JP2003300865A - Cleanser - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cleanser which holds an excellent cleansing force, can also be used by patients of atopic dermatitis, contact dermatitis, or the like, can reduce an itch sense, and gives an excellent sense of use. <P>SOLUTION: This liquid or pasty cleanser is characterized by containing a surfactant as a main cleansing component and an extract of Machilus Thunbergii in an amount of 10 to 50 wt.% based on the total amount of the cleanser. A toilet soap is characterized by containing the waste solvent extract of the Machilus Thunbergii or the bark or leaf powder of the Machilus Thunbergii in an amount of about 0.1 to 15 pts.wt. based on the total amount of the cleanser. These cleansers have each an itch sense-abating action. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a cleansing agent that promotes a reduction in itching sensation, and more particularly, it has excellent detergency and can be used even if suffering from atopy or contact dermatitis. The present invention relates to a cleaning agent which is pleasant to the touch and excellent in usability.

[0002]

2. Description of the Related Art Conventionally, it has been typified by relief of itching and redness associated with skin diseases (eczema, pruritus, pruritus cutis, etc.), allergic skin diseases (atopy, contact dermatitis etc.) and other skin rashes. There is no example of a detergent containing an extract (material) such as root bark, bark or branches and leaves of a Cupressaceae plant of the genus Tabanus for the purpose of relieving or relieving other skin symptoms.

On the other hand, Japanese Patent Application Laid-Open No. 5-97647 discloses that
A cosmetic containing a solvent extract of the bark and leaves of the plant of the genus Tabanula of the Lauraceae family is disclosed. According to this cosmetic, it is disclosed that a whitening effect on the skin and a moist feeling can be obtained. Further, Japanese Patent Laid-Open No. 63-196514 discloses that an organic solvent extract of bark and leaves of the plant of the genus Cupressaceae can be used as a prophylactic / therapeutic agent for protozoal diseases. In addition, the root or bark of the plant of the genus Cupressaceae is used as a medicine for sprained muscles, trochanteric leg pedicles, and the like.

[0004]

DISCLOSURE OF THE INVENTION The present inventor has found that an aqueous solution containing a water-soluble component leached or extracted from the bark of Tabunoki (Machilus Thunbergii, also known as Inugus) causes allergic skin diseases (atopy, contact dermatitis, etc.). ) And skin diseases (eczema, pruritus, pruritus dermatitis, etc.), and the same action effect as above on an aqueous solution containing water-soluble components extracted from root bark, branches and leaves of Tabuki Found that there is.

The object of the present invention is to retain excellent detergency,
It is an object of the present invention to provide a cleansing agent which can be used even if suffering from atopy or contact dermatitis and has an excellent feeling of use that can relieve itching.

[0006]

Means for Solving the Problems The means of the present invention adopted for solving the above-mentioned problems is that the invention according to claim 1 is a liquid or paste-like cleaning agent having an external appearance that has a relieving effect on pruritus. And its main cleaning component is a surfactant, and the extract of the plant of the genus Cupressaceae
Is 0.1 to 80% by weight (preferably 10 to 5)
The substance contained in a proportion of 0% by weight is the gist.

According to the second aspect of the present invention, the water-solvent extract of the plant of the Lauraceae family Lauraceae is contained in an amount of 0.1 to 2.0 parts by weight per 100 parts by weight of the soap base, and the appearance shape thereof is A cleaning agent characterized by being solid and having an action of relieving itching is summarized.

According to the third aspect of the present invention, the powder of bark of the Lauraceae plant of the Lauraceae family, the powder of leaf of the leaf tree, or a mixture of both is 0.1 to 100 parts by weight of the soap base.
A cleaning agent characterized by being contained in a proportion of 15 parts by weight (preferably 0.5 to 10 parts by weight), having a solid external shape and having a relieving action for pruritus. And

A fourth aspect of the present invention is the cleaning agent according to any one of the first to third aspects, wherein "the plant is Tabulberry (Machilus Thunbergii) or Phyllotus chinensis (Machijus ja).
ponica) is the gist.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The mode for carrying out the present invention will be described below based on Examples, but these are merely typical examples.

First, a plant of the genus Tabanus is an evergreen tree belonging to the Lauraceae family. In Japan, Tabuki (Machilus
Thunbergii), also known as the Inugus, or Hosobatab (Machiju)
s japonica), also known as akagashi, grows naturally. Tabunoki is an evergreen tree that is distributed in the central southern part of Honshu, Shikoku, Kyushu, Okinawa, Korea, China, etc. On the other hand, Hosoba is an evergreen tree that is distributed west of Honshu Kinki, Ogasawara, Shikoku, Kyushu, Okinawa, and South Korea, and grows naturally in the mountains of relatively warm regions. The bark of this tree is
In Korea, it is used as a substitute for "Koboku," and is also called "thumb." The bark of magnolia family Magnolia obovata is used for "Koboku".
In China, the bark of Magnolia ojjicinalis is used.

Also, the above Hosobatab, Machil from India
us Mascrantrha, Taiwanese genus plant
Kusanoi), Alisantab (Machilus arisaensis),
Other tabula species such as Aeotab (Machilus zuihoensisi), Aodasoki (Mascrantrha pseudolongifollia) can also be used, and the powder of tabuki leaves and bark is used as a raw material of incense under the name of tab powder, so purchase this. It can also be used.

The extract (product) of the plant of the genus Tabanus can be prepared by the following method.

The bark, root bark or branches and leaves of tabuki are fragmented and water is added, or water is added to tab powder and leaching or decocting is performed to extract water-soluble components. However, the physical conditions such as the extraction time and the temperature are matters that are appropriately determined depending on the type and shape of the raw material (particularly, the degree of fragmentation and the degree of cutting). Known water-soluble components include quercetin, distilin, dl-catechin, and mucus. The constituent monosaccharides of mucus are D-xylose and L-arabinose, and the main chain is composed of β-bond of D-xylopyranose,
It is an arabinoxylan having a structure in which L-arabinofuranose branches as a side chain (Murase et al., Agricultural.,
45 (4), 156-161, (1971)).

Extract (substance) obtained by slicing the bark, root bark or leaves of tabuki or extracting tab powder with a hydrophilic solvent such as ethanol, methanol or acetone.
Is concentrated under reduced pressure to give a soft extract, and water is added to this soft extract to prepare an aqueous solution.

The bark, root bark, or branches and leaves of Tabuki are cut into pieces, and infiltration of outside air is blocked to dry-distill them as in the case of producing wood vinegar. The obtained dry distillation liquid also corresponds to the extraction liquid (product) according to the present invention. In this case, for example, poorly soluble organic components such as low-boiling point alkaloids may be mixed in, so the organic components in the dry distillation liquid may be extracted and removed with an organic solvent, or separated and removed by another known separation method. preferable.

It is preferable to concentrate the extract (substance), dry-distilled liquid or the like to form a high-concentration solution, and to dilute it with water before use because it can be stably stored for a long period of time.

Further, the extract (substance), the dry distillation liquid, and the partially purified product thereof are pulverized by a freeze-drying method or a spray-drying method, erranded, dissolved in water, and further diluted with water if necessary. You may do so.

Next, as the surfactant used in the present invention, an anionic surfactant, a cationic surfactant, an amphoteric surfactant, a nonionic surfactant can be used alone or in combination thereof, There is no particular limitation.

As the anionic surfactant, higher fatty acid salt (soap), polyoxyethylene (POE) alkyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, dialkyl sulfosuccinate, Higher fatty acid amide sulfonate, alkyl allyl sulfonate, higher alcohol sulfate ester salt, POE alkyl ether sulfate ester salt, glycerin fatty acid ester sulfate ester salt, higher fatty acid alkylolamide sulfate ester salt, alkyl phosphate ester salt, acyl glutamic acid A salt, an acyl sarcosinate, an acyl amino acid salt such as acyl-β-alanine, a collagen hydrolyzate acyl compound and the like can be applied, and any of them is an alkali metal salt such as sodium or potassium, or an alkali metal such as calcium or magnesium. It is used as an alkaline earth metal salt, an ammonium salt, an organic amine salt such as monoethanolamine, dietanolamine, and triethanolamine, and a basic amino acid salt such as L-lysine.

Any of the above-mentioned higher fatty acids can be used regardless of the number of constituent carbons or the type of salt thereof, but particularly preferred are higher fatty acids having 8 to 24 carbon atoms. More specifically, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, saturated linear fatty acids represented by arachidic acid, myristooleic acid, palmitooleic acid, oleic acid, elaidic acid. , Eicosenoic acid, linoleic acid, linolenic acid, eicosadienoic acid,
Eicosatrienoic acid, an unsaturated straight chain fatty acid represented by arachidonic acid and the like, hydroxydodecanoic acid, hydroxytetradecanoic acid, hydroxyhexadecanoic acid, saturated hydroxy fatty acid represented by hydroxyeicoic acid and the like,
Unsaturated hydroxy fatty acids typified by lysine oleic acid, isolauric acid, isomyristic acid, isopalmitic acid, isostearic acid, isoacids typified by isoarachidic acid and the like can be mentioned.

Examples of the above-mentioned cationic surfactants include alkyl amine salts, polyamine fatty acid salts, alkyl quaternary ammonium salts such as alkyl trimethyl ammonium salts, and the like.

As the above-mentioned amphoteric surfactant, amino acid type, betaine type, sulfuric acid ester type, sulfonic acid type, phosphoric acid ester type amphoteric surfactant and the like can be used.

As the nonionic surfactant, POE is used.
Examples thereof include ethylene lauryl ether.

The blending amount of these surfactants is not particularly limited, but is preferably 2% by weight or more, more preferably 5%.
It is more than weight%. If it is 2% by weight or less, it is difficult to obtain satisfactory cleaning power and foamability as a cleaning agent.

Further, in addition to the surfactant, amine oxide and fatty acid diethanolamide may be blended in order to improve the foaming property and to give an appropriate viscosity, and a pearl brightener such as fatty acid glycol diester and distearic acid. By using together with a thickener such as polyethylene glycol or hydroxyethyl cellulose, it becomes possible to improve long-term stability over time.

When magnesium sulfate or magnesium nitrate is added to the cleaning agent of the present invention, a rust preventive action for stainless steel can be obtained and corrosion of water pipes and stainless steel bathtubs can be prevented, and calcium chloride is added. Then, the final product can be prevented from freezing, and the final product can be stabilized by adding magnesium chloride, calcium nitrate, or calcium acetate, and aluminum chloride, aluminum sulfate,
Alternatively, it is preferable to add aluminum nitrate to obtain an astringent effect on the skin, and to add magnesium acetate to obtain a deodorizing effect.

Incorporation of inorganic and organic alkali salts of amino acids, typified by sodium glutamate, inorganic and organic acid salts of amino acids, or calcium lactate improves the usability such as feeling of touch and moisture retention of skin. Plan
When urea is added, the moisturizing property can be improved.

In addition to the above components, for example, a wetting agent, a coloring agent, a preservative, a texture improving agent, a fragrance, which is usually used in a detergent,
A sterilizing or antibacterial agent, an anti-inflammatory agent, an ultraviolet absorber, etc. can be used within a range that does not impair the effects of the present invention. .

The cleansing agent according to the present invention can be widely used as a skin cleansing agent such as a whole body cleansing agent, a hair and scalp cleansing agent and a face cleansing agent.

[0031]

The present invention will be described in more detail with reference to the following examples. However, the present invention is not limited to these examples, and the mixing ratio and the like can be appropriately designed and changed. .

First, the method for producing the extract of the plant of the genus Tabanus used in the examples will be described.

(Extract 1) Taboki (Machilus Thunber)
gii) 40g of raw material obtained by slicing the bark into 4 parts of purified water
00 ml was added, and the mixture was decocted at 60 to 80 ° C. for 48 hours, and soluble components were filtered out to prepare Extract 1.

(Extract 2) Taboki (Machilus Thunber)
40 g of raw material obtained by dividing the root bark of gii) into 4 g of purified water
00 ml was added, and the mixture was digested for 48 hours (35 to 45 ° C.), the soluble component was filtered off, and the extract 2 was prepared.

(Extract 3) Taboki (Machilus Thunber)
Raw material 40 obtained by dividing the branches and leaves (including heartwood) of gii) into pieces
400 ml of purified water was added to g, and percolation was performed for 24 hours by a percolation method (room temperature 1 to 35 ° C.) to produce an extract 3.

(Extract 4) Taboki (Machilus Thunber)
40 g of dried raw material obtained by dividing the bark of gii into 400 m of water
1 was added, and the mixture was cold-soaked (15 to 25 ° C.) for 48 hours, and soluble components were separated by filtration. Then, the extract was freeze-dried to obtain an amorphous powder, redissolved in 200 ml of ethanol, and allowed to stand overnight, and then the precipitate part and the soluble part were separated, and an itching effect was observed in the soluble part. .

Alkaloids could not be confirmed from the precipitate, and the main component was arabinoxylan having a structure in which the main chain was β-bond of D-xylopyranose and L-arabinofuranose was branched as a side chain. It turned out that

It was found that the soluble portion contained sugars and polyphenols, and when separated and analyzed by chromatography, quercetin, catechin and the like could be detected.

When the extracts 1 to 3 were analyzed in the same manner, the main components of the soluble part and the precipitate were the same as those of the extract 4.

Next, an example of the formulation of a typical detergent (body soap) having a liquid appearance and containing the extract of Tubus cypress will be illustrated.

Formulation Example 1 1) Extract 1 15 to 35% by weight 2) N-coconut oil fatty acid acylglycine potassium 8 to 18% by weight 3) Diethanol laurate 3 to 8% by weight 4) Polyethylene glycol distearate 0.5 to 4% by weight 5) More specifically, for example, 12.7 parts by weight of potassium N-coconut oil fatty acid acylglycine in a mixed solution of 50 parts by weight of purified water and 1, 2.5 parts by weight of extract. Then, 5 parts by weight of lauric acid diethanolamide and 2.5 parts by weight of polyethylene glycol distearate are added and dissolved by heating at about 80 ° C. When the mixture is allowed to cool and purified water is added to adjust the total amount to 100 weight, the detergent of Formulation Example 1 can be produced.

Formulation Example 2 1) Extract 1 20 to 40% by weight 2) N-coconut oil fatty acid amidoplobetaine 3 to 10% by weight 3) Potassium soap base 5 to 15% by weight 4) Coconut oil fatty acid diethanolamide 1 ~ 6 wt% 5) Stearylmethylammonium chloride 0.1-1 wt% 6) Purified water Formulation Example 2 can also be produced by the same procedure as in Formulation Example 1 above. The above-mentioned prescription examples 1 and 2 are prescription examples of the liquid detergent for the whole body (body soap).

Formulation Example 3 1) Extract 2 10 to 30% by weight 2) O- [2-Hydroxyloxy-3- (trimethylammonio) propyl] chloride 0.1 to 2% by weight of human hydroxycellulose 3) Lauryldimethylaminoacetic acid betaine 0.3 to 1.5% by weight 4) Polyoxyethylene sulfosuccinate lauryl disodium 8-15% by weight 5) Coconut oil fatty acid diethanolamide 1-8% by weight 6) Purified water formulation example 4 1) Extract 2 15-35% by weight 2) Lauryl Dimethylaminoacetic acid betaine 0.3 to 1.5% by weight 3) Sodium polyoxyethylene lauryl ether acetate 7 to 17% by weight 4) Coconut oil fatty acid diethyl alcohol 1 to 8% by weight 5) Stearyltrimethylammonium chloride 6) Prescription water or more Nos. 3 and 4 are prescriptions for a liquid detergent for hair and scalp, and can be produced by the same procedure as in Prescription Example 1 above.

Formulation Example 5 1) Extract 3 25 to 45% by weight 2) N-coconut oil fatty acid amidoplobetaine 8.5 to 18.5% by weight 3) Diethanol laurate 1 to 8% by weight 4) Purified water Formulation Example 6 1 ) Extract 3 25 to 50 wt% 2) Potassium soap substrate 10 to 20 wt% 3) Lauric acid diethanolamide 1 to 8 wt% 4) Purified water formulation example 7 1) Extract 3 25 to 50 wt% 2) Polyoxyethylene lauryl ether 10 to 20% by weight 3) Lauric acid diethanolamide 1 to 8% by weight 4) Purified water The above formulation examples 5 to 7 are liquid detergents for washing hands, fingers, arms and the like ( Body soap) prescription example,
It can be produced by the same procedure as in Formulation Example 1 above.

When the foaming characteristics of the cleaning agents of the above formulation examples were compared with the foaming characteristics of the comparative examples prepared by substituting purified water for the Tabuki extract (product), the foaming characteristics of both were almost the same. It was about the same, and it was found that the Tubus cypress extract did not affect the cleaning action.

Next, when a questionnaire survey was conducted on the feeling of use when using the cleaning agent of each of the above prescription examples,
The following answers were obtained.

1) The itching sensation of the whole body was great every time when sweating, and the itchiness was felt even when the commercially available body shampoo was used. However, when the body shampoo of Prescription Example 1 was used, itching after use was observed. There was almost no feeling (female: 13
Age, 37 years old).

2) Itching was itchy on the rub area (inner thigh) and buttocks, but when the body shampoo of Prescription Example 2 was used, the itching sensation was relieved and almost no itchiness was felt.

3) It has a moisturizing sensation on the skin and retains a smooth feeling for a long time as compared to a commercially available body shampoo. 4) Washing hands with the cleaning agent of Prescription Example 5 shows good defoaming and smooth feeling. was there.

5) The affected area of atopy had a strong itching sensation, and the hot water at the time of bathing caused the area to be sore and painful that even the commercially available body shampoo introduced at the pharmacy could be used only once or twice a week. However, even if the body shampoo of Prescription Example 1 was used, it did not bleed into the skin and there was no itchiness,
A moist feeling was obtained (male: 58 years old).

6) I had atopic symptoms on my whole body, and I was using baby soap for infants, but my skin was still dry and itchy, and it became red. When the body shampoo of Formulation Example 2 was used, itching also stopped, the moist feeling lasted for a long time, and it was extremely comfortable (male: 48 years old).

There were no physiological or pathological complaints of concern from users who experienced the use, and no one complained of discomfort or discomfort during use.

Next, a so-called toilet soap having a solid appearance will be described.

Toilet soap of the first embodiment: Tab powder (bark) 3
Add 1 L of water to 0-300 g, 20-60 minutes, 60-
The extract 5 was prepared by decocting at 80 ° C. and separating soluble components by filtration, and the extract 5 was added to 100 parts by weight of 100 parts by weight of sodium soap base (neat soap; water content: 10 to 15%).
1% to 2.0 parts by weight were added, and the mixture was kneaded at about 40 ° C. and then molded to manufacture the toilet soap of the first example.

When the content of the aqueous solvent extract is 0.1 parts by weight or less, the expected effect of relieving the itching sensation cannot be obtained,
If the blending amount is 2.0 parts by weight or more, the final product detergent (toilet soap) tends to be too soft and difficult to mold.

Toilet soap of the second embodiment : 0.1 to 15 parts by weight of tab powder (bark or leaves) (preferably 0.1% by weight) per 100 parts by weight of sodium soap base (neat soap; water content: 10 to 15%). 5 to 10 parts by weight, more preferably 0.5 to 5 parts by weight) was added, and the mixture was kneaded at about 40 ° C. and then molded to produce the toilet soap of the second example.

When the amount of the powder of the plant bark or the powder of leaves is 0.1 parts by weight or less, the expected relieving action of the itchiness cannot be obtained, and the amount of each mixture is 10 parts by weight or more. , There is a tendency that sufficient foaming characteristics cannot be obtained.

When the men (58 years old, 48 years old) and women (37 years old) used the toilet soaps of the first and second examples once or more daily, and a questionnaire about the feeling of use was found, Responded that the same feeling of use as the body shampoo according to the present invention can be obtained.

The active ingredient contained in the extract according to the present invention is considered to be polyphenols represented by quercetin and catechin, but its actual condition is not clear. Therefore, the mechanism of action related to the antipruritic effect is also unknown.

[0060]

EFFECTS OF THE INVENTION As described above, Tabuki (Machilus Thunbergi)
Leaching from i) bark, root bark, branches and leaves, or powders of these
Detergents containing the extract or the powder obtained by brewing or carbonization are allergic skin diseases (atopy, contact dermatitis, etc.) and skin diseases (eczema, pruritus, pruritus cutaneus, etc.), and other It can be used even by a person suffering from a skin eruption, and can relieve pruritus after use, resulting in extremely effective effects.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) C11D 17/08 C11D 17/08 // A61K 35/78 A61K 35/78 C (72) Inventor Toshi Kondo Mie 1-23-4 Yabashi, Suzuka-shi, Japan (72) Inventor Hidenori Kondo 13F term at 1612 Tsubakiichinomiyacho, Suzuka-shi, Mie (reference) 4C083 AA111 AA112 AC242 AC642 AC662 AC692 AC712 AD072 BB01 CC23 CC38 DD21 DD22 DD23 EE13 4C088 AB33 AC01 BA09 MA16 MA27 MA34 MA63 ZA89 4H003 AB03 AB09 AB44 AC13 BA01 BA12 EB09 EB43 ED02 FA21 FA33

Claims (4)

[Claims] 1. A cleaning agent having a liquid or paste-like appearance that has a relieving effect on itching sensation, the main cleaning component of which is a surfactant, and a water extract of a Cupressaceae plant ) Is 10
A cleaning agent, characterized in that it is contained in a proportion of ˜50% by weight. 2. A water solvent extract of the plant of the genus Tabinus, belonging to the Lauraceae family, is contained in an amount of 0.1 to 2.0 parts by weight per 100 parts by weight of the soap base, and its appearance is solid. A cleaning agent characterized by having a relieving effect on itching sensation. 3. Percent by weight of soap base, either powder of bark of the Lauraceae plant of the Lauraceae family, leaf powder, or a mixture of both is contained in a proportion of 0.1 to 15 parts by weight. A cleaning agent characterized by having a solid external shape and having a relieving action of a pruritus sensation. 4. The plant is tabulberry (Machilus Thunber).
The cleaning agent according to any one of claims 1 to 3, wherein the cleaning agent is gii) or Hachiba tab (Machijus japonica).