JP2003225283A - Plural-room vessel - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a plural-room vessel of which the number of the components is small and which can be manufactured not only simply and inexpensively, but also without staining the inside of the vessel. <P>SOLUTION: The plural-room vessel has a vessel main body formed of a moisture-permeable and gas-permeable flexible resin sheet 50 so that it has at least two chemical agent holding rooms 3 and 5 partitioned by a partition part so that they can communicate with each other as occasion demands, i.e., the first holding room 3 which holds chemicals having properties of moisture absorption, easy oxidation and hydrolysis and the second holding room 5 which holds chemicals not having the properties of moisture absorption, easy oxidation and hydrolysis, and has a third holding room 7 which is disposed in the first holding room 3 and holds at least either a desiccant or a deoxidizer. The third holding room 7 is so formed as to be continuous to and integral with the vessel main body, by folding a part 52 of the resin sheet 50 constituting the vessel main body into the first holding room 3. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement of a flexible multi-chamber container for containing and storing a drug such as a liquid agent, a powder agent or a solid agent, and more specifically, an easily oxidizable agent contained in the container, The present invention relates to a flexible multi-chamber container useful for preventing oxidation, hydrolysis or moisture absorption of a hygroscopic drug or a hydrolyzable drug and storing the drug in a stable state.

[0002]

2. Description of the Related Art Conventionally, as a multi-chamber container of this type, there is known one in which a chamber containing a drug is covered with a water-impermeable and / or gas-impermeable film to form a space. (JP-A-10-236538). This Japanese Patent Application Laid-Open No. 10-236538 discloses various measures for preventing oxidation and moisture absorption of a drug. For more information,
(1) For connecting a pouch made of a film having moisture permeability and gas permeability to a chamber containing a drug directly or via another member to prevent the drug from oxidizing and absorbing moisture. Those containing a desiccant or oxygen scavenger, (2) Those in which a moisture-absorbing sheet or oxygen-absorbing sheet is welded and fixed to a drug-containing chamber without using a pouch, and (3) a chamber containing the drug. It is disclosed that a moisture-absorbing sheet or an oxygen-absorbing sheet is welded in a space formed by covering with a moisture-impermeable and / or gas-impermeable film.

[0003]

In the case of the above example (1), a pouch for containing a desiccant or the like, which is formed separately from the container body, is connected to the chamber containing the drug. Therefore, there is a drawback that the number of parts is large and the manufacturing is time-consuming, resulting in high manufacturing cost. In addition, there is a risk that bacteria and the like may enter the room and stain the inside of the room during the work of connecting the pouches. In the case of (2),
Since the water-absorbent sheet and the oxygen-absorbent sheet are welded and fixed to the chamber containing the drug, not only the manufacturing process is time-consuming and the manufacturing cost is high, but also the water-absorbent sheet and the oxygen-absorbing sheet are required. During the work of welding and fixing the heat-resistant sheet, various bacteria may enter the room and stain the inside of the room. Furthermore, even in the case of (3) where the water-absorbing sheet or the oxygen-absorbing sheet is welded in the space formed by covering the chamber containing the drug with the water-absorbing sheet or the oxygen-absorbing sheet, Not only is there a disadvantage that the work of welding the heat-resistant sheet and the oxygen-absorbing sheet is troublesome, leading to high costs, and there is also a risk that various bacteria and the like enter the space. Also known is a multi-chamber container in which the chamber itself for accommodating a drug is made of a water-impermeable and / or gas-impermeable film (Japanese Patent Laid-Open No. 10-23).
6541). This Japanese Patent Laid-Open No. 10-236541 also discloses the above (1) and (2) in order to prevent the oxidation and moisture absorption of the drug.
It is disclosed that the multi-chamber container is adopted, and this multi-chamber container has the same drawbacks as the multi-chamber container disclosed in JP-A-10-236538.

The present invention has been completed in order to solve the above-mentioned problems, and can be manufactured at a low cost with an extremely simple structure, and moreover, it is possible to manufacture the interior of the room as little as possible. The object is to provide a multi-compartment container.

[0005]

Means for Solving the Problems The present invention, which achieves the above objects, accommodates a drug having hygroscopicity, oxidizability, and hydrolyzability, which is partitioned by a partition part so that they can communicate with each other as necessary. At least two drug storage chambers, a first storage chamber for storing the drug and a second storage chamber for storing a drug that is not hygroscopic, easily oxidizable, or hydrolyzable, and arranged in the first storage chamber. A multi-chamber container having a container body formed of a flexible resin sheet so as to have at least one of a desiccant and an oxygen scavenger, and the container body is configured. By folding a part of the resin sheet into the first storage chamber, the third storage chamber is continuous from the container main body and is formed integrally with the container main body. To do. Further, the invention according to claim 2 requires the desiccant and the oxygen scavenger by opening the third storage chamber containing at least one of the desiccant and the oxygen scavenger so as to be opened. According to the above, it can be taken out from the third storage chamber. Further, in the invention according to claim 3, a spacer means for preventing the wall surface of the first storage chamber and the wall surface of the third storage chamber from intimately contacting each other is provided in the first storage chamber. It is characterized in that it is interposed between the wall portion and the wall portion of the third storage chamber. In addition, claim 4
The invention described in (3) is characterized in that a hydrophobic microporous membrane is provided on the wall surface of the third storage chamber. Further, the invention according to claim 5 is characterized in that at least the first housing chamber in the container body is covered with and adhered to a film having low gas permeability and moisture permeability. Further, the invention according to claim 6 is formed by covering the entire body of the container with a film having low gas permeability and moisture permeability so as to be adhered thereto, and weakly sealing the partition portion so as to be wide and peelable. As a result, the amount of gas permeation and the amount of water permeation between the at least two drug storage chambers through the partition are smaller than the amount of gas permeation and water permeation to the outside through the container body. It is characterized by having done.
Further, in the invention according to claim 7, the film is composed of a multilayer sheet having an outer layer and an inner layer, and the inner layer is composed of a resin having adhesion such as weak tackiness or easy blocking property. Characterize. In the invention according to claim 8, the inner layer is selected from the group consisting of EVA resin, low density polyethylene, linear polyethylene, styrene-butadiene thermoplastic elastomer, polyolefin thermoplastic elastomer, and polyester thermoplastic elastomer. It is characterized in that it is made of a resin.

In the present invention, the third accommodating chamber for accommodating at least one of the desiccant and the oxygen scavenger folds a part of the resin sheet constituting the container body into the first accommodating chamber. According to the present invention, it is possible to obtain a multi-chamber container which has a small number of parts and which can be manufactured easily and at a low cost because it is formed continuously with the container body as one body with the container body. . In the multi-chamber container according to the present invention, a desiccant or the like is not welded to a chamber containing a medicine such as a pouch containing a desiccant or a water-absorbent sheet like a conventional multi-chamber container, and the like, Since a part of the resin sheet forming the container body is simply stored in the third storage chamber formed by folding the first storage chamber in which the drug is stored, the present invention According to this, it is possible to obtain a multi-chamber container that can be manufactured without contaminating the inside of the chamber.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings. 1A and 1B show a multi-chamber container according to an embodiment of the present invention, in which FIG. 1A is a front view and FIG. 1B is a vertical sectional view. The multi-chamber container body 1 includes a first drug-accommodating chamber 3 for accommodating a drug having hygroscopicity, an easily oxidizable property and a hydrolyzable property, and a first drug-accommodating chamber 3 for accommodating a drug having no hygroscopic property, an easily oxidizable property and a hydrolyzable property. A flexible resin sheet is provided as having a second drug storage chamber 5 and a third storage chamber 7 that stores at least one of a desiccant and an oxygen scavenger. The first accommodating chamber 3 and the second accommodating chamber 5 are partitioned by a partition portion 9 so that they can communicate with each other as needed. In the illustrated embodiment, the partition 9 is weakly sealed so that it can be peeled off,
When the container is used to administer medicine to a patient, the weakly sealed partition 9 is peeled off, so that the first storage chamber 3
And the second storage chamber 5 can communicate with each other. The third storage chamber 7 is formed integrally with the container body 1 as described later, and is disposed in the first storage chamber 3,
In the third storage chamber 7, the influence of moisture and gas in the first storage chamber 3 of the hygroscopic, easily oxidizable, and hydrolyzable drug stored in the first storage chamber 3 In order to reduce the amount, at least one of the oxygen scavenger and the desiccant is contained as described above. A port portion 11 is provided at the lower end portion of the multi-chamber container body 1, and the medicine is contained in the container body 1 via the port portion 11 before the partition portion 9 is formed. Further, when the medicine contained in the container body 1 is administered to the patient, the weakly sealed partition 9 is peeled off as described above to make the accommodation chambers 3 and 5 communicate with each other and to accommodate the accommodation chamber 3 By mixing the medicines contained in 5 and 5, the infusion set can be connected to the port portion 11 to administer the drug to the patient via the infusion set. In addition, 13 is a container hanging hole formed at the upper end of the container body 1.

The multi-chamber container configured as described above can be formed by using the flexible resin sheet 50 formed in a long loop shape as shown in FIG. 2 as an example. Here, explaining the production of the multi-chamber container according to the present invention,
First, as shown in FIG. 2, a part 52 of the long loop-shaped resin sheet 50 is folded inward of the loop-shaped sheet 50, so that the folded part 52 of the long loop-shaped sheet 50 is folded. Thus, the third storage chamber 7 is configured. After accommodating at least one of the desiccant and the oxygen scavenger from the side or the upper side in the third accommodating chamber 7 thus configured, both side portions 54 and the upper end portion 56 of the loop-shaped sheet 50 are accommodated.
The first storage chamber 3,
The second storage chamber 5 and the third storage chamber 7 are sealed. Then, the port portion 11 (see FIG.
(Refer to FIG. 4), the drug is housed in the seat portion 58 forming the first housing chamber 3 and the seat portion 60 forming the second housing chamber 5 via the port portion 11, respectively, and a rubber stopper body is formed. To close the port portion 11. The drug is applied to the sheet portion 58,
After being accommodated in the sheet 60, the partition portion 9 (see FIG. 1) is formed by weakly sealing the substantially central portion 62 of the loop-shaped sheet 50 in a laterally peelable manner. As the flexible resin sheet 50 forming the container body 1, a single layer sheet made of a resin such as polyethylene or polypropylene or a multilayer sheet made of a mixed resin thereof can be used.

In the above-mentioned example, after the desiccant and / or the oxygen scavenger is stored in the third storage chamber 7, both side portions 54 and the upper end portion 5 of the loop-shaped sheet 50 are stored.
Although the sheet 6 is strongly sealed so that it cannot be peeled off, the sheet portion 52 that is folded inward to form the third storage chamber 7 is formed.
The third storage chamber 7 can be opened by, for example, weakly peelingly sealing the surfaces of the upper end portions facing each other so as to be peelable. In the case of such a configuration, the third storage chamber 7 can be opened and the desiccant and the oxygen scavenger can be taken out from the third storage chamber 7 if necessary, so after the use of the container, The desiccant and oxygen absorber can be separated from the container body and discarded.

As described above, in the multi-chamber container according to the present invention, the third storage chamber 7 for storing at least one of the desiccant and the oxygen scavenger is a flexible resin sheet constituting the container body. Since it is configured to be continuous with the container body and integrated with the container body, the number of parts can be reduced as compared with the conventional multi-chamber container, and the container can be easily and inexpensively manufactured. In addition, the resin sheet 5 that constitutes the container body 1
Since at least one of the desiccant and the oxygen scavenger is simply stored in the third storage chamber 7 formed by folding the part 52 of 0 into the container main body, it should be manufactured without contaminating the inside of the container as much as possible. You can

In the example shown in FIG. 1, the weakly sealed partition 9 is formed over the entire boundary area between the accommodating chambers 3 and 5, but as shown in FIG. The substantially central portion 9a in the horizontal direction may be weakly sealed so that it can be peeled off, and both side portions 9b of the partition 9 can be strongly sealed so that it cannot be peeled off.
Further, in the example shown in FIG. 1, the partition 9 is weakly peeled off so that the first storage chamber 3 and the second storage chamber 5 can be communicated with each other as necessary. However, not limited to this, any structure can be adopted as long as the first storage chamber 3 and the second storage chamber 5 can be communicated with each other as necessary. For example,
As shown in FIG. 4, it is possible to employ a structure in which a non-peelable partition 9'is provided with a plug 90 that can be opened as required. In the example shown in FIG. 4, a substantially tubular support member 92 that communicates with the first storage chamber 3 and the second storage chamber 5 is provided in the non-separable partition portion 9 ′, and the support member is provided. The plug 90 is inserted into the plug 92.
Are supported by the support member 92. The stopper 90 is formed in a substantially cylindrical shape using, for example, hard vinyl chloride, polycarbonate, or the like, and the support member 92 is formed in a substantially tube shape using, for example, vinyl chloride. Stopper 9
0 is configured as having a substantially cylindrical main body composed of a small-diameter solid portion 90a and a large-diameter hollow portion 90b, and cuts around the outer periphery of the boundary between the solid portion 90a and the hollow portion 90b. Thus, the brittle portion 90c having a thin wall is provided. The plug body 90 is supported by the support member 92 with the hollow portion 90b inserted into the tubular support member 92 and the solid portion 90a protruding from the tubular support member 92. In this example, the brittle portion 90c is cut by laterally pressing the plug 90 during drug application to the patient, and the hollow portion 90b is opened to open the first storage chamber 3 and the second storage chamber 5. Can be communicated with.

In the illustrated embodiment, the first storage chamber 3
A hygroscopic, oxidizable, and hydrolyzable powder agent (not shown) is housed inside, and a medicinal solution that is neither hygroscopic, oxidizable nor hydrolyzable is stored in the second housing chamber 5 ( (Not shown) is accommodated. Examples of the powder agent accommodated in the first accommodating chamber 3 include substances having hygroscopicity, oxidizability and hydrolyzability such as antibiotics, anticancer agents, steroids, thrombolytic agents and vitamins. You can Further, examples of the liquid agent stored in the second storage chamber 5 include a solution or dilution liquid of the drug stored in the first storage chamber 3, such as physiological saline solution and glucose solution. You can Further, as the desiccant contained in the third accommodation chamber 7, for example, silica gel, zeolite,
Examples thereof include a silica gel molded product and an integrated oxygen absorber. Similarly, as the oxygen scavenger to be stored in the third storage chamber 7, AGELESS (trade name) manufactured by Mitsubishi Gas Chemical Co., Inc., oxygen scavenger using amorphous copper, or the like can be used.

As shown in FIG. 1, hygroscopicity, easy oxidation,
A film 15 having a low gas permeability and a low water permeability may be entirely welded to the first storage chamber 3 in which the hydrolyzable drug is stored. Alternatively, the first accommodating chamber 3 may be covered with the film 15 having low gas permeability and low moisture permeability by vacuum adhesion. In this way, if the first accommodating chamber 3 accommodating the hygroscopic, easily oxidizable, and hydrolyzable drug is covered with the film 15 having low gas permeability and low moisture permeability, the film can be closely attached. Thus, the permeation of gas and water from the outside of the container can be minimized, and a drug having hygroscopicity, easy oxidation and hydrolyzability can be stably stored.

Film 1 having low gas permeability and moisture permeability
As the material of 5, it is possible to use polyester resins such as polyethylene terephthalate and polybutylene terephthalate, polyethylene naphthalate, polyvinyl alcohol, ethylene vinyl alcohol copolymer, polyamide such as polyvinylidene chloride and nylon, and cellophane. . Alternatively, a metal foil film such as aluminum or a silicon oxide vapor-deposited polyethylene terephthalate (silica pet) film can be used. Further, as shown in FIG. 5, the film 15 includes an outer layer 15a and an inner layer 15a.
It can also be configured as a multilayer film having b. In this case, the inner layer 15b can be made of a resin or rubber having an adhesive property such as weak adhesive property or easy blocking property. Specifically, EVA resin, low density polyethylene, linear low density polyethylene, styrene-
Butadiene-based thermoplastic elastomer (commercially available as "Clayton (trade name)" manufactured by Shell Japan),
The inner layer 15b can be made of a resin such as a polyolefin-based thermoplastic elastomer or a polyester-based thermoplastic elastomer. Since it is necessary to check whether or not foreign substances are erroneously mixed in the container during drug administration, when the container is used for drug administration, the film 15 is peeled off for the check. Can be used.

Since there is no resin that has no moisture and gas permeability, the third accommodating chamber 7 formed integrally with the container body 1 by the resin sheet forming the container body 1 as described above. Has moisture permeability and gas permeability. However, since the wall surface of the first storage chamber 3 and the wall surface of the third storage chamber 7 are in close contact with each other, water permeability and gas permeability of the third storage chamber 7 are impaired, and the third storage chamber is impaired. There is a possibility that the desiccating agent and deoxidizing agent accommodated in 7 may interfere with the desiccating and deoxidizing actions of the agent accommodated in the first accommodating chamber 3. Therefore, in order to prevent the wall surface of the first storage chamber 3 and the wall surface of the third storage chamber 7 for storing the drug having hygroscopicity, easy oxidization and hydrolyzability from coming into close contact with each other, the first storage Spacer means may be arranged between the wall of the chamber 3 and the wall of the third storage chamber 7.

As shown in FIG. 6, the spacer means 17 can be constituted by a plurality of knurls extending parallel to the outer surface of the third storage chamber 7, and as shown in FIG. Alternatively, the outer surface of the third storage chamber 7 may be formed with a concave-convex surface that is vertically, horizontally, or diagonally formed. Further, as shown in FIG. It may be configured by shaping a concave-convex surface. Further, the spacer means 17 composed of the uneven surface as shown in FIGS. 6 to 8 may be formed on the inner surface of the first storage chamber 3. Further, spacer means configured separately from the third storage chamber 7 and the first storage chamber 3 may be interposed between the first storage chamber 3 and the third storage chamber 7. .

When the spacer means 17 is interposed between the wall portion of the first storage chamber 3 and the wall portion of the third storage chamber 7 as described above, Third accommodation room 7
Since it is possible to prevent close contact with the wall surface of the third storage chamber 7, the desiccant contained in the third storage chamber 7 can be removed without impairing gas permeability and water permeability of the third storage chamber 7. The drying action and the deoxidizing action of the oxygen agent can be propagated to the drug contained in the first housing chamber 3.

Further, in the above-mentioned example, the gas permeability and the water permeability of the third storage chamber 7 are ensured by the chemical characteristics of the resin sheet forming the third storage chamber 7. In addition to this, if the gas permeability and the moisture permeability of the third storage chamber 7 are physically secured, the desiccant contained in the third storage chamber 7 and the drying action of the oxygen absorber and It becomes possible to further improve the deoxidizing action. More specifically, as shown in FIG. 9, by providing the hydrophobic microporous membrane 19 on the wall surface forming the third storage chamber 7, the gas permeability and the water permeation of the third storage chamber 7 can be improved. The sex can be secured at a higher level. The hydrophobic microporous membrane 19 is 0.01 to 10 millimicrons (preferably 0.2
Those with pores having a pore size in the range of .about.1.0 millimicron) can be used. Before forming the container main body, a vent hole 52a is formed in the resin sheet portion 52 forming the third storage chamber 7, and the hydrophobic microporous membrane 19 is covered with the vent hole 52a, for example,
The resin sheet portion 52 constituting the third housing chamber 7 is preliminarily liquid-tightly attached by heat welding or caulking, and then the resin sheet portion 52 is placed inside the sheet constituting the container body as described above. It should be folded in.

This hydrophobic microporous membrane 1
9 is a porous membrane made of tetrafluoroethylene (PTFE, commercially available "Teflon (trade name)"), high density polyethylene (commercially available "Tyvek (trade name)") ), A polypropylene (commercially available “Duraguard (trade name)”) porous membrane can be used, but it must be installed liquid-tight on the wall of the third storage chamber 7. Any porous film can be used as long as it has a water-repellent property on the surface. In addition, when the porous membrane of ethylene tetrafluoride is attached to the resin wall portion which constitutes the third accommodation chamber 7 by heat welding, the ethylene tetrafluoride constitutes the third accommodation chamber 7. Since it does not heat-weld to the resin wall part, the porous membrane of tetrafluoroethylene is laminated on the mesh of high density polyethylene, and the porous membrane of ethylene tetrafluoride is accommodated in the third through the mesh of high density polyethylene. It is advisable to heat-weld the walls forming the chamber 7. When the container according to the present invention is used, the weakly sealed partition 9 is peeled off to remove the drug solution stored in the second storage chamber 5 and the powder agent stored in the first storage chamber 3. In order to prevent the hydrophobic microporous membrane 17 from being deformed or damaged by the pressure applied when the second storage chamber 5 is pressed to mix the two, as shown in FIG. A protective film 21 for protection may be attached to the wall portion forming the third storage chamber 7 by heat welding so as to cover the hydrophobic micromembrane 19. In this case, as the material of the protective film 21, a high density polyethylene porous film can be used.

As described above, when the hydrophobic microporous membrane 19 is attached to the third storage chamber 7, the oxygen absorber,
Since the third accommodation chamber 7 for accommodating the desiccant can be physically provided with gas permeability and moisture permeability, the oxygen scavenging agent accommodated in the third accommodation chamber 7 and the deoxidizing action of the desiccant. And, the drying action can be spread extremely effectively to the powder agent contained in the first containing chamber 3.

Incidentally, the hydrophobic microporous membrane 1
Even when 9 is mounted, the spacer means as described above may be interposed between the wall portion of the first storage chamber 3 and the wall portion of the third storage chamber 7. In that case, it is possible not only to prevent the wall surface of the first storage chamber 3 and the wall surface of the third storage chamber 7 from intimately contacting each other, but also to attach the hydrophobic micro It is also possible to avoid the situation where the porous membrane 19 is blocked by the wall surface of the first storage chamber 3.

An example in which only the first storage chamber 3 in the container body 1 is covered with and adhered to the film 15 having a low gas permeability and a low moisture permeability has been described above, but as shown in FIG.
The entire container body may be covered with a film 15 having a low gas permeability and a low water permeability so as to be in close contact. In this case, the first container chamber 3 and the second container chamber 5 are weakly peelable from each other. It is preferable that the sealed partition 9 has a gas permeation amount and a water permeation amount smaller than the water permeation amount and the gas permeation amount from the inside of the container body to the outside.

In the example shown in FIG. 11, the container body 1
A film 15 having a low gas permeability and a low water permeability is covered and adhered to the whole, and a weak seal width W of the partition 9 (a width measured in the longitudinal direction of the container body 1 in FIG. 11) is formed to be wide. There is. If the weak seal width W of the partition 9 is widened, the amount of water permeation and the amount of gas permeation from the second storage chamber 5 to the first storage chamber 3 through the partition 9 can be changed from inside the container body to the outside. Since it can be made smaller than the gas permeation amount and the water permeation amount into the first accommodating chamber 3, it is easy to oxidize, absorb moisture,
The hydrolyzable powder agent can be stably stored. As a result of repeated studies and experiments, it was found that it is suitable when the weak seal width W of the partition 9 is 15 mm or more. However, the weak seal width W of the partition 9 may be set to 15 mm or less in consideration of the hygroscopicity, easy oxidization, and hydrolyzability of the contained drug.

In the illustrated embodiment, the example in which there are two storage chambers for storing the medicine has been described, but the number of storage chambers is not limited to two, and three or more storage chambers may be provided. That is clear. Moreover, although the case where the container body is formed by using the loop-shaped resin sheet has been described, the container body may be formed by using, for example, two resin sheets. Furthermore, although the present invention has been described using a specific embodiment, it is obvious that the present invention is not limited to this and includes appropriate modifications without departing from the spirit of the present invention.

[0025]

As described above, according to the present invention, the third accommodating chamber for accommodating at least one of the desiccant and the oxygen scavenger is provided with a part of the resin sheet constituting the container main body. Since it is configured as an integral part of the container body that is continuous from the container body by folding it into one storage chamber, the multi-chamber container according to the present invention has a small number of parts and can be manufactured easily and inexpensively. It is possible to manufacture it without polluting the inside of the container as much as possible.

[Brief description of drawings]

FIG. 1 shows a multi-chamber container according to an embodiment of the present invention,
(A) is a front view and (b) is a longitudinal sectional view.

FIG. 2 is a perspective view of a loop-shaped resin sheet that can be used to manufacture the multi-chamber container shown in FIG.

FIG. 3 is a partial front view showing a modified example of the partition of the multi-chamber container shown in FIG.

FIG. 4 is a partial cross-sectional view showing another modified example of the partition of the multi-chamber container shown in FIG.

FIG. 5 is a vertical cross-sectional view of a modified example in which a film having low gas permeability and moisture permeability is formed as a multilayer film.

FIG. 6 is a partial front view of a multi-chamber container provided with spacer means for preventing the wall surface of the first storage chamber and the wall surface of the third storage chamber from coming into close contact with each other.

FIG. 7 is a partial front view of a multi-chamber container including a modification of the spacer means shown in FIG.

FIG. 8 is a partial front view of a multi-chamber container provided with another modification of the spacer means.

FIG. 9 is a partial vertical cross-sectional view of a third storage chamber provided with a hydrophobic microporous membrane.

FIG. 10 is a partial vertical cross-sectional view of a third storage chamber provided with a protective film for a hydrophobic microporous membrane.

FIG. 11 shows a multi-chamber container according to a modified example in which a film having low gas permeability and low water permeability is covered and adhered to the entire container body, (a) is a front view, and (b) is a longitudinal sectional view. is there.

[Explanation of symbols]

1 Flexible container body 3 First storage room 5 Second storage room 7 Third Containment Room 9 Peelable weakly sealed partition 15 Films with low gas and water permeability 17 Spacer means 19 Hydrophobic microporous membrane 50 Resin sheet that constitutes the container body W Weakly sealed partition width

Claims (8)

[Claims] 1. A first storage chamber for storing a hygroscopic, oxidizable, hydrolyzable drug and a hygroscopic, oxidizable, hydrolyzed chamber which are partitioned by a partitioning section so that they can communicate with each other as necessary. At least two drug accommodating chambers, a second accommodating chamber accommodating a non-decomposable drug, and a third accommodating at least one of a desiccant and an oxygen scavenger disposed in the first accommodating chamber Is a multi-chamber container having a container body formed of a flexible resin sheet so as to have a storage chamber of, and a part of the resin sheet constituting the container body in the first storage chamber. A multi-chamber container, wherein the third accommodation chamber is formed by being folded and is continuous with the container body and is integrated with the container body. 2. The desiccant and the oxygen scavenger are sealed by opening the third storage chamber in which at least one of the desiccant and the oxygen scavenger is stored so that the third desiccant and the oxygen scavenger can be used as needed. The multi-chamber container according to claim 1, wherein the multi-chamber container can be taken out from the accommodation chamber. 3. A spacer means for preventing the wall surface of the first storage chamber and the wall surface of the third storage chamber from intimately contacting each other; The multi-chamber container according to claim 1 or 2, which is interposed between the container and the wall of the storage chamber. 4. The multi-chamber container according to claim 1, wherein a hydrophobic microporous membrane is provided on the wall surface of the third storage chamber. 5. The compound according to any one of claims 1 to 4, wherein a film having low gas permeability and moisture permeability is coated and adhered to at least the first storage chamber in the container body. Chamber container. 6. The partition part is formed by covering the entire body of the container with a film having a low gas permeability and a low water permeability so as to be in close contact therewith, and forming the partition part with a wide width and a weakly peelable seal. The gas permeation amount and the water permeation amount between the at least two drug storage chambers via the container are smaller than the gas permeation amount and the water permeation amount to the outside via the container body. 4. The multi-chamber container according to any one of 4 above. 7. The film is a multilayer film composed of an outer layer and an inner layer, and the inner layer is composed of a material having adhesiveness such as weak tackiness or easy blocking property. Or a multi-chamber container according to item 6. 8. The resin wherein the inner layer is selected from the group consisting of EVA resin, low density polyethylene, linear low density polyethylene, styrene-butadiene thermoplastic elastomer, polyolefin thermoplastic elastomer, polyester thermoplastic elastomer. The multi-chamber container according to claim 7, which is configured by: