JP2003335679A - Vitamin b1-containing liquid preparation for internal application - Google Patents
Vitamin b1-containing liquid preparation for internal applicationInfo
- Publication number
- JP2003335679A JP2003335679A JP2002138002A JP2002138002A JP2003335679A JP 2003335679 A JP2003335679 A JP 2003335679A JP 2002138002 A JP2002138002 A JP 2002138002A JP 2002138002 A JP2002138002 A JP 2002138002A JP 2003335679 A JP2003335679 A JP 2003335679A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- liquid preparation
- internal use
- gluconate
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】この発明は、ビタミンＢ１類
含有内服用液剤、詳細にはビタミンＢ１類の苦味を防止
して服用しやすくした内服用液剤に関するものであり、
医療や食品の分野で利用される。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid preparation for oral administration containing vitamin B1s, and more particularly to a liquid preparation for internal use which prevents the bitterness of vitamin B1s and makes it easier to take.
Used in the medical and food fields.
【０００２】[0002]
【従来の技術】ビタミンＢ１類は、精神的、身体的疲労
回復などの薬効を有しており、医薬品や食品に広く用い
られている。しかしながら、ビタミンＢ１類は特異な苦
味及び臭いを有しており、これを内服用液剤に添加する
際には、添加量を抑制するか、または、甘味剤や香料を
加えて調節するなどして商品化されている。また、ビタ
ミンＢ１類にグルコン酸カルシウムなどを配合して風味
を改善した液剤が提案されている（特開平１０−６７６
５９号公報）。2. Description of the Related Art Vitamin B1 has a medicinal effect such as recovery from mental and physical fatigue, and is widely used in medicines and foods. However, vitamin B1 has a peculiar bitterness and odor, and when it is added to a liquid medicine for internal use, the addition amount is suppressed or a sweetener or a flavor is added to adjust the content. It has been commercialized. In addition, a liquid formulation in which calcium gluconate or the like is mixed with vitamin B1 to improve the flavor has been proposed (Japanese Patent Laid-Open No. 10-676).
59 publication).
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、上記の
ような工夫にもかかわらず、ビタミンＢ１類の添加量が
増すにつれて特異な苦味及び臭いが増し、ユーザーのコ
ンプライアンスの点から、未だ十分にビタミンＢ１類の
苦味や臭いを防止して服用しやすくした内服用液剤は得
られていない。However, in spite of the above-mentioned measures, the peculiar bitterness and smell increase as the amount of vitamin B1 added increases, and vitamin B1 is still sufficient from the viewpoint of user compliance. There is no liquid medicine for internal use that prevents bitterness and odor of various kinds and makes it easier to take.
【０００４】[0004]
【課題を解決するための手段】この発明の発明者らは、
ビタミンＢ１類に、グルコン酸塩および有機酸のカルシ
ウム塩を配合することにより、ビタミンＢ１類の苦味を
防止して服用しやすい内服用液剤が得られることを見出
した。さらに、ビタミンＢ１類特有の臭いも抑制して、
いっそう服用しやすい内服用液剤が得られることも見出
した。SUMMARY OF THE INVENTION The inventors of the present invention have
It has been found that by mixing gluconate and calcium salt of an organic acid with vitamin B1s, it is possible to obtain a liquid preparation for internal use which prevents the bitterness of vitamins B1s and is easy to take. Furthermore, it suppresses the odor peculiar to vitamin B1s,
It was also found that an internal-use liquid preparation that is easier to take can be obtained.
【０００５】この発明の内服用液剤は、ビタミンＢ１
類、グルコン酸塩、および有機酸のカルシウム塩を含有
することを特徴とする。The liquid preparation for internal use of this invention is vitamin B1.
And calcium salts of organic acids.
【０００６】[0006]
【発明の実施の形態】この発明の内服用液剤に用いられ
るビタミンＢ１類としては、例えば、チアミン、オクト
チアミン、フルスルチアミン、ビスベンチアミン、ベン
ホチアミン、チアミンジスルフィド、ジセチアミン、ま
たは、これらの塩などが挙げられる。BEST MODE FOR CARRYING OUT THE INVENTION Examples of the vitamin B1 used in the liquid preparation for internal use of the present invention include thiamine, octothiamine, fursultiamine, bisbentamine, benfotiamine, thiamine disulfide, dicethiamine, and salts thereof. Is mentioned.
【０００７】この発明の内服用液剤中のビタミンＢ１類
の配合量は、０．００１〜０．０３ｗ／ｖ％であり、好
ましくは０．００３〜０．０２ｗ／ｖ％である。The amount of vitamin B1 compounded in the liquid preparation for internal use of the present invention is 0.001 to 0.03 w / v%, preferably 0.003 to 0.02 w / v%.
【０００８】この発明の内服用液剤に用いられるグルコ
ン酸塩としては、例えばグルコン酸カルシウム、グルコ
ン酸マグネシウム、グルコン酸ナトリウム、グルコン酸
カリウムなどが挙げられるが、グルコン酸カルシウムが
特に好ましい。Examples of the gluconate used in the liquid medicine for internal use of the present invention include calcium gluconate, magnesium gluconate, sodium gluconate, potassium gluconate, etc., but calcium gluconate is particularly preferable.
【０００９】この発明の内服用液剤中のグルコン酸塩の
配合量は、ビタミンＢ１類の配合量の５〜３００倍量で
あり、好ましくは１０〜１００倍量である。The content of gluconate in the liquid preparation for internal use according to the present invention is 5 to 300 times, preferably 10 to 100 times that of vitamin B1.
【００１０】この発明の内服用液剤に用いられる有機酸
のカルシウム塩としては、例えば、乳酸、クエン酸、酒
石酸、コハク酸、リンゴ酸、マレイン酸、フマル酸、酢
酸、グルタミン酸、アスパラギン酸などのカルシウム塩
が挙げられるが、乳酸カルシウムが特に好ましい。Examples of the calcium salt of an organic acid used in the liquid preparation for oral use of the present invention include calcium such as lactic acid, citric acid, tartaric acid, succinic acid, malic acid, maleic acid, fumaric acid, acetic acid, glutamic acid and aspartic acid. Salts may be mentioned, but calcium lactate is particularly preferred.
【００１１】この発明の内服用液剤中の有機酸のカルシ
ウム塩の配合量は、ビタミンＢ１類の配合量の２〜１０
０倍量であり、好ましくは５〜５０倍量である。The amount of the calcium salt of an organic acid contained in the liquid preparation for oral administration of the present invention is 2 to 10 of the amount of vitamin B1 compounded.
The amount is 0 times, preferably 5 to 50 times.
【００１２】また、この発明の内服用液剤中のグルコン
酸塩と有機酸のカルシウム塩の配合比率は、５：１〜
１：２、好ましくは３：１〜１：１である。The compounding ratio of the gluconate and the calcium salt of the organic acid in the liquid medicine for oral use of the present invention is 5: 1 to.
It is 1: 2, preferably 3: 1 to 1: 1.
【００１３】この発明の内服用液剤には、上記の成分の
他に、各種のビタミン類（例えば、ビタミンＢ２、ビタ
ミンＢ６、ビタミンＢ１２、ビタミンＡ、ビタミンＣ、
ビタミンＥなど）、ニコチン酸アミド、チオクト酸アミ
ド、システイン、イノシトール、カフェイン、ｐＨ調節
剤（グルコノラクトンなど）、香料（ｌ−メントール、
ハッカ油など）、保存剤（安息香酸、プロピレングリコ
ールなど）などを配合しても良い。In addition to the above components, the liquid preparation for internal use of the present invention contains various vitamins (for example, vitamin B2, vitamin B6, vitamin B12, vitamin A, vitamin C,
Vitamin E, etc.), nicotinic acid amide, thioctic acid amide, cysteine, inositol, caffeine, pH regulators (gluconolactone, etc.), fragrances (1-menthol,
Mint oil, etc.), preservatives (benzoic acid, propylene glycol, etc.) and the like may be added.
【００１４】この発明の内服用液剤は、ビタミンＢ１類
の苦味が抑えられたものであるが、さらに所望により、
甘味剤（例えば、ステビア、アスパルテーム、砂糖、ブ
ドウ糖、ソルビトールなど）、矯味剤（アスパラギン酸
など）を配合しても良い。The liquid preparation for internal use according to the present invention suppresses the bitterness of vitamin B1s, but if desired,
A sweetener (eg, stevia, aspartame, sugar, glucose, sorbitol, etc.) and a corrigent (aspartic acid, etc.) may be added.
【００１５】この発明の内服用液剤は、常法により、精
製水に上記の成分を添加して混合し、溶解して製造する
ことができる。The liquid medicine for internal use of the present invention can be produced by adding the above-mentioned components to purified water, mixing and dissolving them by a conventional method.
【００１６】[0016]
【発明の効果】この発明の内服用液剤のビタミンＢ１類
の苦味防止効果を、以下の試験例により示す。
試験例１
（試験方法）後記の実施例１及び比較例１〜３で得られ
た液剤を用いて５名による官能試験を行い、次の評価基
準によりビタミンＢ１類（オクトチアミン）の苦味防止
効果を判定した。結果を表１に示す。
（評価基準）
評点 １：ビタミンＢ１特有の味をまったく感じない
評点 ２：ビタミンＢ１特有の味をかろうじて感じる
評点 ３：ビタミンＢ１特有の味を区別できるが、やや
弱く感じる
評点 ４：ビタミンＢ１特有の味を区別できる
評点 ５：ビタミンＢ１特有の味をはっきり区別できるEFFECTS OF THE INVENTION The bitterness-preventing effect of vitamin B1 of the liquid preparation for oral use of the present invention is shown by the following test examples. Test Example 1 (Test Method) A sensory test was conducted by 5 persons using the liquid agents obtained in Example 1 and Comparative Examples 1 to 3 described below, and the bitterness-preventing effect of vitamin B1s (octothiamine) was evaluated according to the following evaluation criteria. Was judged. The results are shown in Table 1. (Evaluation Criteria) Score 1: Score that does not feel the taste unique to Vitamin B2: Score that barely feels the taste unique to Vitamin B3: The taste that is unique to Vitamin B1 can be distinguished, but slightly weaker Score 4: Peculiar to Vitamin B1 Taste distinguishing score 5: Vitamin B1 specific taste can be clearly distinguished
【表１】
（注）ＧＣＡ：グルコン酸カルシウム ＬＣＡ：乳酸
カルシウム
表１から明らかなように、この発明の内服用液剤は、ビ
タミンＢ１類の苦味を防止する効果を奏する。[Table 1] (Note) GCA: calcium gluconate LCA: calcium lactate As is clear from Table 1, the liquid preparation for internal use of the present invention has an effect of preventing the bitterness of vitamin B1s.
【００１７】[0017]
【実施例】実施例１
オクトチアミン ５ｍｇ
グルコン酸カルシウム １００ｍｇ
乳酸カルシウム ５０ ｍｇ
グルコノラクトン ３００ｍｇ
精製水 全１００ｍｌ
精製水に上記成分を混合し溶解して、この発明の内服用
液剤を得た。Example 1 Octothamine 5 mg Calcium gluconate 100 mg Calcium lactate 50 mg Gluconolactone 300 mg Purified water 100 ml The above components were mixed and dissolved in purified water to obtain a liquid preparation for internal use of the present invention.
【００１８】実施例２
塩酸フルスルチアミン １０ｍｇ
グルコン酸カルシウム ５００ｍｇ
乳酸カルシウム ２５０ｍｇ
グルコノラクトン ３００ｍｇ
精製水 全１００ｍｌ
精製水に上記成分を混合し溶解して、この発明の内服用
液剤を得た。Example 2 Fursultiamine hydrochloride 10 mg Calcium gluconate 500 mg Calcium lactate 250 mg Gluconolactone 300 mg Purified water 100 ml The above components were mixed and dissolved in purified water to obtain the liquid preparation for internal use of the present invention.
【００１９】比較例１
オクトチアミン ５ｍｇ
グルコン酸カルシウム １００ｍｇ
グルコノラクトン ３００ｍｇ
精製水 全１００ｍｌ
精製水に上記成分を混合し溶解して、内服用液剤を得
た。Comparative Example 1 Octothiamine 5 mg Calcium gluconate 100 mg Gluconolactone 300 mg Purified water 100 ml The above components were mixed and dissolved in purified water to obtain a liquid preparation for internal use.
【００２０】比較例２
オクトチアミン ５ｍｇ
乳酸カルシウム １００ｍｇ
グルコノラクトン ３００ｍｇ
精製水 全１００ｍｌ
精製水に上記成分を混合し溶解して、内服用液剤を得
た。Comparative Example 2 Octothiamine 5 mg Calcium lactate 100 mg Gluconolactone 300 mg Purified water 100 ml The above components were mixed and dissolved in purified water to obtain a liquid preparation for internal use.
【００２１】比較例３
オクトチアミン ５ｍｇ
グルコノラクトン ３００ｍｇ
精製水 全１００ｍｌ
精製水に上記成分を混合し溶解して、内服用液剤を得
た。Comparative Example 3 Octothiamine 5 mg Gluconolactone 300 mg Purified water Total 100 ml The above components were mixed and dissolved in purified water to obtain a liquid preparation for internal use.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 嶋崎 保夫 大阪市中央区道修町３丁目４番７号 藤沢 薬品工業株式会社内 (72)発明者 山川 昌宏 大阪府豊中市蛍池西町１丁目９−16 Ｆターム(参考） 4C076 AA12 BB01 CC24 DD43T FF52 4C086 AA01 AA02 BC83 MA03 MA05 MA17 MA52 NA09 ZC25 ─────────────────────────────────────────────────── ─── Continued front page (72) Inventor Yasuo Shimazaki 3-4-7 Doshomachi, Chuo-ku, Osaka Fujisawa Within Pharmaceutical Industry Co., Ltd. (72) Inventor Masahiro Yamakawa 1-9-16 Hotaruike Nishimachi, Toyonaka City, Osaka Prefecture F term (reference) 4C076 AA12 BB01 CC24 DD43T FF52 4C086 AA01 AA02 BC83 MA03 MA05 MA17 MA52 NA09 ZC25
Claims (4)
有機酸のカルシウム塩を含有することを特徴とする内服
用液剤。1. A liquid preparation for internal use, which contains vitamin B1s, gluconate, and a calcium salt of an organic acid.
である請求項１記載の内服用液剤。2. The internal use liquid preparation according to claim 1, wherein the calcium salt of the organic acid is calcium lactate.
ある請求項１または２記載の内服用液剤。3. The liquid preparation for internal use according to claim 1, wherein the gluconate is calcium gluconate.
請求項１〜３のいずれか１項記載の内服用液剤。4. The liquid preparation for internal use according to claim 1, wherein the vitamin B1s are octothiamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002138002A JP2003335679A (en) | 2002-05-14 | 2002-05-14 | Vitamin b1-containing liquid preparation for internal application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002138002A JP2003335679A (en) | 2002-05-14 | 2002-05-14 | Vitamin b1-containing liquid preparation for internal application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003335679A true JP2003335679A (en) | 2003-11-25 |
Family
ID=29699561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002138002A Pending JP2003335679A (en) | 2002-05-14 | 2002-05-14 | Vitamin b1-containing liquid preparation for internal application |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2003335679A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006052169A (en) * | 2004-08-12 | 2006-02-23 | Wakoudou Kk | Sol-like or gel-like administration assistant food |
| JP2022040725A (en) * | 2020-08-31 | 2022-03-11 | 株式会社タイショーテクノス | Thiamine odor inhibitor, liquid composition, and method for inhibiting occurrence of thiamine odor |
-
2002
- 2002-05-14 JP JP2002138002A patent/JP2003335679A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006052169A (en) * | 2004-08-12 | 2006-02-23 | Wakoudou Kk | Sol-like or gel-like administration assistant food |
| JP2022040725A (en) * | 2020-08-31 | 2022-03-11 | 株式会社タイショーテクノス | Thiamine odor inhibitor, liquid composition, and method for inhibiting occurrence of thiamine odor |
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