JP2003502276A - Skin lightening composition containing ascorbic acid compound - Google Patents

Abstract

  (57) [Summary] Disclosed are compositions comprising (a) an ascorbic acid compound; (b) a charged, reflective particulate material; (c) a structural compound; and (d) a cosmetically acceptable carrier. These preferred uses are skin lightening compositions. Here, the ascorbic acid compound is ascorbic acid or a derivative thereof.

Description

Detailed Description of the Invention

[0001]

[Industrial applications]

  The present invention relates to topical compositions. In particular, it relates to a topical skin whitening composition.

[0002]

[Problems to be Solved by the Invention]

Consumers frequently use cosmetic products to improve their own skin care and skin health and / or physical appearance. Rough and / or damaged skin and pigmentation (such as age spots, freckles, and brown spots due to direct sunlight exposure, skin aging or environmental damage to human skin) will generally be treated by consumers It is a place to be. Whitening of the skin is of particular interest to some Asians.

Ultraviolet (UV) irradiation tends to cause sunburn, which results in blackening and / or pigmentation of the skin. The condition resulting from deficiency or loss of tyrosinase, an enzyme involved in the production of melanin that causes pigmentation, is commonly known as, for example, leukoplakia. The resulting UV irradiation on exposure to sunlight promotes the formation of melanin complexes in the melanocytes in the basal layer of the epidermis. Melanin is then secreted from melanocyte dendrites and diffuses into keratinocytes, resulting in skin pigmentation. Such pigmentation can be pigmented spots, freckles, spots, an unpleasant overall blackening and / or unevenness of the underlying skin.

A wide variety of compounds and / or components, such as ascorbic acid and its derivatives, kojic acid and its derivatives, hydroquinone, arbutin, and glycyrrhizia (gl).
Various extracts such as ycyrrhiza) are known and commonly used for skin lightening. In recent years, the components synthesized by the state of the art, which are useful for whitening the skin, are also available in a wide variety and in a series of product forms.

L-Ascorbic acid (eg Vitamin C) is a cosmetic component useful as a skin lightening and / or leveling agent and as a reducing agent, UV-absorbing agent, and melanogenesis inhibitor. However, L-ascorbic acid tends to be unstable during formulation, imparting a yellowish (undesirable) color to the composition, which eventually turns brownish. This can lead to a decrease in product value.

Certain combinations have been made to stabilize compositions containing ascorbic acid. Japanese Patent Laid-Open No. H1-213212 (August 2, 1989)
Published on 8th) discloses a stable cosmetic composition containing an ascorbic acid derivative and gluconic acid. Japanese Patent Application Laid-Open No. H1-305009 (issued on Dec. 8, 1989) of Yamada et al. Discloses a stable cosmetic composition containing an ascorbic acid derivative and cyclodextrin. Sato et al., JP H3-632
No. 08 (published March 19, 1991) discloses a composition containing ascorbic acid and phenoxyethanol. While such a combination provides acceptable stability of the composition, a change in the appearance of the product to yellow or brown is still visible, especially during storage. Therefore, it is desirable to stabilize compositions that contain ascorbic acid and, in particular, have elevated levels of ascorbic acid present simultaneously in the formulation.

Based on the above, there is a need for a stable skin whitening composition that increases the concentration of ascorbic acid compounds and maintains an excellent product aesthetic. No technology provides all of the advantages and benefits of the present invention.

[0008]

[Means for Solving the Problems]

The present invention describes compositions containing (a) an ascorbic acid compound, (b) a charged, reflective particulate material, (c) a structural compound, and (d) a cosmetically acceptable carrier. These and other features, aspects and advantages of the present invention will be better understood upon a reading of the claims which follow and are attached.

[0009]

DETAILED DESCRIPTION OF THE INVENTION

While the specification particularly points out and distinctly claims the invention, it is believed that the invention will be better understood from the following description. All percentages, ratios, and concentrations of constituents expressed herein are based on the total amount of actual composition unless otherwise indicated. All measurements herein are made at 25 ° C., unless expressly stated otherwise. All publications, patent applications, and issued patents mentioned herein are incorporated herein by reference in their entirety. Citation of any reference does not admit a determination as to its availability as prior art to the claimed invention.

As used herein, “comprising” means that other steps and other ingredients that do not affect the final result can be added. This term
The terms “consisting of” and “consisting of es”
"sentially of)". As used herein, "topical application" means applying or spreading a substance on the surface of the skin. As used herein, "skin lightening" refers to changing the appearance of the skin to a more transparent, lighter, and / or whiter appearance, and improving pigmentation as compared to pre-treatment. Represent As used herein, "cosmetically acceptable" means that these compositions or ingredients thus described have human skin without undue toxicity, incompatibility, instability, allergic reaction, etc. It means that it is suitable to be used in contact.

As used herein, a “safe and effective amount” is within the sound judgment of a practitioner skilled in the art and has obvious advantages, preferably those apparent in skin appearance or feel. Is sufficient to cause significant effects), and is sufficient to avoid serious side effects, such as a reasonable risk of benefit. Means the amount of a compound or composition that provides a proportion. As used herein, a "mixture" is meant to include a simple combination of substances and any compounds that result from such a combination. All components useful herein, such as active agents and other components, are
They are classified or described by their cosmetic and / or therapeutic benefit, or their mode of action. However, it should be understood that the active agents and other components useful herein may in some cases provide cosmetic and / or therapeutic benefits or act in multiple modes of action. is there. Therefore, the classification herein is for convenience only and is not intended to limit the components to particular or tabulated applications.

The present invention is directed to a composition comprising an ascorbic acid compound, a charged, reflective particulate material, a structural compound, and a cosmetically acceptable carrier. Without being bound by theory, it is believed that the high reducing ability of ascorbic acid compounds provides for enhanced cellular respiration, enzyme activation and antioxidant. Furthermore, it is believed that topical application of ascorbic acid compounds tends to suppress oxidation of the melanin complex itself and its precursors, as well as inhibit tyrosinase activity in melanosomes. Thus, a composition containing an ascorbic acid compound also
It is believed that the skin can be provided with the benefits of preventing melanogenesis and reducing age spots, spots, and / or freckles that are integral with skin pigmentation.

Increasing the concentration of ascorbic acid in the composition will generally improve the effectiveness of the composition. For example, increasing the concentration of ascorbic acid in the skin lightening composition will improve the whitening properties of the skin. Unfortunately, compositions with such increased levels of ascorbic acid tend to be unstable, especially because the physical properties of the product, such as the product turning yellow or brown, are not edible and increase these levels. Until now, it has been considered difficult. However, we have found that the inclusion of structural compounds in the composition allows us to maintain the ascorbic acid compounds and the physical properties inherent to those compositions, even when the compositions contain significantly higher concentrations of ascorbic acid compounds. I found. Such improved stability is particularly effective in aqueous compositions.

A. Ascorbic Acid Compound The composition of the present invention comprises an ascorbic acid compound. Ascorbic acid compounds are selected for their compatibility with other components. The ascorbic acid compound may be included as a substantially pure material, eg, an extract obtained by suitable physical and / or chemical separation from natural (eg, plant) sources. The compositions of the present invention preferably contain from about 1.0% to about 10.% of the ascorbic acid compound.
0%, more preferably about 2.0% to about 5.0%. In the present specification, the "ascorbic acid compound" means the following formula (I)

[0015]

[Chemical 1]

Is ascorbic acid or a derivative thereof, wherein V and W are independently -O.
H, R ¹ is —CH (OH) —CH ₂ OH, and salts thereof. Preferably, the ascorbic acid compounds useful herein are ascorbates or derivatives thereof, including non-toxic alkali metal, alkaline earth metal and ammonium salts well known to those skilled in the art, by methods well known in the art. Includes, but is not limited to, the sodium, potassium, lithium, calcium, magnesium, barium, ammonium and protamine salts produced. More preferably, the ascorbate salts useful herein are of formula (II):

[0017]

[Chemical 2]

Is a metal ascorbate having R ² and R ³ are independently selected from hydrogen and straight or branched chain alkyl having 1 to about 8 carbons, and M ¹ is a metal , And x are integers from 1 to about 3. More preferably, R ² and R ³ are hydrogen and one carbon atom.
To about 3 independently selected from straight or branched chain alkyl, M ¹ is sodium,
It is potassium, magnesium, or calcium.

Examples of other preferred ascorbates having the formula (II) include monovalent metal salts of ascorbic acid (eg sodium ascorbate, potassium ascorbate), divalent metal salts (eg ascorbic acid). Magnesium, calcium ascorbate) and trivalent metal salts (eg aluminum ascorbate). Preferably, the ascorbate salts useful herein have the following formula (III)

[0020]

[Chemical 3]

Is a water-soluble ascorbic acid ester having: wherein A is a sulfate or phosphate, R ⁴ and R ⁵ are hydrogen and a straight or branched chain alkyl having 1 to about 8 carbon atoms. Independently selected, M ² is a metal and y is an integer from 1 to about 3. More preferably, R ⁴ and R ⁵ are independently selected from hydrogen and from 1 to about 3 linear or branched alkyl carbon atoms, M ² is sodium, potassium, magnesium, or calcium.

Typical water-soluble salt derivatives include L-ascorbic acid sodium phosphate and L
-Potassium ascorbate phosphate, L-magnesium ascorbate phosphate, L
Examples include, but are not limited to, L-ascorbic acid phosphoric acid ester salts such as calcium ascorbic acid phosphoric acid and L-ascorbic acid aluminum phosphoric acid. L-ascorbic acid sulfate salt can also be used. Examples include L-sodium ascorbate sulfate, L-potassium ascorbate sulfate, L
-Magnesium ascorbate sulfate, L-calcium ascorbate sulfate, L-
Aluminum ascorbate sulfate may be mentioned.

B. Charged, Reflective Particulates The compositions of the present invention also include charged, reflective particulates (“charged materials”) from about 0.01% to about 5.0% by weight of the composition, preferably about 0.1%. % To about 5.0% by weight
And more preferably essentially comprises from about 0.5% to about 2.0% by weight. The charged material preferably comprises a reflective particulate material such as titanium dioxide coated with a coating material that provides a net charge greater than the zeta potential of the uncoated metal oxide. Such charged substances can be dispersed throughout the carrier.

Without being limited by theory, reactive particulate materials, such as titanium dioxide, usually have fairly high surface activity, which is believed to render the formulation unstable. In addition, such reflective particulate materials tend to form agglomerates, for example agglomerating with each other, resulting in precipitation of the reflective particulate material. Such problems can be solved by coating the reflective particulate material (metal oxide) with a coating material that provides a net charge greater than the zeta potential of the uncoated reflective particulate material. Typically the coating material is p
H about 4 to about 8.5 gives a zeta potential greater than about ± 20 mV (eg, in either the positive or negative direction). Moreover, such coating materials impart steric hindrance to the reflective particulate material, resulting in the prevention of such agglomerates of charged materials. This adds stability during formulation and prevents agglomeration of the reflective particulate material (metal oxide).

Microparticles and their charge are well known in the skilled and ordinary industry and are described in RJ Hunter's “Zeta Potential in Colloid Science: Principles and Principles and Application)
, (1981), Academic Press; JN Israelachvili's "Intramolecular and Surface Tensions: Application to Colloids and Biological Systems"
th Applications to Colloidal and Biological Systems) "(1985),
Published by Academic Press; and Hugeben N.G.
Hoogeven, NG) et al. “Colloids and surfaces, physics and engineering aspects (Col
loids and Surfaces, Physiochemical and Engineering Aspects) ", Vol. 117, p. 77 (1966). All of these publications cited herein are incorporated herein by reference.

Preferably, all charged materials have a net cationic or anionic charge.
Since all particles have the same charge, it is believed that their repulsive forces prevent clot formation and lead to a uniform distribution throughout the hydrophilic phase. As a result, even lower concentrations of (i) reflective particulate material provide maximum visible light reflection to the composition, (ii) without giving a powdery or grainy, sensory negative impression, and (iii) Reduces prescription instability. Therefore, the use of charged substances provides efficient coverage with much lower concentrations of charged substances. The refractive index of the charged materials useful in the compositions of the present invention is usually at least about 2, and more preferably at least about 2.5 (eg about 2 to about 3). Refractive index is measured by conventional methods. For example, the refractive index measuring method applicable to the present invention is J.A.
"Lange's Handbook of", edited by JA Dean
Chemistry), 14th Edition (McGraw Hill, New York,
1992), Section 9, Refractive Index Measurements, all incorporated herein by reference.

Preferred charged materials are those that are undiluted (ie, essentially pure, powder prior to binding with any carrier) having a primary particle size of from about 100 nm to about 300 nm,
More preferably, it is about 100 nm to about 250 nm. Preferred charged materials, when dispersed in the composition, are about 100 nm to about 1000 nm, more preferably about 100 nm to about 400 nm, even more preferably about 200 nm to about 300 n.
It has a primary particle size of m. The primary particle size is ASTM notation E20-85 "0.2-75
Standard Practice for Particulate Size Analysis of Particulate Sub
stances in the Range of 0.2 to 75 Micrometers by Optical Microscopy) ''
It can be measured using ASTM, Volume 14.02, 1993, which is incorporated herein by reference. The particles may have a variety of shapes including spheres, spheroids, ellipses, lamellas, irregular shapes, needles and clubs, as long as they provide the desired refractive index. The microparticles can take various physical forms including rutile, anatase, or a combination thereof.

(I) Reflective particulate material: The reflective particulate material herein is a metal oxide, preferably titanium dioxide, zinc oxide, zirconium dioxide, aluminum oxide, and combinations thereof, more preferably titanium dioxide, Particles of an inorganic material composed of zinc oxide and combinations thereof (combinations are intended to include particles comprising one or more of these materials, as well as mixtures of these particulate materials), and Most preferably it consists essentially of titanium dioxide. The reflective particulate material may be a composite material. For example, without limitation, other materials such as silica, silicone resins, mica, and nylon may be deposited or mixed on the core.

Inorganic particulate materials such as titanium dioxide, zinc oxide, zirconium dioxide, or aluminum oxide are commercially available from a number of sources. Examples of suitable particulate materials include Tronox® (titanium dioxide series) and SAT-T CR8 commercially available from US Cosmetics.
37 (rutile titanium dioxide), titanium dioxide CR-50 commercially available from Ishihara Sangyo Kaisha, and Tayca Corporatio.
Commercially available from Titanium Dioxide JA-1. The composition may contain other inorganic or organic particulate materials. However, it is preferred that the particulates of the composition of the present invention consist essentially of the particulate materials described in this section.

(Ii) Coating Material: The reflective particulate material described above is preferably coated with a coating material that imparts a net charge greater than the zeta potential of the uncoated reflective particulate material. Thus, any coating material can be used as long as the net charge (cationic or anionic) imparted to the reactive particulate is greater than the untreated reflective particulate material. However, all of the microparticles in the composition are preferably treated to the same net charge, e.g., to give the advantage of repulsion between the reactive microparticles without mixing cationic or anionic coating materials. It However, it will be understood by those skilled in the art that small amounts of oppositely charged coating material may be used as long as the overall repulsive force is maintained.

As an example of the coating material that imparts a cationic charge, a cationic polymer (
(Natural and / or synthetic) and cationic surfactants, but are not limited thereto. Preferred cationic coating materials are selected from the group consisting of chitosan, hydroxypropyl chitosan, quaternium-80, polyquaternium-7, and mixtures thereof. Examples of coating materials that give anionic charge include anionic polymers (
(Natural and / or synthetic) and anionic surfactants, but are not limited thereto. Preferred anionic coating materials are ammonium polyacrylate, sodium polyacrylate, potassium polyacrylate, ethylene acrylic acid copolymer, hydrolyzed wheat protein polysiloxane copolymer, dimethicone copolyol phosphate, dimethicone copolyol acetate, dimethicone. Copolyol laurate, dimethicone copolyol stearate, dimethicone copolyol behenylate, dimethicone copolyol isostearate, dimethicone copolyol hydroxystearate, phosphate ester, sodium chondroitone sulfate, hyaluronic acid Sodium acid salt, ammonium hyaluronate, sodium alginate, ammonium alginate, ammonium laurate, sodium laurate Potassium laurate, ammonium myristic acid, sodium myristic acid, potassium myristic acid, ammonium palmitate, sodium palmitate, potassium palmitate, ammonium stearate, sodium stearate, stearic acid, ammonium oleate, sodium oleate, oleic acid It is selected from the group consisting of potassium and mixtures thereof. An anionic coating material selected from the group consisting of ammonium polyacrylate, sodium polyacrylate and mixtures thereof,
More preferable.

The charged substance (eg, treated with a coating substance) may be essentially undiluted, in powder form, or predispersed in various types of carriers, which may be water, a low-grade carrier. Polyhydric alcohol (for example, C _1-4 ) and propylene glycol, polyethylene glycol (for example, molecular weight 200-600 g / m
ol), polypropylene glycol (for example, a molecular weight of 425 to 2025 g / mo)
l), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol ester, butanediol, ether propanol, ethoxylated ether, propoxylated ether. Included include, but are not limited to, included organic hydrophilic diluents such as low molecular weight glycols and polyols, and mixtures thereof. Preferably, the charged particulate material is predispersed in water, glycerin, butylene glycol, propylene glycol and mixtures thereof. Examples of commercially available charged particulate materials include Kobo BG60DC (breath dispersion of chitosan treated with titanium dioxide and butylene glycol), Kobo G.
LW75CAP (a dispersion of ammonium polyacrylate treated with titanium dioxide, water and glycerin), GLW75CAP-MP (a dispersion of ammonium polyacrylate treated with titanium dioxide, water, glycerin, methylparaben and propylparaben). And Kobo Products Inc. (Plainfield, NJ)
Available from.

C. Structural Compound The composition of the present invention comprises a structural compound. As used herein, “structural compound (structur
"ing compound)" refers to a compound that forms a gel network system, an organized structure such that the system may be present in a hydrophobic or hydrophilic component. Structural compounds are believed to help impart good rheological properties to the composition and contribute to the stability and favorable aesthetic properties of the composition. Preferably, the structural compound is from about 1.0% to about 10.0% of the composition, more preferably from about 2.0%.
There is about 8.0%. Preferably, the structural compound comprises an aliphatic alcohol and an amphipathic surfactant. Without wishing to be bound by theory, it is believed that the fatty alcohols are oriented to form a layered structure with the amphipathic surfactant, thus maintaining the oil and water phases. In addition, such a systematic structure called “aliphatic alcohol gel network system” is considered to impart stability to the composition.

The fatty alcohols useful herein are the group consisting of straight or branched chain saturated C _12-30 fatty alcohols, straight or branched chain saturated C _12-30 diols and mixtures thereof. It is a linear or branched saturated aliphatic alcohol selected from Preferred fatty alcohols are cetyl alcohol, stearyl alcohol and mixtures thereof. Preferably, the fatty alcohols useful herein are about 1.
0% to 10.0%, more preferably about 1.0% to about 5.0%.

Amphiphilic surfactants useful herein include surfactants, any of a wide variety of nonionic, cationic, anionic, zwitterionic, amphoteric, and surfactants thereof. A mixture of Examples of the wide variety of additional surfactants useful herein are "McCutcheon's Detach
ergents and Emulsifiers) "(North American version), (1986) [Published by Allured Publishing Corporation]
, All of which are incorporated herein by reference. In addition,
US Pat. No. 4,800,197 (issued Jan. 24, 1989), such as z), is incorporated herein by reference in its entirety as an example of representative surfactants useful herein. . Preferably, the amphipathic surfactant useful herein is present in the composition from about 1.0% to 10.0%, more preferably from about 2.0% to about 6.0%.

Preferred nonionic surfactants useful herein are the condensation products of alkylene oxides with fatty acids and fatty alcohols. (For example, the polyalkylene oxide moiety is esterified with a fatty acid at one end and an aliphatic alcohol etherified at the other end (eg, attached via an ether bond).) These materials have the general formula R ² CO. (X ¹ ) _z OR ³ , wherein R ² and R ³ have independent carbon numbers of about 10
Is about 30 alkyls, X ¹ is —OCH ₂ CH ₂ (eg, derived from ethylene glycol or oxide) or —OCH ₂ CHCH ₃ — (derived from propylene glycol or oxide), and z is about 6 ~ Is an integer of about 100.

Examples of such alkylene oxides that derive nonionic surfactants include:
Ceteth-6, Ceteth-10, Ceteth-12, Ceteareth-6, Ceteareth-10
, Ceteareth-12, Ceteareth-20, Steareth-6, Steareth-10,
Steareth-12, Steareth-20, Steareth-21, Steareth-100
, PEG-6 stearate, PEG-10 stearate, PEG-12 stearate, PEG-100 stearate, PEG-10 glyceryl stearate, P
E-20 glyceryl stearate, PEG-30 glyceryl cocoate, PEG
-80 glyceryl cocoate, PEG-80 glyceryl tallowate, PEG-
-200 glyceryl tallowate, PEG-8 dilaurate, PEG-10 distearate, glyceryl monostearate, glyceryl distearate, glyceryl monolaurate, glyceryl dilaurate and mixtures thereof.

The structural compound may further contain a co-thickening agent. Representative examples of co-thickeners useful herein are materials derived primarily from natural sources such as polysaccharides and gums. A wide variety of polysaccharides known in the art may be used. As used herein, "polysaccharide" means a component containing a repeating backbone of sugar (ie, carbohydrate) units. Examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, carboxylic acid propionate cellulose acetate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and the like. And the like, but is not limited thereto.

[0039] Cellulose substituted with alkyl groups are also useful herein. In these polymers, the hydroxy groups of the cellulose polymer are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form hydroxyalkylated cellulose, which is then further _C10-30 linear or branched. The chain alkyl group is modified via an ether bond. Typically these polymers are
C _10-30 is an ether of a hydroxyalkyl cellulose of a straight or branched chain alcohol. Examples of alkyl groups useful herein include stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e., alkyl groups derived from the alcohol of coconut oil), palmityl, oleyl, linoleyl, linolenyl, ricinoleyl, And those selected from the group consisting of behenyl, and mixtures thereof. Among the alkyl hydroxyalkyl cellulose ethers, preferred is an ether of cetyl alcohol and hydroxyethyl cellulose, which is a substance called cetyl hydroxyethyl cellulose in CTFA notation.
This material is tradenamed Natrosol® CS Plus (CS P
lus) is sold by Aqualon Corporation.

Other useful polysaccharides include scleroglucan containing a straight chain of (less than 3) linked glucose units with less than 6 linked glucose every 3 units.
s), as a commercial example, Michel Mercier Products Inc.
(Cleaarogel® CS11 from Mountainside, NJ). Examples of the gum include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, carrageenan calcium, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, hydroxypropyltrimonium chloride guar, hectorite, hyaluronic acid. , Silicon hydroxide, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, carrageenan potassium, propylene glycol alginate, sclerotin gum, carboxymethyldextran sodium, carrageenan sodium, tragacanth gum, xanthan gum, and the like. Mention may be made of substances selected from the group consisting of mixtures.

D. Cosmetically Acceptable Carrier The composition of the present invention comprises a cosmetically acceptable carrier. The term "cosmetically acceptable carrier" as used herein refers to one or more compatible solid or liquid fillers, diluents, spreading agents and the like, which are cosmetic products as defined herein. Be acceptable. The term "compatible", as used herein, means that the components of the composition of the invention can be mixed with one another in a manner such that they do not interact under normal use conditions to substantially reduce the efficacy of the composition. Means that. The cosmetically acceptable carrier useful herein is selected from the group consisting of hydrophobic components, hydrophilic liquid carriers, pH adjusting agents, water, and mixtures thereof. The type of carrier utilized in the present invention depends on the type of product desired and may include, but is not limited to, several carriers. Carriers include solutions, aerosols, emulsions (including oil-in-water or water-in-oil), gels, solids, and liposomes.

(1) Hydrophobic Component The hydrophobic component useful in the present invention includes lipids, oils, oily or other hydrophobic components. The hydrophobic component is used as an emollient. A wide variety of suitable hydrophobic components are known and are used herein. Numerous examples of these are from Sagarin's “Cosmetics, Scienc.
e and Technology) "2nd edition, Volume 1, pages 32-43 (1972). Examples of suitable hydrophobic components include mineral oils, petrolatum, C _7-40 straight and branched chain hydrocarbons, C _1-30 alcohol esters, glycerides, alkylene glycol esters, propoxy and ethoxylated derivatives, sugar esters. , vegetable oils and hydrogenated vegetable oils, animal fats, and alkyl ethers of C _{4 to 20} polypropylene glycol, carboxylic acid esters of C _{1 to 20} polypropylene glycol, and alkyl ethers of di -C _{8 to 30} and the like, which It is not limited to. Examples of hydrophobic moieties useful herein are US Pat. No. 5,306, Letton et al.
, 514 (issued April 26, 1994), “Merck Index (Merck
Index) ”, 10th edition, headword 7048, 1033 pages (1983), and“ International Cosmetic Ingredient Dictionary ”, 5th edition, Volume 1, pages 415-417 (1993). ing.

Fatty acid sugar esters useful herein include C ₁ of the sugar and one or more carboxylic acid moieties.
_To C ₃₀ monoesters or polyesters, preferably having a degree of esterification of 7 to 8 and fatty acid moieties being C ₁₈ mono- and / or di-unsaturated moieties and behenic acid moieties (
A sucrose polyester having a molar ratio of unsaturated part: behenic acid part of 1: 7 to 3: 5), more preferably, about 7 benzoic acid moieties and 1 oleic acid moiety are present in the molecule. Octyl ester of sucrose, such as sucrose ester of cottonseed oil fatty acid. Preferably, the composition contains about 2.0% to about 95.0% hydrophobic component, more preferably about 40.0 to about 85.0%. The hydrophobic component includes components derived from animals, plants, or petroleum, which may be of natural or synthetic (eg, artificial) origin.

(2) Hydrophilic Liquid Carrier The composition of the present invention may contain a hydrophilic liquid carrier (HLC). A preferred HLC may contain a dermatologically acceptable non-aqueous hydrophilic diluent. Examples of hydrophilic diluents include low molecular weight monohydric alcohols (i.e., _C1-6 ), low molecular weight glycols and polyhydric alcohols such as polyols, examples of which include propylene glycol, butylene glycol, hexylene. Glycol,
Dipropylene glycol, polyethylene glycol (that is, a molecular weight of 200 to 1
000 g / mol), polypropylene glycol (ie, molecular weight 425-2)
0.25 g / mol), glycerol, 1,2,4-butanetriol, 1,2,
6-hexanetriol, and mixtures thereof, but not limited to these. Preferably, the composition has an HLC of about 30% to about 95%, more preferably about 40%.
% To about 90%. HLC includes water and one or more water-soluble or water-dispersible components. Precise amounts of water in the formulation will vary with the range required and the optional ingredients selected.

(3) pH Adjusting Agent A cosmetically acceptable pH adjusting agent useful herein may be included. As used herein, the term “pH adjuster” refers to any component that acts to raise or lower the pH of the entire composition to an optimum pH, thereby preventing the constituent components (particularly the ascorbic acid compound) from being altered. . The optimum pH depends on the choice of ascorbic acid compound. For example, when the composition includes L-magnesium ascorbyl phosphate (MAP), the optimum pH is about 7.0 to about 8.0. Suitable pH adjusting agents herein include acetates, phosphates, citrates, triethanolamine and carbonates. The above pH adjusters are often used in combination to match the optimum pH specific to the composition. The total concentration of the pH adjuster by weight of the composition is about 0.01% to about 5.0%, preferably about 0.5%.
It is about 2.0%.

(4) Other Active Agents The cosmetically acceptable compounds useful herein include, in different ways, to further enhance and / or provide other benefits of the ascorbic acid compound. It may contain other active substances that function. Examples of such substances include vitamin B ₃
Examples include, but are not limited to, compounds, antioxidants and radical scavengers, anti-inflammatory agents, antimicrobial agents, sunscreens and sunscreens, and chelating agents. Other actives useful herein include Vitamin A [ie, many sources, such as Sigma Chemical Company (St. Louis, Mo.), and Boerhinger Mannh].
eim) (Indianapolis, Ind.) and US Pat. No. 4,677,120 to Parish et al. (issued June 30, 1987), US Pat. No. 4 to Parish et al. No. 5,885,311 (issued December 5, 1989), US Patent No. 5,049,584 (issued September 17, 1991), Purcell et al., US Patent No. 5, Purcell et al. , 12
No. 4,356 (issued June 23, 1992) and Reissue Patent No. 34,075 (issued September 22, 1992) of Purcell and the like] and vitamin K. To be

(I) Vitamin B ₃ Compounds Vitamin B ₃ compounds reinforce the cosmetic benefits of the skin, especially including signs of skin aging, especially wrinkles, lines, and pores. Rectify the condition.
Abundance of vitamin B ₃ compound is preferably from about 0.01% to about 50%, more preferably from about 0.1% to about 10%, even more preferably from about 0.5% to about 10%, and more Even more preferably, it is about 1% to about 5%. As used herein, the term "vitamin B ₃ compound" refers to the following formula:

[0048]

[Chemical 4]

Wherein R is —CONH ₂ (eg nicotinic acid amide),
-COOH (e.g., nicotinic acid), or -CH ₂ OH (e.g., nicotinyl alcohol), refers to any salt of these derivatives, and the. Typical derivatives of the vitamin B ₃ compound include non-vasodilators of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and nicotinic acid amide N-oxide. An acid ester is mentioned. Suitable esters of nicotinic acid include nicotinic acid esters of alcohols having 1 to about 22 carbon atoms, preferably 1 to about 16 carbon atoms, and more preferably about 1 to about 6 carbon atoms. The alcohols are preferably straight-chain or branched, cyclic or acyclic, saturated or unsaturated (including aromatic), and substituted or unsubstituted. The ester is preferably non-vasodilator. As used herein, the term "non-vasodilatory" does not cause a normally flushing reaction after application of the ester to the skin in the subject composition (such compounds are not visible to the naked eye). Although it may cause dilation, it is not the visible flushing reaction of the majority of the general population, ie the ester is non-reddening). Non-vasodilators of nicotinic acid include tocopherol nicotinate and inositol hexanicotinate; tocopherol nicotinate is preferred.

Another derivative of the vitamin B ₃ compound is a derivative of nicotinic acid amide obtained as a result of replacing one or more hydrogens of the amide group. Examples of nicotinic acid amide derivatives useful in the present invention include, for example, active nicotinic acid compounds (eg, nicotinic azide or nicotinyl chloride) and amino acid and nicotinyl alcohol esters of organic carboxylic acids (eg, 1 to 1 carbon atoms). (But not limited to) nicotinyl amino acids derived from about 18 reactions. Specific examples of such derivatives include nicotinuric acid (C ₈ H ₈ N ₂ O ₃ ) and nicotinyl hydroxamic acid (C ₆ H ₆ N ₂ O ₂ ) having the following chemical structures.

[0051]

[Chemical 5]

[0052] Typical nicotinyl alcohol esters include nicotinyl alcohol esters such as carboxylic acids salicylic acid, acetic acid, glycolic acid, palmitic acid. Other examples of Vitamin B ₃ compounds useful herein are 2-chloronicotinamide, 6-aminonicotinamide, 6-methyl nicotinamide, n- methyl nicotinamide, n, n- diethyl nicotinamide, n- (Hydroxymethyl)
-Nicotinamide, quinolinamide, nicotinanilide, n-benzylnicotinamide, n-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, nialamide, 1
-(3-pyridylmethyl)) urea, 2-mercaptonicotinic acid, nicomol, and niaprazine, but not limited to these.

Examples of the above vitamin B ₃ compounds are well known to those skilled in the art, for example, Sigma Chemical Company (St. Louis, Mo.), ICN Biomedicals Inc. (Irvine, Calif.). And many sources from, but not limited to, the Aldrich Chemical Company (Milwaukee, WI). One or more vitamin B ₃ compounds may be used herein. Preferred vitamin B ₃ compounds are niacinamide and tocopherol nicotinate.
Nicotinic acid amide is more preferred. When used, the salts, derivatives, and salt derivatives of nicotinamide preferably have substantially the same effectiveness as nicotinamide in the methods of conditioning skin conditions described herein.

Salts of vitamin B ₃ compounds are also useful in the present invention. Examples of salts of Vitamin B ₃ compounds useful in the present invention include organic or inorganic salts, having an anionic inorganic species (eg chloride, bromide, iodide, carbon, preferably chloride). , And (mono-, di-, and tri-C _1-18 carboxylic acid salts, such as acetates,
Organic salts such as, but not limited to, organic carboxylates, including salicylates, glycolates, lactates, malates, citrates, and preferably monocarboxylates such as acetates. . Salts of these and other vitamin B ₃ compounds are those which can be readily prepared by the skilled technician, for example, W.. W. Wenner, "The Reaction of L-Ascorbic Acid and D-Isoascorbic Acid with Nicotinic Acid and Its Amides (The Raction of L-Ascorbic an
d D-isoascorbic Acid with Nicotiniric Acid and Its Amide), J. Organic
Chemistry, Vol. 14, pp. 22-26 (1949). Wenner describes the synthesis of nicotinamide with ascorbate.

In a preferred embodiment, the nitrogen ring of the vitamin B ₃ compound is substantially chemically free (eg unbound and / or unhindered) or applied to the skin. Later it is substantially chemically liberated (the term "chemically liberated" is hereinafter referred to instead as "non-complexed"). More preferably the vitamin B ₃ compound is essentially not a complex. Therefore, the composition is vitamin B ₃ compound salt, or containing a complex otherwise, if the composition is applied to the skin, such complex is preferably sufficiently reversible, More preferably it is essentially reversible. For example, such a complex has a pH of substantially about 5
． It should be reversible from 0 to about 6.0. Such reversibility can be easily determined by those skilled in the art.

More preferably the vitamin B ₃ compound is substantially uncomplexed in the composition prior to application to the skin. Or minimize the formation of the complex undesired, or as a specific method for preventing substantially to exclude materials that produce a vitamin B ₃ compound and the irreversibility of the complex or other complex, the pH adjustment, ionic strength adjustment, the use of surfactants, and vitamin B ₃ compounds and therewith include blending different phases of material to form a complex. Such methods are generally well known to those skilled in the art. Thus, in a preferred embodiment, the vitamin B ₃ compound contains a limited amount of the salt form, more preferably in the substantial salts of a vitamin B ₃ compound is none.
Preferably the vitamin B ₃ compound contains such salts of less than about 50%, more preferably is essentially none has the form of a salt. vitamin B ₃ compound in the compositions herein having a pH of about 4 to about 7 typically contain less than about 50% salt. Vitamin B ₃ compounds are pure materials substantially, or natural (e.g., plant) may be included as an extract obtained by suitable physical and / or chemical separation from the raw material. Vitamin B ₃ compound is preferably sufficiently pure, more preferably essentially pure.

(Ii) Antioxidants and Radical Scavengers Antioxidants and radical scavengers are useful for UV irradiation causing scale-like peeling or tissue changes in the stratum corneum and for other environmental causes that may cause skin damage. It is especially useful for protecting the skin against active substances. Tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, other tocopherol esters, butylated hydroxybenzoic acid and its salts, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (commodity) Commercially available under the name Trolox®), gallic acid and its alkyl esters, especially propyl gallate, uric acid and its salts and alkyl esters, sorbic acid and its salts, amines (eg N, N). -Diethylhydroxylamine, amino-guanidine), sulfhydryl compounds (ie glutathione), dihydroxyfumaric acid and its salts, lysine pidolate, arginine pyrrolate, nordihydroguaiaretic acid, bioflavonoids, lysine, methionine, proline, super acid Dismutase, silymarin, tea extracts, grape skin /
Antioxidants and radical scavengers such as seed extract, melanin, and rosemary extract may be used. Preferred antioxidants / radical scavengers are selected from tocopherol sorbate and other tocopherol esters, more preferably tocopherol sorbate. For the use of tocopherol sorbate in topical compositions and those applicable to the present invention, see Donald.
U.S. Pat. No. 4,847,071 to Bissett et al. (July 1, 1989)
Issued on the 1st).

(Iii) Anti-inflammatory Agents Anti-inflammatory agents enhance skin appearance benefits by, for example, contributing to uniformity and preferred skin tone and / or color. Preferably, anti-inflammatory agents include steroidal anti-inflammatory agents and non-steroidal anti-inflammatory agents. The preferred steroidal anti-inflammatory to use is hydrocortisone. There are various compounds within this group that are well known to those of skill in the art. For a detailed disclosure of the chemical structure, synthesis, side effects, etc. of non-steroidal anti-inflammatory agents, the reference may be a standard textbook, see K. et al. D. KD Rainsford's "Anti-inflammatory and Anti-Rheumatic Drugs" I-II
Volume I, CRC Press (CRC Press, Boca Raton) (198
5 years), and R. A. Volume 1 of "Anti-inflammatory Agents, Chemistry and Pharmacology" by RA Scherrer and others, Academic Press, New York, (1974) are listed, and each is referred to as a reference. Incorporated herein by reference.

So-called "natural" anti-inflammatory agents are also useful. Such anti-inflammatory agents are conveniently obtained as extracts from natural sources (ie, by-products of plants, fungi, microorganisms) by suitable physical and / or chemical isolation. For example, alpha bisabolol, aloe vera, Manjistha [Akane (
genus Rubia), especially extracts from the rubia cordifolia], and Guggal [genus Commiphora plants, especially from Commiphora Mukul], cola (kola) )
Extracts, chamomile and sea whip extracts may be used. Further useful anti-inflammatory agents herein are licorice [compounds of the genus Glycyrrhiza glabra family, glycyrrhetinic acid, glycyrrhizinic acid, and their derivatives (eg salts and esters)]. Can be mentioned.
Suitable salts of the above compounds include metal and ammonium salts. Suitable esters include esters of C _2-24 , preferably C _10-24 , more preferably C _16-24 saturated or unsaturated acids.

(Iv) Antimicrobial agent, when used, means a compound capable of destroying, preventing the development of, or preventing the pathogenic effects of microorganisms. Antimicrobial agents are useful, for example, in controlling acne. Preferred antimicrobial agents useful in the present invention are benzoyl peroxide, erythromycin, tetracycline, clindamycin, azelaic acid, sulfaresorcinol phenoxyethanol, and Irgasan® DP300 [Ciba Geigy. Corp
.), The United States]. The safe and effective amount of antimicrobial agent added to the compositions of the present invention is preferably from about 0.001% to about 10%, more preferably from about 0.01% to about 5%, and even more preferably about 0. 0.05% to about 2%.

(V) Sunscreens and Sunscreens Sunscreens and sunscreens usually add to the composition of the present invention to prevent excessive scale-like peeling and tissue alteration of the stratum corneum due to exposure to ultraviolet light. May be. Suitable sunscreens or sunscreens can be organic or inorganic. A wide variety of conventional sunscreens and sunscreens are suitable for use herein. U.S. Patent No. 5, issued to Haffey et al. On February 11, 1992, which discloses a number of suitable sunscreens and sunscreens.
U.S. Pat. No. 5,073,372 issued to Turner et al. On Dec. 17, 1991; issued to Turner et al. On Dec. 17, 1991; No. 5,073,371; and Segarin et al., "Cosmetics Science and Techn.
ology ”(1972) Chapter VIII, p. 189 et seq. Preferred among such sunscreens and sunscreens useful in the present composition are 2-ethylhexyl p-methoxycinnamic acid (commercially available as PARSOL MCX), butyl methoxydi. Benzoylmethane, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid, octyldimethyl-p-aminobenzoic acid, octocrylene, 2-ethylhexyl N
, N-dimethyl-p-aminobenzoic acid, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy- t-Butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3-benzylidenecamphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, Eusolex (registered trademark) 6300 , Octocrylene, Parsol 1789, and mixtures thereof.

Also, US Pat. No. 4,937,370 by Sabatelli issued June 26, 1990, and US Pat. No. 4,999,186 issued by Sabatelli et al., March 12, 1991. Sunscreens and sunscreens as disclosed are also particularly useful in the compositions of the present invention. The sunscreens and sunscreens disclosed therein have two distinct chromophore moieties with different UV absorption spectra in the molecule. One of the chromophore moieties absorbs primarily in the UVB radiation range and the other strongly absorbs in the UVA radiation range. These sunscreens and sunscreens provide more efficient, broader UV absorption, lesser skin penetration and longer efficacy than conventional sunscreens and sunscreens. Exact amount depends on the sunscreen selected and the desired sun protection factor (SPF)
Depends on SPF is a commonly used light protection indicator of sunscreens for erythema. Federal Register, Vol. 43, No. 166, 38206
~ Page 38269 (August 25, 1978).

The sunscreens or sunscreens herein may be added to improve the skin, in particular to increase its resistance to being washed off or rubbed off with water. The preferred sunscreens and sunscreens that provide such advantages are copolymers of ethylene and acrylic acid. A composition containing such a copolymer is 198
It is disclosed in U.S. Pat. No. 4,663,157 by Brock issued May 5, 1995.

(Vi) Chelating Agent As used herein, a “chelating agent” is a complex-forming agent that prevents a metal ion from easily participating in or catalyzing a chemical reaction. Represents a compound that reacts so that metal ions can be removed from the system. The inclusion of a chelating agent is particularly useful for protection from UV radiation that contributes to excessive scale-like peeling or tissue changes in the stratum corneum, and from other environmental chemicals that damage the skin. Is. Typical chelating agents useful herein are those by Bissett 19
U.S. Pat. No. 5,487,884, issued Jan. 30, 1996, Bush et al., WO 91/16035 and WO 91/16034, published October 31, 1995. ing. Preferred chelating agents are furyl dioximes and their derivatives.

(5) Other Components In addition to the above components, the composition of the present invention further comprises a water-soluble or solubilized preservative [hydroxybenzoic acid, benzyl alcohol, EDTA, pronopol (Bron).
opol) (2-bromo-2-nitropropropane-1,3-diol), and phenoxypropanol Germall 115, including methyl, ethyl, propyl, and butyl esters] and preservatives. Agent enhancer; Other skin whitening / leveling agents (including kojic acid and arbutin) [Kvarnes (
Kvalnes) et al., WO 95/23780 (issued September 8, 1995)]; skin conditioning agent; skin permeation enhancer; skin protectant; skin soothing agent; skin rejuvenating agent; ultraviolet absorber or scattering agent; sequestering agent Anti-acne agents; anti-androgens; depilatory agents; keratolytic / exfoliant / exfoliants such as salicylic acid; panthenol moisturizers such as D-panthenol; soluble or colloidal solubilizing moisture such as hyaluronic acid. Rising agent and Celanese Superabsorbent
ent Materials) (Port Smith, Virginia, USA) and described in US Pat. No. 4,076,663, Sanwet® IM-1000, IM-1500, and IM-. Starch graft polyacrylate sodium such as 2500; proteins and polypeptides and their derivatives; organic hydroxy acids; medicinal astringents; topical analgesics; film formers; absorbents (
Oil absorbents such as clays and polymeric absorbents); abrasives; anti-caking agents, anti-pressurizing agents; defoamers; binders; biological additives; fillers; colorants; fragrances, Essential oil,
And solubilizers thereof; natural extracts; compounds that stimulate collagen production.

E. Method of Making the Composition The composition of the present invention is usually made by any of the methods conventionally used to make skin care compositions, particularly skin lotions, known in the art. Such methods typically involve mixing the components to a relatively uniform state in one or more steps, with or without heating, cooling, and the like. Typical methods are, for example, Harry's Cosmeticology, 7th Edition, Harry & Wilkinson (Hill Publis
hers), London, 1982).

[0067]

【Example】

The following examples further describe and exemplify the embodiments within the scope of the present invention. These examples are presented solely for purposes of illustration and are to be construed as limiting the invention, as many modifications of the invention are possible without departing from the spirit and scope of the invention. is not. Where applicable, the ingredients are chemical names or CTFA
Identified by name, or otherwise defined below. The compositions shown below can be prepared by any conventional method known in the art. Suitable methods and formulations are shown below.

[0068]

[Table 1]

The above composition is preferably manufactured as follows. (1) A water-soluble component other than the ascorbic acid compound and sodium citrate is dissolved, and the solution is heated to about 75 ° C. (2) Separately, an ascorbic acid compound and an aqueous solution of sodium citrate are mixed, and a mixed solution thereof is obtained. (3) (1) and (2) are mixed, the temperature is maintained at about 75 ° C, and (4) the mixture of the structural compound and the oil component is heated to about 80 ° C. Then, (5) add mixture (4) to aqueous phase (3), then homogenize at high pressure, and (6) add Kobo GLW75CAP-MP and glycerin to the mixture at about 30 ° C.

The embodiments disclosed and shown in the previous examples have many advantages. For example, the compositions herein contain elevated levels of ascorbic acid compounds for skin lightening, and the aesthetics of the product such that the product does not turn yellow or brown in appearance even after prolonged storage. Shows the improvement of. The above detailed description of the embodiments and embodiments of the present invention has been given only by way of illustration, and many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. It is understood that such obvious modifications and changes are intended to fall within the scope of the appended claims.

[Procedure for Amendment] Submission for translation of Article 34 Amendment of Patent Cooperation Treaty

[Submission date] November 22, 2000 (2000.11.22)

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be amended] Claims

[Correction method] Change

[Contents of correction]

[Claims]

─────────────────────────────────────────────────── ─── Continued front page    (81) Designated countries EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, I T, LU, MC, NL, PT, SE), OA (BF, BJ , CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, K E, LS, MW, SD, SZ, UG, ZW), EA (AM , AZ, BY, KG, KZ, MD, RU, TJ, TM) , AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, D K, EE, ES, FI, GB, GE, GH, GM, HR , HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, L V, MD, MG, MK, MN, MW, MX, NO, NZ , PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, U S, UZ, VN, YU, ZW (72) Inventor Asako Yamaguchi             1-14-8, Fukaehonmachi, Higashinada-ku, Kobe City, Hyogo Prefecture             306 (72) Inventor Toru Sumiyoshi             23-13 Hamakaze-cho, Ashiya-shi, Hyogo F term (reference) 4C083 AB211 AC071 AC072 AC122                       AC302 AC342 AC392 AC402                       AC442 AD351 AD352 AD631                       AD641 AD642 BB02 BB03                       BB44 BB45 BB46 BB47 BB60

Claims (8)

[Claims] 1. (A) an ascorbic acid compound, (B) charged, reflective particulate matter, (C) structural compound, and (D) Cosmetically acceptable carrier A composition comprising: 2. The composition according to claim 1, wherein the structural compound comprises an aliphatic alcohol and an amphipathic surfactant. 3. A composition according to claim 2, wherein the cosmetically acceptable carrier is selected from the group consisting of hydrophobic components, hydrophilic liquid carriers, pH adjusting agents, and mixtures thereof. 4. The cosmetically acceptable carrier further comprises vitamin B ₃ compounds, antioxidants and radical scavengers, anti-inflammatory agents, antimicrobial agents, sunscreens and sunscreens, and chelating agents. The composition according to claim 2, comprising at least one other active substance selected from the group. 5. The composition of claim 4, wherein the structural compound further comprises a co-thickener selected from the group consisting of gums and polysaccharides. 6. (A) about 1.0% to about 10.0% ascorbic acid compound, (B) about 0.01% to about 5.0% charged, reflective particulate material, (C) about 1.0% to about 10.0% structural compound, and (D) About 30.0% to about 95.0% cosmetically acceptable carrier. A composition comprising: 7. The structure of claim 6, wherein the structural compound comprises about 1.0% to about 10.0% aliphatic alcohol, and about 1.0% to about 10.0% amphiphilic surfactant. The composition as described. 8. The cosmetically acceptable carrier comprises from about 2.0% to about 95%.
． 8. The composition of claim 7, comprising 0% hydrophobic component, about 30.0% to about 95.0% hydrophilic liquid carrier, and about 0.01% to about 5.0% pH adjusting agent. .