JP2003508022A - Il−1炎症性ハプロタイプと関連する病気の診断および治療方法 - Google Patents

Il−1炎症性ハプロタイプと関連する病気の診断および治療方法

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Publication number
JP2003508022A
JP2003508022A JP2001506870A JP2001506870A JP2003508022A JP 2003508022 A JP2003508022 A JP 2003508022A JP 2001506870 A JP2001506870 A JP 2001506870A JP 2001506870 A JP2001506870 A JP 2001506870A JP 2003508022 A JP2003508022 A JP 2003508022A
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disease
allele
methods
polymorphic
inflammatory
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JP2003508022A5 (https=
Inventor
ダブリュ ダフ,ゴードン
コックス,アンジェラ
ジェーン キャンプ,ニコラ
ジオヴィネ,フランチェスコ サヴェリオ ディ
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インターリューキン ジェネティックス インコーポレイテッド
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Priority claimed from US09/345,217 external-priority patent/US6268142B1/en
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Publication of JP2003508022A publication Critical patent/JP2003508022A/ja
Publication of JP2003508022A5 publication Critical patent/JP2003508022A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

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  • Pain & Pain Management (AREA)
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JP2001506870A 1999-06-30 2000-06-30 Il−1炎症性ハプロタイプと関連する病気の診断および治療方法 Pending JP2003508022A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/345,217 US6268142B1 (en) 1997-05-29 1999-06-30 Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype
US09/345,217 1999-06-30
PCT/US2000/018318 WO2001000880A2 (en) 1999-06-30 2000-06-30 Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplotype

Publications (2)

Publication Number Publication Date
JP2003508022A true JP2003508022A (ja) 2003-03-04
JP2003508022A5 JP2003508022A5 (https=) 2007-09-13

Family

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JP2001506870A Pending JP2003508022A (ja) 1999-06-30 2000-06-30 Il−1炎症性ハプロタイプと関連する病気の診断および治療方法

Country Status (7)

Country Link
US (3) US6730476B1 (https=)
EP (1) EP1194590A2 (https=)
JP (1) JP2003508022A (https=)
AU (1) AU784224B2 (https=)
CA (1) CA2378221A1 (https=)
IL (1) IL147182A0 (https=)
WO (1) WO2001000880A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis
IL147182A0 (en) * 1999-06-30 2002-08-14 Interleukin Genetics Inc Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplorype
WO2002000933A2 (en) * 2000-06-23 2002-01-03 Interleukin Genetics, Inc. Screening assays for identifying modulators of the inflammatory or immune responses
AU2002320100A1 (en) * 2001-06-15 2003-01-02 Interleukin Genetics, Inc. Methods for detecting and treating the early onset of aging-related conditions
CN1753903B (zh) 2001-11-19 2010-05-12 白介素遗传公司 影响转录和对炎性和传染性疾病的敏感性的白细胞介素-1基因座的功能多态性
US20080311581A1 (en) * 2001-11-19 2008-12-18 David Wyllie Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases
US20070264645A1 (en) * 2002-01-25 2007-11-15 Kenneth Kornman IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US20050064462A1 (en) * 2003-06-17 2005-03-24 Bernd Stein Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms
US20060234274A1 (en) * 2005-03-29 2006-10-19 Auckland Uniservices Limited Methods of diagnosis
US8105775B2 (en) * 2005-10-25 2012-01-31 Interleukin Genetics, Inc. IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US8101360B2 (en) * 2006-11-15 2012-01-24 Interleukin Genetics, Inc. IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
WO2009027509A1 (en) 2007-08-31 2009-03-05 Vestas Wind Systems A/S Wind turbine siting and maintenance prediction
CA2723247A1 (en) * 2008-05-02 2009-11-05 Interleukin Genetics, Inc. Detecting genetic predisposition to osteoarthritis associated conditions
WO2009142474A1 (en) * 2008-05-23 2009-11-26 Erasmus University Medical Center Rotterdam Genetic markers predicting age at menopause
ITMI20091054A1 (it) * 2009-06-15 2010-12-16 Istituto Ortopedico Galeazzi S P A Metodi per lo screening di polimorfismi genetici associati alla risposta immune per la valutazione della predisposizione atletica e kit relativi
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
CA3011363A1 (en) 2016-01-12 2017-07-20 Interleukin Genetics, Inc. Methods for predicting response to treatment
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
KR102252384B1 (ko) * 2018-10-08 2021-05-14 차의과학대학교 산학협력단 조기폐경 진단을 위한 분석방법 및 키트
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
IT202000003988A1 (it) * 2020-02-26 2021-08-26 Allelica S R L Metodo per una prognosi predittiva dell’insorgenza di menopausa
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044150A1 (en) * 1997-03-27 1998-10-08 Gemini Research Ltd. Polymorphisms of an il-1 receptor antagonist gene
WO1998054359A1 (en) * 1997-05-29 1998-12-03 Gordon Duff Prediction of inflammatory disease associated with il-1 geneloci polymorphisms

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
US5593826A (en) 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
US6210877B1 (en) * 1997-03-10 2001-04-03 Interleukin Genetics, Inc. Prediction of coronary artery disease
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis
US6746839B1 (en) * 1998-01-12 2004-06-08 Interleukin Genetics, Inc. Diagnostics and therapeutics for an obstructive airway disease
US6635418B2 (en) * 1998-02-13 2003-10-21 Igen International, Inc. Assay methods for nucleic acid in a sample
IL147182A0 (en) * 1999-06-30 2002-08-14 Interleukin Genetics Inc Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplorype
EP1212464B1 (en) * 1999-08-30 2006-02-22 Interleukin Genetics, Inc. Diagnostics and therapeutics for osteoporosis
AU2002320100A1 (en) * 2001-06-15 2003-01-02 Interleukin Genetics, Inc. Methods for detecting and treating the early onset of aging-related conditions
CN1753903B (zh) * 2001-11-19 2010-05-12 白介素遗传公司 影响转录和对炎性和传染性疾病的敏感性的白细胞介素-1基因座的功能多态性

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044150A1 (en) * 1997-03-27 1998-10-08 Gemini Research Ltd. Polymorphisms of an il-1 receptor antagonist gene
WO1998054359A1 (en) * 1997-05-29 1998-12-03 Gordon Duff Prediction of inflammatory disease associated with il-1 geneloci polymorphisms

Also Published As

Publication number Publication date
CA2378221A1 (en) 2001-01-04
AU784224B2 (en) 2006-02-23
AU6067900A (en) 2001-01-31
US20050064453A1 (en) 2005-03-24
WO2001000880A2 (en) 2001-01-04
WO2001000880A3 (en) 2001-11-15
US6730476B1 (en) 2004-05-04
EP1194590A2 (en) 2002-04-10
US20090163460A1 (en) 2009-06-25
IL147182A0 (en) 2002-08-14

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