JP2003520214A5 - - Google Patents
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- Publication number
- JP2003520214A5 JP2003520214A5 JP2001552725A JP2001552725A JP2003520214A5 JP 2003520214 A5 JP2003520214 A5 JP 2003520214A5 JP 2001552725 A JP2001552725 A JP 2001552725A JP 2001552725 A JP2001552725 A JP 2001552725A JP 2003520214 A5 JP2003520214 A5 JP 2003520214A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric protein
- protein according
- death receptor
- streptavidin
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037865 fusion proteins Human genes 0.000 description 24
- 108020001507 fusion proteins Proteins 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 21
- 238000000034 method Methods 0.000 description 14
- 102000009058 Death Domain Receptors Human genes 0.000 description 12
- 108010049207 Death Domain Receptors Proteins 0.000 description 12
- 108010090804 Streptavidin Proteins 0.000 description 11
- 230000001939 inductive effect Effects 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 8
- 108090001008 Avidin Proteins 0.000 description 6
- 230000006907 apoptotic process Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 108010039471 Fas Ligand Protein Proteins 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 description 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108700012411 TNFSF10 Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 description 1
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 description 1
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17803800P | 2000-01-24 | 2000-01-24 | |
| US60/178,038 | 2000-01-24 | ||
| US21558000P | 2000-06-30 | 2000-06-30 | |
| US60/215,580 | 2000-06-30 | ||
| PCT/US2001/002256 WO2001052664A1 (en) | 2000-01-24 | 2001-01-24 | Immune modulation with death receptor-induced apoptosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520214A JP2003520214A (ja) | 2003-07-02 |
| JP2003520214A5 true JP2003520214A5 (enExample) | 2008-03-27 |
| JP4898049B2 JP4898049B2 (ja) | 2012-03-14 |
Family
ID=26873890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001552725A Expired - Fee Related JP4898049B2 (ja) | 2000-01-24 | 2001-01-24 | デスレセプター誘導アポトーシスによる免疫調節 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1250055B1 (enExample) |
| JP (1) | JP4898049B2 (enExample) |
| AT (1) | ATE481475T1 (enExample) |
| AU (1) | AU784614B2 (enExample) |
| CA (1) | CA2396979C (enExample) |
| DE (1) | DE60143074D1 (enExample) |
| WO (1) | WO2001052664A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7927602B2 (en) | 2002-07-23 | 2011-04-19 | University Of Louisville Research Foundation, Inc. | Fas ligand-avidin/streptavidin fusion proteins |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| WO2002002751A2 (en) * | 2000-06-30 | 2002-01-10 | University Of Louisville Research Foundation, Inc. | Alteration of cell membrane |
| US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| AU2020334237B2 (en) * | 2019-08-19 | 2025-11-13 | Universität Basel | Cell therapy methods |
| CN115717124B (zh) * | 2022-11-23 | 2025-05-16 | 香港城市大学深圳福田研究院 | 用于分离外泌体的纳米材料及其制备方法、应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101004174B1 (ko) * | 1995-06-29 | 2010-12-24 | 임뮤넥스 코포레이션 | 세포소멸을 유도하는 시토킨 |
| US6004942A (en) * | 1995-08-30 | 1999-12-21 | The Regents Of The University Of California | Methods for treating arthritis by administering an apoptosis regulator |
| GB9523469D0 (en) * | 1995-11-16 | 1996-01-17 | Sandoz Ltd | Organic compounds |
| US6046310A (en) * | 1996-03-13 | 2000-04-04 | Protein Design Labs., Inc. | FAS ligand fusion proteins and their uses |
| WO1998020896A1 (en) * | 1996-11-15 | 1998-05-22 | Health Research Inc. | A method for inducing apoptosis of primary central nervous system b cell lymphomas |
| GB9721075D0 (en) * | 1997-10-03 | 1997-12-03 | Cancer Res Campaign Tech | Materials and methods relating to the stimulation of cells |
-
2001
- 2001-01-24 EP EP01905011A patent/EP1250055B1/en not_active Expired - Lifetime
- 2001-01-24 AU AU32933/01A patent/AU784614B2/en not_active Ceased
- 2001-01-24 JP JP2001552725A patent/JP4898049B2/ja not_active Expired - Fee Related
- 2001-01-24 WO PCT/US2001/002256 patent/WO2001052664A1/en not_active Ceased
- 2001-01-24 CA CA2396979A patent/CA2396979C/en not_active Expired - Fee Related
- 2001-01-24 AT AT01905011T patent/ATE481475T1/de not_active IP Right Cessation
- 2001-01-24 DE DE60143074T patent/DE60143074D1/de not_active Expired - Lifetime
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