JP2003523193A5 - - Google Patents

Info

Publication number

JP2003523193A5

JP2003523193A5 JP2001560240A JP2001560240A JP2003523193A5 JP 2003523193 A5 JP2003523193 A5 JP 2003523193A5 JP 2001560240 A JP2001560240 A JP 2001560240A JP 2001560240 A JP2001560240 A JP 2001560240A JP 2003523193 A5 JP2003523193 A5 JP 2003523193A5

Authority

JP

Japan

Prior art keywords

compound

nucleic acid

peptide

sequence

seq

Prior art date

2001-02-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 description 22
• 108090000765 processed proteins & peptides Proteins 0.000 description 18
• 102000039446 nucleic acids Human genes 0.000 description 14
• 108020004707 nucleic acids Proteins 0.000 description 14
• 150000007523 nucleic acids Chemical class 0.000 description 14
• 101710176122 28 kDa heat- and acid-stable phosphoprotein Proteins 0.000 description 5
• 102100027336 Regenerating islet-derived protein 3-alpha Human genes 0.000 description 5
• 229920001184 polypeptide Polymers 0.000 description 5
• 102000004196 processed proteins & peptides Human genes 0.000 description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
• 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 description 4
• 239000012634 fragment Substances 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 102000045222 parkin Human genes 0.000 description 4
• 238000000034 method Methods 0.000 description 3
• 239000008194 pharmaceutical composition Substances 0.000 description 3
• 238000012216 screening Methods 0.000 description 2
• 101000581815 Homo sapiens Regenerating islet-derived protein 3-alpha Proteins 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 102000049256 human REG3A Human genes 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 239000000523 sample Substances 0.000 description 1