JP2003529370A5 - - Google Patents

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Publication number
JP2003529370A5
JP2003529370A5 JP2001572983A JP2001572983A JP2003529370A5 JP 2003529370 A5 JP2003529370 A5 JP 2003529370A5 JP 2001572983 A JP2001572983 A JP 2001572983A JP 2001572983 A JP2001572983 A JP 2001572983A JP 2003529370 A5 JP2003529370 A5 JP 2003529370A5
Authority
JP
Japan
Prior art keywords
antibody
antibody fragment
tumor
fragment
angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001572983A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003529370A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/010505 external-priority patent/WO2001075109A2/en
Publication of JP2003529370A publication Critical patent/JP2003529370A/ja
Publication of JP2003529370A5 publication Critical patent/JP2003529370A5/ja
Pending legal-status Critical Current

Links

JP2001572983A 2000-03-31 2001-03-30 血管浸透性に対する有害な作用を有さないve−カドヘリンに対する拮抗薬抗体 Pending JP2003529370A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54096700A 2000-03-31 2000-03-31
US09/540,967 2000-03-31
PCT/US2001/010505 WO2001075109A2 (en) 2000-03-31 2001-03-30 Antagonist antibodies to ve-cadherin without adverse effects on vascular permeability

Publications (2)

Publication Number Publication Date
JP2003529370A JP2003529370A (ja) 2003-10-07
JP2003529370A5 true JP2003529370A5 (cg-RX-API-DMAC7.html) 2008-05-15

Family

ID=24157649

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001572983A Pending JP2003529370A (ja) 2000-03-31 2001-03-30 血管浸透性に対する有害な作用を有さないve−カドヘリンに対する拮抗薬抗体

Country Status (12)

Country Link
US (4) US7371574B2 (cg-RX-API-DMAC7.html)
EP (1) EP1268799B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003529370A (cg-RX-API-DMAC7.html)
AT (1) ATE425255T1 (cg-RX-API-DMAC7.html)
AU (1) AU2001249737A1 (cg-RX-API-DMAC7.html)
CA (1) CA2404576A1 (cg-RX-API-DMAC7.html)
CY (1) CY1109097T1 (cg-RX-API-DMAC7.html)
DE (1) DE60137915D1 (cg-RX-API-DMAC7.html)
DK (1) DK1268799T3 (cg-RX-API-DMAC7.html)
ES (1) ES2323938T3 (cg-RX-API-DMAC7.html)
PT (1) PT1268799E (cg-RX-API-DMAC7.html)
WO (1) WO2001075109A2 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7481999B2 (en) 1998-05-05 2009-01-27 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin-mediated function
CA2506037A1 (en) 2002-11-14 2004-06-10 Adherex Technologies, Inc. Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion
JP2004175689A (ja) * 2002-11-25 2004-06-24 Kureha Chem Ind Co Ltd 癌転移抑制剤
US20040167076A1 (en) 2003-02-14 2004-08-26 Stamer W. Daniel Modulation of aqueous humor outflow by targeting vascular-endothelial-cadherin in schlemm's canal cells
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
US9207242B2 (en) * 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
WO2011071541A2 (en) * 2009-12-11 2011-06-16 The Scripps Research Institute Cadherin modulatory agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5036003A (en) * 1987-08-21 1991-07-30 Monsanto Company Antibodies to VPF
WO1993008210A1 (en) * 1991-10-18 1993-04-29 Beth Israel Hospital Association Vascular permeability factor targeted compounds
US5776427A (en) * 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
DE69332948T2 (de) * 1992-03-05 2003-11-27 Board Of Regents, The University Of Texas System Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren
US5646250A (en) * 1992-04-17 1997-07-08 Doheny Eye Institute Cadherin polypeptides
CA2111573C (en) * 1992-04-17 2002-11-26 Shintaro Suzuki Cadherin materials and methods
US5597725A (en) * 1992-04-17 1997-01-28 Doheny Eye Institute Cadherin-specific antibodies and hybridoma cell lines
US5840301A (en) * 1994-02-10 1998-11-24 Imclone Systems Incorporated Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
US5861499A (en) * 1994-02-10 1999-01-19 Imclone Systems Incorporated Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
US5730977A (en) * 1995-08-21 1998-03-24 Mitsui Toatsu Chemicals, Inc. Anti-VEGF human monoclonal antibody
US20050222037A1 (en) * 1998-05-05 2005-10-06 Adherex Technologies, Inc. Compounds and methods for modulating VE-cadherin-mediated function
WO1999057149A2 (en) * 1998-05-05 1999-11-11 Adherex Technologies, Inc. Compounds and methods for modulating nonclassical cadherin-mediated functions
US20030206902A1 (en) * 2001-03-05 2003-11-06 Fang Liao Ve-cadherin and vegfr-2 antagonists for therapeutic modulation of angiogenesis

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