JP2003517006A5 - - Google Patents
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- Publication number
- JP2003517006A5 JP2003517006A5 JP2001544774A JP2001544774A JP2003517006A5 JP 2003517006 A5 JP2003517006 A5 JP 2003517006A5 JP 2001544774 A JP2001544774 A JP 2001544774A JP 2001544774 A JP2001544774 A JP 2001544774A JP 2003517006 A5 JP2003517006 A5 JP 2003517006A5
- Authority
- JP
- Japan
- Prior art keywords
- helix
- concentration
- syncytium
- syncytium formation
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17104299P | 1999-12-16 | 1999-12-16 | |
| US60/171,042 | 1999-12-16 | ||
| US23457200P | 2000-09-22 | 2000-09-22 | |
| US60/234,572 | 2000-09-22 | ||
| PCT/US2000/034194 WO2001044286A2 (en) | 1999-12-16 | 2000-12-15 | Five-helix protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517006A JP2003517006A (ja) | 2003-05-20 |
| JP2003517006A5 true JP2003517006A5 (OSRAM) | 2008-10-02 |
| JP4925540B2 JP4925540B2 (ja) | 2012-04-25 |
Family
ID=26866680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544774A Expired - Fee Related JP4925540B2 (ja) | 1999-12-16 | 2000-12-15 | ５−ヘリックスタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7053179B2 (OSRAM) |
| EP (1) | EP1237912B1 (OSRAM) |
| JP (1) | JP4925540B2 (OSRAM) |
| AT (1) | ATE380822T1 (OSRAM) |
| CA (1) | CA2395291C (OSRAM) |
| DE (1) | DE60037450T2 (OSRAM) |
| ES (1) | ES2296665T3 (OSRAM) |
| WO (1) | WO2001044286A2 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150088A (en) * | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| US6818740B1 (en) | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6747126B1 (en) * | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
| US7960504B2 (en) * | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| CA2359892A1 (en) * | 1999-01-08 | 2000-07-13 | Panacos Pharmaceuticals, Inc. | Methods of eliciting broadly neutralizing antibodies targeting hiv-1 gp41 |
| CA2395291C (en) | 1999-12-16 | 2012-09-11 | Whitehead Institute For Biomedical Research | Five-helix protein |
| US20030082525A1 (en) * | 1999-12-16 | 2003-05-01 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| US6861253B2 (en) | 2001-01-05 | 2005-03-01 | Aventis Pasteur S.A. | Polypeptide inducing antibodies neutralizing HIV |
| FR2819256B1 (fr) * | 2001-01-05 | 2004-04-30 | Aventis Pasteur | Polypeptide induisant des anticorps neutralisant le vih |
| DK1479691T3 (da) | 2001-05-31 | 2007-03-12 | John Erickson | Langvarigt aktive fuionspeptidinhibitorer for HIV infektion |
| CA2450548C (en) | 2001-06-15 | 2012-05-01 | F. Hoffmann-La Roche Ag | Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments |
| US20030125515A1 (en) * | 2001-07-11 | 2003-07-03 | Genfa Zhou | End-locked five-helix protein |
| WO2003027255A2 (en) * | 2001-09-27 | 2003-04-03 | Tibotec Pharmaceuticals Ltd. | Anti-fusion assay |
| PT1442124E (pt) * | 2001-10-05 | 2007-02-28 | Sanofi Pasteur | Antigénio polipeptídico formando uma estrutura que mimetiza o estado intermédio da gp41 |
| US20030219451A1 (en) * | 2001-10-29 | 2003-11-27 | Whitehead Institute For Biomedical Research | Stable helical C peptides and uses therefor |
| FR2832715A1 (fr) * | 2001-11-29 | 2003-05-30 | Hippocampe | Polypeptides inhibiteurs de l'infectivite des virus de l'immunodeficience humaine |
| US20060241027A1 (en) * | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| US7056519B2 (en) | 2002-05-17 | 2006-06-06 | Aventis Pasteur S.A. | Methods for inducing HIV-neutralizing antibodies |
| US20040076637A1 (en) * | 2002-09-27 | 2004-04-22 | Delmedico Mary Kay | HIV-derived HR1 peptides modified to form stable trimers, and their use in therapy to inhibit transmission of human immunodeficiency virus |
| CA2443365C (en) * | 2002-11-19 | 2010-01-12 | F. Hoffmann-La Roche Ag | Methods for the recombinant production of antifusogenic peptides |
| AU2003265420A1 (en) * | 2003-08-14 | 2005-03-10 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Polypeptide multimers having antiviral activity |
| CA2565658A1 (en) * | 2004-05-06 | 2005-11-17 | Conjuchem Biotechnologies Inc. | Compounds for specific viral target |
| ATE516048T1 (de) * | 2004-06-01 | 2011-07-15 | Merck Sharp & Dohme | Mit hiv gp41 in wechselwirkung stehende menschliche antikörper |
| EP2354153A3 (en) * | 2004-06-01 | 2012-05-30 | Merck Sharp & Dohme Corp. | Stable peptide mimetic of HIV gp41 fusion intermediate |
| US7491489B2 (en) * | 2004-11-22 | 2009-02-17 | The University Of Hong Knog | Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof |
| EP2314320A2 (en) * | 2005-04-05 | 2011-04-27 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Method for shielding functional sites or epitopes on proteins |
| CN101088557A (zh) | 2006-06-12 | 2007-12-19 | 天津市扶素生物技术有限公司 | 用于预防或治疗hiv感染的药用组合物及其应用 |
| US20100029568A1 (en) * | 2007-03-12 | 2010-02-04 | Thomas Jefferson University | Tighter-binding c-peptide inhibitors of hiv-1 entry |
| US9217011B2 (en) * | 2007-09-07 | 2015-12-22 | Complix Nv | Non-natural proteinaceous scaffold made of three non-covalently associated peptides |
| GB0720503D0 (en) * | 2007-10-22 | 2007-11-28 | Angeletti P Ist Richerche Bio | New compound |
| GB2471692A (en) | 2009-07-08 | 2011-01-12 | Complix Nv | HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats |
| US9050063B2 (en) * | 2012-03-30 | 2015-06-09 | Sandance Technology Llc | Systems and methods for determining suitability of a mechanical implant for a medical procedure |
| CN106946994B (zh) * | 2017-03-09 | 2019-11-26 | 中国医学科学院病原生物学研究所 | 一种抑制丙型肝炎病毒感染的蛋白及其应用 |
| CN110551179B (zh) * | 2018-05-31 | 2022-03-15 | 中国科学院微生物研究所 | 一种经修饰的抗hiv多肽及其制备方法和用途 |
| EP4519285A1 (en) | 2022-05-03 | 2025-03-12 | F. Hoffmann-La Roche AG | Hiv gp41 variants for immunodiagnostic assays |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5444044A (en) | 1992-03-26 | 1995-08-22 | New York Blood Center | Synthetic polypeptides as inhibitors of HIV-1 |
| AU688733B2 (en) | 1992-07-20 | 1998-03-19 | Duke University | Compounds which inhibit HIV replication |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US5780221A (en) | 1995-05-03 | 1998-07-14 | Whitehead Institute For Biomedical Research | Identification of enantiomeric ligands |
| US6475491B1 (en) * | 1995-06-07 | 2002-11-05 | Trimeris, Inc. | Treatment of HIV and other viral infections using combinatorial therapy |
| JP3903503B2 (ja) | 1996-11-18 | 2007-04-11 | 住友電気工業株式会社 | 可溶性ポリペプチド |
| AU6649698A (en) * | 1997-01-28 | 1998-08-18 | Regents Of The University Of California, The | Peptide probes to coil proteins and methods for making the same |
| US6818740B1 (en) | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6150088A (en) | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| US6090911A (en) | 1997-10-22 | 2000-07-18 | University Of Massachusetts | Reversible hydrogels |
| US6656906B1 (en) | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| JP5101764B2 (ja) | 1998-07-30 | 2012-12-19 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | Ｈｉｖ膜融合のインヒビター |
| US6747126B1 (en) | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
| US7960504B2 (en) | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| CA2359892A1 (en) * | 1999-01-08 | 2000-07-13 | Panacos Pharmaceuticals, Inc. | Methods of eliciting broadly neutralizing antibodies targeting hiv-1 gp41 |
| US20030082525A1 (en) | 1999-12-16 | 2003-05-01 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| CA2395291C (en) | 1999-12-16 | 2012-09-11 | Whitehead Institute For Biomedical Research | Five-helix protein |
| JP5180422B2 (ja) | 2000-09-22 | 2013-04-10 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | Ｈｉｖ浸入のペプチドインヒビター |
-
2000
- 2000-12-15 CA CA2395291A patent/CA2395291C/en not_active Expired - Fee Related
- 2000-12-15 JP JP2001544774A patent/JP4925540B2/ja not_active Expired - Fee Related
- 2000-12-15 US US09/738,945 patent/US7053179B2/en not_active Expired - Fee Related
- 2000-12-15 ES ES00986475T patent/ES2296665T3/es not_active Expired - Lifetime
- 2000-12-15 EP EP00986475A patent/EP1237912B1/en not_active Expired - Lifetime
- 2000-12-15 WO PCT/US2000/034194 patent/WO2001044286A2/en not_active Ceased
- 2000-12-15 DE DE60037450T patent/DE60037450T2/de not_active Expired - Lifetime
- 2000-12-15 AT AT00986475T patent/ATE380822T1/de not_active IP Right Cessation
-
2005
- 2005-06-13 US US11/151,598 patent/US7504224B2/en not_active Expired - Fee Related
-
2009
- 2009-01-20 US US12/321,300 patent/US8058012B2/en not_active Expired - Fee Related
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