end side of the housing, and the first inflow port and the first inflow port are provided. The two inlets and the outlets are each constituted by a protruding portion projecting in a tubular shape,
A filter wherein the outer diameter and / or inner diameter of the protrusion of the second inlet and the protrusion of the outlet are different from each other.

  (18) The second flow path and the third flow path are connected to the outflow port and the second inflow port via an adapter, and the adapter is connected to the outflow port and the second outflow port. The filter according to the above (16) or (17), wherein the filter can be mounted only in an appropriate direction with respect to the inlet.

  ADVANTAGE OF THE INVENTION According to this invention, the air etc. which were accommodated in the 2nd container, for example, can be discharged | emitted (recovered) to a 1st container easily and reliably.

Further, the bypass circuit (bypass channel) using the third channel is provided between the middle of the second channel and the second inlet of the filter, or between the second container and the second container of the filter. Since it is provided between the inlet and the inlet, the length of the bypass circuit is short and the operability is good.
Further, according to the present invention, it is possible to prevent erroneous connection of the flow path (circuit) during assembly.

  Hereinafter, a blood processing filter system and a filter of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

  FIG. 1 is a plan view schematically showing a first embodiment of the blood processing filter system of the present invention.

  A blood processing filter system 1 shown in FIG. 1 is a system for filtering (separating) a target unnecessary substance from blood, and includes a blood collection bag (first container) 2 for storing collected blood, and a target And a bag (second container) 3 for storing the blood filtered by the filter 4.

Here, the blood includes not only whole blood but also blood components such as red blood cells, plasma, and platelets.
Unwanted substances include, for example, leukocytes, platelets, microaggregates, viruses, bacteria, prions, and pathogenic substances.

  When the unnecessary matter is a leukocyte, the blood processing filter system 1 may separate one or more of lymphocytes, granulocytes, and monocytes.

  When the unwanted matter is a virus, examples of the virus include HAV, HBV, HCV, HIV, HTLV-I, CMV, parvovirus B19, fillovirus, and hantavirus.

  As shown in FIG. 1, one end of a flexible tube 6 is connected to the lower side of the blood collection bag 2 in FIG. 1 so as to communicate with the inside of the blood collection bag 2 (blood storage portion). A blood sampling needle 5 is attached to the end via a hub 51. The hub 51 is provided with a cap (not shown) that encloses the blood collection needle 5. The main part of the fourth flow path is constituted by the lumen of the tube 6.

  A lower end of the blood collection bag 2 in FIG. 1 is connected to one end of a flexible tube 7 that communicates with the blood collection bag 2, and the other end of the tube 7 is closed. The other end of the tube 7 constitutes a connecting portion of the filter 4 connected to a tube 8 described later.

  Further, it is preferable that an anticoagulant is put in the blood collection bag 2 in advance. This anticoagulant is usually a liquid, and examples thereof include an ACD-A solution, a CPD solution, a CPDA-1 solution, and a heparin sodium solution. The amount of these anticoagulants is an appropriate amount according to the expected blood collection amount.

  As a constituent material of the blood collection bag 2, for example, a material mainly composed of polyvinyl chloride, soft polyvinyl chloride, soft polyvinyl chloride (for example, a copolymer with a small amount of another polymer material, a polymer blend, a polymer alloy) Etc.), ethylene-vinyl acetate copolymer and the like.

  The filter 4 has a housing 41 and a filter medium (filter medium) 42 provided in the housing 41. The filter medium 42 is provided so as to partition (divide) the inside of the housing 41 into an inflow chamber (inflow space) 43 and an outflow chamber (outflow space) 44. The housing 41 has a first inlet 45 and a second inlet 46 communicating with the inflow chamber 43, and an outlet 47 communicating with the outflow chamber 43.

  The shapes and structures of the first inflow port 45, the second inflow port 46, and the outflow port 47 are not particularly limited, but as will be described later, these are each configured by a protruding portion (tubular protruding portion) that protrudes in a tubular shape. It is preferable that the ends of the tubes 8, 11, 9 can be connected to the tubular protrusion.

  In this case, the tubular protrusions forming the first inlet 45, the second inlet 46, and the outlet 47 are preferably fitted and connected to the lumen of the tube (see FIG. 5). A connection may be made by fitting a tube into the lumen of the protruding portion (see FIG. 6).

  As a constituent material of the housing 41 of the filter 4, polycarbonate, polyvinyl chloride, soft polyvinyl chloride, ethylene-vinyl acetate copolymer, acrylonitrile-butadiene-styrene copolymer (ABS resin), acrylonitrile-styrene copolymer ( AS resin).

  In addition, examples of a constituent material of the filter medium 42 include a porous body such as polyether polyurethane, polyester polyurethane, polyethylene terephthalate, and polybutylene terephthalate, and a nonwoven fabric.

  The type of the filter 4 is not particularly limited, and is appropriately selected depending on the application and the like. Examples thereof include a leukocyte removal filter, a microaggregate (fine aggregate) removal filter, a virus removal filter, and the like.

  In addition, there are two types of leukocyte removal filters, i.e., a type that separates only white blood cells, and a type that separates white blood cells and platelets, and it is also possible to simultaneously filter fine aggregates.

  In addition, there are two types of microaggregate removal filters, in which only fine aggregates are separated by filtration, and types in which fine aggregates and platelets are separated by filtration.

  Further, the virus removal filter includes a type that filters out only a virus and a type that filters out one or both of an endotoxin and a fine aggregate together with the virus. In addition, leukocytes and platelets can be selectively filtered out.

  Also, endotoxin removal filters include a type that filters out only endotoxin, and a type that filters out one or both of a virus and a fine aggregate together with endotoxin. In addition, leukocytes and platelets can be selectively filtered out.

  One end of a flexible tube 8 is connected to the first inflow port 45 of the filter 4 so as to communicate with the inflow chamber 43, and the other end of the tube 8 is closed. The main part of the first flow path is constituted by the lumen of the tube 8. The other end of the tube 8 constitutes a connecting portion connected to the tube 7 of the blood collection bag 2. By connecting the other end of the tube 8 to the other end of the tube 7, the inflow chamber 43 of the filter 4 and the inside of the blood collection bag 2 communicate with each other via the tubes 7 and 8.

  One end of a flexible tube 9 is connected to the outlet 47 of the filter 4 so as to communicate with the outlet chamber 44. The other end of the tube 9 is connected to the upper side of the bag 3 in FIG. It is connected so as to communicate with the inside (blood storage unit). The main part of the second flow path is constituted by the lumen of the tube 9.

  A branch connector (branch portion) 12 which is a three-way branch pipe is provided in the middle of the tube 9, and one end of a flexible tube (bypass circuit) 11 is connected to the branch connector 12. . That is, in the branch connector 12, the lumen of the tube 9 and the lumen of the tube 11 communicate with each other. The other end of the tube 11 is connected to a second inlet 46 of the filter 4 so as to communicate with the inflow chamber 43. Note that the main part of the third flow path is constituted by the lumen of the tube 11.

  As the branch connector 12, for example, a Y-shaped pipe, a T-shaped pipe, a T-shaped pipe, a three-way cock, or the like can be used.

  As a constituent material of each of the tubes 6, 7, 8, 9 and 11, for example, a material mainly composed of polyvinyl chloride, soft polyvinyl chloride, and soft polyvinyl chloride (for example, a small amount of another polymer material) , A polymer blend, a polymer alloy, etc.), an ethylene-vinyl acetate copolymer and the like.

  As the constituent material of the bag 3, for example, the same material as that of the blood collection bag 2 can be used.

  Between the branch connector 12 of the tube 9 and the filter 4, a clamp (clamp member) 13 is provided as second flow path regulating means. This clamp 13 is preferably arranged near the branch connector 12.

  By attaching and detaching the clamp 13, the flow of the fluid (blood or air) flowing through the tube 9 located on the filter 4 side from the branch connector 12 (the junction of the second flow path and the third flow path) is regulated. You. That is, when the clamp 13 is attached, the tube 9 is closed by the clamp 13 and its flow path is closed (blocked). When the clamp 13 is removed, the flow path is opened.

  In the middle of the tube 11, a check valve (backflow prevention means) 14 is provided as third flow path regulating means. This check valve 14 is preferably arranged near the filter 4.

  The check valve 14 regulates the flow of the fluid (blood or air) flowing in the tube 11 in one direction from the bag 3 (branch connector 12) to the filter 4. That is, the flow of the fluid (blood or air) from the bag 3 (branch connector 12) to the filter 4 becomes possible, and the flow of the fluid (blood or air) in the opposite direction is prevented (prevented).

  The check valve 14 will be briefly described. The check valve 14 has a valve body in which a pair of plate-like opening / closing members (not shown) is formed, and each opening / closing member has an elastic force (restoring force). ), The flow path in the check valve 14 is closed. When the blood flow or the air flow is directed from the filter 4 side to the bag 3 (branch connector 12) side, that is, from the distal end side to the proximal end side of the check valve 14, the pressure by the blood or air causes each of the opening and closing members. And acts on the outer surface of the front end side so as to bring the opening and closing members into close contact with each other. Therefore, blood and air do not flow from the filter 4 side to the bag 3 (branch connector 12) side.

  On the other hand, when the blood flow or the air flow is directed from the bag 3 (branch connector 12) side to the filter 4 side, a predetermined pressure is applied to the tapered surface on the base end side of each opening / closing member by the blood or air. The opening and closing members are displaced in the direction in which they are separated by the pressure, and the flow path in the check valve 14 is opened. Thereby, blood and air flow from the bag 3 (branch connector 12) side to the filter 4 side.

  An orifice (constriction) is provided between the outlet 47 of the filter 4 or the branch connector 12 of the tube 9 and the filter 4 as flow rate (flow rate) adjusting means for adjusting the flow rate (flow rate) at the time of blood filtration. It may be provided. In this case, since the tube 11 is provided so as to bypass the orifice, it is possible to easily and reliably discharge air from the bag 3 to the blood collection bag 2 described later.

  The tube 7 and the tube 8 may be connected in advance (the inside of the blood collection bag 2 as the first container and the other end of the first flow path may be connected).

Next, the operation (use method) of the blood processing filter system 1 will be described.
The case where the blood processing filter system 1 is applied to a system for filtering (separating) leukocytes from blood (the case where a leukocyte removal filter is used as the filter 4) will be described.

  First, a predetermined amount of blood is collected from a donor (blood donor) into the blood collection bag 2 using the blood collection needle 5. Then, if necessary, the tube 6 is sealed by fusion with a tube sealer or the like, and the sealed portion is cut to separate and remove the tube 6 on the blood collection needle 5 side.

  Next, the tube 7 on the blood collection bag 2 side and the tube 8 on the filter 4 side are aseptically connected. Thereby, the inflow chamber 43 of the filter 4 and the inside of the blood collection bag 2 communicate with each other via the tubes 7 and 8. This connection can be performed using, for example, a tube connection device described in JP-A-6-78971.

  Next, the blood is filtered by the filter 4, that is, leukocytes are separated (separated) from the blood. In this case, for example, by suspending the blood collection bag 2 containing blood on a stand, the blood collection bag 2 may be arranged at a high position, and gravity may be used. The blood collection bag 2 may be pressurized using a bag pressurizing device described in Japanese Patent Application Laid-Open Publication No. H10-15064. Note that the clamp 13 has been removed.

  Thereby, the blood stored in the blood collection bag 2 flows through the tubes 7 and 8, flows into the inflow chamber 43 from the first inlet 45 of the filter 4, and the leukocytes are filtered by the filter medium 42 ( Separated).

  The blood that has passed through the filter medium 42 and from which leukocytes have been separated (the blood after filtration) flows into the outflow chamber 44, flows out of the outflow port 47 of the outflow chamber 44, flows through the tube 9, and is introduced into the bag 3 ( Collected).

  On the other hand, since the check valve 14 is provided on the tube 11, the blood and leukocytes before filtration flow out from the second inlet 46 of the filter 4 and are filtered from the check valve 14 by the check valve 14. Flow to the third side (downstream side) is prevented (prevented).

  After all the blood after the filtration is stored in the bag 3, the clamp 13 is attached between the branch connector 12 of the tube 9 and the filter 4. As a result, the tube 9 is closed by the clamp 13, and the flow path is closed (blocked).

  Next, the air stored in the bag 3 is discharged (transmitted) from the bag 3 to the blood collection bag 2. In this case, for example, the bag 3 is pressed using the bag pressing device.

  Thus, the air stored in the bag 3 passes through the tubes 9 and 11, the second inlet 46 of the filter 4, the inflow chamber 43, the first inlet 45, and the tubes 8 and 7 in this order. Then, the blood is sent to the blood collection bag 2.

  That is, when the bag 3 is pressurized, the air stored in the bag 3 is discharged (sent out) from the bag 3, flows in the tubes 9 and 11, and flows through the second inlet 46 of the filter 4. Flows into the inflow chamber 43, flows out of the first inflow port 45, flows through the tubes 8 and 7, and is introduced (collected) into the blood collection bag 2.

  On the other hand, the air stored in the bag 3 is prevented from flowing out to the outflow chamber 44 side of the filter 4 by the clamp 13 (prevention).

  After all the air stored in the bag 3 has been stored in the blood collection bag 2, the clamp 13 is removed, and the blood processing filter is used by using the air stored in the blood collection bag 2 (using air as a medium). Blood remaining in the circuit of the system 1 (particularly, blood remaining in the inflow chamber 43 of the filter 4) is filtered by the filter 4 and collected in the bag 3. Thus, the collected blood can be filtered without waste and collected in the bag 3.

  When blood remaining in the circuit of the blood processing filter system 1 is collected, for example, the blood collection bag 2 is pressurized using the bag pressurizing device. Subsequent operations are the same as those described above, and a description thereof will be omitted. Thus, the processing by the blood processing filter system 1 is completed.

  As described above, according to the blood processing filter system 1, the tube 11 forms the bypass circuit (bypass flow path) that connects the middle of the tube 9 and the second inlet 46 of the filter 4. Therefore, the air stored in the bag 3 is passed through the tubes 9 and 11, the second inlet 46 of the filter 4, the inflow chamber 43, the first inlet 45, and the tubes 8 and 7 in this order. Thus, the blood can be reliably discharged (collected) to the blood collection bag 2.

  Further, in this blood processing filter system 1, the bypass circuit by the tube 11 is provided between the middle of the tube 9 and the second inlet 46 of the filter 4, so that the length of the bypass circuit is short, and operability is reduced. Is good.

  An orifice (constricted portion) is provided between the outlet 4 of the filter 4 or the branch connector 12 of the tube 9 and the filter 4 as flow rate (flow rate) adjusting means for adjusting the flow rate (flow rate) at the time of blood filtration. Even if provided, air can be easily and reliably discharged from the bag 3 to the blood collection bag 2.

Next, a second embodiment of the blood processing filter system of the present invention will be described.
FIG. 2 is a plan view schematically showing a second embodiment of the blood processing filter system of the present invention.

  Hereinafter, the blood processing filter system 1 of the second embodiment will be described focusing on differences from the above-described first embodiment, and description of similar items will be omitted.

  As shown in FIG. 2, the blood processing filter system 1 of the second embodiment has a check valve (backflow prevention means) 15 as a second flow path regulating means.

  That is, in the blood processing filter system 1 of the second embodiment, the check valve (backflow prevention means) 15 is provided between the branch connector 12 of the tube 9 and the filter 4. This check valve 15 is preferably arranged near the branch connector 12.

  The check valve 15 allows the flow of fluid (blood or air) flowing through the tube 9 located on the filter 4 side from the branch connector 12 (the junction of the second flow path and the third flow path). It is regulated in one direction from the side 4 to the bag 3 (branch connector 12). That is, the flow of the fluid (blood or air) from the filter 4 to the bag 3 (branch connector 12) is enabled, and the flow of the fluid (blood or air) in the opposite direction is prevented (prevented).

  The configuration of the check valve 15 is the same as that of the check valve 14 in the above-described first embodiment, and a description thereof will be omitted.

  According to the blood processing filter system 1, the same effects as those of the blood processing filter system 1 of the above-described first embodiment can be obtained.

  In the first embodiment described above, it is necessary to perform the attachment / detachment operation of the clamp 13. However, in the blood processing filter system 1, since the check valve 15 is provided as the second flow path regulating means, It is not necessary to perform such attaching / detaching operation, time and labor are not required, and the above-described processing can be performed more reliably.

Next, a third embodiment of the blood processing filter system of the present invention will be described.
FIG. 3 is a plan view schematically showing a third embodiment of the blood processing filter system of the present invention.

  Hereinafter, the blood processing filter system 1 according to the third embodiment will be described focusing on differences from the above-described first embodiment, and description of the same items will be omitted.

  As shown in FIG. 3, in the blood processing filter system 1 of the third embodiment, one end of a flexible tube (bypass circuit) 11 is placed above the bag (second container) 3 in FIG. 3 (blood storage section).

  Therefore, the air stored in the bag 3 passes through the tube 11, the second inlet 46 of the filter 4, the inflow chamber 43, the first inlet 45, the tubes 8 and 7, in this order, The blood is collected (transmitted) to the blood collection bag 2 and collected in the blood collection bag 2.

  According to the blood processing filter system 1, the same effects as those of the blood processing filter system 1 of the above-described first embodiment can be obtained.

Next, a fourth embodiment of the blood processing filter system of the present invention will be described.
FIG. 4 is a plan view schematically showing a fourth embodiment of the blood processing filter system of the present invention.

  Hereinafter, the blood processing filter system 1 of the fourth embodiment will be described focusing on the differences from the above-described second embodiment, and the description of the same items will be omitted.

  As shown in FIG. 4, in the blood processing filter system 1 of the fourth embodiment, one end of a flexible tube (bypass circuit) 11 is placed above the bag (second container) 3 in FIG. 3 (blood storage section).

  Therefore, the air stored in the bag 3 passes through the tube 11, the second inlet 46 of the filter 4, the inflow chamber 43, the first inlet 45, the tubes 8 and 7, in this order, The blood is collected (transmitted) to the blood collection bag 2 and collected in the blood collection bag 2.

  According to the blood processing filter system 1, the same effects as those of the blood processing filter system 1 of the above-described second embodiment can be obtained.

Next, an embodiment of the filter of the present invention will be described.
5 to 7 are cross-sectional side views each showing an embodiment of the filter of the present invention.

  As shown in FIG. 5, the filter 4 has a housing 41 and a filter medium 42 provided in the housing 41, and the inside of the housing 41 is partitioned into an inflow chamber 43 and an outflow chamber 44 by the filter medium 42. . On the inner wall surface of the housing 41, a plurality of projections 48 functioning as spacers for holding the filter medium 42 at a predetermined position are formed.

  A first inlet 45 is provided at one end (upper side in FIG. 5) of the housing 41, and a second inlet 46 and an outlet 47 are provided at the other end (lower side in FIG. 5) of the housing 41. Are provided side by side.

  The first inflow port 45, the second inflow port 46, and the outflow port 47 are each formed of a protruding portion (tubular protruding portion) that protrudes in a tubular shape. In this case, the second inlet 46 and the outlet 47 project substantially parallel in the same direction.

  The first inflow port 45, the second inflow port 46, and the outflow port 47 have a tube (first flow path) 8, a tube (third flow path) 11, and a tube (second flow path), respectively. (Road) 9 is connected.

  In the filter 4, the tubes 9 and 11 are connected to the outflow port 47 and the second inflow port 46, respectively, at the time of assembling into the blood processing filter system 1. At this time, the tube 9 and the tube 11 are connected. There is an erroneous connection preventing means for preventing erroneous connection such as erroneous reverse connection. Hereinafter, the configuration of the erroneous connection prevention means will be described in detail.

  As shown in FIG. 5, the outer diameters of the tubular projections forming the second inlet 46 and the projections forming the outlet 47 are different from each other. That is, the outer diameter of the projection forming the outflow port 47 is larger than the outer diameter of the tubular projection forming the second inflow port 46. The inner diameter of the tube 9 to be connected to the outlet 47 (fitted so as to cover) is also larger than the inner diameter of the tube 11 to be connected to the second inlet 46 (fitted so as to cover). I have.

  With such a configuration, when the tubes 9 and 11 are erroneously connected to the outlet 47 and the second inlet 46 by mistake, the inner diameters of the tubes 11 and 9 are changed to the outlet 47 and the second inlet 46. The outer diameter of the second inlet 46 does not match, and it is easy to notice that the connection cannot be made or that the connection is incorrect.

  The filter 4 shown in FIG. 6 is different from the filter 4 shown in FIG.

  As shown in FIG. 6, the inner diameters of the tubular protrusions forming the second inlet 46 and the protrusions forming the outlet 47 are different from each other. In other words, the inner diameter of the protrusion forming the outlet 47 is larger than the inner diameter of the tubular protrusion forming the second inlet 46. The outer diameter of the tube 9 to be connected to the outlet 47 (connected to be inserted into the lumen) is also the outer diameter of the tube 11 to be connected to the second inlet 46 (connected to be inserted into the lumen). It is larger.

  With such a configuration, when the tubes 9 and 11 are erroneously connected to the outflow port 47 and the second inflow port 46 by mistake, the outer diameters of the tubes 11 and 9 are increased. It does not match the inside diameter of the second inflow port 46, so it is easy to notice that the connection cannot be made or that the connection is incorrect.

  The filter 4 shown in FIG. 7 is different from that of FIGS. 5 and 6 in the configuration of the erroneous connection preventing means, and is otherwise the same.

  In the filter 4 shown in FIG. 7, the tubes 9 and 11 are connected to the outlet 47 and the second inlet 46 via an adapter (connector) 49. The adapter 49 is configured so that it can be mounted only in an appropriate direction with respect to the outflow port 47 and the second inflow port 46. The details will be described below.

  The adapter 49 has a tubular projection 491 to which the tube 9 is fitted and connected, and a tubular projection 492 to which the tube 11 is fitted and connected, and on the opposite side (upper side in FIG. 7). A concave portion 493 in which the tubular protrusion of the outlet 47 fits in a liquid-tight manner, and a concave portion 494 in which the tubular protrusion of the second inlet 46 fits in a liquid-tight manner. The tubular protrusion 491 and the recess 493 communicate with each other, and the tubular protrusion 492 and the recess 494 communicate with each other. A convex portion 495 is formed between the concave portions 493 and 494.

  The outer diameter of the tubular protrusion of the outlet 47 is larger than the outer diameter of the tubular protrusion of the second inlet 46, and correspondingly, the inner diameter of the recess 493 is larger than the inner diameter of the recess 494.

  When the adapter 49 is properly mounted on the filter 4, the tubular protrusion of the outlet 47 fits into the recess 493, and the tubular protrusion of the second inlet 46 fits into the recess 494. Further, the convex portion 495 is fitted or inserted into a concave portion (space) formed between the outflow port 47 and the second inflow port 46 (see the arrow in FIG. 7).

  If the adapter 49 is to be mounted in the opposite direction (inappropriate direction) with respect to the outlet 47 and the second inlet 46, the outlet 47 having an outer diameter larger than the tubular protrusion of the second inlet 46 is used. Since the tubular projection cannot be fitted into the concave portion 494, the adapter 49 cannot be attached, thereby preventing incorrect connection of the adapter 49 (misconnection of the tubes 9 and 11 to the outlet 47 and the second inlet 46). Is done.

  In FIG. 7, the outer diameters of the tubular protrusion 491 and the tubular protrusion 492 are different, and the outer diameters of the tubes 9 and 11 connected thereto are also different. Outer diameters of 491 and 492 may be equal, and outer diameters of tubes 9 and 11 may be equal.

  Each of the filters 4 shown in FIGS. 5 to 7 described above can be applied to any of the blood processing filter systems shown in FIGS. 1 to 4 described above. It may be used by being incorporated in a circuit.

  As described above, the blood processing filter system and the filter of the present invention have been described based on the illustrated embodiments. However, the present invention is not limited to these, and the configuration of each unit may be any configuration having the same function. Can be replaced by

  The present invention may be a combination of any two or more configurations (features) of the above embodiments.

It is a top view showing typically a 1st embodiment of the blood processing filter system of the present invention. It is a top view showing typically the 2nd embodiment of the blood processing filter system of the present invention. It is a top view showing typically the 3rd embodiment of the blood processing filter system of the present invention. It is a top view showing typically a 4th embodiment of the blood processing filter system of the present invention. It is a sectional side view showing an embodiment of a filter of the present invention. It is a sectional side view showing other embodiments of a filter of the present invention. It is a sectional side view showing other embodiments of a filter of the present invention.

Explanation of reference numerals

Reference Signs List 1 blood processing filter system 2 blood collection bag 3 bag 4 filter 41 housing 42 filter material 43 inflow chamber 44 outflow chamber 45 first inflow port 46 second inflow port 47 outflow port 48 protrusion 49 adapter 491, 492 tubular protrusion 493, 494 Concave part 495 Convex part 5 Blood collection needle 51 Hub 6-9, 11 Tube 12 Branch connector 13 Cleanme 14, 15 Check valve

Claims (18)

A blood processing filter system for processing blood,
A filter having a housing, a filter medium for partitioning the housing into an inflow chamber and an outflow chamber, a first inflow port and a second inflow port communicating with the inflow chamber, and an outflow port communicating with the outflow chamber; ,
A first flow path having one end communicating with the first inflow port and the other end communicating with a first container for storing blood;
A second container for storing the blood that has passed through the filter medium of the filter,
A second flow path having one end communicating with the outlet and the other end communicating with the second container;
A blood processing filter system comprising: a third flow path having one end communicating with the second flow path and the other end communicating with the second inflow port.   The air in the second container passes through the second flow path, the third flow path, the second inflow port, the inflow chamber, the first inflow port, and the first flow path. The blood processing filter system according to claim 1, wherein the blood processing filter system is delivered to the first container via an order.   The apparatus according to claim 1, further comprising a second flow path regulating unit that regulates a flow of a fluid flowing through the second flow path located on the filter side with respect to a junction of the second flow path and the third flow path. 3. The blood processing filter system according to 1 or 2. A blood processing filter system for processing blood,
A filter having a housing, a filter medium for partitioning the housing into an inflow chamber and an outflow chamber, a first inflow port and a second inflow port communicating with the inflow chamber, and an outflow port communicating with the outflow chamber; ,
A first flow path having one end communicating with the first inflow port and the other end communicating with a first container for storing blood;
A second container for storing the blood that has passed through the filter medium of the filter,
A second flow path having one end communicating with the outlet and the other end communicating with the second container;
A blood processing filter system comprising: a third flow path having one end communicating with the second container and the other end communicating with the second inlet.   The air in the second container passes through the third channel, the second inlet, the inflow chamber, the first inlet, and the first channel in this order, 5. The blood processing filter system of claim 4, wherein the blood processing filter system is delivered to a first container.   The blood processing filter system according to claim 4 or 5, further comprising a second flow path regulating means for regulating a flow of a fluid flowing through the second flow path.   The blood processing filter system according to any one of claims 1 to 6, further comprising a third flow path regulating means for regulating a flow of a fluid flowing through the third flow path.   8. The third flow path restricting means is a backflow prevention means for enabling a flow of a fluid from the second container side to the filter side and for preventing a flow of a fluid in the opposite direction. A blood processing filter system according to claim 1.   The blood processing filter system according to any one of claims 1 to 8, further comprising the first container, wherein the first container communicates with the other end of the first flow path. A blood collection needle for collecting blood from a donor,
The blood processing filter system according to claim 9, further comprising a fourth flow path having one end communicating with the first container and the other end communicating with the blood collection needle.   In the filter, the first inflow port is provided at one end of the housing, and the second inflow port and the outflow port are provided side by side at the other end of the housing. 11. The blood processing filter system according to any one of 10 above.   When assembling the blood processing filter system, the blood processing filter system further includes an erroneous connection preventing means for preventing the erroneous connection between the second flow path and the third flow path with respect to the outlet and the second inlet. Item 12. A blood processing filter system according to Item 11.   The second inflow port and the outflow port are each formed of a protrusion projecting in a tubular shape, and the outside diameters of the second inflow port and the outflow port are different from each other. Item 13. The blood processing filter system according to item 11 or 12.   The second inflow port and the outflow port each have a protrusion protruding in a tubular shape, and the inside diameters of the second inflow port and the outflow port are different from each other. 13. The blood processing filter system according to 11 or 12.   The second flow path and the third flow path are connected to the outlet and the second inlet via an adapter, and the adapter is attached to the outlet and the second inlet. The blood processing filter system according to claim 11 or 12, wherein the blood processing filter system is configured to be mounted only in an appropriate direction. A housing, and a filter medium for partitioning the inside of the housing into an inflow chamber and an outflow chamber, wherein the housing communicates with the first inflow port and the second inflow port communicating with the inflow chamber, and the communication with the outflow chamber. An outlet and a filter provided,
The first inflow port is provided on one end side of the housing, the second inflow port and the outflow port are provided side by side on the other end side of the housing, and the first inflow port and the first inflow port are provided. The two inlets and the outlets are each constituted by a protruding portion projecting in a tubular shape,
A filter wherein the outer diameter and / or inner diameter of the protrusion of the second inlet and the protrusion of the outlet are different from each other. The blood processing filter system according to any one of claims 1 to 10, further comprising a housing, and a filter medium for partitioning the inside of the housing into an inflow chamber and an outflow chamber, and the housing communicates with the inflow chamber. A filter provided with a first inflow port, a second inflow port, and an outflow port communicating with the outflow chamber,
The first inflow port is provided on one end side of the housing, the second inflow port and the outflow port are provided side by side on the other end side of the housing, and the first inflow port and the first inflow port are provided. The two inlets and the outlets are each constituted by a protruding portion projecting in a tubular shape,
A filter wherein the outer diameter and / or inner diameter of the protrusion of the second inlet and the protrusion of the outlet are different from each other.   The second flow path and the third flow path are connected to the outlet and the second inlet via an adapter, and the adapter is attached to the outlet and the second inlet. The filter according to claim 16 or 17, wherein the filter is configured to be mounted only in an appropriate direction.

Images