JP2003259861A5 - - Google Patents
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- JP2003259861A5 JP2003259861A5 JP2003029752A JP2003029752A JP2003259861A5 JP 2003259861 A5 JP2003259861 A5 JP 2003259861A5 JP 2003029752 A JP2003029752 A JP 2003029752A JP 2003029752 A JP2003029752 A JP 2003029752A JP 2003259861 A5 JP2003259861 A5 JP 2003259861A5
- Authority
- JP
- Japan
- Prior art keywords
- accumulated
- bacterium according
- purine nucleoside
- purine
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【特許請求の範囲】
【請求項１】ポリミキシンＢおよび／またはコリスチンによる生育阻害に対する耐性を有し、かつプリンヌクレオシド生産能を有するバチルス属細菌。
【請求項２】バチルス・ズブチリスに属する請求項１に記載の細菌。
【請求項３】バチルス・アミロリケファシエンスに属する請求項１に記載の細菌。
【請求項４】前記プリンヌクレオシドはイノシンである請求項１〜３のいずれか一項に記載の細菌。
【請求項５】前記プリンヌクレオシドはキサントシンである請求項１〜３のいずれか一項に記載の細菌。
【請求項６】前記プリンヌクレオシドはグアノシンである請求項１〜３のいずれか一項に記載の細菌。
【請求項７】請求項１〜６のいずれか一項に記載の細菌を培地で培養し、プリンヌクレオシドを生成して培地中に蓄積させ、同培地からプリンヌクレオシドを採取することを特徴とするプリンヌクレオシドの製造方法。
【請求項８】請求項１〜６のいずれか一項に記載の細菌を培地で培養し、生成、蓄積したヌクレオシドをリン酸化し、生成、蓄積したプリンヌクレオチドを採取することを特徴とするプリンヌクレオチドの製造方法。
【請求項９】前記プリンヌクレオチドは５'−イノシン酸、５'−キサンチル酸または５'−グアニル酸である請求項８に記載の方法。
【請求項１０】請求項５に記載の細菌を培地で培養し、生成蓄積したキサントシンをリン酸化し、生成、蓄積した５'−キサンチル酸をアミノ化し、そして生成蓄積した５'−グアニル酸を採取することを特徴とする５'−グアニル酸の製造方法。
[Claims]
1. A bacterium belonging to the genus Bacillus, which is resistant to growth inhibition by polymyxin B and / or colistin and has a purine nucleoside-producing ability.
2. The bacterium according to claim 1, which belongs to Bacillus subtilis.
3. The bacterium according to claim 1, which belongs to Bacillus amyloliquefaciens.
4. The bacterium according to claim 1, wherein said purine nucleoside is inosine.
5. The bacterium according to claim 1, wherein said purine nucleoside is xanthosine.
6. The bacterium according to claim 1, wherein the purine nucleoside is guanosine.
7. The method according to claim 1, wherein the bacterium according to any one of claims 1 to 6 is cultured in a medium, a purine nucleoside is generated and accumulated in the medium, and the purine nucleoside is collected from the medium. A method for producing a purine nucleoside.
8. A purine comprising culturing the bacterium according to claim 1 in a medium, phosphorylating the produced and accumulated nucleosides, and collecting the produced and accumulated purine nucleotides. A method for producing a nucleotide.
9. The method according to claim 8 , wherein said purine nucleotide is 5'-inosinic acid , 5'-xanthylic acid or 5'-guanylic acid .
10. The bacterium according to claim 5, which is cultured in a medium, phosphorylates xanthosine produced and accumulated, aminates 5'-xanthylic acid produced and accumulated, and converts 5'-guanylic acid produced and accumulated. A method for producing 5'-guanylic acid, which comprises collecting.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002103333 | 2002-02-11 | ||
| RU2002103333/13A RU2260040C2 (en) | 2002-02-11 | 2002-02-11 | Method for production of inosibe and inosine-5'-monophosphate, bacterium strain of genus bacillus as inosine producer (variants) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003259861A JP2003259861A (en) | 2003-09-16 |
| JP2003259861A5 true JP2003259861A5 (en) | 2006-03-02 |
| JP4385611B2 JP4385611B2 (en) | 2009-12-16 |
Family
ID=28673168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003029752A Expired - Lifetime JP4385611B2 (en) | 2002-02-11 | 2003-02-06 | Method for producing purine nucleosides and nucleotides |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4385611B2 (en) |
| RU (1) | RU2260040C2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101089559B1 (en) * | 2004-03-31 | 2011-12-06 | 아지노모토 가부시키가이샤 | Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus Bacillus or Escherichia |
| RU2320717C2 (en) * | 2005-09-14 | 2008-03-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Method for producing purine nucleosides by fermentation method using microorganisms belonging to bacillus genus |
| RU2333949C2 (en) * | 2005-09-14 | 2008-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | STRAINS OF BACTERIA Bacillus subtilis AND Bacillus amyloliquefaciens - PRODUCENTS OF INOSINE AND METHOD FOR PRODUCING INOSINE USING THEM |
| SK287315B6 (en) | 2006-06-02 | 2010-06-07 | Biotika, A. S. | A method for polymyxin B isolation from fermented soil |
| SK287293B6 (en) | 2006-06-15 | 2010-05-07 | Biotika, A. S. | A method for fermentation of polymyxin B by means of productive microorganism Bacillus polymyxa |
| JP5434597B2 (en) | 2008-01-11 | 2014-03-05 | 味の素株式会社 | Plant disease resistance enhancer and plant disease control method using the same |
| KR101916611B1 (en) * | 2017-12-15 | 2018-11-07 | 씨제이제일제당 (주) | Novel polypeptide and method of producing IMP using the same |
| EP3861109A1 (en) | 2018-10-05 | 2021-08-11 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| CN111830153A (en) * | 2020-07-14 | 2020-10-27 | 南京品生医学检验实验室有限公司 | Method for detecting concentrations of polymyxin B1and polymyxin B2 in serum |
| CN111665307A (en) * | 2020-07-14 | 2020-09-15 | 南京品生医疗科技有限公司 | Kit for detecting concentrations of polymyxin B1and polymyxin B2 in serum |
-
2002
- 2002-02-11 RU RU2002103333/13A patent/RU2260040C2/en active
-
2003
- 2003-02-06 JP JP2003029752A patent/JP4385611B2/en not_active Expired - Lifetime
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