JP2004210715A5 - - Google Patents
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- JP2004210715A5 JP2004210715A5 JP2002382121A JP2002382121A JP2004210715A5 JP 2004210715 A5 JP2004210715 A5 JP 2004210715A5 JP 2002382121 A JP2002382121 A JP 2002382121A JP 2002382121 A JP2002382121 A JP 2002382121A JP 2004210715 A5 JP2004210715 A5 JP 2004210715A5
- Authority
- JP
- Japan
- Prior art keywords
- osteoclast formation
- formation inhibitor
- sulfated glycosaminoglycan
- inhibitor according
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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【特許請求の範囲】
【請求項１】 硫酸化グリコサミノグリカン又はその塩を有効成分として含有する破骨細胞形成抑制剤。
【請求項２】 硫酸化グリコサミノグリカンが、ウロン酸がＬ−イズロン酸及び／又はＤ−グルクロン酸であり、硫黄含量が３％〜１６％（W/W％）である硫酸化グリコサミノグリカンであることを特徴とする請求項１記載の破骨細胞形成抑制剤。
【請求項３】 硫酸化グリコサミノグリカンが、コンドロイチナーゼＡＢＣによる分解とイオン交換高速液体クロマトグラフィーによる分析を組み合わせた二糖組成分析において、N-アセチル-ガラクトサミンの４位水酸基と６位水酸基にのみ硫酸基を有している不飽和二糖が１０〜８０％であるコンドロイチン硫酸であることを特徴とする請求項１又は２に記載の破骨細胞形成抑制剤。
【請求項４】 硫酸化グリコサミノグリカンが、ゲル濾過法により測定される平均分子量が、１,５００〜１５０,０００である請求項１〜３の何れかに記載の破骨細胞形成抑制剤。
[Claims]
An osteoclast formation inhibitor comprising a sulfated glycosaminoglycan or a salt thereof as an active ingredient.
2. A sulfated glycosaminoglycan wherein the uronic acid is L-iduronic acid and / or D-glucuronic acid and the sulfur content is 3% to 16% (W / W%). The osteoclast formation inhibitor according to claim 1, which is noglycan.
3. The sulfated glycosaminoglycan is analyzed for disaccharide composition analysis by combining degradation by chondroitinase ABC and analysis by ion-exchange high performance liquid chromatography in the 4- and 6-hydroxyl groups of N-acetyl-galactosamine. The osteoclast formation inhibitor according to claim 1 or 2, wherein the unsaturated disaccharide having a sulfate group only is chondroitin sulfate of 10 to 80%.
4. The osteoclast formation inhibitor according to claim 1, wherein the sulfated glycosaminoglycan has an average molecular weight of 1,500 to 150,000 as measured by a gel filtration method. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002382121A JP4567942B2 (en) | 2002-12-27 | 2002-12-27 | Osteoclast formation inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002382121A JP4567942B2 (en) | 2002-12-27 | 2002-12-27 | Osteoclast formation inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004210715A JP2004210715A (en) | 2004-07-29 |
| JP2004210715A5 true JP2004210715A5 (en) | 2006-02-09 |
| JP4567942B2 JP4567942B2 (en) | 2010-10-27 |
Family
ID=32817794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002382121A Expired - Fee Related JP4567942B2 (en) | 2002-12-27 | 2002-12-27 | Osteoclast formation inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4567942B2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0401069D0 (en) | 2004-04-26 | 2004-04-26 | Anamar Medical Ab | Use of Compounds for the Treatment of Diseases and Conditions |
| JPWO2006068146A1 (en) * | 2004-12-20 | 2008-06-12 | 生化学工業株式会社 | New chondroitin sulfate fraction |
| EP1859803B1 (en) * | 2005-03-14 | 2016-10-19 | Seikagaku Corporation | Promoter for hard tissue formation |
| JP5051999B2 (en) * | 2005-11-17 | 2012-10-17 | 国立大学法人名古屋大学 | Treatment for inflammatory bone and cartilage diseases |
| JP2007224286A (en) * | 2006-01-25 | 2007-09-06 | Tottori Univ | Process for acquiring polysaccharide from living body tissue |
| JP5099617B2 (en) * | 2006-03-16 | 2012-12-19 | 国立大学法人東京農工大学 | Periodontal disease preventive and therapeutic agent |
| JP5063940B2 (en) * | 2006-06-20 | 2012-10-31 | 生化学工業株式会社 | Chondroitin sulfate / iron colloid preparation and method for producing the same |
| US20110129544A1 (en) * | 2007-02-22 | 2011-06-02 | Tatsuya Miyazaki | Bone/Cartilage Formation-Stimulation Agent |
| CN102802638B (en) * | 2009-12-09 | 2015-11-25 | 新加坡科技研究局 | glucosaminoglycan mixture |
| DK2707396T3 (en) * | 2011-05-12 | 2019-01-28 | Gnosis Spa | Biotechnological sulfated chondroitin sulfate at position 4 or 6 on the same polysaccharide chain and process for its preparation |
| CN105924544B (en) * | 2016-05-16 | 2018-03-09 | 山东大学 | A kind of high sulfated chondroitin sulfate and preparation method and application |
-
2002
- 2002-12-27 JP JP2002382121A patent/JP4567942B2/en not_active Expired - Fee Related
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