JP2003529370A5 - - Google Patents
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- Publication number
- JP2003529370A5 JP2003529370A5 JP2001572983A JP2001572983A JP2003529370A5 JP 2003529370 A5 JP2003529370 A5 JP 2003529370A5 JP 2001572983 A JP2001572983 A JP 2001572983A JP 2001572983 A JP2001572983 A JP 2001572983A JP 2003529370 A5 JP2003529370 A5 JP 2003529370A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibody fragment
- tumor
- fragment
- angiogenesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 25
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 25
- 206010028980 Neoplasm Diseases 0.000 description 9
- 230000033115 angiogenesis Effects 0.000 description 7
- 102000008790 VE-cadherin Human genes 0.000 description 6
- 108010018828 cadherin 5 Proteins 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 206010027476 Metastases Diseases 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 208000003200 Adenoma Diseases 0.000 description 1
- 206010001233 Adenoma benign Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 201000005409 Gliomatosis cerebri Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 201000001256 adenosarcoma Diseases 0.000 description 1
- 210000002867 adherens junction Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54096700A | 2000-03-31 | 2000-03-31 | |
| US09/540,967 | 2000-03-31 | ||
| PCT/US2001/010505 WO2001075109A2 (en) | 2000-03-31 | 2001-03-30 | Antagonist antibodies to ve-cadherin without adverse effects on vascular permeability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003529370A JP2003529370A (ja) | 2003-10-07 |
| JP2003529370A5 true JP2003529370A5 (cg-RX-API-DMAC7.html) | 2008-05-15 |
Family
ID=24157649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001572983A Pending JP2003529370A (ja) | 2000-03-31 | 2001-03-30 | 血管浸透性に対する有害な作用を有さないve−カドヘリンに対する拮抗薬抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7371574B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1268799B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003529370A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE425255T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2001249737A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2404576A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1109097T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60137915D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1268799T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2323938T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1268799E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001075109A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7481999B2 (en) | 1998-05-05 | 2009-01-27 | Adherex Technologies, Inc. | Compounds and methods for modulating OB-cadherin-mediated function |
| CA2506037A1 (en) | 2002-11-14 | 2004-06-10 | Adherex Technologies, Inc. | Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion |
| JP2004175689A (ja) * | 2002-11-25 | 2004-06-24 | Kureha Chem Ind Co Ltd | 癌転移抑制剤 |
| US20040167076A1 (en) | 2003-02-14 | 2004-08-26 | Stamer W. Daniel | Modulation of aqueous humor outflow by targeting vascular-endothelial-cadherin in schlemm's canal cells |
| GB0602063D0 (en) | 2006-02-02 | 2006-03-15 | Univ Manchester | Cell Culture |
| US9207242B2 (en) * | 2008-10-09 | 2015-12-08 | The University Of Hong Kong | Cadherin-17 as diagnostic marker and therapeutic target for liver cancer |
| WO2011071541A2 (en) * | 2009-12-11 | 2011-06-16 | The Scripps Research Institute | Cadherin modulatory agents |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5036003A (en) * | 1987-08-21 | 1991-07-30 | Monsanto Company | Antibodies to VPF |
| WO1993008210A1 (en) * | 1991-10-18 | 1993-04-29 | Beth Israel Hospital Association | Vascular permeability factor targeted compounds |
| US5776427A (en) * | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6004555A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| DE69332948T2 (de) * | 1992-03-05 | 2003-11-27 | Board Of Regents, The University Of Texas System | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
| US5646250A (en) * | 1992-04-17 | 1997-07-08 | Doheny Eye Institute | Cadherin polypeptides |
| CA2111573C (en) * | 1992-04-17 | 2002-11-26 | Shintaro Suzuki | Cadherin materials and methods |
| US5597725A (en) * | 1992-04-17 | 1997-01-28 | Doheny Eye Institute | Cadherin-specific antibodies and hybridoma cell lines |
| US5840301A (en) * | 1994-02-10 | 1998-11-24 | Imclone Systems Incorporated | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
| US5861499A (en) * | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
| US5730977A (en) * | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| US20050222037A1 (en) * | 1998-05-05 | 2005-10-06 | Adherex Technologies, Inc. | Compounds and methods for modulating VE-cadherin-mediated function |
| WO1999057149A2 (en) * | 1998-05-05 | 1999-11-11 | Adherex Technologies, Inc. | Compounds and methods for modulating nonclassical cadherin-mediated functions |
| US20030206902A1 (en) * | 2001-03-05 | 2003-11-06 | Fang Liao | Ve-cadherin and vegfr-2 antagonists for therapeutic modulation of angiogenesis |
-
2001
- 2001-03-30 JP JP2001572983A patent/JP2003529370A/ja active Pending
- 2001-03-30 DK DK01922997T patent/DK1268799T3/da active
- 2001-03-30 DE DE60137915T patent/DE60137915D1/de not_active Expired - Lifetime
- 2001-03-30 AT AT01922997T patent/ATE425255T1/de active
- 2001-03-30 CA CA002404576A patent/CA2404576A1/en not_active Abandoned
- 2001-03-30 PT PT01922997T patent/PT1268799E/pt unknown
- 2001-03-30 AU AU2001249737A patent/AU2001249737A1/en not_active Abandoned
- 2001-03-30 EP EP01922997A patent/EP1268799B1/en not_active Expired - Lifetime
- 2001-03-30 ES ES01922997T patent/ES2323938T3/es not_active Expired - Lifetime
- 2001-03-30 WO PCT/US2001/010505 patent/WO2001075109A2/en not_active Ceased
-
2002
- 2002-01-02 US US10/040,128 patent/US7371574B2/en not_active Expired - Fee Related
-
2008
- 2008-03-26 US US12/056,173 patent/US20090060909A1/en not_active Abandoned
- 2008-03-26 US US12/056,146 patent/US20080317750A1/en not_active Abandoned
- 2008-03-26 US US12/056,116 patent/US20080311121A1/en not_active Abandoned
-
2009
- 2009-05-25 CY CY20091100557T patent/CY1109097T1/el unknown
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