JP2003508478A - Skin Balance Moisturizing Cream - Google Patents

Abstract

  (57) [Summary] The present invention relates to an oil-free skin care composition for moisturizing the skin, the composition comprising (a) a humectant comprising glycerin and propylene glycol, (b) isohexadecane, cyclomethicone, dimethicone, dimethicone. -Contains a softener including copolyol and trimethylsiloxysilicate, (c) a keratolytic agent, and (d) water. The skin care composition according to the present invention can provide effective humidification by a combination of a softening action of a softener, a moisture retaining action of a humectant, and a coating action of a lubricant. The combination of these components keeps the skin soft, smooth and soft by opposing the effects of water loss. The compositions according to the invention are non-face-forming and have a long-lasting humidifying action without the use of occlusive materials.

Description

Detailed Description of the Invention

The present invention is directed to US Provisional Patent Application No. 60/153, filed September 9, 1999.
, 005, the disclosure of which is incorporated herein by reference.

FIELD OF THE INVENTION The present invention relates to non-comedogenic skin care compositions which combine the softening action of emollients with the water retaining action of humectants and the coating action of lubricants to treat skin. Effectively moisturizes and keeps the skin soft, smooth and pliable by counteracting the effects of water loss.

BACKGROUND OF THE INVENTION It is known that skin protection and long lasting moisturizing action are best achieved with water-in-oil emulsions. See, for example, US Pat. No. 3,818,105. However, such emulsions impair aesthetic values due to a greasy after-feel when applied to the skin. On the other hand, a product based on a specific water, that is, an oil-in-water emulsion, has no oil content and is not sticky,
It does not have sufficient humidifying properties. U.S. Pat. No. 4,389,419 contains a mixture of petrolatum or mineral oil, quaternary ammonium emulsifiers, emollients of fatty alcohols and fatty esters for moisturizing and conditioning the skin. Disclosed is a water-out emulsion composition for skin care. This composition keeps the skin soft, smooth and pliable against the effects of water loss, but the presence of its petrolatum and mineral oil renders this composition difficult to emulsify and unacceptably cosmetically acceptable. ing.

The above-mentioned problems with effective skin moisturizing products are further exacerbated in the teen market, where the moisturizing modality is thought to conflict with maintaining skin free of acne and comedones. Is. Teens usually avoid such moisturizers because they perceive (in them) the skin in question to deteriorate. However, moderate hydration is required to heal and to reduce dryness, which allows the integrity of the barrier function of the skin to be maintained.

Accordingly, there remains a need for effective skin moisturizing compositions that are effective in moisturizing the skin without leaving a greasy feel to the skin and are non-comedogenic. .

Therefore, a specific composition of a softening agent, a moisturizing agent and a keratolytic agent (in the present invention) facilitates easy spreading, rapid absorption, long-term sustainability, and non-comedy forming light feeling. It was unexpectedly discovered that a water-based cream emulsion with a greasy, oil-free, non-greasy feel was obtained.

SUMMARY OF THE INVENTION Accordingly, the present invention is directed to an oil-free skin care composition for moisturizing the skin, the composition comprising: (a) a humectant comprising glycerin and propylene glycol; It contains a softening agent including hexadecane, cyclomethicone, dimethicone, dimethicone copolyol and trimethylsiloxysilicate, (c) keratolytic agent, and (d) water.

The skin care composition according to the present invention achieves an effective moisturizing action by the combination of the softening action of the softening agent, the water retaining action of the moisturizing agent and the coating action of the lubricant. The combination of these ingredients counteracts the effects of water loss, thus keeping the skin soft, smooth and supple. The composition according to the invention is non-comedogenic and has a long lasting moisturizing action without the use of occlusive materials.

DETAILED DESCRIPTION The present invention relates to a skin care composition for moisturizing the skin containing a moisturizer, emollient, keratolytic agent and water. This skin care composition according to the invention is oil-free, water-based, ie an oil-in-water emulsion. In the context of the present invention, the term "oil-free" includes petrolatum or any component with its general name including "oil" in its generic name including, for example, mineral oil and the like. Means no.

The skin care composition according to the present invention contains at least one moisturizer which actively attracts moisture when it is necessary to reduce the condition of dry skin. Retaining this increases the water content of the upper layers in the skin.
This allows the water content of the skin to be increased without a heavy, occlusive feel.

Preferably, the humectant is present in an amount of about 2% to about 10% by weight, based on the total composition. Humectants suitable for use in the present invention include glycerin, propylene glycol, and mixtures thereof. In a particularly preferred embodiment, the humectant is from about 1% to about 5% glycerin and about 1 to about 5% propylene glycol by weight of the composition, and more preferably about 1%. A mixture of 2 wt% to about 3 wt% glycerin and about 2 wt% to about 3 wt% propylene glycol.

The above skin care composition according to the present invention also contains a softening agent. The emollient useful in this skin care composition according to the present invention comprises a mixture of isohexadecane, cyclomethicone, dimethicone, dimethicone copolyol, and trimethylsiloxysilicate. These emollients act indirectly to soften the stratum corneum by slowing the loss of moisture to the environment, allowing the skin to be remoisturized from within.

The dimethicone and trimethylsiloxysilicate described above provide long-lasting lubricity with protection of the skin and a light-feeling feel, and do not interfere with dead sweating of the skin. Also, the combination of cyclomethicone and dimethicone copolyol is commonly used in the preparation of water-in-cyclomethicone emulsions. In the skin care compositions according to the invention, these cyclomethicone and dimethicone copolyols are used as a supply system for the softeners. Since it is a water-based emulsion, that is, an oil-in-water emulsion, when it is applied to the skin, its volatile components evaporate, giving a cooling effect to the skin and producing a relatively heavy feeling. Leaves some more effective skin conditioning agents on the skin.

In addition to providing softness, the dimethicone copolyols described above are silicone glycol copolymers that provide softness and humectant benefits. Examples of commercially available dimethicone copolyols useful in the present invention sold by Dow Corning Corporation are DC 190, DC 193, DC Q2-5220, DC2501.
Wax, DC 2-5324 fluid and DC 3225C (this latter material is sold as a mixture with cyclomethicone). In addition, cetyl dimethicone copolyol is commercially available as a mixture with polyglyceryl-4 isostearate (and) hexyl laurate, and the trade name is ABIL.RTM.WE-09 (Go
(available from ldschmidt)).

Trimethylsiloxysilicate is a polymeric material according to the general chemical formula [(CH ₂ ) ₃ SiO _1/2 ] _x [SiO ₂ ] _y , where x is an integer from about 1 to about 500,
y is an integer of about 1 to about 500. A preferred commercially available trimethylsiloxysilicate is sold by Dow Corning as a mixture with dimethicone as DC 593.

Suitable dimethicones useful as emollients in the skin care compositions of the present invention are commercially available from Dow Corning as the Dow Corning 200 series. further,
Particularly preferred dimethicones for use in the skin care compositions of the present invention are
Available from Dow Corning as DC 200/350 cst.

In a preferred embodiment, the skin care composition according to the invention described above contains from about 3% to about 15% by weight of emollient. A particularly preferred composition is from about 1.0% to about 4.0% isohexadecane by weight, from about 1.0% to about 5.0% DC 3225C by weight, based on the total weight of the composition. 0.5% by weight to about 3.0
% DC 593 and about 0.5% to about 3.0% DC 200/350 cst.

The keratolytic agents useful in the skin care compositions according to the present invention should be effective in preventing acne and comedones. Suitable keratolytic agents include alpha hydroxy acids and beta hydroxy acids. Further, the most preferred keratolytic agent is salicylic acid. Preferably, the keratolytic agent is from about 0.25% to about 2.0%, more preferably from about 0.5% to about 2.0% by weight of the present invention, based on the total composition. Is present in a skin care composition according to

Preferably, the skin care composition according to the invention contains a stabilizing effective amount of an emulsifier. Preferably the emulsifier is about 1. based on the composition as a whole.
0% to about 10.0% by weight, more preferably about 3.0% to about 6.0%.
Present in% by weight. Any emulsifier compatible with each component of the above composition can be used. However, it has been found that when stearic acid is the primary emulsifier, this emulsifier also acts to provide the skin feel of the product. In addition, when used as a mixed emulsifier, cetyl alcohol and stearyl alcohol also provide lubricity to the skin. Therefore, in a preferred embodiment, the emulsifier used in the skin care composition of the invention described above is
From about 0.5% to about 3.0%, more preferably from about 1% to about 2% by weight of each mixture of stearic acid, cetyl alcohol and stearyl alcohol, based on the total composition. is there.

The above emulsions can be further stabilized by the addition of small amounts of thickeners. This thickener is about 0.01% by weight, based on the weight of the coating composition above.
To about 10% by weight. Further, about 0.01% to about 5% by weight
Is preferred, with a range of about 0.03% to about 1.0% by weight being particularly preferred. The thickener is a homopolymer or copolymer of olefinically unsaturated carboxylic acid or anhydride monomers containing at least one activated carbon-carbon olefin double bond and at least one carboxyl group. , Or a non-bonding thickener or stabilizer such as an alkali-soluble acrylic emulsion. Alternatively, a hydrophobically-modified alkali-soluble acrylic emulsion or a hydrophobically-modified nonionic polyol polymer, that is, a hydrophobically-modified urethane polymer, or a combination thereof such as a combination thereof such as a combination thereof is used. Sticking agents or stabilizers can also be used. The above copolymers are preferably copolymers of polycarboxylic acid monomers and hydrophobic monomers. Furthermore, the preferred carboxylic acid is acrylic acid. Preferably, the above homopolymers and copolymers are crosslinked.

Homopolymers of polyacrylic acid are described, for example, in US Pat. No. 2,798,053, the disclosure of which is incorporated herein by reference. Examples of useful homopolymers include Carbopol® TM934, 940, 941, Ultrez 10, ETD 2050 and 974P polymers, which are available from the BF Goodrich Company. The above polymers are homopolymers of unsaturated and polymerizable carboxylic acid monomers such as acrylic acid, methacrylic acid, maleic acid, itaconic acid and maleic anhydride.

Hydrophobically modified polyacrylic acid polymers are described, for example, in US Pat. No. 5,349.
, 030, the disclosure of which is incorporated herein by reference.
These polymers consist of relatively large hydrophilic moieties with water affinity (polyacrylic acid moieties) and relatively small hydrophobic moieties with oil affinity (long carbon chain acrylates). Part that can be derived from). Typical acrylic esters of higher alcohols are decyl acrylate, lauryl acrylate,
These are stearyl acrylate, behenyl acrylate and melysyl acrylate, and their corresponding methacrylic acid esters. It is understood that it is understood that more than one carboxylic acid monomer and more than one acrylate or vinyl ester or ether or styrenic compound can be used in the above monomer charge. The above polymer can be dispersed in water and neutralized with a basic substance to increase the viscosity of the aqueous composition to form a gel or to emulsify or suspend the substance to be supplied. A useful polymer is Ca
rbopol® TM 1342 and 1382 and Pemulen® TM TR-1, TR-
Sold as 2, 1621 and 1622, all of which are available from BF Goodrich. A particularly preferred material is Pemulen TR-1 (CTFA name: acrylate / 10-30.alkyl acrylate crosspolymer).

Neutralizing agents suitable for use in neutralizing acidic groups containing a hydrophilic gelling agent according to the present invention include sodium hydroxide, potassium hydroxide, ammonium hydroxide,
Includes monoethanolamine, diethanolamine and triethanolamine.

Preferably, the skin care composition according to the present invention provides a suitable environment for the efficacy of the keratolytic agent to provide skin moisture when the pH value is in the range of 4.5 to 6.5. It has a constant pH value to maintain balance. Preferably, the pH value of this composition is in the range of 5.5 to 6.5.

Generally, the moisture content of the skin care composition according to the present invention is in the range of about 75% to about 85% by weight, preferably about 75% to about 80% by weight water. Such a relatively high water content gives the cream a lightweight feel and makes it easier to dispense. Such compositions are preferably from about 75,000 cps to about 300,000.
Formulated to have a product viscosity of 0 cps.

The skin care compositions according to the invention described above may contain additional ingredients commonly found in skin care compositions such as preservatives, antioxidants, perfumes, chelating agents and the like. However, these components must be physically and chemically compatible with each of the other components in the composition. Examples of preservatives that are suitable for use in skin care compositions of the present invention comprises an alkyl-paraben and phenoxyethanol C ₁ -C _4. Generally, this preservative is present in an amount in the range of about 0.5% to about 2.0% by weight, preferably about 1.0% to about 1.5% by weight, based on the total composition. is doing. In a preferred embodiment, the preservative is about 0.2% to about 0.5% by weight methylparaben, about 0.2% to about 5.%.
A mixture of 0% by weight propylparaben and about 0.05% to about 0.10% butylparaben. A particularly preferred commercially available preservative that can be used in the skin care compositions according to the present invention is PHENONIP ™, which is a phenoxyethanol, methylparaben, ethylparaben, propylparaben, available from Nipa Laboratories, Wilmington, Del. And a substantially colorless viscous liquid mixture of butylparaben.

Preferably, an oil soluble antioxidant is present in the skin care composition according to the invention. Suitable antioxidants are butylated hydroxytoluene (BHT), ascorbyl palmitate, butylated hydroanisole (BHA), phenyl-α-naphthylamine, hydroquinone, propyl gallate, nordihydroguaiac fatty acid,
And mixtures thereof. Preferably, the antioxidant is BHT,
About 0.02% to about 0.05%, most preferably about 0.02% to about 0.10% by weight is present in the composition.

Fragrances suitable for use in the skin care compositions according to the invention are well known in the art. Particularly preferred materials are those capable of providing fruity (fruit-scented) and / or floral (flower-scented) aromas, such as Mod Twist commercially available from Haarmann & Reimer.

In a particular embodiment of the present invention the above composition contains a chelating agent.
A chelating agent useful in the compositions of the present invention is ethylenediaminetetraacetic acid (EDT
A) and its derivatives and salts, dihydroxyethyl glycine, citric acid, tartaric acid, and mixtures thereof. The chelating agent should be used in a stabilizing effective amount, which amount is from about 0.01% to about 2%, preferably from about 0.05% to about 1%, by weight of the total composition. Can be within the range of. Most preferably, the chelating agent is EDTA.

Still other ingredients are sunscreens, antioxidants, and ascorbic acid, vitamin B, biotin, pantothenic acid, vitamin D, vitamin E and vitamin C.
And vitamins, and substances such as sodium bisulfite that help protect the skin from aging. It also contains other oligosaccharides, such as yeast extract, ginkgo biloba, bisabolol, panthenol, alpha-hydroxy acid and melibiose, which reduce irritation, reduce oxidation, cure and retinoid metabolism. And the prevention of elastase production, etc., helps prevent skin aging.

In order to make the product non-comedogenic, it is necessary to select ingredients that have a low comedogenic ability.

The skin care composition according to the present invention effectively moisturizes by the combination of the softening action of the softening agent, the water retaining action of the moisturizing agent and the coating action of the lubricant to prevent the action of water loss. By countering, the skin can be kept soft, smooth and pliable. The composition according to the invention has a long lasting moisturizing action without the use of occlusive materials.

The compositions of the present invention can be made by well known mixing or blending processes. It is preferred that each phase of the emulsion be made separately and that each component be contained in a suitable phase, but that the retinoid compound be omitted initially. The emulsion is then formed by adding the oily phase to the aqueous phase, usually with stirring, and it is necessary to cool the emulsion as the retinoid compound is added. The following is an example of a preferred method for making a skin care composition according to the present invention.

Salicylic Acid (Premix 1): In a separate container, salicylic acid is added to propylene glycol and mixed until clear.

Phase A (Main Batch) 1. Add purified water to the mixing vessel. 2. Start the side sweep scraper and stirrer. 3. Add EDTA and mix until dispersed. 4. Sprinkle Pemulen TR-1 into the container and mix well until dispersed. 5. Heat to 70 ° C to 75 ° C while mixing the above composition. After that, 70 ℃
At ~ 75 ° C, sprinkle Carbopol ultrez 10 into the container and mix until dispersed. 6. Further, at 70 ° C. to 75 ° C., methylparaben is added and mixing is continued. 7. Glycerin is added and mixing is continued. 8. The above composition is maintained at 70 ° C to 75 ° C and used for phase separation.

Phase B (oil phase) 9. After adding isohexadecane to another container, add cetyl alcohol,
Heat to 75-80 ° C to allow all ingredients to melt spontaneously. 10. At about 55 ° C to 65 ° C, propylparaben is added followed by butylparaben and mixed after each addition until well dispersed. 11. Add butylated hydroxytoluene and mix. Continue heating to 12.75 ° C to 80 ° C and add stearic acid. The composition spontaneously melts and disperses. In addition, stearyl alcohol is added, followed by DC 3225C, followed by DC 593 and mixed until uniform. 13. Add dimethicone to disperse all ingredients well. 14. The above composition is maintained at 75-80 ° C and used for phase separation.

Phase separation 15. When the oily phase is 75 ° C. to 80 ° C. and the aqueous phase is 70 ° C. to 75 ° C., the oily phase (Phase B) is gradually added to the aqueous phase (Phase A), and the time is 5 minutes to 10 minutes. Homogenize for minutes to ensure a homogeneous batch. 16. Add triethanolamine slowly and mix for 10 minutes or until a homogeneous batch is obtained. 17. Stop the homogenizer, mix the composition and cool to 40-45 ° C. 18. Salicylic acid is added to the above premix. 19. Add fragrance and mix for 20-25 minutes or until uniform. Viscosity and pH values are measured at 20.25 ° C.

The following examples are intended to illustrate the invention without limiting it essentially.

[0038] Example

[Table 1]

─────────────────────────────────────────────────── ─── Continued front page    (81) Designated countries EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, I T, LU, MC, NL, PT, SE), OA (BF, BJ , CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, K E, LS, MW, MZ, SD, SL, SZ, TZ, UG , ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, C A, CH, CN, CR, CU, CZ, DE, DK, DM , DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, K E, KG, KP, KR, KZ, LC, LK, LR, LS , LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, R U, SD, SE, SG, SI, SK, SL, TJ, TM , TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW (72) Inventor Gomez Anna Louisa             2203 New Sau, Australia             Dulwich Hill, Swales,             Marker Surr Parade 15 F-term (reference) 4C083 AB051 AC011 AC012 AC072                       AC121 AC122 AC172 AC242                       AC471 AC472 AC482 AC531                       AC532 AC542 AC551 AC911                       AC912 AD092 AD151 AD161                       AD162 AD171 AD172 AD642                       BB01 BB45 BB47 CC02 CC05                       DD05 DD31 EE05 EE10 EE12                       FF05

Claims (10)

[Claims] 1. An oil-free skin care composition for moisturizing skin, comprising: (e) a moisturizer containing glycerin and propylene glycol; (f) isohexadecane, cyclomethicone, dimethicone, dimethicone co. A composition comprising a softening agent containing a polyol and trimethylsiloxysilicate, (g) a keratolytic agent, and (h) water. 2. The method of claim 1, further comprising a stabilizing effective amount of an emulsifier.
The composition according to. 3. A composition according to claim 2, wherein the emulsifier is selected from stearic acid, cetyl alcohol and stearyl alcohol. 4. The method of claim 1, further comprising a stabilizing effective amount of a thickener.
The composition according to. 5. The composition of claim 1, wherein the keratolytic agent is selected from salicylic acid. 6. The composition of claim 1, further comprising an effective amount of preservative. 7. The composition of claim 1, further comprising an effective amount of chelating agent. 8. The composition according to claim 7, wherein the chelating agent is selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof. 9. The composition according to claim 1, which further contains an antioxidant. 10. The antioxidant is butylated hydroxytoluene (BHT).
10. The composition according to claim 9, selected from: ascorbyl palmitate, butylated hydroanisole (BHA), phenyl-α-naphthylamine, hydroquinone, propyl gallate, nordihydroguaiac fatty acid, and mixtures thereof.