JP2003250488A - Food composition and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a powder-containing tablet capable of preventing a low hardness tablet and the abrasion, breaking, chipping, etc., of the tablet occurring in the tablet highly incorporated with a substance having a very low forming property such as beer yeast powder, and excellent in stability as a product. <P>SOLUTION: This powder-containing tablet is characterized by containing one kind or more selected from a group consisting of beer yeast powder, mineral yeast powder, hem iron powder, chitosan powder, a protein powder, royal jelly powder and a plant powder, and an edible soluble fiber by 0.01-50.00 pt.wt. The method for producing the powder-containing tablet is characterized by granulating one king or more selected from a group consisting of beer yeast powder, mineral yeast powder, hem iron powder, chitosan powder, a protein powder, royal jelly powder and a plant powder by using an aqueous solution of the edible soluble fiber and tableting. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a tablet having a high content of a powdered active ingredient such as brewer's yeast powder, and a method for producing the same.

[0002]

2. Description of the Related Art In order to efficiently ingest the nutritional components contained in brewer's yeast powder, the amount taken per day is very large. It is necessary to reduce the compounding amount of the additive to be compounded as.

However, when a tablet containing a large amount of brewer's yeast powder is produced, its moldability is very poor, so that an appropriate tablet hardness cannot be obtained and abrasion, cracking, chipping, etc. of the tablet occur. Is being watched.

JP-A-55-162984 is known as a prior art for solving such a problem, but it is a food additive such as light anhydrous silicic acid, aluminum silicate, aluminum hydroxide and magnesium aluminometasilicate. As an additive that is not permitted as above is essential, it lacks versatility.

As a related technique, Japanese Patent Laid-Open No. Sho 61-61
However, the content of brewer's yeast powder is as low as 10 to 40% by weight. In a similar manner
5373, Japanese Patent Publication No. 06-29190, JP-A-63-21
1224, JP 07-324033 A, JP 10
No. 225285 and Japanese Patent Application Laid-Open No. 2000-178662 are known, but their purpose is different from the technique for increasing the hardness of tablets. Further, as for JP-A-2001-342129, a lubricant for hardened oil and fat must be added.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a tablet having a high content of powder such as brewer's yeast powder and having satisfactory hardness as a tablet, and a method for producing the tablet.

[0007]

Means for Solving the Problems When the present invention produces tablets containing a large amount of powder such as brewer's yeast powder, by adding soluble dietary fiber and, if necessary, a calcium material, The present inventors have found that the tablet hardness of a tablet containing a large amount of powder such as brewer's yeast powder can be increased, and that a tablet containing a large amount of powder having excellent stability as a product can be obtained, which led to the present invention. An object of the present invention is to provide a tablet having a high content of powder such as brewer's yeast powder, and a method for producing the same.

That is, the present invention is as follows: Beer yeast powder, mineral yeast powder, heme iron powder,
Chitosan powder, protein powder, royal jelly powder,
1. A powder-containing tablet comprising one or more kinds selected from the group consisting of: and vegetable powder, and soluble dietary fiber; Beer yeast powder, mineral yeast powder, heme iron powder,
Chitosan powder, protein powder, royal jelly powder,
And at least one selected from the group consisting of plant powder and 5
2. The powder-containing tablet according to 1, wherein the tablet contains 0.00 to 99.99 parts by mass. 3. The powder-containing tablet according to 1, characterized in that it contains 0.01 to 50.00 parts by mass of soluble dietary fiber. Granulating and tableting one or more selected from the group consisting of beer yeast powder, mineral yeast powder, heme iron powder, chitosan powder, protein powder, royal jelly powder, and plant powder using an aqueous soluble dietary fiber solution. 4. A method for producing a powder-containing tablet, which is characterized by: Beer yeast powder, mineral yeast powder, heme iron powder,
Chitosan powder, protein powder, royal jelly powder,
And at least one selected from the group consisting of vegetable powder, soluble dietary fiber, and a calcium material, and a brewer's yeast powder-containing tablet, 6. 6. The powder-containing tablet according to 5, wherein the soluble dietary fiber to be blended is 0.01 to 50.00 parts by mass and the calcium material is 0.10 to 49.99 parts by mass. Beer yeast powder, mineral yeast powder, heme iron powder, chitosan powder, protein powder, royal jelly powder, and one or more selected from the group consisting of plant powder are granulated using an aqueous soluble dietary fiber solution, and a calcium material is blended. The present invention relates to a method for producing a powder-containing tablet, which is characterized by being compressed into tablets, and a powder-containing tablet obtained by the production method according to 8.4 or 7.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention is described in detail below.
As powder to be contained in the tablet, minerals are incorporated into the yeast cells, such as brewer's yeast powder, zinc yeast, magnesium yeast, iron yeast, selenium yeast, chromium yeast, manganese yeast, copper yeast, molybdenum yeast, and iodine yeast. Heme iron powder, chitosan powder, protein powder, royal jelly powder, green tea powder, kale powder, barley obtained by enzymatic treatment of mineral yeast powder and hemoglobin, followed by ultrafiltration or isoelectric precipitation, and drying. Active ingredients such as plant powders such as young leaf powder can be used.

Such a powdered active ingredient can be incorporated in a tablet in an amount of 50% by mass or more. In particular, when brewer's yeast powder, which has a large daily intake, is used as the powder active ingredient, the amount of the additive compounded can be reduced, and an excellent tablet suitable for a large intake can be obtained. The beer yeast powder is mixed in the tablet in an amount of 50% by mass or more, preferably 70% by mass or more, and particularly preferably 90% by mass or more.

The brewer's yeast powder is generally obtained when the beer is mainly fermented, and the raw yeast recovered is sieved, debittered, washed, centrifuged, washed with water, drum-dried, crushed and sieved. Therefore, a commercially available product can be used regardless of the manufacturing method.

As the soluble dietary fiber in the present invention,
Guar gum, xanthan gum, locust bean gum,
Examples thereof include soluble dietary fibers derived from natural products such as tragacanth gum, karaya gum, gum arabic, gelatin and pullulan, and it is particularly preferable to use guar gum.

Examples of the calcium material include dolomite, egg shell calcium, scallop shell calcium, oyster shell calcium, coral calcium, sea urchin shell calcium, petrified seaweed calcium, pearl calcium, beef bone calcium, fish bone meal calcium, fish scale calcium, milk calcium. Calcined calcium such as, or high natural calcium content such as uncalcined calcium, or calcium carbonate, calcium phosphate, calcium lactate, calcium gluconate,
Examples thereof include calcium salts such as calcium citrate and calcium chloride, and all commercially available food products can be used. In the present invention, the above calcium materials can be used alone or in combination of two or more kinds.

A general method for producing a natural calcium-enriched product is a series of processes in which raw materials are selected, coarsely crushed, sieved, heat sterilized, and then crushed to a predetermined particle size. Dolomite, for example, roughly crushes rough dolomite,
It is obtained by heat sterilization and crushing. The general method of producing egg shell calcium is to select raw materials, coarsely crush,
After sieving, it is sterilized by heating, for example, at 100 ° C., and pulverized to have a predetermined particle size. In general, for coral calcium, first, coral sand or coral fossil is collected, washed with water and then foreign matter is removed, and then, for example, 100 ° C.
After being heated and sterilized and dried as described above, it is manufactured by a method of pulverizing to a predetermined particle size.

Next, of the calcium salts, for example, calcium carbonate is a method in which calcium oxide obtained by calcining limestone is reacted with water to form calcium hydroxide, and carbon dioxide is passed through this to obtain colloidal or light calcium carbonate. Alternatively, there is a method of reacting a calcium carbonate solution with a sodium carbonate solution to obtain precipitated calcium carbonate, or a method of pulverizing natural limestone to obtain heavy calcium carbonate. Further, there are calcium salts obtained by reacting calcium carbonate or calcium oxide with various acidic solutions. For example, calcium lactate is generally produced by adding calcium carbonate as a neutralizing agent to obtain crude calcium lactate during the lactic acid fermentation and purifying it, or by adding calcium carbonate to synthetic lactic acid.

The amount of soluble dietary fiber used in the present invention is 0.01 to 50.00% by mass, preferably 0.1.
01 to 30.0% by mass, particularly preferably 0.01 to 2
It is 0.0 mass%. The soluble fiber content is 50.
When it exceeds 0% by mass, the content of the powdered active ingredient such as brewer's yeast powder is reduced correspondingly, and as a result, the daily intake must be increased and the burden on the ingestor becomes large. If the amount of soluble dietary fiber is less than 0.01% by mass, appropriate tablet hardness may not be obtained, and tablets may be worn out, cracked, chipped, etc. desirable.

The soluble dietary fiber is 0.0001 to 1 part by mass, preferably 0.001 part by weight, based on the powdered active ingredient.
~ 0.3 parts by mass can be added.

Similarly, the blending amount of the calcium material in the present invention is 0.10 to 49.99 mass%, preferably 0.50 to 20.00 mass%, and particularly preferably 1.00 to 10.00. It is% by mass. When the content of calcium material exceeds 49.99% by mass, the content of brewer's yeast powder decreases accordingly, and as a result, the daily intake has to be increased, and the burden on the ingestor is large. Become. In addition, the compounding amount of calcium material is 0.10 mass%
If it is less than the above range, an appropriate tablet hardness cannot be obtained, and the tablet may be worn out, cracked, chipped, or the like, so that it is preferably within the above range.

The calcium material is 0.0001 to 2.0 parts by mass, preferably 0.0
01 to 1.0 parts by mass can be added.

In the present invention, an inactive component may be contained in addition to the soluble dietary fiber and the calcium material for the purpose of enhancing the productivity. Such inactive ingredients include dextrin, wheat starch, rice starch, corn starch, potato starch, pregelatinized starch, partially pregelatinized starch,
Lactose, maltose, reduced lactose, reduced maltose, sorbitol,
Mannitol, erythritol, xylitol, white sugar,
Glucose, agar, soybean dietary fiber, crystalline cellulose, methyl cellulose, ethyl cellulose, low-substituted hydroxypropyl cellulose, hydroxypropyl methyl cellulose phthalate, hydroxypropyl methyl cellulose acetate succinate, carboxymethyl ethyl cellulose, cellulose acetate phthalate, hydroxyethyl cellulose, hydroxypropyl starch, Polyvinylpyrrolidone, carmellose, carmellose calcium, carmellose sodium, croscarmellose sodium, sodium carboxymethyl starch, hardened vegetable oil, vegetable oil powder, carnauba wax, cacao oil powder, sucrose fatty acid ester, stearic acid, magnesium stearate, stearin Aluminum acid, calcium stearate, silicon dioxide, It can be given torque, aluminum silicate, calcium hydrogen phosphate, and the like.

Further, according to the present invention, in addition to brewer's yeast powder, for example, zinc yeast, magnesium yeast, iron yeast,
Mineral yeast powder, such as selenium yeast, chrome yeast, manganese yeast, copper yeast, molybdenum yeast, and iodine yeast, in which minerals are incorporated into yeast cells, and hemoglobin are treated with an enzyme, followed by ultrafiltration or isoelectricity. As heme iron powder, chitosan powder, protein powder, royal jelly powder, and plant powder obtained by performing point precipitation and drying,
Even when producing tablets containing a high content of active ingredients such as green tea powder, kale powder, and barley young leaf powder, low tablet hardness, abrasion,
It is possible to prevent cracks and chips.

The tablet of the present invention does not depend on its shape and weight and is manufactured according to a general manufacturing method.

For example, a mixture of a powdered active ingredient and the soluble dietary fiber is compression-molded according to a conventional method to give a tablet, or the powdered active ingredient is granulated by an appropriate method and then the soluble dietary fiber is prepared. Further, if necessary, a calcium material is added, and compression molding is performed according to a conventional method to give tablets, or the powdered active ingredient is granulated with the soluble dietary fiber, and then the calcium material or the inactive material is added as necessary. The ingredients and the like can be added, and the mixture can be compression molded into tablets according to a conventional method. The calcium material and the inactive ingredient may be added during mixing, or may be used when the powdered active ingredient is granulated. In that case, two or more kinds of the calcium ingredient and the inactive ingredient are used in combination. It doesn't matter. It should be noted that particularly high hardness is obtained when the powdered active ingredient is granulated using a solution in which soluble dietary fiber is dissolved, and then a calcium material is added and compression molding is performed. Further, for the purpose of improving tableting suitability, crushing or sieving may be performed before tableting so as to obtain an appropriate particle size. The powdered active ingredients may be used in combination of two or more kinds.

The method for producing granules will be described below.
As a method of using the binder in the granulation step, a method of adding water or an aqueous ethanol solution as a binding solution to a powder active ingredient, or the soluble dietary fiber as required, or a mixture to which the calcium material is added, is used. is there. The ethanol concentration of the aqueous ethanol solution to be used can be adjusted by the hygroscopicity of each powder, the average particle size, the bulk specific gravity and the like. If necessary, a highly viscous solution containing the soluble dietary fiber is used as a binding solution, a highly viscous solution containing the inactive ingredient is used as a binding solution, or the soluble food is used. By using a highly viscous solution in which a mixture of the fiber and the above-mentioned inactive component is dissolved as the binding solution, the working time of the granulation step can be made efficient.

As a granulation method, a wet granulation method is suitable,
Specifically, the fluidized bed granulation method, the stirring granulation method, the extrusion granulation method, the crushing granulation method, the rolling granulation method and the like are effective. In the fluidized bed granulation method, the fluidized powder is granulated by spraying the binding liquid onto the fluidized powder in a fluidized bed granulator. In the stirring granulation method, powder is mixed, kneaded and granulated simultaneously in a closed structure by rotating a stirring blade at a high speed in a mixing tank while adding a binding solution. In the extrusion granulation method, the wet mass kneaded by adding the binding solution is forcedly extruded from a screen of an appropriate size by a screw type or basket type method to perform granulation. In the crushing and granulating method, the wet mass kneaded by adding the binding solution is sheared and ground by a rotary blade of a granulator, and the centrifugal force ejects it from the outer peripheral screen for granulation. In the rolling granulation method, the raw material powder that has been drawn to the outer wall by the centrifugal force of the rotating rotor rolls by the air blown up from the slit, and at this time the binding liquid sprayed from the spray gun creates a snowball type. Granulation is performed by growing spherical granules having a uniform particle size.

The granules can be dried by hot air heating type (shelf drying, vacuum shelf drying, fluidized bed drying), conduction heat transfer type (flat pan type,
Any method such as a shelf box type, a drum type) or freeze-drying can be used. In the hot air heating type, the material and hot air are brought into direct contact with each other, and at the same time, the evaporated water is removed. In the conductive heat transfer type, the material is indirectly heated through the heat transfer wall. In freeze-drying, the material is frozen at -10 ° C to -40 ° C and then warmed under high vacuum (2-0.1 Torr) to sublime and remove water.

The powder-containing tablet obtained according to the present invention contains the powdered active ingredient as high as 50% by weight or more,
It is suitable as a tablet of a powdered active ingredient which has an appropriate hardness and is required to be contained in a large amount. It is possible to prevent tablet low hardness, tablet abrasion, cracking, chipping, etc. that occur in tablets containing a substance with extremely poor moldability such as brewer's yeast powder, and a tablet with excellent stability as a product can get.

Examples of the present invention will be shown below, but the present invention is not limited thereto.

Example 1 Beer yeast powder 4.50 kg
And 0.25 kg of guar gum were put into a fluidized bed granulator (manufactured by Paulec), and 2.00 kg of water was sprayed while flowing, and then the weight loss on drying was 5% or less at 80 ° C. for 20 to 30 minutes. Was dried. After drying, 0.25 kg of crystalline cellulose was mixed and sized with a sieve (16 mesh), followed by tableting. (Tabletting machine: rotary tableting machine, rotation speed: 30 rotations, tablet weight: 300 mg, tableting pressure: 20
00kg)

Example 2 Beer yeast powder 4.50 kg
Was poured into a fluidized bed granulator (manufactured by Powrex) and sprayed with 2.00 kg of a 0.5% guar gum aqueous solution while being fluidized, and then 20% at 20 ° C. so that the loss on drying was 5% or less.
Dry for -30 minutes. After drying, 0.49 kg of crystalline cellulose was mixed and sized with a sieve (16 mesh), followed by tableting. (Tabletting machine: rotary tableting machine, rotation speed: 30 rotations, tablet weight: 300 mg, tableting pressure: 200
0kg)

Example 3 Beer yeast powder 4.50 kg
Was poured into a fluidized bed granulator (manufactured by Powrex) and sprayed with 2.00 kg of a 0.5% guar gum aqueous solution while being fluidized, and then 20% at 20 ° C. so that the loss on drying was 5% or less.
Dry for -30 minutes. After drying, 0.49 kg of eggshell calcium was mixed, and the mixture was sized with a sieve (16 mesh) and then tableted. (Tabletting machine: rotary tableting machine, rotation speed: 30 rotations, tablet weight: 300 mg, tableting pressure: 200
0kg)

Comparative Example 1 Tablets were produced in the same manner as in Example 1 except that dextrin was used instead of guar gum.

Comparative Example 2 Tablets were produced in the same manner as in Example 2 except that 0.5% dextrin aqueous solution was used instead of 0.5% guar gum aqueous solution.

[Comparative Example 3] Tablets were produced in the same manner as in Example 2 except that a 5.0% dextrin aqueous solution was used instead of the 0.5% guar gum aqueous solution.

Examples 1, 2, 3 and Comparative Example 1,
Ten tablets of a few tablets were taken and the tablet hardness was measured.

Further, 20 tablets each of the above-mentioned Examples 1, 2 and 3 and Comparative Examples 1, 2 and 3 were taken and placed in a tablet friability tester and subjected to a friability test for 10 minutes at a rotation speed of 25 rpm. I went. The results are shown in Table 1.

[0037]

[Table 1]

As shown in Table 1, in Examples 1, 2 and 3, sufficient tablet hardness was obtained, friability (weight percentage of the reduced mass relative to the initial weight) was low, and tablets were cracked or chipped. Was not recognized.

On the other hand, in Comparative Example 1, Comparative Example 2 and Comparative Example 3, the tablet hardness was low and the friability was high.

[0040]

EFFECTS OF THE INVENTION According to the present invention, it is possible to prevent low tablet hardness, tablet abrasion, cracking, chipping and the like which occur in tablets containing a high content of a substance having extremely poor moldability such as brewer's yeast powder. It is possible to obtain a powder-rich tablet having excellent stability as a product.

Continued front page    F term (reference) 4B018 LE01 MD04 MD33 MD41 MD47                       MD77 MD81 ME02 MF08                 4B041 LD06 LE01 LH07 LH09 LH17                       LK02 LK33 LK40 LK42 LP12                 4B048 PE02 PE03 PN01 PN06 PS01                       PS02

Claims (8)

[Claims] 1. A beer yeast powder, a mineral yeast powder, a heme iron powder, a chitosan powder, a protein powder, a royal jelly powder, and one or more kinds selected from the group consisting of a plant powder, and a soluble dietary fiber. Powder containing tablets. 2. 50.00-99.99 parts by mass of at least one selected from the group consisting of beer yeast powder, mineral yeast powder, heme iron powder, chitosan powder, protein powder, royal jelly powder, and plant powder. The powder-containing tablet according to claim 1, wherein: 3. Soluble dietary fiber 0.01 to 50.00
The powder-containing tablet according to claim 1, wherein the powder-containing tablet comprises a mass part. 4. A beer yeast powder, a mineral yeast powder, a heme iron powder, a chitosan powder, a protein powder, a royal jelly powder, and one or more kinds selected from the group consisting of plant powders are granulated using an aqueous soluble dietary fiber solution. A method for producing a powder-containing tablet, which comprises tableting. 5. A beer yeast powder, a mineral yeast powder, a heme iron powder, a chitosan powder, a protein powder, a royal jelly powder, and one or more kinds selected from the group consisting of a plant powder, a soluble dietary fiber, and a calcium material. A powder-containing tablet characterized by: 6. The soluble dietary fiber blended is from 0.01 to 5
0.00 parts by mass, 0.10 to 49.9 of calcium material
The powder-containing tablet according to claim 5, which is 9 parts by mass. 7. A soluble dietary fiber aqueous solution is used to granulate at least one selected from the group consisting of beer yeast powder, mineral yeast powder, heme iron powder, chitosan powder, protein powder, royal jelly powder, and plant powder. A method for producing a powder-containing tablet, which comprises blending a calcium material and tableting. 8. A powder-containing tablet obtained by the method according to claim 4 or 7.