JP2003518501A5 - - Google Patents
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- JP2003518501A5 JP2003518501A5 JP2001548121A JP2001548121A JP2003518501A5 JP 2003518501 A5 JP2003518501 A5 JP 2003518501A5 JP 2001548121 A JP2001548121 A JP 2001548121A JP 2001548121 A JP2001548121 A JP 2001548121A JP 2003518501 A5 JP2003518501 A5 JP 2003518501A5
- Authority
- JP
- Japan
- Prior art keywords
- lattice
- crystal
- basic
- basic lattice
- orthorhombic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
Description
【請求項１０】
以下の結晶学的特徴：
−基本的格子の結晶パラメーター：ａ＝４２．６Å
ｂ＝８０．６Å
ｃ＝１３７．０Å
α＝β＝γ＝９０．０゜
−斜方晶系
−空間群Ｐ２1２1２1
−基本的格子の結晶格子による酵素分子の数＝４
を有することを特徴とする請求項４〜９のいずれか一項記載の複合体。
以下の結晶学的特徴：
−基本的格子の結晶パラメーター：ａ＝４２．６Å
ｂ＝８０．６Å
ｃ＝１３７．０Å
α＝β＝γ＝９０．０゜
−斜方晶系
−空間群Ｐ２1２1２1
−基本的格子の結晶格子による酵素分子の数＝４
を有することを特徴とする請求項４〜９のいずれか一項記載の複合体。
本発明による複合体は、以下の結晶学的特徴：
−基本的格子の結晶パラメーター：ａ＝４２．６Å
ｂ＝８０．６Å
ｃ＝１３７．０Å
α＝β＝γ＝９０．０゜
−斜方晶系
−空間群Ｐ２1２1２1
−基本的格子の結晶格子による酵素分子の数＝４
によって特徴付けることができる。
−基本的格子の結晶パラメーター：ａ＝４２．６Å
ｂ＝８０．６Å
ｃ＝１３７．０Å
α＝β＝γ＝９０．０゜
−斜方晶系
−空間群Ｐ２1２1２1
−基本的格子の結晶格子による酵素分子の数＝４
によって特徴付けることができる。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR99/16409 | 1999-12-23 | ||
| FR9916409A FR2802817B1 (fr) | 1999-12-23 | 1999-12-23 | Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete |
| PCT/FR2000/003600 WO2001047528A2 (fr) | 1999-12-23 | 2000-12-20 | Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518501A JP2003518501A (ja) | 2003-06-10 |
| JP2003518501A5 true JP2003518501A5 (ja) | 2005-12-22 |
Family
ID=9553772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001548121A Pending JP2003518501A (ja) | 1999-12-23 | 2000-12-20 | 新規なグリコシダーゼ阻害剤および特に糖尿病を治療するためのその薬理学的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20030143713A1 (ja) |
| EP (1) | EP1239863A2 (ja) |
| JP (1) | JP2003518501A (ja) |
| AU (1) | AU2687301A (ja) |
| CA (1) | CA2395305A1 (ja) |
| FR (1) | FR2802817B1 (ja) |
| WO (1) | WO2001047528A2 (ja) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050085555A1 (en) * | 1997-08-21 | 2005-04-21 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
| US20030013772A1 (en) * | 2000-02-23 | 2003-01-16 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
| EP1177197B1 (en) * | 1999-04-30 | 2006-08-09 | Cellgate, Inc. | Polyamines and their use in therapy |
| CA2463771A1 (en) * | 2001-10-16 | 2003-04-24 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
| JP2004189714A (ja) * | 2002-12-09 | 2004-07-08 | Rasanen Tiina-Liisa | すい臓炎の治療と予防ならびに肝臓再生機能の誘導のための薬剤 |
| CA2623025A1 (en) | 2005-09-20 | 2007-03-29 | Schering Corporation | 1- [ [1- [ (2-amin0-6-methyl-4-pyridinyl) methyl] -4-flu0r0-4-piperidinyl,] carbonyl] -4- [2- (2-pyridinyl) -3h-imidaz0 [4 , 5-b] pyridin-3-yl] piperidine useful as histamine h3 antagonist |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2700111T3 (es) * | 2007-06-28 | 2019-02-14 | Basf Beauty Care Solutions France Sas | Composición adelgazante |
| FR2917971B1 (fr) | 2007-06-28 | 2009-10-23 | Engelhard Lyon Soc Par Actions | Composition amincissante |
| US8153611B2 (en) * | 2007-06-28 | 2012-04-10 | Basf Beauty Care Solutions France S.A.S. | Use of sulfated oligosaccharides as slimming cosmetic ingredients |
| CA2703203C (en) | 2007-10-22 | 2015-12-15 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| AU2009249237A1 (en) | 2008-05-19 | 2009-11-26 | Schering Corporation | Bicyclic heterocycle derivatives and use thereof as GPR119 modulators |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US20110166124A1 (en) | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| AR073412A1 (es) | 2008-10-03 | 2010-11-03 | Schering Corp | Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende. |
| WO2010045306A2 (en) | 2008-10-16 | 2010-04-22 | Schering Corporation | Azine derivatives and methods of use thereof |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| EP2379547A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| EP2379565A1 (en) | 2008-12-19 | 2011-10-26 | Schering Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| US8283360B2 (en) | 2008-12-19 | 2012-10-09 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic derivatives and methods of use thereof |
| WO2010075271A1 (en) | 2008-12-23 | 2010-07-01 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| WO2010075273A1 (en) | 2008-12-23 | 2010-07-01 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| JP2012513469A (ja) | 2008-12-23 | 2012-06-14 | シェーリング コーポレイション | ピリミジン誘導体及びその使用法 |
| CA2755253A1 (en) | 2009-03-18 | 2010-09-23 | Schering Corporation | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| EP2414348B1 (en) | 2009-04-03 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders |
| EP2440553B1 (en) | 2009-06-12 | 2017-08-23 | Merck Sharp & Dohme Corp. | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
| EP2477498A4 (en) | 2009-09-14 | 2013-02-27 | Merck Sharp & Dohme | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS |
| EP2485735B1 (en) | 2009-10-08 | 2015-07-29 | Merck Sharp & Dohme Corp. | Inhibitors of fatty acid binding protein (fabp) |
| AU2010313469A1 (en) | 2009-10-29 | 2012-06-07 | Merck Sharp & Dohme Corp. | Bridged Bicyclic Piperidine Derivatives and methods of use thereof |
| WO2011062889A1 (en) | 2009-11-23 | 2011-05-26 | Schering Corporation | Pyrimidine ether derivatives and methods of use thereof |
| WO2011062885A1 (en) | 2009-11-23 | 2011-05-26 | Schering Corporation | Fused bicyclic pyrimidine derivatives and methods of use thereof |
| WO2011066137A1 (en) | 2009-11-24 | 2011-06-03 | Schering Corporation | Substituted biaryl derivatives and methods of use thereof |
| US9173886B2 (en) * | 2010-03-12 | 2015-11-03 | Trana Discovery, Inc. | Antiviral compounds and methods of use thereof |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| ITMI20130555A1 (it) * | 2013-04-09 | 2014-10-10 | Giuliani Spa | Composizione farmaceutica o cosmetica per contrastare l¿invecchiamento della pelle attraverso un¿azione antiinfiammatoria |
| US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1768934A1 (de) * | 1968-07-15 | 1972-03-16 | Bayer Ag | Verfahren zur Anreicherung von Polypeptiden,vorzugsweise von Enzymen und Enzym-Inhibitoren |
| US4228274A (en) * | 1976-09-28 | 1980-10-14 | Merck & Co., Inc. | 1-Substituted glycopyranosides |
| DE3123520A1 (de) * | 1981-06-13 | 1982-12-30 | Bayer Ag, 5090 Leverkusen | Gesaettigte aminocyclitderivate, ihre herstellung undsie enthaltende arzneimittel |
| US5141739A (en) * | 1986-07-03 | 1992-08-25 | Advanced Magnetics, Inc. | Delivery of x-ray contrast agents using receptor mediated endocytosis |
| WO1989008098A2 (en) * | 1988-02-19 | 1989-09-08 | The Upjohn Company | Lipophilic polyamines useful for treating hypercholesterolemia |
| ATE83658T1 (de) * | 1988-11-25 | 1993-01-15 | Lubec Gert | Behandlung von durch glucose ausgeloester quervernetzung von collagen bei diabetes mellitus-patienten durch arginin, spermidin, kreatin oder agmatin. |
| US5077313A (en) * | 1988-11-25 | 1991-12-31 | Gert Lubec | Process for inhibiting pathological collagen cross-linking in diabetes patients |
| DD298412A5 (de) * | 1989-04-28 | 1992-02-20 | ������@���Kk�� | Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele |
| AU5739494A (en) * | 1992-12-03 | 1994-06-22 | Aristidis S. Charonis | Protective role of polyamines in modifications of basement membrane macromolecules |
| US5744453A (en) * | 1996-01-05 | 1998-04-28 | Mintz; Clifford S. | Polyamine conjugates for treatment of infection |
| NL1004379C2 (nl) * | 1996-10-29 | 1998-05-08 | Borculo Cooep Weiprod | Toepassing van suikeraminen en suikeramiden als lijm, alsmede nieuwe suikeraminen en suikeramiden. |
| US7087648B1 (en) * | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
-
1999
- 1999-12-23 FR FR9916409A patent/FR2802817B1/fr not_active Expired - Fee Related
-
2000
- 2000-12-20 WO PCT/FR2000/003600 patent/WO2001047528A2/fr not_active Application Discontinuation
- 2000-12-20 US US10/168,703 patent/US20030143713A1/en not_active Abandoned
- 2000-12-20 JP JP2001548121A patent/JP2003518501A/ja active Pending
- 2000-12-20 EP EP00990069A patent/EP1239863A2/fr not_active Withdrawn
- 2000-12-20 AU AU26873/01A patent/AU2687301A/en not_active Abandoned
- 2000-12-20 CA CA002395305A patent/CA2395305A1/fr not_active Abandoned
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