JP2004198161A - Method for fetching data for spectral measurement and computer program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for performing automatic calibration so as to enable an accurate measurement when a deviation occurs in inputted data or before starting the data inputting, in a data fetching method for measuring the concentration of glucose in blood. <P>SOLUTION: The data fetching method has a measuring process for performing measurement according to a region to be measured, a judging process for judging whether the measured value in the measuring process is within a proper range and a calibration process performed when the measured value is judged not to be within the proper range. The calibration process is equipped with a moving process for relatively moving a calibrating substance, a light emitting part and a light detecting part so as to irradiate the calibrating substance becoming a reference value for adjusting frequency with the measuring light from a light emitting device to detect the reflected light from the calibrating substance by the light detecting part when the measuring value is judged not to be within the proper range in the judging process, a light emitting and detecting part for irradiating the calibrating substance with the measuring light to detect the reflected light from the calibrating substance and a calibration process for adjusting frequency in an analyzing process on the basis of the reflected light. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a technique for acquiring data for spectrometry using a non-invasive technique. More specifically, the present invention relates to a spectrometry data acquisition method capable of inputting data input from a measurement target and data for calibrating when the data is out of order.
[0002]
[Prior art]
A conventional non-invasive blood glucose measurement technique is described in Patent Document 1, for example. Here, a technique for realizing a measuring device capable of non-invasively measuring the glucose concentration in blood is disclosed.
[0003]
[Patent Document 1]
JP-A-2002-202258
As a technique for noninvasively analyzing components in blood using a finger as an object to be measured, for example, an apparatus for measuring the oxygen concentration in an artery is provided. The catalog of the pulse oximeter commercialized by Casio has an opening for inserting a finger, inserts an index finger or the like into the opening, and irradiates the finger with infrared light or the like. , Calculate the desired measurement.
[0005]
[Problems to be solved by the invention]
Patent Literature 1 discloses “pressing and holding means” for performing measurement by congesting a finger as an object to be measured, but has the drawback that congestion causes pain to the subject.
When a test of more than 400 people was performed using a prototype that realized the technique described in Patent Document 1 while supplementing the disadvantages, the problem that measurement became impossible occurred about 25%. In addition to the cause that the measurement was not possible due to the finger being displaced at the time of input, the input data was confused due to the unstable voltage of the power supply supplied to the measuring device and the heat generated by prolonged use time of the device. That is also one of the causes.
[0006]
Therefore, the problem to be solved by the present invention is to provide a method for acquiring data for spectral measurement, which is automatically calibrated so that accurate measurement can be performed when input data is out of order or before data input is started. To provide.
It is an object of the present invention to provide a method for acquiring data for spectral measurement, which automatically performs calibration so that accurate measurement can be performed when input data is inconsistent.
The invention according to claims 5 to 7 is a computer program for causing a computer to execute a data acquisition method for spectroscopic measurement for automatically calibrating an input data if an error occurs. The purpose is to provide.
[0007]
[Means for Solving the Problems]
In order to solve the above-described problems, the present invention is characterized in that a control procedure that automatically performs a “calibration process” under predetermined conditions is adopted.
[0008]
(Claim 1)
According to the first aspect of the present invention, there is provided a measurement process for performing measurement by a measured part, a determination process for determining whether a measured value based on the measurement process is within an appropriate range, and determining that the measurement value is not within an appropriate range. And a calibration process for performing measurement calibration when the measurement is performed.
The measurement process is a light emission step of emitting measurement light including near infrared light from the light emitting device,
A light receiving step of receiving the reflected light of the measurement light reflected from the measurement site using the measurement light emitted in the light emission step.
Further, the determination process includes an analysis step of analyzing the reflected light received in the light receiving step,
A determination step of determining whether the pre-analysis data or the analysis result of the analysis step is within an appropriate range.
Further, in the calibration process, when it is determined that the measurement light is not within the appropriate range in the determination step, the measurement light is irradiated from the light emitting device to the calibration substance whose reflected light is a reference value for frequency adjustment, and A moving step of relatively moving the calibration substance, the light-emitting section and the light-receiving section so that the reflected light can be received by the light-receiving section; and a light-emitting and light-receiving section that irradiates the calibration substance with measurement light and receives the reflected light. And a calibration step for adjusting the frequency in the analysis step based on the reflected light received in the light emission and reception step.
[0009]
(Glossary)
The “measurement site” is a site of the body such as a finger, a cheek, a palm, an arm, etc. of the measurement subject to be measured. The glucose concentration in blood can be measured non-invasively. The measurement principle is described in, for example, JP-A-2002-202258.
The principle of "measurement of blood glucose concentration" described in JP-A-2002-202258 will be briefly described. Near-infrared irradiating means for continuously finely dividing the wavelength of near-infrared light in a wavelength range of 0.8 to 2.5 μm and irradiating the object to be measured, and the object to be measured irradiated by the near-infrared irradiating means Photoelectric conversion means for receiving the light transmitted therethrough and performing photoelectric conversion, and analyzing and calculating the absorbance spectrum obtained based on the detection signal photoelectrically converted by the photoelectric conversion means, thereby detecting the light in the blood in the object to be measured. This is a measurement using a spectroscopic blood glucose level measuring device, comprising: a glucose concentration calculating means for quantifying the glucose concentration.
[0010]
“The case where the pre-analysis data or the analysis result of the analysis step is not in the appropriate range” refers to a range that cannot be realized in practice. The data before analysis (light reception data obtained in the light reception process of the measurement process) may have a normal value due to data abnormalities in the light reception process of the measurement process, abnormalities in the hardware that controls the measurement process, or runaway of software. It is no longer the range.
Regarding the “moving step”, a hardware configuration is required so that the moving step itself contributes to the data and does not cause an abnormality in the pre-analysis data. For example, when a motor is used in the moving mechanism, the motor is arranged so that noise or vibration of the motor does not affect the light emitting step or the light receiving step, or such a motor is adopted.
"The relative movement between the calibration substance and the light emitting unit and the light receiving unit" means that the calibration substance may be moved, the light emitting unit and the light receiving unit may be moved, or both may be moved. Is also good. This is because the purpose of movement can be achieved by relatively moving.
[0011]
(Claim 2)
The invention according to claim 2 limits the method for capturing data for spectrometry according to claim 1.
That is, the calibration material is ceramic and polystyrene. Further, the method of capturing data for spectrometry includes a moving step of the calibration process including a moving step to the ceramic and a light emitting and receiving step for the ceramic, and a moving step to the polystyrene and a light emitting and receiving step to the polystyrene.
The wavelength formed by the reflected light illuminating the piece of polystyrene with the measuring light has a distinct peak, and the wavelength formed by the reflected light illuminating the piece of ceramic with the measuring light has a flat waveform. Therefore, the calibration can be performed using the peak while adjusting the zero point using the flat waveform, so that the calibration is suitable.
The transfer step to the ceramic and the light emitting and receiving step for the ceramic, and the transfer step to the polystyrene and the light emitting and receiving step to the polystyrene may be performed first and then later.
[0012]
(Claim 3)
The invention according to claim 3 limits the method for capturing data for spectrometry according to any one of claims 1 and 2, and performs a zero-point adjustment in an analysis step before the measurement process. The present invention relates to a method for acquiring data for spectroscopic measurement in which a calibration process is performed.
That is, at the time of start-up, a calibration step for adjusting the zero point is always performed before the measurement process.
[0013]
(Claim 4)
According to a fourth aspect of the present invention, there is provided a method for capturing data for spectral measurement according to any one of the first to third aspects,
Including a determination time determination step of determining whether the determination step is completed within a predetermined time,
If the determination step is not completed within a predetermined time in the determination time determination step, the present invention relates to a spectrometry data acquisition method in which a moving step, a light emitting and receiving step, and a calibration step are performed.
That is, a case where the determination process takes longer than a predetermined time is regarded as an “error”, and the calibration process is performed.
[0014]
(Claim 5)
A fifth aspect of the present invention is a program for causing a computer to implement a method for acquiring data for spectral measurement for measuring glucose concentration in blood.
The program includes a measurement process for performing measurement by a measured part, a determination process for determining whether a measurement value based on the measurement process is within an appropriate range, and a determination process when the determination process determines that the measurement value is not within an appropriate range. A calibration process for performing measurement calibration.
The measurement process includes a light-emitting step of emitting measurement light including near-infrared light from the light-emitting device, and a light-receiving step of receiving reflected light of the measurement light reflected on the measurement target portion using the measurement light emitted in the light-emitting step. And a process. The determining process includes an analyzing step of analyzing the reflected light received in the light receiving step, and a determining step of determining whether the pre-analysis data or the analysis result in the analyzing step is within an appropriate range. Further, in the calibration process, when it is determined that the measurement light is not within the appropriate range in the determination step, the measurement light is irradiated from the light emitting device to the calibration substance whose reflected light is a reference value for frequency adjustment, and A moving step of relatively moving the calibration substance, the light-emitting section and the light-receiving section so that the reflected light can be received by the light-receiving section; and a light-emitting and light-receiving section that irradiates the calibration substance with measurement light and receives the reflected light. And a calibration step for adjusting the frequency in the analysis step based on the reflected light received in the light emission and reception step.
[0015]
(Claim 6)
The invention according to claim 6 limits the computer program according to claim 5,
The present invention relates to a computer program for performing a start-up calibration step for performing a zero-point adjustment in an analysis step before a measurement process.
[0016]
(Claim 7)
The invention according to claim 7 limits the computer program according to any one of claims 5 and 6,
Including a determination time determination step of determining whether the determination step is completed within a predetermined time,
The present invention relates to a computer program for performing a moving step, a light emitting / receiving step, and a calibration step when the determining step is not completed within a predetermined time in the determining time determining step.
[0017]
The computer program according to any one of claims 5 to 7 can be provided by being stored in a recording medium. Here, the “recording medium” is a medium that can carry a program that cannot occupy space by itself, such as a flexible disk, a hard disk, a CD-ROM, an MO (magneto-optical disk), and a DVD-ROM. ROM and the like.
Further, it is also possible to transmit the program according to the present invention from a computer storing the program to another computer via a communication line.
[0018]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention will be described in more detail based on embodiments and drawings. The drawings used here are FIGS. 1 to 4. FIG. 1 is a block diagram showing an embodiment of the present invention. FIG. 2 and FIG. 3 are flowcharts showing the first and second embodiments. FIG. 4 is a block diagram showing a hardware configuration.
[0019]
(Fig. 1)
FIG. 1 shows the basic structure of a spectroscopic blood glucose level measuring device for measuring the glucose concentration in blood by non-invasive typified by JP-A-2002-202258.
Japanese Patent Application Laid-Open No. 2002-202258 discloses a spectroscopic blood glucose level measuring device that continuously divides the wavelength of near-infrared light having a wavelength range of 0.8 to 2.5 μm into fine particles and irradiates the object to be measured. An infrared irradiation unit, a photoelectric conversion unit that receives light transmitted by the near-infrared irradiation unit and transmitted through the object to be measured, and photoelectrically converts the light, and obtains the light based on a detection signal photoelectrically converted by the photoelectric conversion unit. And a glucose concentration calculating means for quantifying the glucose concentration in the blood in the measured object by analyzing and calculating the obtained absorbance spectrum.
[0020]
A light source, an acousto-optic variable vibration filter that receives light from the light source, and outputs near-infrared light in a wavelength range of 0.8 to 2.5 μm, and a high-frequency vibrator that applies acoustic vibration to the acousto-optic variable vibration filter And a high-frequency generator for applying a high frequency to the high-frequency vibrator.
Further, the medium of the acousto-optic variable vibration filter may be limited to a birefringent crystal material.
Further, the photoelectric conversion unit may be a photoelectric conversion device including a light receiving element that receives light transmitted through the object to be measured and supplies a detection signal that gives an absorbance spectrum.
Further, it is assumed that the glucose concentration calculating means is an absorbance spectrum waveform analyzer to which a detection signal from the light receiving element is supplied and a glucose concentration calculator for converting the absorbance spectrum into a glucose concentration, and further, which is selected in the absorbance spectrum. May be converted values based on the absorbance at at least five or more wavelengths in the 1.44 μm, 1.94 μm, and 0.8 to 2.5 μm bands.
[0021]
The near-infrared irradiating unit having the near-infrared spectroscopic unit having the acousto-optic variable vibration filter as a constituent element includes: a light source; an acousto-optic variable vibration filter to which light is incident from the light source; It comprises a high-frequency vibrator for applying vibration and a high-frequency generator for applying a high frequency to the high-frequency vibrator. Specifically, as illustrated in FIG. 1, it is configured to include a high-frequency power supply 1, a high-frequency vibrator 2, an acousto-optic variable vibration filter 3, and a light source 4.
[0022]
The high-frequency generator 1 is a commonly used one, and is not particularly limited, as long as it has a high-frequency generation capability that can be arbitrarily controlled. The high-frequency vibrator 2 may apply acoustic vibration to the acousto-optic variable vibration filter 3, and a piezo element is used. The high frequency applied to the piezo element depends on the type and performance of the medium of the acousto-optic variable vibration filter, but if it is controlled so that near-infrared light in a wavelength range of 0.8 to 2.5 μm is dispersed. Often, 30 to 100 MHz, particularly 30 to 80 MHz, is preferable. As the light source 4, tungsten? A halogen lamp or the like is used, but is not limited thereto.
[0023]
The medium of the acousto-optic variable vibration filter 3 is made of a birefringent crystal spectral material. In an acousto-optic variable vibration filter, when acoustic vibration is applied to the birefringent crystal, a periodic change in density occurs, and a change in the refractive index due to the change in density propagates in the direction of the acoustic vibration. Therefore, when light is incident thereon, some light rays based on the refractive index of each wavefront are reflected. It is designed so that a difference between the respective path lengths occurs and near-infrared light is output.
[0024]
The birefringent crystal spectroscopy material is not particularly limited and can be arbitrarily selected. For the measurement of blood glucose, it can output finely divided irradiation light having a wavelength range of 0.8 to 2.5 μm. What is necessary is just to select a suitable birefringent crystal spectral material. For example, tellurium dioxide (TeO2), lithium niobate (LiNbO3), lithium tantalate (LiTaO3), gallium phosphide (GaP), lead molybdate (PbMoO4), germanium (Ge), iridium phosphide (InP), selenide Examples include arsenic thallium (Ti3AsSe3), quartz glass (SiO2), calcite (CaCO3), and water (H2O). Those whose composition and the like are controlled are preferable, and tellurium dioxide is particularly preferable.
[0025]
By irradiating the human body with near-infrared light obtained by using such a birefringent crystal spectral material, it is possible to form an absorbance spectrum effective for calculating the concentration of glucose. As an acousto-optic tunable wavelength filter suitable for use in the spectroscopic blood sugar level measuring device of the present invention, for example, a super-optical tunable filter described in U.S. Pat. No. 5,120,961 and Japanese Patent Publication No. 10-512678 is disclosed. An acoustic tunable filter (AOTF) can be mentioned. Further, in order to avoid the temperature drift of the acousto-optic variable vibration filter, a method described in JP-A-10-38690 can be adopted.
[0026]
As the irradiation light, near-infrared light having a wavelength in the range of 0.8 to 2.5 μm is suitable, and if the wavelength is shorter than this range, the signal level of glucose absorbance measurement becomes weak and is not suitable for analysis. On the other hand, at wavelengths longer than this range, there is a problem in that the light absorption increases and the transmittance is lacking.
[0027]
In the near-infrared irradiating means, light obtained by continuously finely dividing the wavelength of near-infrared light having a wavelength range of 0.8 to 2.5 μm irradiated onto the object to be measured has a fine resolution of 0.001 μm or less. It is spectral and the wavelength resolution is preferably 1 nm or less. Multi-point measurement is possible by using such finely divided light as irradiation light, and there are several denatured forms depending on the form of binding of protein and glucose, each of which produces light absorption at a different wavelength. Can capture blood glucose. As a result of successfully measuring the light absorption phenomenon of the mutant in detail by this multi-point measurement, a comprehensive analysis can be performed, so that accurate calculation of the blood glucose concentration becomes possible. As the number of measurement points, for example, at least 200 points, usually several hundred points can be selected.
[0028]
Next, an irradiation method of near-infrared light in the near-infrared irradiation means will be described. The following three types of irradiation methods can be given.
A first method is a transmission method in which the near-infrared light is applied to an object to be measured and light transmitted through the object to be measured is directly condensed to a light receiving element.
In the second method, the near-infrared light is applied to the object to be measured, and the light transmitted through the object to be measured is reflected by a reflector provided on the back side of the object to be measured, and This is a transmission / reflection method in which light transmitted through the object again is condensed on a light receiving element.
A third method is a diffuse reflection method in which the near-infrared light is applied to the object to be measured, and the diffusely reflected light is collected on a light receiving element.
[0029]
Either method can be adopted, but the first transmission method is simple in terms of the apparatus and operation.
In the first transmission method, specifically, as shown in FIG. 1, in the configuration of the spectroscopic blood glucose level measuring device of the present invention, the irradiation light c is applied to the object 7 to be measured and the transmitted light is received d. It is a method obtained as.
As a measurement target, a blood sample collected from a human body, a part of the human body, for example, a limb finger, an earlobe, or a part where a capillary exists, which is suitable for observation of blood flow, can be used.
[0030]
The figure shows an object to be measured 7, an optical fiber 8 for guiding light d transmitted through the object to be measured 7, a lens 9, and a light receiving element 10 for receiving the light and performing photoelectric conversion to a detection signal.
Although the light receiving element 10 is not particularly limited, for example, an element manufactured as a polycrystalline film on a ceramic substrate is used. As the light receiving material, it is preferable to employ a material capable of efficiently condensing the transmitted light, and for example, Pbs can be used.
[0031]
The glucose concentration calculating means is for analyzing and calculating the absorbance spectrum to convert it into a glucose concentration, and is composed of a calculation electronic circuit and an analysis electronic circuit. As shown in FIG. 1, an analog detection signal e obtained by the light receiving element 10 is converted into a digital detection signal f via a photoelectric conversion unit 11, and is input to a calculation control unit 12 for performing spectrum waveform analysis, and The analysis and calculation are performed by the circuit and the analysis electronic circuit. The measurement result and the identification result are transmitted to the numerical value display means 13 and the numerical value telegraphing means 14. For example, the numerical value and related information can be displayed together with the spectrum on the monitor of the blood glucose level measuring device main body. It can also be transmitted to an electronic file and managed.
[0032]
In the analysis electronic circuit, a "blood spectrum database" configured as medical clinical data is accumulated, and the "blood spectrum database" contains many data such as those with different blood glucose concentrations and those with different binding states between protein and glucose. Therefore, by comparing and comparing the blood spectrum obtained by the measurement with these data, the measurement result of the blood glucose concentration can be obtained from the corresponding data. Further, in the analysis electronic circuit, in addition to the quantitative results, it is possible to obtain the identification results such as the location and level of the mutant due to the binding of protein and glucose.
[0033]
In the above-described spectroscopic blood sugar level measuring device, the acousto-optic variable vibration filter is incorporated, and quick measurement is possible, and specifically, a measurement speed of about several thousand points / second can be achieved. . The measurement is repeated several times to several tens of times at each wavelength to obtain an average value, and the set wavelength range is scanned several times to several tens times to collect the average value, thereby obtaining accuracy of the measurement data. Can be enhanced.
[0034]
(Fig. 2)
Subsequently, the process up to the output of the analysis result in the first embodiment will be described with reference to FIG.
There are roughly three processes, which are a measurement process of performing measurement by a measured part, a determination process of determining whether a measurement value based on the measurement process is within an appropriate range, and an appropriate process in the determination process. This is a calibration process for performing measurement calibration when it is determined that the value is out of the range. Then, after the calibration process, the process returns to the measurement process. Note that TRON is adopted as the OS for these control processes. By using TRON for the OS, the startup speed is faster and stability is increased compared to those that used MS-DOS. The OS is not limited to TRON or MS-DOS, but may be windows, Linux, or the like.
[0035]
The measurement process includes a light-emitting step of emitting measurement light including near-infrared light from the light-emitting device, and a light-receiving step of receiving the reflected light of the measurement light reflected on the measured portion using the measurement light emitted in the light-emitting step. Is provided. The determining process includes an analyzing step of analyzing the reflected light received in the light receiving step, and a determining step of determining whether the pre-analysis data in the analyzing step is within an appropriate range. In the determination process, if it is determined that the value is within the appropriate range, the analysis result is output and the process ends. If it is determined that the value is not within the proper range, the process returns to the measurement process via the calibration process.
[0036]
Further, in the calibration process, when it is determined that the measurement light is not within the appropriate range in the determination step, the measurement light is irradiated from the light emitting device to the calibration substance whose reflected light is a reference value for frequency adjustment, and A moving step of relatively moving the calibration substance, the light-emitting section, and the light-receiving section so that the light-receiving section can receive the reflected light; and a light-emitting and receiving section for irradiating the calibration substance with the measurement light and receiving the reflected light. And a calibration step for adjusting the frequency in the analysis step based on the reflected light received in the light emitting and receiving step.
[0037]
“When the pre-analysis data in the analysis step is not in the appropriate range” in the determination step refers to a range that cannot be realized in practice. The data before analysis (light reception data obtained in the light reception process of the measurement process) may have a normal value due to data abnormalities in the light reception process of the measurement process, abnormalities in the hardware that controls the measurement process, or runaway of software. It is no longer the range.
Note that the determination symmetry may be not the pre-analysis data but the analysis result, that is, the calculation result as the glucose concentration in the blood.
[0038]
As a result of the provision of the calibration process, when an error occurs in the data input from the subject, the data input can be performed again through the calibration process. For this reason, the number of data input errors due to the abnormality of the device has been reduced. In addition, it has been found that although the patient has to endure the troublesomeness of the calibration process, it is easy for the subject to obtain the results to obtain cooperation.
[0039]
(Fig. 3)
Next, based on FIG. 3, the process up to the output of the analysis result in the second embodiment will be described. The difference from the embodiment shown in FIG. 2 is that the calibration process is always performed before the measurement process.
In this way, it is possible to prevent a situation in which the pre-analysis data in the analysis process is not in an appropriate range due to a malfunction of hardware or a runaway of software that governs the measurement process. As a result, data input abnormalities immediately after use decreased.
[0040]
(FIG. 4)
FIG. 4 is a block diagram showing the relationship between the calibration unit, the calibration switch, and the control unit employing TRON as the OS, and the relationship between the above-described spectral analyzer using AOTF, the signal input unit, and the control unit. ing. By using TRON for the OS, the startup speed is faster and stability is increased compared to those that used MS-DOS.
Although not shown in detail, the hardware shown in FIG. 4 is integrally formed. In other words, a finger pad for the subject to input data, a calibration switch for executing calibration when an abnormality occurs, a display for displaying the analysis results, etc. are integrated. Provided as easy to use.
[0041]
(FIG. 5)
FIG. 5 shows a second embodiment. There are two differences from the embodiment shown in FIG. The first difference is that the optical fibers 6 and 8 used in the embodiment shown in FIG. 1 are omitted. The second difference is that, in the embodiment shown in FIG. 1, the irradiation light that has passed through the object to be measured is received, but in the embodiment shown in FIG. It is shown as receiving light. According to the embodiment shown in FIG. 5 as well, measurement data for measuring blood glucose concentration can be obtained.
[0042]
【The invention's effect】
According to the first to fourth aspects of the present invention, it is possible to provide a method for acquiring data for spectral measurement, which automatically performs calibration so that accurate measurement can be performed when input data is inconsistent. .
Further, according to the invention of claims 5 to 7, when the input data is out of order, the computer is caused to execute a spectrometry data acquisition method for automatically calibrating so that accurate measurement is possible. Computer program was provided.
[Brief description of the drawings]
FIG. 1 is a block diagram showing an embodiment of the present invention.
FIG. 2 is a flowchart illustrating a first embodiment.
FIG. 3 is a flowchart illustrating a second embodiment.
FIG. 4 is a block diagram illustrating a hardware configuration.
FIG. 5 is a block diagram showing a second embodiment.
[Explanation of symbols]
1: High frequency generator 2: High frequency oscillator (piezo element)
3: acousto-optic variable filter 4: light source 5: condenser lens 6: optical fiber 7: non-measurement target 8: optical fiber 9: condenser lens 10: light receiving element 11: photoelectric conversion unit 12: operation control unit 13: display unit 14: Telegraph unit a: High frequency b: Light c: Irradiation light d: Light reception e: Analog detection signal f: Digital detection signal

Claims (7)

A method for capturing data for spectrometry for measuring blood glucose concentration,
A measurement process for performing measurement by a measured part, a determination process for determining whether or not a measured value based on the measurement process is within an appropriate range, and performing a measurement calibration when the determination process determines that the value is not within an appropriate range. With a calibration process,
The measurement process is a light emission step of emitting measurement light including near infrared light from the light emitting device,
A light receiving step of receiving the reflected light of the measurement light reflected on the measurement site using the measurement light emitted in the light emission step,
The determination process includes an analysis step of analyzing the reflected light received in the light receiving step, and a determination step of determining whether the pre-analysis data or the analysis result of the analysis step is within an appropriate range,
In the calibration process, when it is determined in the determining step that the reflected light is out of the proper range, the reflected light reflected from the measurement light is irradiated with the measurement light from the light emitting device to the calibration substance having the reference value for frequency adjustment, and the reflected light is reflected. A moving step of relatively moving the calibration substance, the light emitting section and the light receiving section so that the light receiving section can receive light, and a light emitting and receiving step of irradiating the calibration substance with measurement light and receiving reflected light. And a calibration step for adjusting the frequency in the analysis step based on the reflected light received in the light emission / reception step. The calibration material is ceramic and polystyrene,
2. The method according to claim 1, wherein the moving step of the calibration process includes a moving step to the ceramic and a light emitting and receiving step for the ceramic, and a moving step to the polystyrene and a light emitting and receiving step to the polystyrene. 3. The method according to claim 1, wherein a start-up calibration step for performing a zero point adjustment in the analysis step is performed before the measurement process. Including a determination time determination step of determining whether the determination step is completed within a predetermined time,
The spectrometry according to any one of claims 1 to 3, wherein, if the determination step is not completed within a predetermined time in the determination time determination step, the moving step, the light emitting / receiving step, and the calibration step are performed. Data acquisition method. This is a program for causing a computer to implement a method of acquiring data for spectral measurement.
The program includes a measurement process for performing measurement by a measured part, a determination process for determining whether a measurement value based on the measurement process is within an appropriate range, and a determination process when the determination process determines that the measurement value is not within an appropriate range. A measurement process comprising a calibration process for performing measurement calibration, a light emission step of emitting measurement light including near infrared light from the light emitting device,
A light receiving step of receiving the reflected light of the measurement light reflected on the measurement site using the measurement light emitted in the light emission step,
The determination process includes an analysis step of analyzing the reflected light received in the light receiving step, and a determination step of determining whether the pre-analysis data or the analysis result of the analysis step is within an appropriate range,
In the calibration process, when it is determined in the determining step that the reflected light is out of the proper range, the reflected light reflected from the measurement light is irradiated with the measurement light from the light emitting device to the calibration substance having the reference value for frequency adjustment, and the reflected light is reflected. A moving step of relatively moving the calibration substance, the light emitting section and the light receiving section so that the light receiving section can receive light, and a light emitting and receiving step of irradiating the calibration substance with measurement light and receiving reflected light. A computer program for causing a computer to execute a calibration step of adjusting a frequency in an analysis step based on the reflected light received in the light emission and reception step. 6. The computer program according to claim 5, wherein a start-up calibration step for performing a zero point adjustment in the analysis step is performed before the measurement process. Including a determination time determination step of determining whether the determination step is completed within a predetermined time,
7. The computer program according to claim 5, wherein, if the determination step is not completed within a predetermined time in the determination time determination step, the moving step, the light emitting / receiving step, and the calibration step are performed. .

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