JP2004121302A - Implant complex - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an implant complex, active and totally absorbable in vivo, for the prosthesis and filling as a substitute for an organism bone. <P>SOLUTION: A porous body 2 made of in-vivo decomposable and absorbable polymers including a large quantity of bioactive bioceramics powder with continuous pores inside is filled in a mesh 1a of a compact mesh body 1 made of in-vivo decomposable and absorbable polymers including bioactive bioceramics powder to make the implant complex. The porous bodies 2 may be layered on one side or both sides of the mesh body 1, or the porous bodies 2 may be mounted on a concavely or convexly curved inner surface of the mesh body 1 or in gaps in the folded mesh body 1. <P>COPYRIGHT: (C)2004,JPO

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a bioactive and degradable absorbent used as a prosthesis, a filler and the like for the purpose of reducing, correcting or increasing many skeletal parts such as skull, jaw, face or chest. Implant complex.
[0002]
[Prior art]
Conventionally, when reducing a skull defect, a metal (such as titanium) punched (mesh-shaped) plate having a large number of holes formed by punching is used to cover the skull defect. Often. Further, a mesh-shaped flat plate or a concavo-convex plate made of a dense or porous body of fired bioceramics (eg, hydroxyapatite (HA), tricalcium phosphate (TCP), octacalcium phosphate (OCP), etc.) is also used. Particularly, in recent years, the use of porous bodies having osteoconductivity for the purpose of replacing living bones has increased.
[0003]
[Problems to be solved by the invention]
Since punching plates made of metal such as titanium lack physical biocompatibility and remain permanently as foreign matter in the supplemented part, they may be corroded or eluted with metal ions during long-term implantation, causing damage to surrounding tissues. Therefore, there is a concern that harm may occur, and there is a problem that the defective portion cannot be completely replaced with bone tissue forever.
[0004]
In addition, the porous body of fired bioceramics is hard but brittle and easily cracked due to the properties specific to ceramics, and there is a great concern that the porous body will be damaged by impact during use. In particular, a porous body having a large porosity is excellent in penetration into bone and osteoconductivity, but has a disadvantage that it is easily broken. Furthermore, there is also a disadvantage that post-molding cannot be performed according to the three-dimensional shape of the portion to be compensated.
[0005]
From another viewpoint, many types of the latter bioceramic porous materials have been developed and studied as scaffolds for hard tissue regeneration in cell engineering (Tissue Engineering), which has been studied rapidly in recent years. .
[0006]
An object of the present invention is to provide a bioactive and bioabsorbable implant composite for filling and replacing a living bone, which can solve the above-mentioned problems at once.
[0007]
[Means for Solving the Problems]
In order to achieve the above object, the implant composite of the present invention has a dense high-strength reticulated network made of a biodegradable and absorbent polymer containing bioactive bioceramic powder, and has continuous pores therein. And a bioactive porous body made of a biodegradable and absorbable polymer containing a large amount of bioactive bioceramic powder, which is more bioactive than the network.
[0008]
This composite replaces living bone composed of a combination of trabecular bone (inside) and cortical bone (surface layer) with an implant composite having a similar structure, but the part that plays the role of cortical bone Is a reticulated body, and the porous body serving as a cancellous bone has a porosity as high as possible, thereby providing a substitute for a living bone (allograft or autograft bone) having a large area and a small material. This material has bioactivity (osteoconductivity, bone replacement) and total resorption, and the porous body is reinforced by a dense network, and the combination of the network and the porous material Is limited to as small as possible, and is a biocompatible complex designed to minimize the amount of biological treatment in the decomposition and absorption process.
[0009]
When this implant complex is fixed to, for example, a defective portion of the skull, the body fluid penetrates through the continuous pores to the inside of the porous body filled with the mesh of the reticulated body, hydrolysis proceeds rapidly, and the bioceramic powder is removed. Osteoblasts penetrate into the porous body due to osteoconductivity, and bone tissue is conductively formed, and the porous body replaces the bone tissue in a relatively short period of time. On the other hand, the reticulate body has a role to protect the skull defect by maintaining sufficient strength until the porous body is gradually replaced with bone tissue, with the hydrolysis gradually progressing from the surface later than the porous body. And eventually disappear by replacing bone tissue.
[0010]
As described above, the implant composite of the present invention degrades and absorbs both the porous body and the reticulated body and is replaced by bone tissue, and does not remain in the living body as a foreign substance. It is possible to eliminate the risk of harm due to such long-term survival in the living body, and it is possible to repair and reconstruct bone defects using the replaced bone tissue.
[0011]
In addition, the network in the implant composite of the present invention contains bioceramic powder, but is made of a biodegradable and absorptive polymer, so that it is too hard and brittle like fired dense ceramics. It has no toughness, has toughness and does not break easily, and can be deformed by heating. Although the porous body also contains a large amount of bioceramic powder, it uses a biodegradable and absorbable polymer as a matrix, so even if it has a high porosity, it is very brittle like a high-magnification porous ceramic. Even during the filling, the spoilers and debris do not fall off, and can be deformed by heating if necessary. As described above, the implant composite of the present invention is not brittle, has sufficient practical strength, can be deformed by heating, and is excellent in handleability.
[0012]
In the implant composite of the present invention, not only the porous body is filled in the mesh of the mesh body, but also a structure in which the porous body is provided in a layer on one or both sides of the mesh body is one powerful embodiment. It is. This configuration has the advantage that bone tissue is formed almost uniformly on one or both surfaces of the implant composite within a relatively short period of time. In addition, the porous body provided in a layered form serves as a cushion material and adheres to the bone around the bone defect, and osteoblasts easily enter the inside of the porous body. The implant composite is directly connected to the bone around the bone defect and is firmly fixed.
[0013]
The implant composite of the present invention may have a structure in which the mesh is concave or convex, and the inside of the mesh is filled with a porous body.Also, the mesh is folded, and the folded mesh is formed. A structure in which a porous body is filled between them may be used. Implant composites with such a structure are used in the field of orthopedic surgery, as well as the skull, mid-face, maxillary and mandibular deficit, for the purpose of supplementing and regenerating living bones lost due to accidents and cancer. It can also be suitably used for repair and reconstruction of other large bone defects.
[0014]
The porous body in the implant composite of the present invention has a porosity of 50 to 90%, continuous pores occupy 50 to 90% of the entire pores, and pores of continuous pores of about 100 to about 400 μm. However, it is desirable from the viewpoints of degradability and absorption and conduction replacement of bone tissue. The content of the bioceramics powder in the porous body is desirably 60 to 90% by weight. At such a content, the osteoconductive ability is sufficiently exhibited, and the porous ceramics can be produced in a relatively short period of time. The body is replaced with bone tissue. In addition, foreign body reaction around the strip caused by hydrolysis of the degradable and absorbable polymer having no osteoconductive ability is further avoided.
[0015]
The mesh in the implant composite of the present invention may be a biodegradable absorbent polymer containing bioceramics powder, a warp and a weft fused at the intersection, or a biodegradable absorbent containing bioceramics powder. A material in which a mesh is formed on a sheet or plate of a conductive polymer is preferably used. In particular, as a sheet or plate of a biodegradable and absorbable polymer, using a forged in the cold, and then further changing the machine direction and forging in the cold, the mesh body formed by forming a mesh has a different direction. Since the molecular chains and crystals of the biodegradable and absorbable polymer are multiaxially oriented in all directions by forging twice, it is difficult to return to the original shape at the temperature of the living body when it is bent and deformed, It has the advantage that it does not cause whitening or cutting even if it is bent and deformed many times. Therefore, by using such a net-like body, it is possible to obtain an implant composite having good bending workability even during surgery.
[0016]
The content of the bioceramics powder in the reticulated body is desirably 10 to 60% by weight. At such a content, sufficient osteoconductive ability can be exhibited without weakening the reticulated body.
[0017]
Another implant composite of the present invention is obtained by stacking the above-described implant material on both surfaces of a porous body made of a biodegradable and absorbent polymer containing continuous pores therein and containing a bioactive bioceramic powder. It is characterized by being provided integrally. Such an implant composite having a sandwich structure can be suitably used as a prosthetic material or the like for a bone defect that needs to be repaired and reconstructed by conducting a thick bone tissue as described above.
[0018]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, specific embodiments of the present invention will be described with reference to the drawings.
[0019]
FIG. 1 is a perspective view of an implant complex according to an embodiment of the present invention, FIG. 2 is a cross-sectional view of the implant complex, and FIG. 3 is an explanatory diagram of one use example of the implant complex.
[0020]
The implant complex 10 is used, for example, as a prosthetic material or the like that covers the defective portion 21 of the skull 20 as shown in FIG. 3, and as shown in FIGS. And a porous body 2 filled in each mesh 1a of the body 1.
[0021]
The reticulated body 1 of the implant composite is a dense and strong reticulated body made of a biodegradable absorbent polymer containing a bioactive bioceramic powder, and is a biodegradable bioreactor containing bioceramic powder. The net-like body is formed by forming a square mesh 1a on a sheet or plate of an absorbent polymer by means such as punching or cutting. The shape of the mesh 1a is not limited to a square, but may be a circle, a rhombus, or any other desired shape.
[0022]
The opening area of the mesh 1a is 0.1 to 1.0 cm. ² The area ratio of the mesh 1a to the net 1 is preferably about 10 to 80%. Further, the thickness of the mesh body 1 is preferably about 0.3 to 1.5 mm, and the width of the warp equivalent portion 1b and the weft equivalent portion 1c of the mesh body 1 is preferably about 2 to 10 mm. When the area ratio of the mesh 1a is less than 10%, the strength of the whole composite is large, but the filling amount of the rapidly hydrolyzing porous body 2 filled in the mesh 1a is small, and the proportion of the network 1 which is slowly hydrolyzed is occupied. The length of time required for the entire implant complex to be degraded and resorbed and replaced with bone tissue increases. On the other hand, when the area ratio of the mesh 1a exceeds 80%, the thickness of the mesh 1 becomes thinner than 0.3 mm, and the width of the warp equivalent portion 1b and the weft equivalent portion 1c becomes smaller than 2 mm, the strength of the mesh 1 decreases. The considerable reduction makes it difficult to obtain a strong implant composite.
[0023]
When it is desired to obtain the reticulated body 1 having good bending workability, a molten molded body of a biodegradable and absorbable polymer containing bioceramics powder is cold-formed (glass transition temperature of the polymer) as the above-mentioned sheet or plate as a material. After forging once in the temperature range from the melting temperature to the melting temperature), the direction (machine direction MD) is changed and then forged once again in the cold state, and the mesh 1a is punched out or cut to form a mesh. May be prepared. In this manner, the biodegradable absorbent polymer sheet or plate forged twice by changing the direction is a molecular chain of the biodegradable absorbent polymer, a domain of a molecular chain assembly, a crystal or the like is multiaxially oriented, or Since it has a structure in which a large number of multiaxially oriented clusters are aggregated, it is difficult to return to its original shape at body temperature when it is bent and deformed at room temperature, and it is whitened and cut even when it is bent and deformed many times Is unlikely to occur. Therefore, the implant composite 10 produced using the mesh 1 in which the mesh 1a is formed on the sheet or plate has good bending workability, and is bent at room temperature to conform to the curved surface of the defective portion 21 of the skull 20. It can be processed and fixed to the defective portion 21. In addition, as a sheet or a plate used as a material of the net-like body 1, a uniaxially or biaxially stretched sheet, a non-stretched sheet, or a compression-molded sheet may be used.
[0024]
Examples of the biodegradable and absorbable polymer as a raw material of the reticulated body 1 include crystalline poly-L-lactic acid, poly-D-lactic acid, poly-D / L-lactic acid, and poly-D-L-lactic acid, whose safety in vivo has been confirmed Glycolic acid and the like are preferred. Considering the strength and hydrolysis rate of the reticulated body 1, these biodegradable and absorbable polymers have a viscosity average molecular weight of 150,000 or more, preferably about 200,000 to 600,000.
[0025]
As the bioceramic powder to be contained in the biodegradable and absorbable polymer of the reticulated body 1, uncalcined, uncalcined hydroxy, which is bioactive, has good osteoconductivity and good biocompatibility. Powders such as apatite, dicalcium phosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, calcite, ceravital, diopsite, and natural coral are used. The content of the bioceramic powder is preferably in the range of 10 to 60% by weight, and if it is less than 10% by weight, osteoconductive formation by the bioceramics powder is insufficient, and if it exceeds 60% by weight, the reticulated body 1 is fragile. Inconveniences such as
[0026]
In the implant material of this embodiment, as described above, the mesh body 1 is formed by forming a mesh 1a on a sheet or plate of a biodegradable and absorbable polymer containing bioceramics powder as the mesh body 1. However, it is also possible to use a reticulated body obtained by fusing the warp and the weft of the biodegradable and absorbent polymer containing the bioceramics powder at the intersection of the warp and the weft (including the belt as well as the round yarn).
[0027]
On the other hand, the porous body 2 filled in each mesh 1a of the network body 1 has a continuous pore inside and is made of a biodegradable absorbent polymer containing bioactive bioceramic powder, A portion of the bioceramic powder is exposed on the surface of the porous body or the inner surface of the continuous pores.
[0028]
The porous body 2 is filled in the mesh 1a of the mesh body 1 by one of the following two methods.
[0029]
In the first method, a suspension is prepared by dissolving the biodegradable and absorbable polymer in a volatile solvent and mixing the bioceramic powder, and the suspension is fiberized by means such as spraying. A fiber aggregate in which the fibers are intertwined is formed. Then, the fiber aggregate is heated and pressurized to form a rectangular parallelepiped porous fiber fusion aggregate that matches the mesh 1a, and the fiber fusion aggregate is immersed in a volatile solvent to shrink the fibers. By fusing and substantially eliminating the fibrous form to form a matrix, the inter-fiber space is changed into a porous body 2 having continuous pores having roundness, and then inserted into the mesh 1a of the reticulated body 1. , Filling.
[0030]
In the second method, the above fiber aggregate is packed into the mesh 1a of the mesh body 1 and heated to a temperature at which the fibers can be fused, whereby the fibers are partially fused to each other to form a porous fiber fusion. The fused fiber aggregate is immersed in a volatile solvent together with the reticulated body 1 to form a porous body 2.
[0031]
The porous body 2 is not required to have the same strength as the reticulated body 1 and needs to be decomposed relatively quickly to replace the bone tissue formed by conduction with the bioceramic powder. As the biodegradable and absorbable polymer, poly-D, L-lactic acid which is safe, relatively quick to decompose, is not very brittle, and which is a mixture of amorphous or crystalline and non-crystalline, L-lactic acid and D, L-lactic acid Copolymers, lactic acid and glycolic acid copolymers, lactic acid and caprolactone copolymers, lactic acid and ethylene glycol copolymers, lactic acid and para-dioxanone copolymers, and the like. , Or a mixture of two or more. Considering the ease of forming a fiber aggregate by fibrillation and the period of decomposition and absorption in a living body, those polymers having a viscosity average molecular weight of about 50,000 to 1,000,000 are preferably used.
[0032]
Further, as the bioceramic powder contained in the porous body 2, all of the bioceramic powder contained in the above-described reticulated body 1 are used. Among them, all of the bioceramic powder is completely absorbed in the living body and completely replaced with bone tissue. Bioabsorbable bioceramic powders are preferred, and especially uncalcined, unfired hydroxyapatite, tricalcium phosphate, and octacalcium phosphate have extremely high bioactivity, have excellent osteoconductivity, and are harmful. It is optimal because it is low and is absorbed by the living body in a short period of time. As these bioceramic powders, those having a particle size of 10 μm or less are preferably used. In particular, those having a particle size of about 0.2 to 5 μm are formed into fibers by spraying or the like to form a fiber aggregate. In this case, the fibers are very preferably used because the fibers are not cut short.
[0033]
The content of the bioceramics powder in the porous body 2 is desirably 60 to 90% by weight, and if it exceeds 90% by weight, the fibers become short when forming into a fiber aggregate by forming into fibers by means such as spraying. On the other hand, if it is less than 60% by weight, conduction formation of the bone tissue is slowed, and it takes time for the porous body 2 to replace the bone tissue. A more preferred content of the bioceramics powder is 60 to 80% by weight.
[0034]
The porous body 2 has a porosity of 50 to 90% (preferably 60 to 80%) in consideration of physical strength, invasion and stabilization of osteoblasts, and continuous pores are 50% of the total pores. Occupies about 90 to 90% (preferably 70 to 90%), and the pore diameter of the continuous pores is desirably about 100 to about 400 μm (preferably 150 to 350 μm). When the porosity exceeds 90% and the pore diameter is larger than 400 μm, the physical strength of the porous body 2 decreases and the porous body 2 becomes brittle. On the other hand, when the porosity is less than 50% and the continuous pores are less than 50% of the total pores and the pore diameter is smaller than 100 μm, it becomes difficult for body fluids and osteoblasts to penetrate, and hydrolysis of the porous body 2 and bone tissue And the time required for the porous body 2 to replace bone cells becomes longer.
[0035]
It is preferable that the porous body 2 contains appropriate amounts of various bone formation factors, growth factors, drugs and the like. The main bone morphogenetic factors are BMP, and the main growth factors are monokines and lymphokines such as IL-1, TNF-α, TNF-β and IFN-γ, or colony stimulating factors or TGF-α. , TGF-β, IGF-1, PDGF, FGF and the like. In addition, as the drug, drugs related to bone growth (such as vitamin D, prostaglandins, or anti- (anti) cancer drugs), and antibacterial agents can be arbitrarily selected. When such a growth factor is contained in the porous body 2, bone formation is remarkably promoted inside the porous body 2, and the porous body 2 is replaced with bone tissue at an early stage. When the drug is impregnated, the drug is absorbed by the skull 20 and the drug effect is sufficiently exerted.
[0036]
The surface (exposed surface) of the porous body 2 may be subjected to an oxidation treatment such as a corona discharge, a plasma treatment, and a hydrogen peroxide treatment. The wetting characteristics are improved, and the osteoblasts can more effectively penetrate and grow inside the porous body 2. Further, the same oxidation treatment may be performed on the surface of the mesh body 1.
[0037]
For example, as shown in FIG. 3, the implant composite 10 having the above-described configuration is applied to the skull 20 so as to cover the defective portion 21 of the skull 20, and the periphery of the screw 30 is formed of a biodegradable and absorbable polymer. Is fixed at several places. At that time, the implant composite 10 is preferably bent so as to conform to the curved surface of the defective portion 21 of the skull 20.
[0038]
When the defective portion 21 of the skull 20 is covered with the implant complex 10 in this manner, the reticulation body 1 is gradually hydrolyzed from the surface by contact with the bodily fluid, and the bodily fluid permeates into the porous body 2 through the continuous pores. Therefore, hydrolysis proceeds promptly. The osteoblasts enter the porous body 2 due to the osteoconductivity of the bioceramic powder contained in the porous body 2, and the bone tissue is conductively formed. Replace with On the other hand, the reticulated body 1 undergoes hydrolysis later than the porous body 2, and maintains sufficient strength to protect the defective portion 21 of the skull 20 until the porous body 2 is replaced with bone tissue to some extent. . Finally, the reticulated body 1 also replaces the bone tissue and disappears.
[0039]
As described above, the implant composite 10 of the present invention can dissolve and absorb the porous body 2 and the reticulated body 1 and replace them with bone tissue, and do not remain in a living body as a foreign substance. It is possible to eliminate the risk of harm due to long-term survival in the living body, and to repair and reconstruct the defective portion 21 of the skull 20 with the replaced bone tissue.
[0040]
In addition, the implant complex 10 of the present invention can be used for a relatively large bone defect such as a repair for a depressed fracture of a mid-face or a repair after removing a lesion such as a bone tumor, in addition to the use example shown in FIG. It is used for repair and reconstruction, and also as a base material for bone lengthening.
[0041]
FIG. 4 is a sectional view of an implant complex according to another embodiment of the present invention, and FIG. 5 is a sectional view of an implant complex according to still another embodiment of the present invention.
[0042]
The implant complex 11 shown in FIG. 4 is obtained by providing the same porous body 2 as the above-described porous body 2 in a layer on one surface of the above-described implant complex 10, and the implant complex 12 shown in FIG. The same porous bodies 2 and 2 as the aforementioned porous bodies 2 are provided in layers on both surfaces of the implant material 10.
[0043]
The layered porous body 2 is formed by heating and pressurizing the above-mentioned fiber aggregate to form a sheet-like porous fiber fusion aggregate, and immersing the fiber fusion aggregate in a volatile solvent to form the porous aggregate 2. The implant composite 10 is changed in form and is laminated on one or both surfaces of the implant composite 10 by means such as heat welding. The thickness of the layered porous body 2 is not particularly limited, but is preferably about 0.5 to 3 mm in consideration of the adhesion to the bone around the bone defect, the period required for decomposition and resorption, and replacement with bone tissue. It is preferable to set the thickness to
[0044]
In such an implant complex 11, 12, the bone tissue is formed almost evenly on one side or both sides in a relatively short period of time, so that the superficial repair and reconstruction of the bone defect portion are quickly performed. In addition, the porous body 2 provided in a layered form serves as a cushioning material and adheres to the bone around the bone defect portion, and osteoblasts easily enter the inside of the layered porous body 2, so that bone tissue is quickly formed. Conduction is formed on the surface layer of the porous body 2, and the implant complexes 11 and 12 are directly bonded to the bone around the bone defect, and are firmly fixed.
[0045]
FIG. 6 is a sectional view of an implant complex according to still another embodiment of the present invention.
[0046]
The implant material 13 is formed by bending the mesh 1 of the above-described implant composite 10 into a U-shape, and the same porous body 2 as the porous body 2 filled in the mesh is formed inside the mesh 1, that is, inside the concave curve. Is also filled. As the reticulated body 1, a reticulated body prepared by forming a mesh on a sheet or plate of the above-described biodegradable and absorbable polymer having good bending workability and forged twice by changing the machine direction is particularly preferably used.
[0047]
Such an implant complex 13 is formed into a size that can be embedded and filled in a defective portion such as a jaw bone, and is used for repairing and reconstructing a defective portion such as a jaw bone.
[0048]
In the implant complex 13 shown in FIG. 6, the reticulated body 1 is concavely curved in a U-shape, but the reticulated body 1 is concavely or convexly curved to a shape corresponding to a bone defect to be reconstructed. The implant composite 13 may be prepared by filling the porous body 2 inside. Further, the porous body 2 may be provided in a layer outside the implant complex 13.
[0049]
FIG. 7 is a cross-sectional view of an implant complex according to still another embodiment of the present invention.
[0050]
The implant complex 14 is obtained by folding the mesh 1 of the implant complex 10 described above into two, and folding it. Between the folded upper and lower meshes 1, 1, the porous body 2 filled with a mesh is formed. The same porous body 2 is filled in layers and integrated by means such as heat welding. As the reticulated body 1, a reticulated body prepared by forming a mesh on a sheet or plate of the above-described biodegradable and absorbable polymer having good bending properties and forged twice by changing the machine direction is preferably used. The net 1 may be folded three or more times, and the porous body 2 may be filled in layers between the nets 1 thus folded in multiple layers.
[0051]
FIG. 8 is a sectional view of an implant composite according to still another embodiment of the present invention.
[0052]
The implant composite 15 has a sandwich structure in which the above-described implant materials 10 and 10 are stacked on both surfaces of the layered porous body 2 and integrated by means such as heat welding. As the layered porous body 2, the same porous body 2 as the above-described porous body 2 filled in the mesh of the network body 1 is used.
[0053]
Since the implant complex 15 and the above-described implant complex 14 have a large overall thickness, they are suitably used as a prosthetic material for a bone defect portion where it is necessary to conduct and reconstruct a thick bone tissue.
[0054]
In these implant composites 15 and 14, between the reticulated body 1 and the reticulated body 1, instead of the porous body 2, the above-described fiber aggregate, or a porous material obtained by heating and pressurizing the fiber aggregate. A fiber-fused assembly (before immersion in a solvent to lose the fibrous form and form a matrix) may be interposed.
[0055]
As described above, the implant composite of the present invention has been described by taking as an example the case of repairing and reconstructing a defective portion of the skull and the defective portion of the jaw bone. However, the implant composite of the present invention can be used in comparison with orthopedic or plastic surgery. It is expected to be used for an extremely large bone defect, and its application site is not particularly limited.
[0056]
【The invention's effect】
In the implant composite of the present invention, the porous body is quickly decomposed and absorbed, and is replaced with bone tissue in a relatively short period of time. The reticulated body, which is relatively slow in total decomposition and absorption, also played a role in protecting the reconstruction site. After that, it is finally decomposed and absorbed and replaced with bone tissue, which eliminates the fear of developing harm because it remains in the body as a foreign substance like a conventional metal punching plate, and was replaced. It has a remarkable effect that the bone tissue can be reliably repaired and reconstructed.
[0057]
The implant composite in which the porous body is provided in a layer on one or both sides has a structure in which the bone tissue is formed substantially evenly on one or both sides of the implant material in a relatively short period of time, and the layered porous body is a cushion material. In addition, it has the effect of closely adhering to the bone around the bone defect portion and directly bonding to the surrounding bone early to be firmly fixed.
[0058]
Furthermore, as a network, an implant composite using a network formed by forming a mesh on a sheet or plate of a biodegradable absorbent polymer forged twice in a different direction has a good bending workability, It also has the effect of being able to bend into a curved shape that matches the repair site.
[0059]
In addition, the implant complex in which the reticulated body is concave or convex and the inside thereof is filled with a porous body can be preferably used for repairing and reconstructing a bone defect part deeply excavated such as a defective part of a jaw bone, and further, An implant composite in which a porous body is filled in a layer between the folded networks, or a sandwich structure in which an implant composite is provided integrally on both sides of a layered porous body. Can be suitably used for a bone defect where bone tissue needs to be formed thick and reconstructed.
[Brief description of the drawings]
FIG. 1 is a perspective view of an implant complex according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view of the implant composite.
FIG. 3 is an explanatory diagram of one usage example of the implant complex.
FIG. 4 is a cross-sectional view of an implant complex according to another embodiment of the present invention.
FIG. 5 is a cross-sectional view of an implant composite according to still another embodiment of the present invention.
FIG. 6 is a cross-sectional view of an implant composite according to still another embodiment of the present invention.
FIG. 7 is a cross-sectional view of an implant composite according to still another embodiment of the present invention.
FIG. 8 is a cross-sectional view of an implant complex according to still another embodiment of the present invention.
[Explanation of symbols]
10,11,12,13,14,15 Implant materials
1 reticulated body
1a mesh
2 porous body
20 skull
21 Bone defect

Claims (11)

A network of biodegradable and absorbent polymer containing bioactive bioceramics powder, consisting of biodegradable and absorbent polymer containing bioporous bioceramics powder with continuous pores inside An implant composite characterized by being filled with a porous body. The implant composite according to claim 1, wherein a porous body is provided in a layer on one or both sides of the reticulated body. The implant composite according to claim 1, wherein the mesh is concave or convex, and the inside of the mesh is filled with a porous body. The implant composite according to claim 1, wherein the reticulated body is folded, and a porous body is filled between the folded reticulated bodies. The porosity of the porous body is 50 to 90%, the continuous pores occupy 50 to 90% of the whole pores, and the pore diameter of the continuous pores is about 100 to about 400 µm. An implant composite as described. The implant composite according to any one of claims 1 to 5, wherein the content of the bioceramic powder in the porous body is 60 to 90% by weight. The implant composite according to any one of claims 1 to 6, wherein the content of the bioceramic powder in the network is 10 to 60% by weight. The implant composite according to any one of claims 1 to 7, wherein the reticulated body is obtained by fusing a warp and a weft of a biodegradable and absorbable polymer containing a bioactive bioceramic powder at the intersection thereof. . The implant composite according to any one of claims 1 to 7, wherein the mesh is formed by forming a mesh on a sheet or plate of a biodegradable and absorbable polymer containing bioactive bioceramic powder. The implant composite according to claim 9, wherein the sheet or plate of the biodegradable and absorbable polymer is forged in a cold state and then forged in a different direction. The implant material according to claim 1 is integrally provided on both surfaces of a porous body made of a biodegradable and absorbent polymer containing continuous pores therein and containing a bioactive bioceramic powder. An implant composite, comprising:

Images