CN1373654A - Skin-balance moisturizing cream - Google Patents

Skin-balance moisturizing cream Download PDF

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Publication number
CN1373654A
CN1373654A CN00812592A CN00812592A CN1373654A CN 1373654 A CN1373654 A CN 1373654A CN 00812592 A CN00812592 A CN 00812592A CN 00812592 A CN00812592 A CN 00812592A CN 1373654 A CN1373654 A CN 1373654A
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Prior art keywords
compositions
skin
acid
agent
skin care
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CN00812592A
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Chinese (zh)
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A·L·戈麦斯
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Johnson and Johnson Research Pty Ltd
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Johnson and Johnson Research Pty Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51—Chelating agents

Abstract

The invention relates to an oil-free skin care composition for moisturizing the skin comprising (a) a humectant comprising glycerin and propylene glycol; (b) an emollient comprising isohexadecane, cyclomethicone, dimethicone, dimethiconecopolyol and trimethyl siloxysilicate; (c) a keratolytic agent; and (d) water. The skin care compositions according to the invention accomplish effective moisturization through a combination of the softening effects of emollients with the moisture retaining action of humectants and coating activities of lubricants. The combination of ingredients counteract the effect of moisture loss, thereby keeping skin soft, smooth and supple. The compositions according to the invention are non-comedogenic and have long lasting moisturizing effects without the use of occlusive materials.

Description

Skin-balance moisturizing cream
The application requires in the priority of the U.S. Patent application 60/153,005 of JIUYUE in 1999 proposition on the 9th, and document content is incorporated by reference in this text to be examined.
Invention field
The present invention relates to a kind of skin care compositions and methods that does not cause acne (non-comedogenic), this compositions is by soft effect and the humidification of humidizer and the coating activity of lubricant in conjunction with emollient, can effectively increase moisture of skin, stop moisture loss, thereby keep skin softness, smooth and submissive.
Background of invention
Known, can the most effectively reach skin care and maximum extension moisture-keeping function by water in oil emulsion.For example can consult United States Patent (USP) 3,818,105.Yet such Emulsion is because its oiliness and oils and fats have influence on the sensation when being applied in skin, and some water based product are that oil in water emulsion is non-oiliness, do not have greasy, but lack enough moisturizations.United States Patent (USP) 4,389,419 disclose a kind of water (water-out) emulsion composition that comprises the skin nursing of vaseline or mineral oil, quaternary ammonium emulsifying agent, aliphatic alcohol and aliphatic ester emollient, and this compositions can increase moisture of skin and regulate skin.This compositions can stop the moisture loss effect, thereby keeps skin softness, smooth and submissive, and the existence of vaseline and mineral oil makes it be difficult to emulsifying, and it is underproof to be cosmetic.
The problem relevant with effective skin moisture-keeping product be in teenager market even more outstanding, and they think that the mode of preserving moisture does not have pimple and acne conflicting with keeping skin.Teenager is avoided wetting agent usually, thinks that humidizer can make problematic skin variation.Yet, need enough hydrations to cure or alleviate dry symptom, thereby keep the integrity of skin barrier function.
Therefore, still need a kind of effectively humidification skin can on skin, not stay the compositions of effective humidification skin of oiliness or greasy sensation again, and this compositions is can not produce acne.
Find a kind of gently, do not have the non-greasy water base facial cream Emulsion of oil, this Emulsion is easy to sprawl, fast Absorption, and long term maintenance, and the particular combinations by emollient, wetting agent and keratolytic reaches and does not cause acne.
Summary of the invention
Therefore, the present invention relates to a kind of no oily skin care composition that is used for humidification skin, said composition comprises:
(a) wetting agent comprises glycerol and propylene glycol;
(b) emollient comprises 2-Methylpentadecane, ring (two) methyl silicone, dimethyl silscone, dimethicone copolyol and trimethylsiloxy esters of silicon acis;
(c) keratolytic;
(d) water.
Skin care compositions and methods of the present invention reaches effective humidification by soft effect and the humidification of humidizer and the coating activity of lubricant in conjunction with emollient.These components combinations can stop the moisture loss effect, thereby keep skin softness, smooth and submissive.Compositions of the present invention is not cause acne, and has the humidification that does not use prolongation under the plugging material (occlusive material).
Detailed description of the Invention
The present invention relates to a kind of skin care compositions and methods that is used for humidification skin, said composition comprises wetting agent, emollient, keratolytic and water.Skin care compositions and methods of the present invention is the water-based emulsions of not having oil, i.e. oil in water emulsion.In the text of the present invention, term " does not have oil " and refer to not have vaseline or any component that " oil " word is arranged in its name, comprises for example mineral oil.
Skin care compositions and methods of the present invention comprises at least a wetting agent that attracts and increase at relatively dry skin place maintenance moisture the upper layers of skin water yield by activity.Thereby increase the moisture of skin amount, and can not feel heavy (heavy) and stop up.
With the total composition is benchmark, and the dosage of preserving moisture should be about 2-10% (weight).Be used for suitable wetting agent of the present invention and comprise glycerol, propylene glycol and their mixture.In the specific embodiments, be benchmark with the total composition, wetting agent is the mixture of about 1-5% (weight) glycerol and about 1-5% (weight) propylene glycol, is more preferably the mixture of about 2-3% (weight) glycerol and about 2-3% (weight) propylene glycol.
Skin care compositions and methods of the present invention also comprises emollient.The mixture that the useful emollient of skin care compositions and methods of the present invention is contained 2-Methylpentadecane, ring (two) methyl silicone, dimethyl silscone, dimethicone copolyol and trimethylsiloxy esters of silicon acis.The emollient effect is to lose in environment by the moisture that slows down to come indirect soften cuticle, makes therefrom humidification again of skin itself.
Dimethyl silscone and trimethylsiloxy esters of silicon acis provide protection and to touch the lubricity that prolongation is provided gently, can not interfere the breathing of skin for skin.Ring (two) methyl silicone and dimethicone copolyol are in conjunction with the Emulsion of common useful preparation water in dimethicone copolyol.In the skin care compositions and methods of the present invention, ring (two) methyl silicone and dimethicone copolyol are as the transmission system of emollient.As water-based emulsions is oil in water emulsion, in case be applied on the skin, the volatile component evaporation provides skin refrigerant effect, stays thick more effective skin conditioning agent on skin.
Dimethicone copolyol is a kind of organosilicon diol copolymer, except that skin moistening is provided, also provides moisture-keeping function.What Dow Corning Corporation sold has DC 190, DC 193, DC Q2-5220, DC 2501 Wax, DC 2-5324 fluid and DC 3225C (be with and ring (two) methyl silicone mixture sell) to the useful dimethicone copolyol example of the present invention.Poly-cetyl dimethicone copolyol with and polyethylene glycol isostearate (with) mixture of lauric acid hexyl ester buys and sells (can obtain from Goldschmidt) with the ABIL.RTM.WE-09 trade name.
The trimethylsiloxy esters of silicon acis is a kind of corresponding chemical general formula [(CH that has 2) 3SiO 1/2] * [SiO 2] yPolymeric material, wherein, x is about the integer of 1-500, y is about the integer of 1-500.Trimethylsiloxy esters of silicon acis commodity are DC 593 that Dow Corning Corporation sells preferably, are the mixture with dimethyl silscone.
The suitable dimethyl silscone that is used as the emollient of skin care compositions and methods of the present invention can be buied with Dow Corning 200 series from Dow CorningCorporation sale.The best dimethyl silscone that is used for skin care compositions and methods of the present invention that can obtain from Dow Corning is DC200/350cst.
In the embodiment, skin care compositions and methods of the present invention comprises about 3-15% (weight) emollient preferably.With the composition total weight is benchmark, the combination of preferably about 1.0-4.0% (weight) 2-Methylpentadecane, about 1.0-5.0% (weight) DC3225C, about 0.5-3.0% (weight) DC 593 and about 0.5-3.0% (weight) DC 200/350cst.
The keratolytic useful to skin care compositions and methods of the present invention should be able to effectively prevent pimple and acne.Suitable keratolytic comprises alpha-hydroxy acid and beta hydroxy acid.Best keratolytic is a salicylic acid.With the total composition is benchmark, and keratin-dissolving dosage is about 0.25-2.0% (weight) in the skin care compositions and methods of the present invention, better is about 0.5-2.0% (weight).
Skin care compositions and methods of the present invention should comprise the emulsifying agent of effective stable quantity.With the total composition is benchmark, and emulsifying dosage is about 1.0-10.0% (weight), better is about 3.0-6.0% (weight).Can use any emulsifying agent that can be compatible with the present composition.Yet, find that stearic acid is main emulsifying agent, it also helps to provide product this dermal sensation.In addition, when as co-emulsifier, spermol and octadecanol also provide the skin lubrication performance.Therefore, in embodiment preferably, the emulsifying agent that is used for skin care compositions and methods of the present invention is to be benchmark with the total composition, and stearic acid, spermol and octadecanol amount respectively are about 0.5-3.0% (weight), better are about the mixture of 1-2% (weight).
By comprising further stable emulsion of a small amount of thickening agent.The thickening agent consumption is the 0.01-10% (weight) of coating composition weight.Better be about 0.01-5% (weight), be preferably in 0.03-1.0% (weight) scope.Thickening agent can be non-associated thickening agent or stabilizing agent, as contains the alkene unsaturated carboxylic acid of at least one carbon-to-carbon olefinic double bonds and at least one carboxyl or the homopolymer or the copolymer of anhydride monomer, or the molten acrylic acid Emulsion of alkali.Perhaps, use associative thickener or stabilizing agent, as molten acrylic acid Emulsion of hydrophobic modified alkali or hydrophobic modified nonionic polymer polyol, promptly hydrophobic modified urethane polymer, or their combination.Copolymer is preferably the copolymer of polybasic carboxylic acid monomer and hydrophobic monomer.Carboxylic acid is an acrylic acid preferably.Be cross-linked homopolymer and copolymer preferably.
For example, at United States Patent (USP) 2,798, described the polyacrylic acid homopolymer in 053, the content that this patent discloses is incorporated herein by reference.Useful homopolymer example comprises the TM 934,940,941 with the Carbopol registration, Ultez 10, ETD 2050 and 974P polymer, and these all can be buied from B.F.Goodrich.The polymer of effect is can polymeric unsaturated carboxylic acid monomer such as the homopolymer of acrylic acid, methacrylic acid, maleic acid, itaconic acid, maleic anhydride etc.
For example, at United States Patent (USP) 5,349, described hydrophobic modified acrylic acid polymer in 030, the content that this patent discloses is incorporated herein by reference.These polymer have big hydrophilic hydrophilic parts (polyacrylic acid part) and less lipophilic hydrophobic parts (from the acrylate of long carbochain).Representational senior alkyl acrylate is decyl acrylate, lauryl acrylate, acrylic acid octadecane ester, acrylic acid docosane ester and acrylic acid melissane ester, and corresponding methacrylate.Should be understood that the carboxylic acid monomer that in raw material monomer, can use more than one and more than one acrylate or vinyl acetate or ether or styrene.Polymer can be scattered in the water and with the alkali neutralization, with thickened aqueous compositions, form gel, but or emulsifying or suspension releaser (deliverable).Useful polymer be BF Goodrich sell with the TM 1342 of Carbopol registration and 1382 and with TM TR-1, the TR-2,1621 and 1622 of Pemulen registration.PemulenTR-1 (CTFA trade mark: acrylate/10-30 alkyl acrylate crosspolymer) preferably.
The suitable nertralizer of the hydrophilic gelling agent that contains acid groups of being used to neutralize comprises sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine and triethanolamine.
Be proper environment and maintenance skin-balance that the emollient effect is provided, the pH of skin care compositions and methods of the present invention should be in the 4.5-6.5 scope.The pH of compositions is preferably in the 5.5-6.5 scope.
The water content of skin care compositions and methods of the present invention generally is about 75-85% (weight), better is about 75-80% (weight).High relatively water content makes cream lighter, is easy to apply.Compositions should be mixed with viscosity and be about 75,000-300, the product of 000cps.
Skin care compositions and methods of the present invention comprises normally used interpolation component in the skin care compositions and methods, for example, antiseptic, antioxidant, spice, intercalating agent etc., compatible as long as these components and other component are physics with chemistry.The example that is used for the suitable preservatives of skin care compositions and methods of the present invention comprises C 1-C 4Alkyl P-hydroxybenzoic acid and phenyl phenol.Anticorrosion dosage is generally the 0.5-2.0% (weight) of total composition, better is about 1.0-1.5% (weight).In the embodiment, antiseptic is the mixture of about 0.2-0.5% (weight) methyl parahydroxybenzoate, 0.2-5.0% (weight) methyl parahydroxybenzoate and 0.05-0.10% (weight) butyl p-hydroxybenzoate preferably.The best commercially available antiseptic that can be used for skin care compositions and methods of the present invention is PHENONIP TM, actual is the colorless viscous liquid mixture of phenyl phenol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate, can be from Nipa Laboratories, Inc., Wilmington, Del buys.
Preferably, in skin care compositions and methods of the present invention, there is the molten antioxidant of oil.Suitable antioxidant comprises butylated hydroxy-methylbenzene (BHT), ascorbic palmitate, butylatedhydroxyanisole (BHA), phenyl-á-naphthylamines, hydroquinone, propyl gallate, nordihydroguaiaretic acid and their mixture.Antioxidant is BHT preferably, and it is measured in compositions and is about 0.02-0.5% (weight), better is about 0.02-0.10% (weight).
The spice that is applicable to skin care compositions and methods of the present invention is known in the art.Preferably can provide the fruit perfume (or spice) and/or the fragrance of a flower, for example, Mod Twist can be from Haarmann﹠amp; Reimer Corp. buys.
Some aspects of the present invention, compositions should comprise intercalating agent.The useful intercalating agent of skin care compositions and methods of the present invention is comprised ethylenediaminetetraacetic acid (EDTA) and its derivant and salt, dihydroxyethylglycin, citric acid, tartaric acid and their mixture.Should use the intercalating agent of effective stable quantity, be benchmark with the composition total weight, and its consumption is about 0.01-2% (weight), better is about 0.05-1% (weight).Best chelating agen should be EDTA.
Other component includes the reagent that helps prevent skin aging, as sunscreen, antioxidative vitamin such as ascorbic acid, vitamin B, biotin, pantothenic acid, vitamin D, vitamin E and vitamin C and sodium bisulfate.By alleviating irradiation, alleviating oxidation and help to prevent skin aging, treatment, influence the biostearin metabolism and suppress to produce in other component of elastoser yeast extract, Semen Ginkgo, bisabolol (bisaboloe), pantothenylol, alpha-hydroxy acid and oligosaccharidase such as 6-(.alpha.-D-galactosido)-D-glucose. are arranged.
For making product not cause acne, should select low acne to produce the component of ability.
Skin care compositions and methods of the present invention reaches effective humidification by soft effect and the humidification of humidizer and the coating activity of lubricant in conjunction with emollient.These components combinations can stop the moisture loss effect, thereby keep skin softness, smooth and submissive.Compositions of the present invention has does not use the humidification that prolongs under the plugging material.
Can adopt known mixing or mixing method to prepare compositions of the present invention.Preferably, separately prepare each phase of Emulsion with the suitable all components that comprises mutually, except common selection begins to omit retinoids.Then, generally stir formation Emulsion simultaneously by oil phase being added water, this Emulsion should cool off when adding retinoids.List the example of the better method of preparation skin care compositions and methods of the present invention below.
Salicylic acid (premixing 1):
In another container, in propylene glycol, add salicylic acid, stir up to transparent
Phase A (in batches main)
1. In 0 mixer, add pure water.
2. Start the side and strike off scraper and agitator.
3. Add EDTA and mixing up to dispersion.
4. Spray Pemulen TR-1, mix up to dispersion.
5. Compositions is heated to 70-75 ℃, stirs simultaneously.At 70-75 ℃, spray Carbopol ultrez10, mix up to dispersion.
6. At 70-75 ℃, add methyl parahydroxybenzoate, continue to mix.
7. Add glycerol and continue and mix.
8. Compositions remains on 70-75 ℃, becomes phase.
Phase B (oil phase)
9. In another container, add 2-Methylpentadecane, add spermol subsequently, be heated to 75-80 ℃, make all components fusion.
10. At about 55-65 ℃, add propyl p-hydroxybenzoate, add butyl p-hydroxybenzoate subsequently, mix up to fine dispersion each back that adds.
11. Add Yoshinox BHT and mixing.
12. Continue to be heated to 75-80 ℃, add stearic acid.Said composition is melted and dispersion.Add octadecanol, add DC 3225C then, and DC 593, mix up to evenly.
13. Add dimethyl silscone, the fine dispersion of all components.
14. Compositions remains on 75-80 ℃, becomes phase.
Become phase
15. When oil phase is in 75-80 ℃, when water is in 70-75 ℃, oil phase (phase B) slowly is added in the water (phase A), homogenize 5-10 minute, guarantee that homogeneous phase is in batches.
16. Slowly add triethanolamine and mixed 10 minutes or up to obtaining homogeneous phase in batches.
17. Close homogenizer, compositions is mixed and is cooled to 40-45 ℃.
18. In this pre-composition, add salicylic acid.
19. Add spice and mixed 20-25 minute or mixed up to evenly.
20. At 25 ℃, measure viscosity and pH.
The following examples are used to illustrate the present invention, but are not construed as limiting the invention.
Embodiment
Component CTFA name water The component trade name ??％(W/W) ????q.s.
????Carbomer Carbopol Ultrez 10 polymer ????0.30
Acrylate/acrylic acid alkyl (C 10-30) the ester cross-linked copolymer ????Pemulen?TR-1 ????0.20
The EDTA disodium ????Trilon?BD ????0.05
Glycerol ????Pricerine?9073 ????3.0
Ring (two) methyl silicone (with) dimethicone copolyol ????DC?3225C ????2.0
2-Methylpentadecane 2-Methylpentadecane ????2.0
Dimethyl silscone (with) the trimethylsiloxy esters of silicon acis ????DC?593 ????2.0
Dimethyl silscone ????DC?200/350cst ????2.0
Octadecanol ????Lanette?18 ????1.0
Stearic acid ????Prisetrine?4900 ????1.0
Spermol ????Lanette?16 ????2.0
Phenyl phenol ﹠ P-hydroxybenzoic acid ????Phenonip ????1.0
Propylene glycol Propylene glycol USP ????3.0
Salicylic acid Salicylic acid ????0.50
Yoshinox BHT ????BHT ????0.02
Triethanolamine ????Trolamine ????1.38
Spice ????ModTwist ????0.5

Claims (10)

1. no oily skin care composition that is used for humidification skin, said composition comprises:
(a) wetting agent comprises glycerol and propylene glycol;
(b) emollient comprises 2-Methylpentadecane, ring (two) methyl silicone, dimethyl silscone, dimethicone copolyol and trimethylsiloxy esters of silicon acis;
(c) keratolytic;
(d) water.
2. compositions as claimed in claim 1 is characterized in that described compositions comprises the emulsifying agent of stabilizing effective amount.
3. compositions as claimed in claim 2 is characterized in that described emulsifying agent is selected from stearic acid, spermol and octadecanol.
4. compositions as claimed in claim 1 is characterized in that described compositions comprises the thickening agent of stabilizing effective amount.
5. compositions as claimed in claim 1 is characterized in that described keratolytic is selected from salicylic acid.
6. compositions as claimed in claim 1 is characterized in that described compositions also comprises the antiseptic of effective dose.
7. compositions as claimed in claim 1 is characterized in that described compositions also comprises the intercalating agent of effective dose.
8. compositions as claimed in claim 7 is characterized in that described intercalating agent is selected from ethylenediaminetetraacetic acid (EDTA) and salt thereof.
9. compositions as claimed in claim 1 is characterized in that described compositions also comprises antioxidant.
10. compositions as claimed in claim 9 is characterized in that described antioxidant is selected from butylated hydroxy-methylbenzene (BHT), ascorbic palmitate, butylatedhydroxyanisole (BHA), phenyl-á-naphthylamines, hydroquinone, propyl gallate, nordihydroguaiaretic acid and their mixture.
CN00812592A 1999-09-09 2000-09-08 Skin-balance moisturizing cream Pending CN1373654A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15300599P 1999-09-09 1999-09-09
US60/153,005 1999-09-09

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CN1373654A true CN1373654A (en) 2002-10-09

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EP (1) EP1214050A1 (en)
JP (1) JP2003508478A (en)
KR (1) KR20020047153A (en)
CN (1) CN1373654A (en)
AU (1) AU7392900A (en)
BR (1) BR0013874A (en)
CA (1) CA2381560A1 (en)
MX (1) MXPA02002608A (en)
WO (1) WO2001017496A1 (en)

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CN102648892A (en) * 2012-05-02 2012-08-29 广州雅纯化妆品制造有限公司 Moisturizing cream
CN104853717A (en) * 2012-12-24 2015-08-19 荷兰联合利华有限公司 Cosmetic composition

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JP4616815B2 (en) * 2006-10-16 2011-01-19 ポーラ化成工業株式会社 A topical skin preparation that gives skin smoothness
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