JP2003516114A - ５０個のヒト分泌タンパク質 - Google Patents
５０個のヒト分泌タンパク質Info
- Publication number
- JP2003516114A JP2003516114A JP2001503879A JP2001503879A JP2003516114A JP 2003516114 A JP2003516114 A JP 2003516114A JP 2001503879 A JP2001503879 A JP 2001503879A JP 2001503879 A JP2001503879 A JP 2001503879A JP 2003516114 A JP2003516114 A JP 2003516114A
- Authority
- JP
- Japan
- Prior art keywords
- human
- seq
- soares
- nci
- cgap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 306
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 133
- 241000282414 Homo sapiens Species 0.000 title abstract description 1163
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 22
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 18
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 18
- 239000013598 vector Substances 0.000 claims abstract description 9
- 102000040430 polynucleotide Human genes 0.000 claims description 246
- 108091033319 polynucleotide Proteins 0.000 claims description 246
- 239000002157 polynucleotide Substances 0.000 claims description 245
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 225
- 229920001184 polypeptide Polymers 0.000 claims description 223
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 223
- 239000002299 complementary DNA Substances 0.000 claims description 138
- 125000003729 nucleotide group Chemical group 0.000 claims description 138
- 239000002773 nucleotide Substances 0.000 claims description 88
- 230000000694 effects Effects 0.000 claims description 68
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 47
- 239000000047 product Substances 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 38
- 230000004071 biological effect Effects 0.000 claims description 33
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 239000012634 fragment Substances 0.000 claims description 17
- 230000014509 gene expression Effects 0.000 claims description 9
- 230000027455 binding Effects 0.000 claims description 6
- 238000012217 deletion Methods 0.000 claims description 5
- 230000037430 deletion Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000004166 bioassay Methods 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 48
- 208000035475 disorder Diseases 0.000 abstract description 25
- 201000010099 disease Diseases 0.000 abstract description 22
- 108091026890 Coding region Proteins 0.000 abstract description 6
- 238000002405 diagnostic procedure Methods 0.000 abstract description 4
- 238000010188 recombinant method Methods 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 184
- 210000001744 T-lymphocyte Anatomy 0.000 description 155
- 210000004556 brain Anatomy 0.000 description 142
- 206010028980 Neoplasm Diseases 0.000 description 128
- 235000018102 proteins Nutrition 0.000 description 123
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 104
- 210000001072 colon Anatomy 0.000 description 85
- 230000001605 fetal effect Effects 0.000 description 70
- 210000001519 tissue Anatomy 0.000 description 66
- 210000000952 spleen Anatomy 0.000 description 60
- 238000012360 testing method Methods 0.000 description 55
- 210000001550 testis Anatomy 0.000 description 53
- 210000002826 placenta Anatomy 0.000 description 52
- 210000004185 liver Anatomy 0.000 description 50
- 210000002460 smooth muscle Anatomy 0.000 description 47
- 208000029742 colonic neoplasm Diseases 0.000 description 38
- 210000004072 lung Anatomy 0.000 description 37
- 210000002536 stromal cell Anatomy 0.000 description 37
- 208000027418 Wounds and injury Diseases 0.000 description 36
- 230000014616 translation Effects 0.000 description 35
- 238000013519 translation Methods 0.000 description 35
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 34
- 210000004443 dendritic cell Anatomy 0.000 description 33
- 210000001638 cerebellum Anatomy 0.000 description 31
- 210000002216 heart Anatomy 0.000 description 31
- 238000003556 assay Methods 0.000 description 30
- 210000001185 bone marrow Anatomy 0.000 description 30
- 210000003734 kidney Anatomy 0.000 description 30
- 210000001161 mammalian embryo Anatomy 0.000 description 30
- 210000000496 pancreas Anatomy 0.000 description 30
- 206010061535 Ovarian neoplasm Diseases 0.000 description 29
- 210000002889 endothelial cell Anatomy 0.000 description 29
- 230000000670 limiting effect Effects 0.000 description 29
- 210000000440 neutrophil Anatomy 0.000 description 29
- 230000036961 partial effect Effects 0.000 description 29
- 206010009944 Colon cancer Diseases 0.000 description 28
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 28
- 210000005153 frontal cortex Anatomy 0.000 description 28
- 210000001616 monocyte Anatomy 0.000 description 28
- 210000002569 neuron Anatomy 0.000 description 28
- 239000000126 substance Substances 0.000 description 28
- 210000003606 umbilical vein Anatomy 0.000 description 28
- 238000004422 calculation algorithm Methods 0.000 description 27
- 210000001525 retina Anatomy 0.000 description 27
- 210000002966 serum Anatomy 0.000 description 27
- 206010052428 Wound Diseases 0.000 description 26
- 230000035876 healing Effects 0.000 description 26
- 230000003511 endothelial effect Effects 0.000 description 25
- 210000002307 prostate Anatomy 0.000 description 24
- 210000001541 thymus gland Anatomy 0.000 description 24
- 206010033128 Ovarian cancer Diseases 0.000 description 23
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 23
- 108010076504 Protein Sorting Signals Proteins 0.000 description 23
- 210000000963 osteoblast Anatomy 0.000 description 22
- 210000002741 palatine tonsil Anatomy 0.000 description 21
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 20
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 20
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 20
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 20
- 239000002158 endotoxin Substances 0.000 description 20
- 210000002458 fetal heart Anatomy 0.000 description 20
- 102000000589 Interleukin-1 Human genes 0.000 description 19
- 108010002352 Interleukin-1 Proteins 0.000 description 19
- 210000004727 amygdala Anatomy 0.000 description 19
- 201000011510 cancer Diseases 0.000 description 19
- 230000002163 immunogen Effects 0.000 description 19
- 235000001014 amino acid Nutrition 0.000 description 18
- 208000011580 syndromic disease Diseases 0.000 description 18
- 206010006187 Breast cancer Diseases 0.000 description 17
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 17
- 210000001789 adipocyte Anatomy 0.000 description 17
- 229940024606 amino acid Drugs 0.000 description 17
- 230000006378 damage Effects 0.000 description 17
- 210000004379 membrane Anatomy 0.000 description 17
- 239000012528 membrane Substances 0.000 description 17
- 230000001537 neural effect Effects 0.000 description 17
- 210000001672 ovary Anatomy 0.000 description 17
- 230000002685 pulmonary effect Effects 0.000 description 17
- 201000000980 schizophrenia Diseases 0.000 description 17
- 208000003950 B-cell lymphoma Diseases 0.000 description 16
- 108020004414 DNA Proteins 0.000 description 16
- 208000017604 Hodgkin disease Diseases 0.000 description 16
- 206010042971 T-cell lymphoma Diseases 0.000 description 16
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 16
- 230000001919 adrenal effect Effects 0.000 description 16
- 210000000988 bone and bone Anatomy 0.000 description 16
- 210000004700 fetal blood Anatomy 0.000 description 16
- 210000004153 islets of langerhan Anatomy 0.000 description 16
- 210000001165 lymph node Anatomy 0.000 description 16
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 15
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 15
- 208000008383 Wilms tumor Diseases 0.000 description 15
- 210000000481 breast Anatomy 0.000 description 15
- 230000000875 corresponding effect Effects 0.000 description 15
- 210000002510 keratinocyte Anatomy 0.000 description 15
- 210000002752 melanocyte Anatomy 0.000 description 15
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 14
- 230000000284 resting effect Effects 0.000 description 14
- ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 13
- SHGAZHPCJJPHSC-NWVFGJFESA-N Tretinoin Chemical compound OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NWVFGJFESA-N 0.000 description 13
- 230000001684 chronic effect Effects 0.000 description 13
- 230000001037 epileptic effect Effects 0.000 description 13
- 150000002500 ions Chemical class 0.000 description 13
- 210000002540 macrophage Anatomy 0.000 description 13
- 201000008026 nephroblastoma Diseases 0.000 description 13
- 229930002330 retinoic acid Natural products 0.000 description 13
- 229960001727 tretinoin Drugs 0.000 description 13
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 12
- 206010021143 Hypoxia Diseases 0.000 description 12
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 12
- 210000002950 fibroblast Anatomy 0.000 description 12
- 102000049953 human LEP Human genes 0.000 description 12
- 208000014674 injury Diseases 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 210000000278 spinal cord Anatomy 0.000 description 12
- 206010012289 Dementia Diseases 0.000 description 11
- 210000003016 hypothalamus Anatomy 0.000 description 11
- 210000001577 neostriatum Anatomy 0.000 description 11
- 210000000653 nervous system Anatomy 0.000 description 11
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 description 10
- 210000000577 adipose tissue Anatomy 0.000 description 10
- 230000001817 pituitary effect Effects 0.000 description 10
- 239000002243 precursor Substances 0.000 description 10
- 210000005267 prostate cell Anatomy 0.000 description 10
- 210000003523 substantia nigra Anatomy 0.000 description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
- 201000009030 Carcinoma Diseases 0.000 description 9
- 102000004388 Interleukin-4 Human genes 0.000 description 9
- 108090000978 Interleukin-4 Proteins 0.000 description 9
- 210000000709 aorta Anatomy 0.000 description 9
- 230000001640 apoptogenic effect Effects 0.000 description 9
- 210000003205 muscle Anatomy 0.000 description 9
- 201000008752 progressive muscular atrophy Diseases 0.000 description 9
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 8
- 206010009900 Colitis ulcerative Diseases 0.000 description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 8
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 description 8
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 8
- 206010025323 Lymphomas Diseases 0.000 description 8
- 206010060862 Prostate cancer Diseases 0.000 description 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 8
- 208000005718 Stomach Neoplasms Diseases 0.000 description 8
- 201000006704 Ulcerative Colitis Diseases 0.000 description 8
- 239000005557 antagonist Substances 0.000 description 8
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 8
- 210000003979 eosinophil Anatomy 0.000 description 8
- 210000000981 epithelium Anatomy 0.000 description 8
- 206010017758 gastric cancer Diseases 0.000 description 8
- 210000001320 hippocampus Anatomy 0.000 description 8
- 102000047217 human NR4A3 Human genes 0.000 description 8
- 238000009396 hybridization Methods 0.000 description 8
- 210000000231 kidney cortex Anatomy 0.000 description 8
- 210000000265 leukocyte Anatomy 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 201000008968 osteosarcoma Diseases 0.000 description 8
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 8
- 201000011549 stomach cancer Diseases 0.000 description 8
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 7
- 208000026310 Breast neoplasm Diseases 0.000 description 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 7
- 208000002495 Uterine Neoplasms Diseases 0.000 description 7
- 239000000556 agonist Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 210000002798 bone marrow cell Anatomy 0.000 description 7
- 206010008118 cerebral infarction Diseases 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 7
- 206010014599 encephalitis Diseases 0.000 description 7
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 7
- 229960005309 estradiol Drugs 0.000 description 7
- 229930182833 estradiol Natural products 0.000 description 7
- 210000001723 extracellular space Anatomy 0.000 description 7
- 210000000867 larynx Anatomy 0.000 description 7
- 210000000716 merkel cell Anatomy 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 230000001394 metastastic effect Effects 0.000 description 7
- 206010061289 metastatic neoplasm Diseases 0.000 description 7
- 239000010955 niobium Substances 0.000 description 7
- 230000035755 proliferation Effects 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 7
- 210000000130 stem cell Anatomy 0.000 description 7
- 210000001258 synovial membrane Anatomy 0.000 description 7
- 210000001685 thyroid gland Anatomy 0.000 description 7
- 206010046766 uterine cancer Diseases 0.000 description 7
- 208000024827 Alzheimer disease Diseases 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 230000010190 G1 phase Effects 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 108700026244 Open Reading Frames Proteins 0.000 description 6
- 230000018199 S phase Effects 0.000 description 6
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 6
- 201000007201 aphasia Diseases 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000003477 cochlea Anatomy 0.000 description 6
- 230000004069 differentiation Effects 0.000 description 6
- 210000001951 dura mater Anatomy 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- 210000005260 human cell Anatomy 0.000 description 6
- 201000005202 lung cancer Diseases 0.000 description 6
- 208000020816 lung neoplasm Diseases 0.000 description 6
- 210000002161 motor neuron Anatomy 0.000 description 6
- 210000003928 nasal cavity Anatomy 0.000 description 6
- 210000003463 organelle Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 210000000813 small intestine Anatomy 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 208000001608 teratocarcinoma Diseases 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 241000399988 Carinoma Species 0.000 description 5
- 208000016192 Demyelinating disease Diseases 0.000 description 5
- 101001131829 Homo sapiens P protein Proteins 0.000 description 5
- 208000009164 Islet Cell Adenoma Diseases 0.000 description 5
- 206010023825 Laryngeal cancer Diseases 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 230000005779 cell damage Effects 0.000 description 5
- 208000037887 cell injury Diseases 0.000 description 5
- 238000003776 cleavage reaction Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 210000004696 endometrium Anatomy 0.000 description 5
- 238000005755 formation reaction Methods 0.000 description 5
- 208000005017 glioblastoma Diseases 0.000 description 5
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 5
- 102000053391 human F Human genes 0.000 description 5
- 108700031895 human F Proteins 0.000 description 5
- 102000047119 human OCA2 Human genes 0.000 description 5
- 230000001024 immunotherapeutic effect Effects 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000000977 initiatory effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 201000002529 islet cell tumor Diseases 0.000 description 5
- 201000005264 laryngeal carcinoma Diseases 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 description 5
- 208000022102 pancreatic neuroendocrine neoplasm Diseases 0.000 description 5
- 210000000664 rectum Anatomy 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 230000007017 scission Effects 0.000 description 5
- 210000002027 skeletal muscle Anatomy 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 206010042863 synovial sarcoma Diseases 0.000 description 5
- 210000000538 tail Anatomy 0.000 description 5
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 description 4
- 101100346656 Drosophila melanogaster strat gene Proteins 0.000 description 4
- 206010026749 Mania Diseases 0.000 description 4
- 241000143392 Oar Species 0.000 description 4
- 206010033799 Paralysis Diseases 0.000 description 4
- 206010033892 Paraplegia Diseases 0.000 description 4
- 201000011252 Phenylketonuria Diseases 0.000 description 4
- 208000000474 Poliomyelitis Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 240000002825 Solanum vestissimum Species 0.000 description 4
- 235000018259 Solanum vestissimum Nutrition 0.000 description 4
- 208000005392 Spasm Diseases 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000002491 angiogenic effect Effects 0.000 description 4
- 101150030721 ata gene Proteins 0.000 description 4
- 210000003651 basophil Anatomy 0.000 description 4
- 230000002490 cerebral effect Effects 0.000 description 4
- 208000026106 cerebrovascular disease Diseases 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 4
- 230000028023 exocytosis Effects 0.000 description 4
- 230000007954 hypoxia Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 201000005296 lung carcinoma Diseases 0.000 description 4
- 230000000527 lymphocytic effect Effects 0.000 description 4
- 201000001441 melanoma Diseases 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 210000004681 ovum Anatomy 0.000 description 4
- 229960003387 progesterone Drugs 0.000 description 4
- 230000003248 secreting effect Effects 0.000 description 4
- 210000004739 secretory vesicle Anatomy 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 206010003591 Ataxia Diseases 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 3
- 206010061666 Autonomic neuropathy Diseases 0.000 description 3
- 208000020925 Bipolar disease Diseases 0.000 description 3
- 208000008720 Bone Marrow Neoplasms Diseases 0.000 description 3
- 206010005949 Bone cancer Diseases 0.000 description 3
- 208000018084 Bone neoplasm Diseases 0.000 description 3
- 201000006474 Brain Ischemia Diseases 0.000 description 3
- 101150013553 CD40 gene Proteins 0.000 description 3
- 208000031229 Cardiomyopathies Diseases 0.000 description 3
- 206010008120 Cerebral ischaemia Diseases 0.000 description 3
- 206010011878 Deafness Diseases 0.000 description 3
- 208000008334 Dermatofibrosarcoma Diseases 0.000 description 3
- 208000004986 Diffuse Cerebral Sclerosis of Schilder Diseases 0.000 description 3
- 208000006050 Hemangiopericytoma Diseases 0.000 description 3
- 101000643741 Homo sapiens Sugar transporter SWEET1 Proteins 0.000 description 3
- 208000016495 Horner Syndrome Diseases 0.000 description 3
- 208000006001 Hypothalamic Neoplasms Diseases 0.000 description 3
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 3
- YLCXGBZIZBEVPZ-UHFFFAOYSA-N Medazepam Chemical compound C12=CC(Cl)=CC=C2N(C)CCN=C1C1=CC=CC=C1 YLCXGBZIZBEVPZ-UHFFFAOYSA-N 0.000 description 3
- 201000009906 Meningitis Diseases 0.000 description 3
- 241000699660 Mus musculus Species 0.000 description 3
- 208000012902 Nervous system disease Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 206010036105 Polyneuropathy Diseases 0.000 description 3
- 241000700157 Rattus norvegicus Species 0.000 description 3
- 108091058545 Secretory proteins Proteins 0.000 description 3
- 102000040739 Secretory proteins Human genes 0.000 description 3
- 206010072148 Stiff-Person syndrome Diseases 0.000 description 3
- 102100036280 Sugar transporter SWEET1 Human genes 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 3
- FMYKJLXRRQTBOR-BZSNNMDCSA-N acetylleucyl-leucyl-norleucinal Chemical compound CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O FMYKJLXRRQTBOR-BZSNNMDCSA-N 0.000 description 3
- 208000009956 adenocarcinoma Diseases 0.000 description 3
- 230000037444 atrophy Effects 0.000 description 3
- 208000028683 bipolar I disease Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 210000002449 bone cell Anatomy 0.000 description 3
- 201000006491 bone marrow cancer Diseases 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 230000003412 degenerative effect Effects 0.000 description 3
- 230000002357 endometrial effect Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 208000016354 hearing loss disease Diseases 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 208000026278 immune system disease Diseases 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000003246 kidney medulla Anatomy 0.000 description 3
- 208000003747 lymphoid leukemia Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008774 maternal effect Effects 0.000 description 3
- 210000004925 microvascular endothelial cell Anatomy 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 201000000585 muscular atrophy Diseases 0.000 description 3
- 230000009826 neoplastic cell growth Effects 0.000 description 3
- 230000004770 neurodegeneration Effects 0.000 description 3
- 208000008795 neuromyelitis optica Diseases 0.000 description 3
- 208000019180 nutritional disease Diseases 0.000 description 3
- 230000003349 osteoarthritic effect Effects 0.000 description 3
- 230000002611 ovarian Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 239000013615 primer Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- 201000002241 progressive bulbar palsy Diseases 0.000 description 3
- 208000019585 progressive encephalomyelitis with rigidity and myoclonus Diseases 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 210000001044 sensory neuron Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 201000004595 synovitis Diseases 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 206010065040 AIDS dementia complex Diseases 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 208000032194 Acute haemorrhagic leukoencephalitis Diseases 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 201000009487 Amblyopia Diseases 0.000 description 2
- 208000006373 Bell palsy Diseases 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 2
- 208000002381 Brain Hypoxia Diseases 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- 208000007774 Broca Aphasia Diseases 0.000 description 2
- 108091028026 C-DNA Proteins 0.000 description 2
- TXCIAUNLDRJGJZ-UHFFFAOYSA-N CMP-N-acetyl neuraminic acid Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-UHFFFAOYSA-N 0.000 description 2
- TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 description 2
- 241000244203 Caenorhabditis elegans Species 0.000 description 2
- 208000022526 Canavan disease Diseases 0.000 description 2
- 206010007688 Carotid artery thrombosis Diseases 0.000 description 2
- 206010057854 Cerebral Toxoplasmosis Diseases 0.000 description 2
- 206010063094 Cerebral malaria Diseases 0.000 description 2
- 201000006867 Charcot-Marie-Tooth disease type 4 Diseases 0.000 description 2
- 208000004139 Choroid Plexus Neoplasms Diseases 0.000 description 2
- 201000000915 Chronic Progressive External Ophthalmoplegia Diseases 0.000 description 2
- 208000006509 Congenital Pain Insensitivity Diseases 0.000 description 2
- 208000029323 Congenital myotonia Diseases 0.000 description 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 206010057070 Dermatofibrosarcoma protuberans Diseases 0.000 description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 2
- 208000003164 Diplopia Diseases 0.000 description 2
- 201000000913 Duane retraction syndrome Diseases 0.000 description 2
- 208000020129 Duane syndrome Diseases 0.000 description 2
- 206010013887 Dysarthria Diseases 0.000 description 2
- 208000002743 Epidural Neoplasms Diseases 0.000 description 2
- 208000001375 Facial Neuralgia Diseases 0.000 description 2
- 206010016717 Fistula Diseases 0.000 description 2
- 208000006411 Hereditary Sensory and Motor Neuropathy Diseases 0.000 description 2
- 208000007514 Herpes zoster Diseases 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 208000007623 Lordosis Diseases 0.000 description 2
- 208000000172 Medulloblastoma Diseases 0.000 description 2
- 208000010495 Meningocele Diseases 0.000 description 2
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 101000931108 Mus musculus DNA (cytosine-5)-methyltransferase 1 Proteins 0.000 description 2
- 208000008238 Muscle Spasticity Diseases 0.000 description 2
- 206010028289 Muscle atrophy Diseases 0.000 description 2
- 101500006448 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Endonuclease PI-MboI Proteins 0.000 description 2
- 206010028570 Myelopathy Diseases 0.000 description 2
- 206010061533 Myotonia Diseases 0.000 description 2
- 208000010316 Myotonia congenita Diseases 0.000 description 2
- BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 description 2
- 206010029098 Neoplasm skin Diseases 0.000 description 2
- 208000003435 Optic Neuritis Diseases 0.000 description 2
- 206010069350 Osmotic demyelination syndrome Diseases 0.000 description 2
- 208000037158 Partial Epilepsies Diseases 0.000 description 2
- 206010061334 Partial seizures Diseases 0.000 description 2
- 208000010366 Postpoliomyelitis syndrome Diseases 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 206010037714 Quadriplegia Diseases 0.000 description 2
- 208000006289 Rett Syndrome Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 206010058571 Spinal cord infarction Diseases 0.000 description 2
- 208000036982 Spinal cord ischaemia Diseases 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 208000004350 Strabismus Diseases 0.000 description 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 2
- 208000004006 Tick-borne encephalitis Diseases 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 201000004810 Vascular dementia Diseases 0.000 description 2
- 208000010094 Visna Diseases 0.000 description 2
- 208000013521 Visual disease Diseases 0.000 description 2
- 208000005248 Vocal Cord Paralysis Diseases 0.000 description 2
- 208000002579 Wernicke Aphasia Diseases 0.000 description 2
- 208000010045 Wernicke encephalopathy Diseases 0.000 description 2
- 230000001594 aberrant effect Effects 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000030741 antigen processing and presentation Effects 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 208000025188 carcinoma of pharynx Diseases 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 208000009885 central pontine myelinolysis Diseases 0.000 description 2
- 208000030394 cerebellar neoplasm Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 208000012790 cranial neuralgia Diseases 0.000 description 2
- 231100000895 deafness Toxicity 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 206010013932 dyslexia Diseases 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000003890 fistula Effects 0.000 description 2
- 201000007186 focal epilepsy Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000002288 golgi apparatus Anatomy 0.000 description 2
- 210000004013 groin Anatomy 0.000 description 2
- 239000011440 grout Substances 0.000 description 2
- 208000021995 hereditary motor and sensory neuropathy Diseases 0.000 description 2
- 208000037584 hereditary sensory and autonomic neuropathy Diseases 0.000 description 2
- 201000006847 hereditary sensory neuropathy Diseases 0.000 description 2
- 208000003906 hydrocephalus Diseases 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 206010023841 laryngeal neoplasm Diseases 0.000 description 2
- 208000036546 leukodystrophy Diseases 0.000 description 2
- 208000002741 leukoplakia Diseases 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 210000004924 lung microvascular endothelial cell Anatomy 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 201000011475 meningoencephalitis Diseases 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 229960004452 methionine Drugs 0.000 description 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
- 208000005264 motor neuron disease Diseases 0.000 description 2
- 201000005545 motor peripheral neuropathy Diseases 0.000 description 2
- 230000020763 muscle atrophy Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 208000018360 neuromuscular disease Diseases 0.000 description 2
- 230000006764 neuronal dysfunction Effects 0.000 description 2
- 230000006576 neuronal survival Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 208000030212 nutrition disease Diseases 0.000 description 2
- 206010030875 ophthalmoplegia Diseases 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 201000003437 pleural cancer Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 208000000813 polyradiculoneuropathy Diseases 0.000 description 2
- 230000001323 posttranslational effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000002987 primer (paints) Substances 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 description 2
- 230000006337 proteolytic cleavage Effects 0.000 description 2
- 230000024833 regulation of cytokine production Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000018198 spasticity Diseases 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 206010048627 thoracic outlet syndrome Diseases 0.000 description 2
- 208000009174 transverse myelitis Diseases 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 206010044652 trigeminal neuralgia Diseases 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 238000010798 ubiquitination Methods 0.000 description 2
- 230000034512 ubiquitination Effects 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- BUJCVBRLTBAYCW-UHFFFAOYSA-N 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one Chemical compound COC1=CC=CC=C1OC(CO)C(=O)C1=CC=C(O)C(OC)=C1 BUJCVBRLTBAYCW-UHFFFAOYSA-N 0.000 description 1
- ABAFKQHGFDZEJO-UHFFFAOYSA-N 4,6,6-trimethylbicyclo[3.1.1]heptane-4-carbaldehyde Chemical compound C1C2C(C)(C)C1CCC2(C)C=O ABAFKQHGFDZEJO-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- BUADUHVXMFJVLH-UHFFFAOYSA-N 7-chloro-3-imidazol-1-yl-2H-1,2,4-benzotriazin-1-ium 1-oxide Chemical compound N1[N+](=O)C2=CC(Cl)=CC=C2N=C1N1C=CN=C1 BUADUHVXMFJVLH-UHFFFAOYSA-N 0.000 description 1
- 230000005730 ADP ribosylation Effects 0.000 description 1
- 102100024643 ATP-binding cassette sub-family D member 1 Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 201000011452 Adrenoleukodystrophy Diseases 0.000 description 1
- 208000006888 Agnosia Diseases 0.000 description 1
- 241001047040 Agnosia Species 0.000 description 1
- 206010001907 Amblyopia alcohol Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000008822 Ankylosis Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010002941 Apallic syndrome Diseases 0.000 description 1
- 206010002953 Aphonia Diseases 0.000 description 1
- 206010003062 Apraxia Diseases 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 241000180579 Arca Species 0.000 description 1
- 206010003101 Arnold-Chiari Malformation Diseases 0.000 description 1
- 208000006740 Aseptic Meningitis Diseases 0.000 description 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 1
- 208000009017 Athetosis Diseases 0.000 description 1
- 206010003805 Autism Diseases 0.000 description 1
- 208000020706 Autistic disease Diseases 0.000 description 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
- 208000037187 Autoimmune Experimental Neuritis Diseases 0.000 description 1
- 208000012219 Autonomic Nervous System disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000001560 Barre-Lieou syndrome Diseases 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 201000006390 Brachial Plexus Neuritis Diseases 0.000 description 1
- 208000004020 Brain Abscess Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 206010006542 Bulbar palsy Diseases 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 102100033787 CMP-sialic acid transporter Human genes 0.000 description 1
- 101710150575 CMP-sialic acid transporter Proteins 0.000 description 1
- 101100002951 Caenorhabditis elegans asp-17 gene Proteins 0.000 description 1
- 101100290380 Caenorhabditis elegans cel-1 gene Proteins 0.000 description 1
- 208000014882 Carotid artery disease Diseases 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 208000014912 Central Nervous System Infections Diseases 0.000 description 1
- 206010008025 Cerebellar ataxia Diseases 0.000 description 1
- 206010008027 Cerebellar atrophy Diseases 0.000 description 1
- 208000015879 Cerebellar disease Diseases 0.000 description 1
- 208000021910 Cerebral Arterial disease Diseases 0.000 description 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 description 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
- 208000034710 Cerebral arteriovenous malformation Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 208000003168 Cervical Rib Syndrome Diseases 0.000 description 1
- 208000015321 Chiari malformation Diseases 0.000 description 1
- 108010058699 Choline O-acetyltransferase Proteins 0.000 description 1
- 102100023460 Choline O-acetyltransferase Human genes 0.000 description 1
- 208000005243 Chondrosarcoma Diseases 0.000 description 1
- 206010008748 Chorea Diseases 0.000 description 1
- 206010008761 Choriomeningitis lymphocytic Diseases 0.000 description 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- 208000006561 Cluster Headache Diseases 0.000 description 1
- 208000006992 Color Vision Defects Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 201000009343 Cornelia de Lange syndrome Diseases 0.000 description 1
- 208000019736 Cranial nerve disease Diseases 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010050702 Crush syndrome Diseases 0.000 description 1
- 208000006081 Cryptococcal meningitis Diseases 0.000 description 1
- 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 201000003863 Dandy-Walker Syndrome Diseases 0.000 description 1
- 208000003471 De Lange Syndrome Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
- 201000010374 Down Syndrome Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 206010014596 Encephalitis Japanese B Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 206010014612 Encephalitis viral Diseases 0.000 description 1
- 208000002403 Encephalocele Diseases 0.000 description 1
- 201000005231 Epithelioid sarcoma Diseases 0.000 description 1
- 208000000832 Equine Encephalomyelitis Diseases 0.000 description 1
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102100032837 Exportin-6 Human genes 0.000 description 1
- 206010015769 Extradural haematoma Diseases 0.000 description 1
- 208000001308 Fasciculation Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 206010016880 Folate deficiency Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 208000024412 Friedreich ataxia Diseases 0.000 description 1
- 201000009010 Frontal lobe epilepsy Diseases 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 201000008892 GM1 Gangliosidosis Diseases 0.000 description 1
- 208000009796 Gangliosidoses Diseases 0.000 description 1
- 244000287680 Garcinia dulcis Species 0.000 description 1
- 208000003078 Generalized Epilepsy Diseases 0.000 description 1
- 208000007223 Gerstmann syndrome Diseases 0.000 description 1
- 102000009127 Glutaminase Human genes 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108010075326 HLA-B51 Antigen Proteins 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 208000016621 Hearing disease Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 208000001799 Hereditary Optic Atrophies Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 108090000246 Histone acetyltransferases Proteins 0.000 description 1
- 102000003893 Histone acetyltransferases Human genes 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 101000855520 Homo sapiens Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
- 101000848655 Homo sapiens E3 ubiquitin/ISG15 ligase TRIM25 Proteins 0.000 description 1
- 101000847050 Homo sapiens Exportin-6 Proteins 0.000 description 1
- 101000615232 Homo sapiens Guanine nucleotide exchange factor DBS Proteins 0.000 description 1
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 description 1
- 101000911772 Homo sapiens Hsc70-interacting protein Proteins 0.000 description 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
- 101000620451 Homo sapiens Leucine-rich glioma-inactivated protein 1 Proteins 0.000 description 1
- 101001018100 Homo sapiens Lysozyme C Proteins 0.000 description 1
- 101001005668 Homo sapiens Mastermind-like protein 3 Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 101000742859 Homo sapiens Retinoblastoma-associated protein Proteins 0.000 description 1
- 101000801195 Homo sapiens TLE family member 5 Proteins 0.000 description 1
- 101000596277 Homo sapiens TSC22 domain family protein 3 Proteins 0.000 description 1
- 206010020365 Homocystinuria Diseases 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010053712 Hypersomnia-bulimia syndrome Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 208000028482 Hypothalamic disease Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010021283 IIIrd nerve paralysis Diseases 0.000 description 1
- 206010021518 Impaired gastric emptying Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000005121 Infratentorial Neoplasms Diseases 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 208000002263 Intracranial Arteriovenous Malformations Diseases 0.000 description 1
- 208000005313 Intracranial Embolism and Thrombosis Diseases 0.000 description 1
- 201000008450 Intracranial aneurysm Diseases 0.000 description 1
- 208000032984 Intraoperative Complications Diseases 0.000 description 1
- 201000005807 Japanese encephalitis Diseases 0.000 description 1
- 241000710842 Japanese encephalitis virus Species 0.000 description 1
- 206010023198 Joint ankylosis Diseases 0.000 description 1
- 201000008178 Kleine-Levin syndrome Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102100022275 Leucine-rich glioma-inactivated protein 1 Human genes 0.000 description 1
- 241000408529 Libra Species 0.000 description 1
- 208000000672 Listeria meningitis Diseases 0.000 description 1
- 208000010415 Low Vision Diseases 0.000 description 1
- 208000016604 Lyme disease Diseases 0.000 description 1
- 102100033468 Lysozyme C Human genes 0.000 description 1
- 201000009035 MERRF syndrome Diseases 0.000 description 1
- 208000002569 Machado-Joseph Disease Diseases 0.000 description 1
- 241000867077 Macropes Species 0.000 description 1
- 208000030162 Maple syrup disease Diseases 0.000 description 1
- 206010026865 Mass Diseases 0.000 description 1
- 102100025134 Mastermind-like protein 3 Human genes 0.000 description 1
- 208000000481 Maternal phenylketonuria Diseases 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 description 1
- 208000015021 Meningeal Neoplasms Diseases 0.000 description 1
- 206010027201 Meningitis aseptic Diseases 0.000 description 1
- 206010027202 Meningitis bacterial Diseases 0.000 description 1
- 206010027209 Meningitis cryptococcal Diseases 0.000 description 1
- 206010027236 Meningitis fungal Diseases 0.000 description 1
- 206010027241 Meningitis haemophilus Diseases 0.000 description 1
- 206010027249 Meningitis meningococcal Diseases 0.000 description 1
- 206010027253 Meningitis pneumococcal Diseases 0.000 description 1
- 206010027260 Meningitis viral Diseases 0.000 description 1
- 201000010924 Meningococcal meningitis Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 241001108995 Messa Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000026072 Motor neurone disease Diseases 0.000 description 1
- 108090000143 Mouse Proteins Proteins 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 208000009433 Moyamoya Disease Diseases 0.000 description 1
- 208000008955 Mucolipidoses Diseases 0.000 description 1
- 208000001089 Multiple system atrophy Diseases 0.000 description 1
- 101100270435 Mus musculus Arhgef12 gene Proteins 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000002038 Muscle Hypertonia Diseases 0.000 description 1
- 208000007379 Muscle Hypotonia Diseases 0.000 description 1
- 208000002740 Muscle Rigidity Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 206010028424 Myasthenic syndrome Diseases 0.000 description 1
- 208000003926 Myelitis Diseases 0.000 description 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 description 1
- 206010069825 Myoclonic epilepsy and ragged-red fibres Diseases 0.000 description 1
- 208000002033 Myoclonus Diseases 0.000 description 1
- 201000009623 Myopathy Diseases 0.000 description 1
- 208000005736 Nervous System Malformations Diseases 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 description 1
- 206010029279 Neurogenic bladder Diseases 0.000 description 1
- 208000008457 Neurologic Manifestations Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 description 1
- 108010077641 Nogo Proteins Proteins 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 1
- 208000014723 Oculomotor Nerve disease Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 208000009702 Optic Disk Drusen Diseases 0.000 description 1
- 208000036584 Optic disc drusen Diseases 0.000 description 1
- 208000001715 Osteoblastoma Diseases 0.000 description 1
- 241000382928 Oxya Species 0.000 description 1
- 206010053869 POEMS syndrome Diseases 0.000 description 1
- 108010067035 Pancrelipase Proteins 0.000 description 1
- 201000010183 Papilledema Diseases 0.000 description 1
- 206010033712 Papilloedema Diseases 0.000 description 1
- 206010033864 Paranoia Diseases 0.000 description 1
- 208000027099 Paranoid disease Diseases 0.000 description 1
- 241000232971 Passer domesticus Species 0.000 description 1
- 241001471187 Patu Species 0.000 description 1
- 208000004983 Phantom Limb Diseases 0.000 description 1
- 241000218633 Pinidae Species 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 208000001391 Posterior Cervical Sympathetic Syndrome Diseases 0.000 description 1
- 206010036631 Presenile dementia Diseases 0.000 description 1
- 208000032319 Primary lateral sclerosis Diseases 0.000 description 1
- 208000024777 Prion disease Diseases 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102000017975 Protein C Human genes 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- 208000002009 Pyruvate Dehydrogenase Complex Deficiency Disease Diseases 0.000 description 1
- 208000021886 Pyruvate carboxylase deficiency Diseases 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 206010037779 Radiculopathy Diseases 0.000 description 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 description 1
- 208000005587 Refsum Disease Diseases 0.000 description 1
- 206010038357 Renal amyloidosis Diseases 0.000 description 1
- 208000010476 Respiratory Paralysis Diseases 0.000 description 1
- 102100029831 Reticulon-4 Human genes 0.000 description 1
- 102100038042 Retinoblastoma-associated protein Human genes 0.000 description 1
- 201000007981 Reye syndrome Diseases 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 206010039729 Scotoma Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000009106 Shy-Drager Syndrome Diseases 0.000 description 1
- 101150094640 Siae gene Proteins 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 206010041347 Somnambulism Diseases 0.000 description 1
- 201000010829 Spina bifida Diseases 0.000 description 1
- 208000029033 Spinal Cord disease Diseases 0.000 description 1
- 208000006097 Spinal Dysraphism Diseases 0.000 description 1
- 208000000133 Spinal Neoplasms Diseases 0.000 description 1
- 208000010112 Spinocerebellar Degenerations Diseases 0.000 description 1
- 206010041896 St. Louis Encephalitis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000003028 Stuttering Diseases 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 201000000002 Subdural Empyema Diseases 0.000 description 1
- 208000002667 Subdural Hematoma Diseases 0.000 description 1
- 208000000573 Supratentorial Neoplasms Diseases 0.000 description 1
- 241000282890 Sus Species 0.000 description 1
- 206010042744 Sympathetic posterior cervical syndrome Diseases 0.000 description 1
- 206010042928 Syringomyelia Diseases 0.000 description 1
- 101150006914 TRP1 gene Proteins 0.000 description 1
- 102100035260 TSC22 domain family protein 3 Human genes 0.000 description 1
- 206010043121 Tarsal tunnel syndrome Diseases 0.000 description 1
- 208000025371 Taste disease Diseases 0.000 description 1
- 208000022292 Tay-Sachs disease Diseases 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 206010044074 Torticollis Diseases 0.000 description 1
- 208000000323 Tourette Syndrome Diseases 0.000 description 1
- 208000016620 Tourette disease Diseases 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 102100021338 Transmembrane ascorbate-dependent reductase CYB561 Human genes 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 241000982080 Trophis Species 0.000 description 1
- LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 description 1
- 208000008593 Ulnar Nerve Compression Syndromes Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 206010046298 Upper motor neurone lesion Diseases 0.000 description 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000143957 Vanessa atalanta Species 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 208000001407 Vascular Headaches Diseases 0.000 description 1
- 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 description 1
- 208000014070 Vestibular schwannoma Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 201000007960 WAGR syndrome Diseases 0.000 description 1
- 208000035562 Wallenberg syndrome Diseases 0.000 description 1
- 201000006449 West Nile encephalitis Diseases 0.000 description 1
- 206010057293 West Nile viral infection Diseases 0.000 description 1
- 201000004525 Zellweger Syndrome Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 208000003554 absence epilepsy Diseases 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 208000004064 acoustic neuroma Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 208000030597 adult Refsum disease Diseases 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 206010003074 arachnoiditis Diseases 0.000 description 1
- 230000010516 arginylation Effects 0.000 description 1
- 201000000034 arteriovenous malformations of the brain Diseases 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000003639 autosomal recessive cerebellar ataxia Diseases 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000028600 axonogenesis Effects 0.000 description 1
- 201000009904 bacterial meningitis Diseases 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 208000006170 carotid stenosis Diseases 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000025222 central nervous system infectious disease Diseases 0.000 description 1
- 208000025997 central nervous system neoplasm Diseases 0.000 description 1
- 201000004559 cerebral degeneration Diseases 0.000 description 1
- 210000004720 cerebrum Anatomy 0.000 description 1
- 208000027473 cervical rib disease Diseases 0.000 description 1
- ZXFCRFYULUUSDW-OWXODZSWSA-N chembl2104970 Chemical compound C([C@H]1C2)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2CC(O)=C(C(=O)N)C1=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000012601 choreatic disease Diseases 0.000 description 1
- 230000002566 clonic effect Effects 0.000 description 1
- 208000018912 cluster headache syndrome Diseases 0.000 description 1
- 201000007254 color blindness Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 208000011664 congenital factor XI deficiency Diseases 0.000 description 1
- 210000000877 corpus callosum Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 208000012106 cystic neoplasm Diseases 0.000 description 1
- 108020001378 cytochrome b561 Proteins 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 230000003210 demyelinating effect Effects 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- HDRXZJPWHTXQRI-BHDTVMLSSA-N diltiazem hydrochloride Chemical compound [Cl-].C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CC[NH+](C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-BHDTVMLSSA-N 0.000 description 1
- KYCIUIVANPKXLW-UHFFFAOYSA-N dimethyl-(2-phenoxyethyl)-(thiophen-2-ylmethyl)azanium Chemical compound C=1C=CSC=1C[N+](C)(C)CCOC1=CC=CC=C1 KYCIUIVANPKXLW-UHFFFAOYSA-N 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 108020002384 diphthine synthase Proteins 0.000 description 1
- 102000005402 diphthine synthase Human genes 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000019564 dysgeusia Nutrition 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 208000005053 encephalomalacia Diseases 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 208000023965 endometrium neoplasm Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 208000014337 facial nerve disease Diseases 0.000 description 1
- 201000007219 factor XI deficiency Diseases 0.000 description 1
- 201000007891 familial visceral amyloidosis Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 150000002211 flavins Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000022244 formylation Effects 0.000 description 1
- 238000006170 formylation reaction Methods 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 230000009760 functional impairment Effects 0.000 description 1
- 201000010056 fungal meningitis Diseases 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 230000006251 gamma-carboxylation Effects 0.000 description 1
- 201000006440 gangliosidosis Diseases 0.000 description 1
- 208000001288 gastroparesis Diseases 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 150000003278 haem Chemical group 0.000 description 1
- 208000010523 haemophilus meningitis Diseases 0.000 description 1
- 230000010370 hearing loss Effects 0.000 description 1
- 231100000888 hearing loss Toxicity 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 208000008675 hereditary spastic paraplegia Diseases 0.000 description 1
- 208000000747 high pressure neurological syndrome Diseases 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 102000051957 human ERBB2 Human genes 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 102000052301 human GNAZ Human genes 0.000 description 1
- 102000043508 human MCF2L Human genes 0.000 description 1
- 102000056245 human TLE5 Human genes 0.000 description 1
- 102000051066 human TRIM25 Human genes 0.000 description 1
- 229960000900 human factor viii Drugs 0.000 description 1
- 238000002169 hydrotherapy Methods 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 206010020765 hypersomnia Diseases 0.000 description 1
- 230000003483 hypokinetic effect Effects 0.000 description 1
- 201000001993 idiopathic generalized epilepsy Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000018197 inherited torticollis Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 1
- 201000007272 intracranial sinus thrombosis Diseases 0.000 description 1
- 230000026045 iodination Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 208000011977 language disease Diseases 0.000 description 1
- 208000004343 lateral medullary syndrome Diseases 0.000 description 1
- 201000010901 lateral sclerosis Diseases 0.000 description 1
- 230000013016 learning Effects 0.000 description 1
- 201000003723 learning disability Diseases 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 208000001419 lymphocytic choriomeningitis Diseases 0.000 description 1
- 210000003738 lymphoid progenitor cell Anatomy 0.000 description 1
- 230000001048 lympholytic effect Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 208000037941 meningococcal disease Diseases 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 201000007769 mucolipidosis Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000007498 myristoylation Effects 0.000 description 1
- 201000003631 narcolepsy Diseases 0.000 description 1
- 230000030363 nerve development Effects 0.000 description 1
- 101150006061 neur gene Proteins 0.000 description 1
- 201000010193 neural tube defect Diseases 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 208000002761 neurofibromatosis 2 Diseases 0.000 description 1
- 208000022032 neurofibromatosis type 2 Diseases 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 201000008051 neuronal ceroid lipofuscinosis Diseases 0.000 description 1
- 230000004031 neuronal differentiation Effects 0.000 description 1
- 208000002040 neurosyphilis Diseases 0.000 description 1
- 239000002581 neurotoxin Substances 0.000 description 1
- 231100000618 neurotoxin Toxicity 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- -1 nucleotide sugars Chemical class 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 206010029864 nystagmus Diseases 0.000 description 1
- 208000028780 ocular motility disease Diseases 0.000 description 1
- 208000020911 optic nerve disease Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 208000021090 palsy Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 208000027232 peripheral nervous system disease Diseases 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 201000005936 periventricular leukomalacia Diseases 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 208000005026 persistent vegetative state Diseases 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 208000004593 pneumococcal meningitis Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000007824 polyneuropathy Effects 0.000 description 1
- 108010039177 polyphenylalanine Proteins 0.000 description 1
- 210000002729 polyribosome Anatomy 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000013823 prenylation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000004765 promyelocyte Anatomy 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 description 1
- 208000015445 pyruvate dehydrogenase deficiency Diseases 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 206010061928 radiculitis Diseases 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 201000009570 retrograde amnesia Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 208000017779 riboflavin transporter deficiency Diseases 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
- 102220278881 rs749263651 Human genes 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 208000008864 scrapie Diseases 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 108010010152 sialic acid transport proteins Proteins 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 208000027765 speech disease Diseases 0.000 description 1
- 206010041525 spina bifida occulta Diseases 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 206010062261 spinal cord neoplasm Diseases 0.000 description 1
- 208000002320 spinal muscular atrophy Diseases 0.000 description 1
- 208000005809 status epilepticus Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 101150038671 strat gene Proteins 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000035581 susceptibility to neural tube defects Diseases 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 235000019669 taste disorders Nutrition 0.000 description 1
- 201000008914 temporal lobe epilepsy Diseases 0.000 description 1
- 208000012720 thalamic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 206010043778 thyroiditis Diseases 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 208000009999 tuberous sclerosis Diseases 0.000 description 1
- 208000013706 tumor of meninges Diseases 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 201000010044 viral meningitis Diseases 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 208000002670 vitamin B12 deficiency Diseases 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13862999P | 1999-06-11 | 1999-06-11 | |
| US60/138,629 | 1999-06-11 | ||
| PCT/US2000/015136 WO2000077022A1 (fr) | 1999-06-11 | 2000-06-01 | 50 proteines humaines secretees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003516114A true JP2003516114A (ja) | 2003-05-13 |
Family
ID=22482894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001503879A Withdrawn JP2003516114A (ja) | 1999-06-11 | 2000-06-01 | ５０個のヒト分泌タンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1185543A4 (fr) |
| JP (1) | JP2003516114A (fr) |
| AU (1) | AU5177000A (fr) |
| CA (1) | CA2382748A1 (fr) |
| WO (1) | WO2000077022A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1567644A4 (fr) * | 2002-04-16 | 2006-04-05 | Origene Technologies Inc | Genes et batteries de genes specifiques de tissus |
| EP2072619A1 (fr) * | 2002-10-18 | 2009-06-24 | Silence Therapeutics Aktiengesellschaft | Nouveau facteur de métastase et ses utilisations |
| MX2007002043A (es) | 2004-08-16 | 2007-10-11 | Quark Biotech Inc | Usos terapeuticos de los inhibidores del rtp801. |
| US20090137484A1 (en) * | 2004-12-01 | 2009-05-28 | National University Of Singapore | Neuronal Network-Interacting Peptide |
| DOP2007000015A (es) | 2006-01-20 | 2007-08-31 | Quark Biotech Inc | Usos terapéuticos de inhibidores de rtp801 |
| US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| GB2450840B (en) | 2006-05-11 | 2010-12-29 | Quark Pharmaceuticals Inc | Screening Systems Utilizing RTP801 |
| EP2026843A4 (fr) | 2006-06-09 | 2011-06-22 | Quark Pharmaceuticals Inc | Utilisations thérapeutiques d'inhibiteurs de rtp801l |
| WO2008106102A2 (fr) | 2007-02-26 | 2008-09-04 | Quark Pharmaceuticals, Inc. | Inhibiteurs de rtp801 et leur utilisation dans le traitement de diverses maladies |
| US8614311B2 (en) | 2007-12-12 | 2013-12-24 | Quark Pharmaceuticals, Inc. | RTP801L siRNA compounds and methods of use thereof |
| WO2020112941A2 (fr) | 2018-11-27 | 2020-06-04 | Teva Czech Industries S.R.O | Formes à l'état solide de sels de lumatépérone et procédés de préparation de lumatépérone et de ses sels |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998054963A2 (fr) * | 1997-06-06 | 1998-12-10 | Human Genome Sciences, Inc. | 207 proteines secretees humaines |
| CA2283299A1 (fr) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 nouvelles proteines secretees |
-
2000
- 2000-06-01 CA CA002382748A patent/CA2382748A1/fr not_active Abandoned
- 2000-06-01 JP JP2001503879A patent/JP2003516114A/ja not_active Withdrawn
- 2000-06-01 AU AU51770/00A patent/AU5177000A/en not_active Abandoned
- 2000-06-01 EP EP00936455A patent/EP1185543A4/fr not_active Withdrawn
- 2000-06-01 WO PCT/US2000/015136 patent/WO2000077022A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5177000A (en) | 2001-01-02 |
| CA2382748A1 (fr) | 2000-12-21 |
| EP1185543A4 (fr) | 2003-09-03 |
| WO2000077022A1 (fr) | 2000-12-21 |
| EP1185543A1 (fr) | 2002-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003513655A (ja) | ２１個のヒト分泌タンパク質 | |
| JP2003528587A (ja) | ２７個のヒト分泌タンパク質 | |
| JP2003514541A (ja) | １８個のヒト分泌タンパク質 | |
| JP2003502062A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2003502058A (ja) | ４８個のヒト分泌タンパク質 | |
| JP2003501011A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2002541833A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2003502061A (ja) | ４８個のヒト分泌タンパク質 | |
| JP2003516114A (ja) | ５０個のヒト分泌タンパク質 | |
| JP2002542766A (ja) | ５０個のヒト分泌タンパク質 | |
| JP2003514543A (ja) | ２３個のヒト分泌タンパク質 | |
| JP2003521242A (ja) | １９個のヒト分泌タンパク質 | |
| JP2003501009A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2003528586A (ja) | ３２個のヒト分泌タンパク質 | |
| JP2003501108A (ja) | ４７個のヒト分泌タンパク質 | |
| JP2003510028A (ja) | ２５個のヒト分泌タンパク質 | |
| JP2003500017A (ja) | ４８個のヒト分泌タンパク質 | |
| JP2002538811A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2002542767A (ja) | ４７個のヒト分泌タンパク質 | |
| JP2003502038A (ja) | ４７個のヒト分泌タンパク質 | |
| JP2002539843A (ja) | ５０個のヒト分泌タンパク質 | |
| JP2003511008A (ja) | ４９個のヒト分泌タンパク質 | |
| JP2003520032A (ja) | ２４個のヒト分泌タンパク質 | |
| JP2003523726A (ja) | ５０個のヒト分泌タンパク質 | |
| JP2003510062A (ja) | ４３個のヒト分泌タンパク質 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Application deemed to be withdrawn because no request for examination was validly filed |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20070807 |