JP2003313137A - Composition for treating osteoporosis - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition having high therapeutic effect on osteoporosis and takable not only as a pharmaceutical but also as a food. <P>SOLUTION: This composition for treating osteoporosis contains Jatrophamacrantha and/or its extract. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to Jatropha.
The present invention relates to a pharmaceutical composition and a food composition for treating osteoporosis, which comprises macrantha and / or an extract thereof.

[0002]

2. Description of the Related Art Osteoporosis is the most common disease among senile bone diseases. It is a condition in which the bones are brittle and weak due to degenerative changes due to aging. It is a disease that causes pain and dysfunction due to compression fractures and fractures of the extremities.

The causes of osteoporosis are endocrine causes,
Nutritional, physical, and genetic causes have been pointed out.

[0004]

An object of the present invention is to provide a composition having a high therapeutic effect on osteoporosis, which composition can be taken not only as a medicine but also as a food.

[0005]

The invention according to claim 1 is a pharmaceutical composition for treating osteoporosis, which comprises Jatropha macrantha and / or an extract thereof.

The invention according to claim 2 is the pharmaceutical composition for treating osteoporosis according to claim 1, which further comprises Lep.
A medicinal composition for treating osteoporosis, which comprises an idium mayenii Walp and / or an extract thereof.

[0007] The invention according to claim 3 is the pharmaceutical composition for treating osteoporosis according to claim 1 or claim 2, further comprising epimedim koreanum and / or an extract thereof. It is a therapeutic pharmaceutical composition.

The invention according to claim 4 is the Jatroph
a macrantha and / or its extract, Lep
It is a food composition for treating osteoporosis, which contains an idium meyenii Walp and / or an extract thereof, and an Epimedim koreanum and / or an extract thereof.

The present inventor is searching for a composition having a high therapeutic effect on osteoporosis, which can be taken not only as a medicine but also as a food, and a composition containing Jatropha macrantha, which is a herb medicine plant, is being investigated. The present invention has been completed by finding that the substance has an excellent therapeutic effect on osteoporosis.

The inventor of the present invention is Jatropha macr.
It has been found that a composition containing antha increases bone density. The present invention has been completed based on these findings.

That is, the present invention relates to Jatropha ma.
The present invention provides a composition for treating osteoporosis, which comprises crantha and / or its extract.

In a preferred embodiment of the present invention, the composition for treating osteoporosis of the present invention increases bone density or suppresses its decrease. In a preferred embodiment of the present invention, the composition for treating osteoporosis of the present invention is Le
pidium meeniiWalp and Epimed
Im koreanum and these extracts are further contained.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The composition for treating osteoporosis of the present invention is characterized by containing Jatropha macrantha and / or its extract. Jatropha
Macrantha is a known herbal plant that grows naturally in the Andes Mountains, and is sometimes called "macho".
The composition for treating osteoporosis of the present invention includes Jatrop
Although any part of hamacrantha may be used, sap is particularly preferable. When sap is used, it can be pulverized by spray drying.

The composition for treating osteoporosis of the present invention comprises Jat
In addition to ropha macrantha and / or its extract, other ingredients may be included. Specifically, Lepidium mayenii Walp, Epimedim koreanum, and extracts thereof are particularly preferable. Lepidium mayeniiW
alp and Epimedim koreanum are known herbal plants, and are sometimes referred to as "maca" and "lambs", respectively. These ingredients are equivalent to the amount of the crude drug, Jatropha macrantha1
It is preferable to contain about 0.1 to 100 parts by weight with respect to parts by weight.

L used in the composition for treating osteoporosis of the present invention
As epidium mayenii Walp, L
Although any part of the epidium mayenii Walp may be used, the root is particularly preferable. If roots are used, they can be dried and powdered. Epimedim ko used in the composition for treating osteoporosis of the present invention
As reanum, Epimedim korea
Any part of num may be used, but leaves are particularly preferable. When leaves are used, they can be dried and powdered.

J used in the composition for treating osteoporosis of the present invention
atropha macrantha, Lepidiu
m meeniini Walp and Epimedim
The koreanum may be used as it is or as an extract thereof. When used as an extract,
It may be extracted from these herbal plants by a conventional method.

The dosage form of the composition for treating osteoporosis of the present invention is not particularly limited, but it is usually preferable to prepare it as a composition for oral administration.

The composition for oral administration of the composition for treating osteoporosis of the present invention comprises Jatropha macrantha and / or its extract, as it is, or as the case requires, using a conventional additive used in other preparations. Then, it can be prepared by a conventional method as an oral preparation such as a liquid preparation, a tablet, a granule, a powder, a capsule, a dry syrup and a chewable tablet.

The dose of the therapeutic agent for osteoporosis of the present invention may vary depending on the body weight, symptoms, etc. of the patient, but is usually Jatro.
pha macrantha 1 to 10000 mg / day, preferably 10 to 10 mg / day, for the adult drug equivalent
It is about 00 mg.

The present invention will be specifically described below with reference to examples and pharmacological tests, but the present invention is not limited thereto.

In the following examples, Jatroph
As a macrontha powder, Jatroph
A sap of a macrantha was pulverized by spray-drying to produce Lepidium mayenii
As Walp powder, Lepidium mayen
ii Walp root dried and powdered, E
As pimedim koreanum powder, Ep
The dried and powdered leaves of imedim koreanum were used.

<Example 1> Jatr was added to 100 ml of distilled water.
A liquid preparation prepared by adding 5000 mg of opha macrantha powder and stirring.

<Example 2> Jatr was added to 100 ml of distilled water.
Opha macrantha powder 250mg and Lep
2500 mg of idium mayenii Walp powder
A liquid agent prepared by adding and stirring.

Example 3 Jatr was added to 100 ml of distilled water.
250 mg of opha macrantha powder and Epi
A liquid preparation prepared by adding 2500 mg of medim koreanum powder and stirring.

Example 4 Jatr was added to 100 ml of distilled water.
250 mg of opha macrantha powder and Epi
medim koreanum powder 2500mg and Le
pidium meenii Walp powder 2500m
A liquid preparation prepared by adding g and stirring.

<Example 5> Jatropha macr
antha powder 100mg, Lepidium mey
enii Walp powder 450mg, Epimedim
koreanum powder 450mg, oligosaccharide 200m
A tablet prepared by mixing g and 100 mg of mineral, crushing, granulating, drying, and further adding hardened oil and a flavor to form tablets.

<Pharmacological Test-Bone Density Measurement Experiment> Ovaries were extracted from 28-week-old SD rat females by a conventional method. A testis was extracted from a 28-week-old SD rat male by a conventional method. Rats were divided into groups according to sex, presence / absence of ovary / testis removal, and type of solution to be administered, and a bone density measurement experiment was performed. The groups are as follows. The administration liquid was freely taken from the water bottle during the experiment.

[0028]

[Table 1]

The sixth, fifth, and fourth lumbar vertebrae bone densities were measured before extraction, four weeks after the extraction, and eight weeks after the extraction. The measurement is a DXA (dual energy absorption method) measuring device for small animals (ALOKA, DCS-600).
Was performed using. The measurement results are shown below.

[0030]

[Table 2]

As the results for the normal group (group I and group V) clearly show, the bone density is increased by the growth in the rat at this stage. However, in the group in which the ovaries / testis were simply removed (group II / VI group), the degree of increase in bone density is lower than that in the normal group (group I / V). This is due to the removal of the ovaries and testes. However, the decrease in the degree of increase in bone density as compared with the normal group is due to the removal of the ovaries / testis, which was ingested with the composition containing the components of Jatropha macrantha (group III / IV / VII / VIII). In, it can be seen that it is effectively suppressed to some extent.

[0032]

The composition of the present invention is effective for treating osteoporosis. Moreover, since the composition of the present invention contains a crude drug or an extract thereof as an active ingredient, it is safe for long-term administration and can be used not only as a medicine but also as a food.

[Brief description of drawings]

FIG. 1 is a graph showing the results of bone density measurement of ovariectomized female rats in a pharmacological test.

Claims (4)

[Claims] 1. Jatropha macrantha
And / or an extract thereof, a pharmaceutical composition for treating osteoporosis. 2. The pharmaceutical composition for treating osteoporosis according to claim 1, which further comprises Lepidium mayen.
A pharmaceutical composition for treating osteoporosis, which comprises ii Walp and / or an extract thereof. 3. The pharmaceutical composition for treating osteoporosis according to claim 1 or 2, further comprising Epimedim.
A pharmaceutical composition for treating osteoporosis, which comprises koreanum and / or an extract thereof. 4. Jatropha macrantha
And / or its extract, Lepidium mayen
ii Walp and / or its extract, and Epi
A food composition for treating osteoporosis, which comprises a median koreanum and / or an extract thereof.