JP2004016707A - Injector type drug capsule - Google Patents
Injector type drug capsule Download PDFInfo
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- JP2004016707A JP2004016707A JP2002179867A JP2002179867A JP2004016707A JP 2004016707 A JP2004016707 A JP 2004016707A JP 2002179867 A JP2002179867 A JP 2002179867A JP 2002179867 A JP2002179867 A JP 2002179867A JP 2004016707 A JP2004016707 A JP 2004016707A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
- A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、注射器型薬剤カプセルに関するものであり、詳しくは、２種の薬剤を別個に収容すると共にこれらを混合して押し出す注射器型薬剤カプセルに関するものである。
【０００２】
【従来の技術】
特開平８−１３１４５９号公報には、歯科治療において歯牙修復材料を投与するための「歯牙修復材用カプセル」が開示されている。斯かる歯牙修復材用カプセルは、２種の薬剤を別個に収容すると共にこれらを混合して押し出す注射器型のカプセルであり、粉体成分が収納され且つ先端部にノズルが固定されたシリンダー状のカプセル本体と、内部に液体成分が収納され且つカプセル本体に後端側から嵌合する液体カップと、先端部に棒状突起を有し且つ液体カップに後端側から嵌合するプランジャーとから構成され、カプセル本体の先端には、薄膜状シールによって封止された混合物取出用の円形穴が設けられ、液体カップの先端には、薄膜状シールによって封止された液体成分の出口用の穴が設けられる。
【０００３】
上記の歯牙修復材用カプセルを使用する場合は、液体カップの奥端までプランジャーを押し込み、液体カップ先端の薄膜状シールを棒状突起によって破ることにより、カプセル本体に液体成分を注入し、カプセル本体内において歯牙修復材料としての混合物（混練物）を得る。なお、カプセル本体における粉体成分と液体成分の混合においては、専用のミキシング装置に歯牙修復材用カプセル全体を装填して機械的振動を与え、また、得られた混練物の取出においては、専用のアプライヤー（注入器具）を使用し、プランジャーと共に液体カップをカプセル本体の奥端に押し込むことにより、カプセル本体先端の薄膜状シールを棒状突起によって押し破り、ノズルから混練物を押し出す。
【０００４】
【発明が解決しようとする課題】
ところで、上記の様なカプセルにおいて粉体成分と液体成分を混合する場合は、ミキシング装置などの専用機器が使用されるが、外部からの振動によって混合するため、十分に混合するには多くの合時間を必要とする。更に、ある種の高粘度の歯牙修復材などは、上記の構造のカプセルに収容した場合、外部振動によっては十分に混合できないと言う問題がある。また、上記の様なカプセルにおいては、製造コストを低減する観点から、一層シンプルな構造が望まれる。
【０００５】
本発明は、上記の実情に鑑みてなされたものであり、その目的は、２種の薬剤を別個に収容すると共にこれらを混合して押し出す注射器型薬剤カプセルであって、シンプルな構造を備え、しかも、収容された２種の薬剤が高粘度の薬剤であっても、これらを簡単に且つ十分に混合することが出来る新規な構造の注射器型薬剤カプセルを提供することにある。
【０００６】
【課題を解決するための手段】
上記の課題を解決するため、本発明の注射器型薬剤カプセルは、２種の薬剤を別個に収容すると共にこれらを混合して押し出す注射器型薬剤カプセルであって、先端に取出口が設けられ且つ第１の薬剤が収容される外側シリンジと、先端に放出口が設けられ且つ第２の薬剤が収容されて前記外側シリンジの後端から挿入される内側シリンジと、当該内側シリンジの放出口を開口する穿孔ロッドが先端に突設され且つ前記内側シリンジの後端から挿入されるプランジャとを備え、前記外側シリンジの薬剤収容領域には、予め収容された第１の薬剤と前記内側シリンジから供給される第２の薬剤とを回転によって撹拌混合する攪拌部材が前記外側シリンジと同軸状に配置され、前記攪拌部材は、その中心部に設けられた軸穴にプランジャの前記穿孔ロッドが挿通され且つ前記プランジャを回転操作されることにより、回転する様になされていることを特徴としている。
【０００７】
上記の注射器型薬剤カプセルにおいては、プランジャの押込み操作により、穿孔ロッドによって内側シリンジ先端の放出口を開口し、内側シリンジの第２の薬剤を外側シリンジに供給する。その際、プランジャの穿孔ロッドは、内側シリンジ先端の放出口を貫通して外側シリンジ先端側の薬剤収容領域に突出する。これにより、攪拌部材は、その中心部に設けられた軸穴にプランジャの穿孔ロッドが挿通されることにより当該穿孔ロッドによって係止される。従って、攪拌部材は、プランジャの回転操作により回転し、薬剤収容領域の第１の薬剤と第２の薬剤を撹拌混合する。そして、各薬剤を混合した後は、内側シリンジの押込み操作により、外側シリンジ先端の取出口通じ、混合された薬剤を押し出す。
【０００８】
【発明の実施の形態】
本発明の注射器型薬剤カプセルの実施形態を図面に基づいて説明する。図１は、注射器型薬剤カプセルの一例の構成要素を示す部品展開斜視図である。図２は、図１の注射器型薬剤カプセルの構成要素を中心線に沿って一部破断して示す側面図である。図３は、図１の注射器型薬剤カプセルの使用態様を中心線に沿って一部破断して示す側面図である。図４は、注射器型薬剤カプセルの他の例の構成要素を示す部品展開斜視図である。図５は、図４の注射器型薬剤カプセルの構成要素を中心線に沿って一部破断して示す側面図である。図６は、図４の注射器型薬剤カプセルの使用態様を中心線に沿って一部破断して示す側面図である。図７は、攪拌部材の幾つかの態様を示す斜視図である。なお、以下の実施形態の説明においては、注射器型薬剤カプセルを「カプセル」と略記する。
【０００９】
本発明のカプセルは、２種の薬剤、すなわち、第１の薬剤（Ａ）及び第２の薬剤（Ｂ）（図３又は図６参照）を別個に収容すると共にこれらを混合して押し出すいわゆる注射器の機能を備えた容器であり、図１、図２、図４及び図５に示す様に、主に、外側シリンジ（１）、内側シリンジ（２）、プランジャ（３）及び攪拌部材（４）とから構成される。
【００１０】
本発明のカプセルに適用される第１の薬剤（Ａ）及び第２の薬剤（Ｂ）としては、混合して使用されるべき薬剤であれば特に制限はなく、医薬品の他、歯牙修復材料（ペースト）、手術補助剤などの医薬品外の物質、接着剤、充填剤などの医療用途以外の物質が挙げられる。第１の薬剤（Ａ）及び第２の薬剤（Ｂ）の少なくとも一方は液体またはゲルである。
【００１１】
上記の外側シリンジ（１）は、第１の薬剤（Ａ）を収容し且つ第１の薬剤（Ａ）と第２の薬剤（Ｂ）を混合するための容器であり、通常は透明性の樹脂材料、典型的には耐薬品性および耐熱性に優れた環状ポリオレフィン、ポリプロピレン、ポリエチレン、ポリエチレンナフタレート、ポリカーボネート、ＡＢＳ樹脂などの樹脂によって一体的に射出成形される。外側シリンジ（１）の構成材料としては、上記の様な樹脂の他、積層構造になされた各種の樹脂、ガラス、セラミックス、金属などが挙げられる。外側シリンジ（１）は略有底円筒状に形成され、その先端中心には取出口（１１）が設けられる。取出口（１１）は、通常、外側シリンジ（１）の先端から突出するノズル状に形成される。また、外側シリンジ（１）の後端には、後述する内側シリンジ（２）の操作の際に外側シリンジ（１）を支持するため、フランジ状に張出された掛止部（１３）が設けられる。
【００１２】
外側シリンジ（１）は、第１の薬剤（Ａ）が収容されて取出口（１１）を薄膜状のシール材やキャップ（図示省略）によって封止される。外側シリンジ（１）の先端側、具体的には外側シリンジ（１）の前半部は薬剤収容領域とされ、当該薬剤収容領域においては、第１の薬剤（Ａ）と第２の薬剤（Ｂ）を混合するため、例えばその半分の容積に相当する部分に第１の薬剤（Ａ）が収容される。なお、外側シリンジ（１）の内容積は、歯牙材料に適用する場合で０．０１〜１０ｃｍ３程度である。
【００１３】
また、本発明の好ましい態様においては、後述の攪拌部材（４）を外側シリンジ（１）内でより確実に進退させるため、図５に示す様に、薬剤収容領域を構成する外側シリンジ（１）の先端側の内周面には、攪拌部材（４）を案内する案内ネジ（１５）が設けられる。案内ネジ（１５）は、これに係合した攪拌部材（４）の正逆回転により、当該攪拌部材を外側シリンジ（１）の軸線に沿って進退させる案内機能を有する。
【００１４】
図１、図２、図４及び図５に示す内側シリンジ（２）は、第２の薬剤（Ｂ）を収容し且つ外側シリンジ（１）内で混合された第１の薬剤（Ａ）及び第２の薬剤（Ｂ）を押し出す容器兼プランジャとして機能する部材であり、上記の外側シリンジ（１）と同様に、通常は各種の樹脂材料により一体的に射出成形される。勿論、ガラス等で構成されてもよい。内側シリンジ（２）は、外側シリンジ（１）の筒内に嵌合する外径の略有底円筒状に形成され、その先端中心には、放出口（２２）が設けられる。内側シリンジ（２）の後端には、後述するプランジャ（３）の操作の際に内側シリンジ（２）を支持するため、フランジ状に張出された掛止部（２３）が設けられる。
【００１５】
内側シリンジ（２）の内部には、第２の薬剤（Ｂ）が収容され、放出口（２２）は、例えば、内側シリンジ（２）と一体に成形された蓋状のシール部（２１）によって封止される。シール部（２１）は、後述の穿孔ロッド（３１）によって開封される部位であり、内側シリンジ（２）の先端面において一部を残して形成された円環状の薄肉部（溝）によって構成される。なお、内側シリンジ（２）の内容積は、歯牙材料に適用する場合で０．０１〜１０ｃｍ３程度である。
【００１６】
また、上記の様に、外側シリンジ（１）の内周面に案内ネジ（１５）が設けられる場合、図４及び図５に示す様に、内側シリンジ（２）の掛止部（２３）を除く部位の外形は２段の有底円筒状に形成される。すなわち、外側シリンジ（１）の奥端まで内側シリンジ（２）を挿入した際に内側シリンジ（２）が外側シリンジ（１）の内周面に密接に嵌合する様に（図６（ｄ）参照）、内側シリンジ（２）の外周部は、案内ネジ（１５）に対応する前半部の外径を後半部の外径よりも小さく設定される。
【００１７】
図１、図２、図４及び図５に示すプランジャ（３）は、内側シリンジ（２）に収容された第１の薬剤（Ａ）を外側シリンジ（１）へ押し出すための押圧部材であり、上記の外側シリンジ（１）と同様に、通常は各種の樹脂材料により一体的に射出成形される。外側シリンジ（１）と同様にガラス等で構成されてもよい。図３又は図６に示す様に、プランジャ（３）は、内側シリンジ（２）の筒内に嵌合する略円柱状に形成され、図１、図２、図４及び図５に示す様に、その先端中心には、内側シリンジ（２）の放出口（２２）を開口する穿孔ロッド（３１）が突設される。また、プランジャ（３）の後端には、後述する様に、プランジャ（３）の押し込み操作および回転操作を容易にするため、例えば扁平箱形に張出された把持部（３３）が設けられる。そして、上記のプランジャ（３）は、内側シリンジ（２）の後端から挿入される。
【００１８】
プランジャ（３）の穿孔ロッド（３１）は、放出口（２２）のシール部（２１）を突き破る機能と、後述の攪拌部材（４）を係止して操作する機能を有する。穿孔ロッド（３１）の長手方向に直交する断面形状は、後述の攪拌部材（４）の軸穴（４１）に嵌合する非円形の形状とされる。例えば、穿孔ロッド（３１）の上記の断面形状は四角形に形成される。
【００１９】
更に、穿孔ロッド（３１）の先端部の形状は、当該穿孔ロッドを外側シリンジ（１）内部に進入させた場合に上記の軸穴（４１）に円滑に挿入し得る様に、先端に向かうに従い断面積が漸次小さくなる形状とされる（図１及び図４参照）。更に、穿孔ロッド（３１）の長さは、プランジャ（３）を内側シリンジ（２）に押し込み、更に内側シリンジ（２）を外側シリンジ（１）に押し込んだ場合、外側シリンジ（１）の取出口（１１）の内部または先端部に達する程度の長さに設定される（図３（ｄ）及び図６（ｄ）参照）。
【００２０】
本発明のカプセルにおいては、収容した第１の薬剤（Ａ）及び第２の薬剤（Ｂ）を強制的に撹拌混合するため、図１、図２、図４及び図５に示す様に、外側シリンジ（１）の先端側の薬剤収容領域、すなわち、外側シリンジ（１）の前半部には、第１の薬剤（Ａ）と第２の薬剤（Ｂ）を回転によって撹拌混合する攪拌部材（４）が外側シリンジ（１）と同軸状に配置される。斯かる攪拌部材（４）は、図７に示す様に、その中心部に設けられた軸穴（４１）にプランジャ（３）の穿孔ロッド（３１）が挿通され且つプランジャ（３）が回転操作されることにより、回転する様になされている。これにより、薬剤の粘度に拘わらず、２種の薬剤を確実に混合することが出来る。
【００２１】
上記の攪拌部材（４）の形態としては、回転によって撹拌機能を発揮し得る限り、例えば図７に示す様に、各種の形態が挙げられる。具体的には、最も簡単な構造の攪拌部材（４）としては、図７（ｇ）に示す様な部材が挙げられる。図 （ｇ）に示す攪拌部材（４）は、軸穴（４１）が設けられたハブ（４０）から複数のバー（４２）を外側シリンジ（１）の半径方向に張出して成る。ハブ（４０）は、攪拌部材（４）の回転中心となる部位であり、上記の穿孔ロッド（３１）を挿通するための軸穴（４１）を備えている。上記の攪拌部材（４）は、その回転により、バー（４２）によって外側シリンジ（１）内の薬剤を撹拌する。
【００２２】
ハブ（４０）の軸穴（４１）の形状（軸芯に垂直な断面形状）は、穿孔ロッド（３１）を係合させた際に当該穿孔ロッドが空回することのない様に、穿孔ロッド（３１）の断面と同様の非円形の形状に形成される。軸穴（４１）の形状としては、図示する様な四角形の他、五角形、六角形、半円形などの適宜の形状を採用し得る。
【００２３】
また、攪拌部材（４）としては、図７（ａ）及び図７（ｂ）に示す様なものでもよい。図７（ａ）及び図７（ｂ）に示す攪拌部材（４）は、軸穴（４１）が設けられたハブ（４０）から複数の羽根（４３）を外側シリンジ（１）の半径方向に張出して成るプロペラ型の部材である。羽根（４３）の数は、通常、２〜５枚程度である。軸穴（４１）の形状は上記の場合と同様である。斯かる攪拌部材（４）は、羽根（４３）が一方向に捻られているため、回転により推力を発生し、回転方向によって外側シリンジ（１）内を進退する様になされている。従って、上記の攪拌部材（４）は、これを正逆回転させることにより、一層すぐれた撹拌混合効果を発揮する。
【００２４】
更に、図５に示す様に外側シリンジ（１）の内周面に案内ネジ（１５）が設けられている場合には、上記のプロペラ型の攪拌部材（４）は、図７（ｃ）及び図７（ｄ）に示す様な形態に構成される。すなわち、図７（ｃ）及び図７（ｄ）に示す攪拌部材（４）においては、図７（ａ）及び図７（ｂ）に示す部材の基本構造に加え、案内ネジ（１５）に係合する突起（４５）が各羽根（４３）の先端に付設される。そして、斯かる撹拌部材（４）は、その回転により案内ネジ（１５）に沿って外側シリンジ（１）の軸方向へ移動可能（進退可能）に構成される（図６参照）。上記の様に、外側シリンジ（１）の案内ネジ（１５）に攪拌部材（４）の突起（４５）を係合させた場合には、攪拌部材（４）を回転させることにより、強制的に攪拌部材（４）を進退させることが出来、粘度の高い薬剤であっても、確実に撹拌混合できる。
【００２５】
また、攪拌部材（４）としては、図７（ｅ）及び図７（ｆ）に示す様な部材が挙げられる。図７（ｅ）及び図７（ｆ）に示す攪拌部材（４）は、中心部に軸穴（４１）が設けられた螺旋円盤型の部材である。斯かる攪拌部材（４）の円盤部（４４）は、各分図に示す様に、一重でも二重でもよい。円盤部（４４）中心のの軸穴（４１）の形状は上記の場合と同様である。
【００２６】
更に、図５に示す様に外側シリンジ（１）の内周面に案内ネジ（１５）が設けられている場合には、上記の螺旋円盤型の攪拌部材（４）は、円盤部（４４）の外周縁が案内ネジ（１５）に係合し、当該撹拌部材の回転により案内ネジ（１５）に沿って外側シリンジ（１）の軸方向へ移動可能に構成される。上記の様に、外側シリンジ（１）の案内ネジ（１５）に攪拌部材（４）の円盤部（４４）の外周縁を係合させた場合には、上記の場合と同様に、攪拌部材（４）を回転させることにより、強制的に攪拌部材（４）を進退させることが出来、粘度の高い薬剤の撹拌混合に好適である。
【００２７】
また、図７に示す各態様の上記の攪拌部材（４）は、通常、耐薬品性および耐熱性に優れたポリオレフィン、ポリプロピレン、ポリエチレン、ポリエチレンナフタレート等の樹脂を射出成形して作製されるが、特に、図７（ａ）〜図７（ｆ）に示す攪拌部材（４）は、柔弾性を有する材料によって構成されるのが好ましい。勿論、金属等の材料で構成されてもよい。攪拌部材（４）は柔弾性材料によって構成されている場合には、外側シリンジ（１）の奥端まで内側シリンジ（２）を押し込んだ際、扁平状態に攪拌部材（４）を変形させることが出来るため、混合した薬剤をより多く効率的に取り出すことが出来る（図３（ｄ）及び図６（ｄ）参照）。
【００２８】
次に、本発明のカプセルの使用方法および機能について図３及び図６を参照して説明する。本発明のカプセルを使用する場合には、先ず、図３（ａ）及び図６（ａ）に示す状態からプランジャ（３）の押込み操作により、内側シリンジ（２）の後端側から先端へ向けてプランジャ（３）を押し込み、図３（ｂ）及び図６（ｂ）に示す様に、穿孔ロッド（３１）によって内側シリンジ（２）先端の放出口（２２）を開口し、そして、内側シリンジ（２）の第２の薬剤（Ｂ）を外側シリンジ（１）の薬剤収容領域に供給する。
【００２９】
上記の様に、内側シリンジ（２）の放出口（２２）を開口させた場合、プランジャ（３）の穿孔ロッド（３１）は、内側シリンジ（２）先端の放出口（２２）を貫通して外側シリンジ（１）先端側の薬剤収容領域に突出する。一方、上記の薬剤収容領域には攪拌部材（４）が配置されており、斯かる攪拌部材（４）はその中心部に軸穴（４１）が設けられているため、上記のプランジャ（３）の押し込み操作により、穿孔ロッド（３１）は、攪拌部材（４）の軸穴（４１）を貫通して攪拌部材（４）を係止する。
【００３０】
次いで、図３（ｃ）及び図６（ｃ）に示す様に、プランジャ（３）を回転操作すると、穿孔ロッド（３１）に係止された攪拌部材（４）が回転し、攪拌部材（４）は、その回転により、外側シリンジ（１）の薬剤収容領域に予め収容された第１の薬剤（Ａ）と内側シリンジ（２）から供給された第２の薬剤（Ｂ）を撹拌混合する。なお、攪拌部材（４）を回転させる場合には、内側シリンジ（２）を回転操作することにより、内側シリンジ（２）と共にプランジャ（３）を回転させてもよい。
【００３１】
また、上記の撹拌混合の際、特に、図６に示す様に、外側シリンジ（１）の内周面に案内ネジ（１５）が設けられ且つ当該案内ネジに攪拌部材（４）が係合している場合には、攪拌部材（４）を回転させることにより、外側シリンジ（１）内で強制的に攪拌部材（４）を進退させることが出来るため、粘度の高い薬剤でも、確実に撹拌混合することが出来る。
【００３２】
そして、第１の薬剤（Ａ）と第２の薬剤（Ｂ）を混合した後は、図３（ｄ）及び図６（ｄ）に示す様に、プランジャ（３）と共に内側シリンジ（２）を外側シリンジ（１）の奥端へ押し込むことにより、外側シリンジ（１）先端の取出口（１１）から混合された薬剤を押し出すことが出来る。
【００３３】
なお、本発明のカプセルは、勿論、指先で操作することも出来るが、通常は専用のアプライヤー（薬剤注入器具）を使用して操作される。斯かるアプライヤーは、概略、先端部にカプセル全体を収納保持するガン状の本体と、当該本体内に配置されて先端側へ伸びるプランジャ送出し用の押し込み棒と、ラック・ピニオン機構を介して押し込み棒に連接する押し込み棒回転操作用の操作バーとから成り、本体に付設された引金状のレバーの把持操作により、押し込み棒を段階的に押出操作してプランジャ（３）、内側シリンジ（２）をそれぞれ押し込み、操作バーを押送操作して押し込み棒を正逆回転させる器具である。
【００３４】
上記の様に、本発明のカプセルは、主に、外側シリンジ（１）、内側シリンジ（２）、プランジャ（３）及び攪拌部材（４）の４つの部材が同軸状に配置されたシンプルな構造を備えている。そして、本発明のカプセルにおいては、外側シリンジ（１）の薬剤収容領域に攪拌部材（４）が予め配置され、内側シリンジ（２）から外側シリンジ（１）の薬剤収容領域に第１の薬剤（Ａ）を供給して第２の薬剤（Ｂ）と混合する際にプランジャ（３）の穿孔ロッド（３１）で攪拌部材（４）を係止し、そして、プランジャ（３）の回転操作により攪拌部材（４）を強制的に回転させる様になされているため、外側シリンジ（１）の薬剤収容領域において第１の薬剤（Ａ）と第２の薬剤（Ｂ）を簡単に且つ十分に混合することが出来る。
【００３５】
更に、本発明のカプセルにおいて、外側シリンジ（１）の内周面に案内ネジ（１５）が設けられ且つ当該案内ネジに攪拌部材（４）が係合している場合には、外側シリンジ（１）内で攪拌部材（４）を回転させつつ強制的に進退させることが出来るため、粘度の高い薬剤でも、確実に撹拌混合することが出来る。なお、本発明のカプセルは、歯牙材料だけでなく、粘性の高い各種の薬剤に好適であり、また、外側シリンジ（１）及び内側シリンジ（２）の形状や大きさは、収容される薬剤や用途に応じて適宜に設計できる。
【００３６】
【発明の効果】
以上説明した様に、本発明の注射器型薬剤カプセルによれば、外側シリンジの薬剤収容領域に攪拌部材が予め配置され、内側シリンジから外側シリンジの薬剤収容領域に第１の薬剤を供給して第２の薬剤と混合する際にプランジャの穿孔ロッドで攪拌部材を係止し、そして、プランジャの回転操作により攪拌部材を強制的に回転させる様になされているため、外側シリンジの薬剤収容領域において第１の薬剤と第２の薬剤を簡単に且つ十分に混合することが出来る。
【図面の簡単な説明】
【図１】注射器型薬剤カプセルの一例の構成要素を示す部品展開斜視図である。
【図２】図１の注射器型薬剤カプセルの構成要素を中心線に沿って一部破断して示す側面図である。
【図３】図１の注射器型薬剤カプセルの使用態様を中心線に沿って一部破断して示す側面図である。
【図４】注射器型薬剤カプセルの他の例の構成要素を示す部品展開斜視図である。
【図５】図４の注射器型薬剤カプセルの構成要素を中心線に沿って一部破断して示す側面図である。
【図６】図４の注射器型薬剤カプセルの使用態様を中心線に沿って一部破断して示す側面図である。
【図７】攪拌部材の幾つかの態様を示す斜視図である。
【符号の説明】
１ ：外側シリンジ
１１：取出口
１３：掛止部
１５：案内ネジ
２ ：内側シリンジ
２１：シール材
２２：放出口
２３：掛止部
３ ：プランジャ
３１：穿孔ロッド
３３：把持部
４ ：攪拌部材
４０：ハブ
４１：軸穴
４２：バー
４３：羽根
４４：円盤
４５：突起
Ａ ：薬剤（第１の薬剤）
Ｂ ：薬剤（第２の薬剤）
Ｃ ：混合薬剤[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a syringe-type drug capsule, and more particularly, to a syringe-type drug capsule that separately accommodates two types of drugs and mixes and extrudes them.
[0002]
[Prior art]
Japanese Patent Application Laid-Open No. Hei 8-131449 discloses a "capsule for a tooth restoration material" for administering a tooth restoration material in dental treatment. Such a tooth restoration material capsule is a syringe-type capsule that separately accommodates two types of drugs and mixes and extrudes them, and has a cylindrical shape in which a powder component is stored and a nozzle is fixed to the tip. Consisting of a capsule body, a liquid cup in which a liquid component is stored and fitted into the capsule body from the rear end side, and a plunger having a rod-shaped projection at the tip end and fitted into the liquid cup from the rear end side At the tip of the capsule body, a circular hole for taking out the mixture sealed by the thin film seal is provided, and at the tip of the liquid cup, a hole for the outlet of the liquid component sealed by the thin film seal is provided. Provided.
[0003]
When using the above-mentioned tooth restoration capsule, the plunger is pushed into the inner end of the liquid cup, and the thin film seal at the tip of the liquid cup is broken by a rod-shaped projection, so that the liquid component is injected into the capsule body, A mixture (kneaded material) as a tooth restoration material is obtained in the inside. In addition, in mixing the powder component and the liquid component in the capsule body, the entire tooth restoration material capsule is loaded into a dedicated mixing device to apply mechanical vibration, and in the removal of the obtained kneaded material, a special mixing device is used. By pushing the liquid cup together with the plunger into the back end of the capsule body using an applier (injection device), the thin film seal at the tip of the capsule body is broken by the rod-shaped projection, and the kneaded material is pushed out from the nozzle.
[0004]
[Problems to be solved by the invention]
By the way, when mixing the powder component and the liquid component in the capsule as described above, a dedicated device such as a mixing device is used. However, since mixing is performed by vibration from the outside, many components are required for sufficient mixing. Needs time. Further, there is a problem that when a certain kind of high-viscosity tooth restorative material is contained in the capsule having the above structure, it cannot be sufficiently mixed by external vibration. In the capsule as described above, a simpler structure is desired from the viewpoint of reducing the manufacturing cost.
[0005]
The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a syringe-type drug capsule that accommodates two types of drugs separately and mixes and extrudes them, and has a simple structure, Moreover, it is an object of the present invention to provide a syringe-type drug capsule having a novel structure that can easily and sufficiently mix two kinds of stored drugs even if they are high-viscosity drugs.
[0006]
[Means for Solving the Problems]
In order to solve the above-mentioned problem, a syringe-type drug capsule of the present invention is a syringe-type drug capsule that separately accommodates two types of drugs, mixes and extrudes them, and has an outlet at the tip and a second port. An outer syringe in which one medicine is stored, an inner syringe in which a discharge port is provided at a distal end and a second medicine is inserted and inserted from the rear end of the outer syringe, and a discharge port of the inner syringe is opened. A perforating rod protruding from the distal end and being inserted from the rear end of the inner syringe; a medicine accommodating area of the outer syringe is supplied with the first medicine contained in advance and the inner syringe; A stirring member that stirs and mixes the second medicine with the second medicine is arranged coaxially with the outer syringe, and the stirring member is provided with a shaft hole provided at the center of the second syringe. The rod is rotated the inserted through and the plunger is characterized by being made so as to rotate.
[0007]
In the above-described syringe-type drug capsule, the discharge port at the tip of the inner syringe is opened by the perforating rod by the pushing operation of the plunger, and the second drug in the inner syringe is supplied to the outer syringe. At this time, the piercing rod of the plunger penetrates the discharge port at the tip of the inner syringe and protrudes into the medicine storage area on the tip side of the outer syringe. Thereby, the stirring member is locked by the perforation rod when the perforation rod of the plunger is inserted into the shaft hole provided at the center thereof. Therefore, the stirring member is rotated by the rotation operation of the plunger, and stirs and mixes the first medicine and the second medicine in the medicine storage area. After mixing the medicines, the mixed medicine is pushed out through the outlet of the tip of the outer syringe by the pushing operation of the inner syringe.
[0008]
BEST MODE FOR CARRYING OUT THE INVENTION
An embodiment of a syringe-type drug capsule of the present invention will be described with reference to the drawings. FIG. 1 is an exploded perspective view showing components of an example of a syringe-type drug capsule. FIG. 2 is a side view showing components of the syringe-type drug capsule of FIG. 1 partially broken along a center line. FIG. 3 is a side view showing a usage mode of the syringe-type drug capsule of FIG. 1 partially broken along a center line. FIG. 4 is an exploded perspective view showing components of another example of the syringe-type drug capsule. FIG. 5 is a side view showing components of the syringe-type drug capsule of FIG. 4 partially broken along a center line. FIG. 6 is a side view showing a usage mode of the syringe-type drug capsule of FIG. 4 partially broken along a center line. FIG. 7 is a perspective view showing some aspects of the stirring member. In the following description of the embodiments, a syringe type drug capsule is abbreviated as “capsule”.
[0009]
The capsule of the present invention is a so-called syringe that separately contains two types of drugs, that is, a first drug (A) and a second drug (B) (see FIG. 3 or FIG. 6) and mixes and extrudes them. 1, 2, 4, and 5, mainly an outer syringe (1), an inner syringe (2), a plunger (3), and a stirring member (4). It is composed of
[0010]
The first drug (A) and the second drug (B) applied to the capsule of the present invention are not particularly limited as long as they are drugs to be mixed and used. Paste), non-medicinal substances such as surgical aids, and substances other than medical uses such as adhesives and fillers. At least one of the first drug (A) and the second drug (B) is a liquid or a gel.
[0011]
The outer syringe (1) is a container for containing the first medicine (A) and mixing the first medicine (A) and the second medicine (B), and is usually a transparent resin. It is injection molded integrally with a material, typically a resin such as a cyclic polyolefin having excellent chemical resistance and heat resistance, polypropylene, polyethylene, polyethylene naphthalate, polycarbonate, and ABS resin. Examples of the constituent material of the outer syringe (1) include, in addition to the above-described resins, various resins having a laminated structure, glass, ceramics, and metals. The outer syringe (1) is formed in a substantially cylindrical shape with a bottom, and an outlet (11) is provided at the center of the tip. The outlet (11) is usually formed in the shape of a nozzle projecting from the tip of the outer syringe (1). At the rear end of the outer syringe (1), a latching portion (13) that protrudes in a flange shape is provided to support the outer syringe (1) when the inner syringe (2) described later is operated. Can be
[0012]
The outer syringe (1) contains the first medicine (A), and the outlet (11) is sealed with a thin film-like sealing material or cap (not shown). The distal end side of the outer syringe (1), specifically, the first half of the outer syringe (1) is a medicine accommodating region. In the medicine accommodating region, a first medicine (A) and a second medicine (B) are provided. Is mixed, for example, the first drug (A) is stored in a portion corresponding to a half volume thereof. The inner volume of the outer syringe (1) is about 0.01 to 10 cm 3 when applied to a tooth material.
[0013]
Further, in a preferred embodiment of the present invention, as shown in FIG. 5, the outer syringe (1) constituting the medicine accommodating area is used to more reliably advance and retreat a stirring member (4) described later in the outer syringe (1). A guide screw (15) for guiding the stirring member (4) is provided on the inner peripheral surface on the distal end side of the. The guide screw (15) has a guide function of moving the stirring member forward and backward along the axis of the outer syringe (1) by forward and reverse rotation of the stirring member (4) engaged with the guide screw (15).
[0014]
The inner syringe (2) shown in FIGS. 1, 2, 4 and 5 contains the second drug (B) and the first drug (A) and the first drug (A) mixed in the outer syringe (1). The second syringe (1) is a member that functions as a container and a plunger that pushes out the medicine (B), and is usually integrally injection-molded with various resin materials similarly to the outer syringe (1). Of course, it may be made of glass or the like. The inner syringe (2) is formed in a substantially bottomed cylindrical shape having an outer diameter fitted into the cylinder of the outer syringe (1), and a discharge port (22) is provided at the center of the tip. At the rear end of the inner syringe (2), a latching portion (23) that protrudes like a flange is provided to support the inner syringe (2) when the plunger (3) described later is operated.
[0015]
The second syringe (B) is accommodated inside the inner syringe (2), and the discharge port (22) is formed by, for example, a lid-shaped seal portion (21) integrally formed with the inner syringe (2). Sealed. The seal portion (21) is a portion to be opened by a perforated rod (31) described later, and is constituted by an annular thin portion (groove) formed by leaving a part on the distal end surface of the inner syringe (2). You. The inner volume of the inner syringe (2) is about 0.01 to 10 cm 3 when applied to a tooth material.
[0016]
Further, when the guide screw (15) is provided on the inner peripheral surface of the outer syringe (1) as described above, as shown in FIGS. 4 and 5, the hook (23) of the inner syringe (2) is changed. The outer shape of the removed part is formed in a two-stage cylindrical shape with a bottom. That is, when the inner syringe (2) is inserted to the far end of the outer syringe (1), the inner syringe (2) fits tightly on the inner peripheral surface of the outer syringe (1) (FIG. 6D). In the outer peripheral portion of the inner syringe (2), the outer diameter of the front half corresponding to the guide screw (15) is set smaller than the outer diameter of the rear half.
[0017]
The plunger (3) shown in FIGS. 1, 2, 4 and 5 is a pressing member for pushing out the first medicine (A) contained in the inner syringe (2) to the outer syringe (1), As in the case of the outer syringe (1), usually, it is integrally injection-molded with various resin materials. Like the outer syringe (1), it may be made of glass or the like. As shown in FIG. 3 or FIG. 6, the plunger (3) is formed in a substantially cylindrical shape to be fitted in the cylinder of the inner syringe (2), and as shown in FIG. 1, FIG. 2, FIG. At the center of the tip, a piercing rod (31) projecting from the discharge port (22) of the inner syringe (2) is protruded. As will be described later, a grip portion (33) protruding in, for example, a flat box shape is provided at the rear end of the plunger (3) to facilitate the pushing operation and the rotating operation of the plunger (3). . Then, the plunger (3) is inserted from the rear end of the inner syringe (2).
[0018]
The piercing rod (31) of the plunger (3) has a function of breaking through the seal portion (21) of the discharge port (22) and a function of engaging and operating a stirring member (4) described later. The cross-sectional shape orthogonal to the longitudinal direction of the piercing rod (31) is a non-circular shape that fits into a shaft hole (41) of the stirring member (4) described later. For example, the above cross-sectional shape of the piercing rod (31) is formed in a square shape.
[0019]
Further, the shape of the distal end portion of the piercing rod (31) is such that the piercing rod can be smoothly inserted into the shaft hole (41) when the piercing rod enters the inside of the outer syringe (1). The shape is such that the cross-sectional area becomes gradually smaller (see FIGS. 1 and 4). Furthermore, the length of the piercing rod (31) is such that when the plunger (3) is pushed into the inner syringe (2) and the inner syringe (2) is pushed further into the outer syringe (1), the outlet of the outer syringe (1) is taken out. The length is set so as to reach the inside or the front end of (11) (see FIGS. 3D and 6D).
[0020]
In the capsule of the present invention, the first medicine (A) and the second medicine (B) contained in the capsule are forcibly stirred and mixed, so that the capsules shown in FIG. 1, FIG. 2, FIG. 4 and FIG. A stirring member (4) that stirs and mixes the first medicine (A) and the second medicine (B) by rotation is provided in the medicine accommodation area on the distal end side of the syringe (1), that is, in the first half of the outer syringe (1). ) Is arranged coaxially with the outer syringe (1). As shown in FIG. 7, the agitating member (4) has a shaft hole (41) provided at the center thereof, the perforating rod (31) of the plunger (3) is inserted, and the plunger (3) is rotated. By doing so, it is made to rotate. Thereby, regardless of the viscosity of the medicine, the two kinds of medicine can be surely mixed.
[0021]
As the form of the stirring member (4), various forms can be mentioned as shown in FIG. 7, for example, as long as a stirring function can be exerted by rotation. Specifically, as the stirring member (4) having the simplest structure, a member as shown in FIG. The stirring member (4) shown in FIG. 7 (g) is formed by extending a plurality of bars (42) in the radial direction of the outer syringe (1) from a hub (40) provided with a shaft hole (41). The hub (40) is a portion serving as a rotation center of the stirring member (4), and has a shaft hole (41) through which the above-described perforated rod (31) is inserted. The rotation of the stirring member (4) stirs the medicine in the outer syringe (1) by the bar (42).
[0022]
The shape of the shaft hole (41) of the hub (40) (the cross-sectional shape perpendicular to the axis) is such that the piercing rod does not idle when the piercing rod (31) is engaged. It is formed in a non-circular shape similar to the cross section of (31). As the shape of the shaft hole (41), an appropriate shape such as a pentagon, a hexagon, and a semicircle can be adopted in addition to the square as shown in the figure.
[0023]
Further, the stirring member (4) may be as shown in FIGS. 7A and 7B. The stirring member (4) shown in FIGS. 7 (a) and 7 (b) is provided with a plurality of blades (43) from a hub (40) provided with a shaft hole (41) in a radial direction of the outer syringe (1). It is a propeller-type member that is extended. The number of blades (43) is usually about 2 to 5 blades. The shape of the shaft hole (41) is the same as in the above case. Since the blade (43) is twisted in one direction, such a stirring member (4) generates a thrust by rotation, and advances and retreats in the outer syringe (1) depending on the rotation direction. Therefore, the above-mentioned stirring member (4) exerts a more excellent stirring and mixing effect by rotating it forward and backward.
[0024]
Further, when a guide screw (15) is provided on the inner peripheral surface of the outer syringe (1) as shown in FIG. 5, the propeller-type stirring member (4) is used as shown in FIG. It is configured as shown in FIG. That is, in the stirring member (4) shown in FIGS. 7 (c) and 7 (d), in addition to the basic structure of the members shown in FIGS. A mating projection (45) is attached to the tip of each blade (43). The stirring member (4) is configured to be movable (movable in the axial direction) of the outer syringe (1) along the guide screw (15) by the rotation thereof (see FIG. 6). As described above, when the projection (45) of the stirring member (4) is engaged with the guide screw (15) of the outer syringe (1), the stirring member (4) is rotated to forcibly. The stirring member (4) can be moved forward and backward, and even if the medicine has a high viscosity, it can be surely stirred and mixed.
[0025]
Further, examples of the stirring member (4) include members as shown in FIGS. 7 (e) and 7 (f). The stirring member (4) shown in FIGS. 7 (e) and 7 (f) is a spiral disk type member provided with a shaft hole (41) in the center. The disk portion (44) of such a stirring member (4) may be single or double as shown in each drawing. The shape of the shaft hole (41) at the center of the disk (44) is the same as in the above case.
[0026]
Further, when a guide screw (15) is provided on the inner peripheral surface of the outer syringe (1) as shown in FIG. 5, the above-mentioned spiral disk type stirring member (4) is provided with a disk part (44). Is engaged with the guide screw (15), and is configured to be movable in the axial direction of the outer syringe (1) along the guide screw (15) by rotation of the stirring member. As described above, when the outer peripheral edge of the disk portion (44) of the stirring member (4) is engaged with the guide screw (15) of the outer syringe (1), the stirring member ( By rotating 4), the stirring member (4) can be forcibly advanced and retracted, which is suitable for stirring and mixing a high-viscosity medicine.
[0027]
In addition, the above-described stirring member (4) of each embodiment shown in FIG. 7 is usually manufactured by injection molding a resin such as polyolefin, polypropylene, polyethylene, or polyethylene naphthalate having excellent chemical resistance and heat resistance. In particular, the stirring member (4) shown in FIGS. 7A to 7F is preferably made of a material having soft elasticity. Of course, it may be composed of a material such as a metal. When the stirring member (4) is made of a soft elastic material, when the inner syringe (2) is pushed into the inner end of the outer syringe (1), the stirring member (4) may be deformed to a flat state. As a result, the mixed medicine can be more efficiently taken out (see FIG. 3D and FIG. 6D).
[0028]
Next, the method of use and functions of the capsule of the present invention will be described with reference to FIGS. When the capsule of the present invention is used, first, the plunger (3) is pushed in from the state shown in FIGS. 3 (a) and 6 (a) to move the inner syringe (2) from the rear end to the front end. 3 (b) and 6 (b) to open the discharge port (22) at the tip of the inner syringe (2) with the piercing rod (31), as shown in FIGS. 3 (b) and 6 (b). The second medicine (B) of (2) is supplied to the medicine storage area of the outer syringe (1).
[0029]
When the outlet (22) of the inner syringe (2) is opened as described above, the piercing rod (31) of the plunger (3) passes through the outlet (22) at the tip of the inner syringe (2). The outer syringe (1) protrudes into the medicine storage area on the distal end side. On the other hand, a stirrer (4) is arranged in the medicine accommodating area, and the stirrer (4) has a shaft hole (41) at the center thereof. , The piercing rod (31) penetrates the shaft hole (41) of the stirring member (4) to lock the stirring member (4).
[0030]
Next, as shown in FIGS. 3 (c) and 6 (c), when the plunger (3) is rotated, the stirring member (4) locked on the piercing rod (31) rotates, and the stirring member (4) is rotated. ) Agitates and mixes the first medicine (A) accommodated in the medicine accommodation area of the outer syringe (1) and the second medicine (B) supplied from the inner syringe (2) by its rotation. When the stirring member (4) is rotated, the plunger (3) may be rotated together with the inner syringe (2) by rotating the inner syringe (2).
[0031]
In addition, at the time of the above-mentioned stirring and mixing, especially, as shown in FIG. 6, a guide screw (15) is provided on the inner peripheral surface of the outer syringe (1), and the stirring member (4) engages with the guide screw. In this case, by rotating the stirring member (4), the stirring member (4) can be forcibly advanced and retracted in the outer syringe (1). You can do it.
[0032]
After mixing the first medicine (A) and the second medicine (B), as shown in FIG. 3D and FIG. 6D, the inner syringe (2) is moved together with the plunger (3). The mixed medicine can be pushed out from the outlet (11) at the tip of the outer syringe (1) by pushing it into the inner end of the outer syringe (1).
[0033]
The capsule of the present invention can of course be operated with a fingertip, but is usually operated using a dedicated applier (drug injection device). Such an applier generally includes a gun-shaped main body that houses and holds the entire capsule at the distal end, a plunger delivery push rod that is disposed in the main body and extends toward the distal end, and a rack and pinion mechanism. An operating bar connected to the push rod for rotating the push rod. The plunger (3) and the inner syringe (3) are pushed out by pushing the push rod in a stepwise manner by gripping a trigger-like lever attached to the main body. 2) is an instrument which pushes in each of them and pushes the operation bar to rotate the push rod forward and reverse.
[0034]
As described above, the capsule of the present invention mainly has a simple structure in which four members of the outer syringe (1), the inner syringe (2), the plunger (3), and the stirring member (4) are coaxially arranged. It has. In the capsule of the present invention, the stirring member (4) is previously arranged in the medicine accommodating area of the outer syringe (1), and the first medicine (from the inner syringe (2) to the medicine accommodating area of the outer syringe (1). When supplying (A) and mixing with the second medicine (B), the stirring member (4) is locked by the perforating rod (31) of the plunger (3), and the stirring is performed by rotating the plunger (3). Since the member (4) is forcibly rotated, the first medicine (A) and the second medicine (B) are easily and sufficiently mixed in the medicine accommodating region of the outer syringe (1). I can do it.
[0035]
Further, in the capsule of the present invention, when the guide screw (15) is provided on the inner peripheral surface of the outer syringe (1) and the stirring member (4) is engaged with the guide screw, the outer syringe (1) is provided. ), The stirring member (4) can be forcibly advanced and retracted while rotating, so that even a highly viscous drug can be reliably stirred and mixed. In addition, the capsule of the present invention is suitable not only for tooth materials but also for various drugs having high viscosity. The shape and size of the outer syringe (1) and the inner syringe (2) are determined according to the size of the contained drug or the like. It can be appropriately designed according to the application.
[0036]
【The invention's effect】
As described above, according to the syringe-type drug capsule of the present invention, the stirring member is previously arranged in the drug storage area of the outer syringe, and the first drug is supplied from the inner syringe to the drug storage area of the outer syringe. When mixing with the medicine of No. 2, the stirring member is locked with the perforating rod of the plunger, and the stirring member is forcibly rotated by the rotation operation of the plunger. The first drug and the second drug can be easily and sufficiently mixed.
[Brief description of the drawings]
FIG. 1 is an exploded perspective view showing components of an example of a syringe-type drug capsule.
FIG. 2 is a side view showing components of the syringe-type drug capsule of FIG. 1 partially broken along a center line.
FIG. 3 is a side view showing a usage mode of the syringe-type drug capsule of FIG. 1 partially broken along a center line.
FIG. 4 is an exploded perspective view showing components of another example of the syringe-type drug capsule.
FIG. 5 is a side view showing components of the syringe-type drug capsule of FIG. 4 partially broken along a center line.
FIG. 6 is a side view showing a usage mode of the syringe-type drug capsule of FIG. 4 partially broken along a center line.
FIG. 7 is a perspective view showing some embodiments of a stirring member.
[Explanation of symbols]
1: Outer syringe 11: Outlet 13: Hook 15: Guide screw 2: Inner syringe 21: Seal material 22: Discharge port 23: Hook 3: Plunger 31: Perforated rod 33: Gripping part 4: Stirring member 40 : Hub 41: Shaft hole 42: Bar 43: Blade 44: Disk 45: Projection A: Drug (first drug)
B: Drug (second drug)
C: Mixed drug
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002179867A JP4182692B2 (en) | 2002-06-20 | 2002-06-20 | Syringe type drug capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002179867A JP4182692B2 (en) | 2002-06-20 | 2002-06-20 | Syringe type drug capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004016707A true JP2004016707A (en) | 2004-01-22 |
| JP4182692B2 JP4182692B2 (en) | 2008-11-19 |
Family
ID=31177164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002179867A Expired - Fee Related JP4182692B2 (en) | 2002-06-20 | 2002-06-20 | Syringe type drug capsule |
Country Status (1)
| Country | Link |
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| JP (1) | JP4182692B2 (en) |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008529663A (en) * | 2005-02-09 | 2008-08-07 | チルドレンズ メディカル センター コーポレイション | Devices that mix and deliver fluids for tissue recovery |
| JP2009542427A (en) * | 2006-07-06 | 2009-12-03 | デピュイ・スパイン・インコーポレイテッド | Mixing equipment |
| JP2012029855A (en) * | 2010-07-30 | 2012-02-16 | Asahi Kasei Kuraray Medical Co Ltd | Cell treatment system |
| JP2013240582A (en) * | 2012-05-07 | 2013-12-05 | Heraeus Medical Gmbh | Mixing device for multi-component systems |
| JP2014018479A (en) * | 2012-07-19 | 2014-02-03 | Okayama Univ | Method for inspecting adaptability of denture base and injection tool used for the method |
| US8809418B2 (en) | 2004-03-21 | 2014-08-19 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
| US8950929B2 (en) | 2006-10-19 | 2015-02-10 | DePuy Synthes Products, LLC | Fluid delivery system |
| US8956368B2 (en) | 2003-06-17 | 2015-02-17 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
| US8992541B2 (en) | 2003-03-14 | 2015-03-31 | DePuy Synthes Products, LLC | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
| US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
| WO2016144868A1 (en) * | 2015-03-06 | 2016-09-15 | Dentsply Sirona Inc. | Dental material delivery system |
| KR101657645B1 (en) | 2015-09-08 | 2016-09-22 | 한국지질자원연구원 | Injection equipment of colloid dispersions for enhanced oil recovery |
| US9642932B2 (en) | 2006-09-14 | 2017-05-09 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
| US9839460B2 (en) | 2003-03-31 | 2017-12-12 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
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| CN109604284A (en) * | 2018-12-04 | 2019-04-12 | 徐州易尚饰家装饰工程有限责任公司 | A kind of hydraulic inside wall of cylinder cleaner |
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| US9839460B2 (en) | 2003-03-31 | 2017-12-12 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
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| US9750840B2 (en) | 2004-03-21 | 2017-09-05 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
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| US8992071B2 (en) | 2012-05-07 | 2015-03-31 | Heraeus Medical Gmbh | Mixing device for multi-component systems |
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| JP2014018479A (en) * | 2012-07-19 | 2014-02-03 | Okayama Univ | Method for inspecting adaptability of denture base and injection tool used for the method |
| JP2018507032A (en) * | 2015-03-06 | 2018-03-15 | デントスプリー シロナ インコーポレイテッド | Dental material delivery system |
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