JP2003220119A - Method for producing capsule - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To develop a method for easily producing a capsule through using only an enclosing material other than gelatin or a combination of it and gelatin. <P>SOLUTION: A chemical compound having a structural unit of [3-O-(β-D- glucopyranosyl)-β-D-glucopyranosyl] is used as the enclosing material of a capsule when the capsule is produced. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing a capsule, and more particularly, to a capsule which is called a so-called soft capsule and is produced using two film sheets of an encapsulating material. The present invention relates to a method for producing an agent. [0002] A typical method for producing capsules is to increase the plasticity of a liquid, paste, or powdered content by adding a polyhydric alcohol such as glycerin or sorbitol to gelatin. This is a method of wrapping with a wrapping material and molding it into a certain shape. More specifically, it is a method in which the content is filled between two wrapping material film sheets, the two wrapping material film sheets are melt-bonded by applying pressure and heat, cut, and dried. . However, gelatin used as a wrapping material is produced from animals such as cows, pigs, birds, and fish, and is essentially a protein. However, there is a problem that it is necessary to remove the pathogenic protein molecule, and the removal is difficult. Also, conventional capsule wrapping materials such as gelatin are mainly thermoreversible gels (low-set gels), so they are susceptible to temperature effects. There were drawbacks such as elution of the contents. [0004] Accordingly, an object of the present invention is to solve the problems of conventional capsules, and more particularly, to provide capsules excellent in temperature resistance very easily. It is to develop a new method that can be manufactured. [0005] The object of the present invention is to provide a conventional coating material with "3-O- (β-D-
The problem is solved by adding an encapsulant having a structural unit of “glucopyranosyl) -β-D-glucopyranos” or by using the encapsulant alone. The wrapping material used in the present invention includes "3-O- (β-D-glucopyranosyl) -β-D
Compounds having the structural unit "-glucopyranos" are used. This corresponds to “3-O (β-Glucopyranosyl) -β
-D-Glucopyranose ". As a typical example, a commercially available product called "curdrun" is used. This "curdlan" is a microorganism (Alcaligene)
s faecalis varmyxogenes), which has unique gelling properties. This is about 65 ° C
When prepared at the following temperature, a thermoreversible low-set gel is formed. When heating is continued to 80 ° C. or higher, a heat-irreversible high-set gel that does not melt even when reheated is obtained. By using this, not only thermoreversible capsules such as conventional products but also capsules that are stable even at high temperatures can be produced by giving a high temperature history in the manufacturing process. More specifically, in the present invention, this "card run"
In the case of using, for example, "curdlan" is mixed with water and deaerated to form a uniform gel, which is formed into a film at a temperature of 60 ° C. or less, whereby a film made of a thermoreversible gel is formed. . Enclose the contents using two pieces of this, 80 ℃
In the following, capsules can be manufactured by cooling after compression. As in the case of conventional capsules, the formulation is a non-temperature-resistant capsule that increases in flexibility with increasing temperature. Furthermore, a preparation obtained by uniformly heating the above preparation to 80 ° C. or higher and then allowing it to cool is a preparation that is extremely stable against temperature changes. In the present invention, a conventional method for producing a capsule using a wrapping material may be carried out using a conventional method. A typical example thereof is a conventional rotary type capsule filling machine. The method can be exemplified. In the present invention, other gelling agents and additives can be added to the encapsulating material, if necessary. For example, pearlizing agents such as gelatin, seaweed extract, agar, pigments and fish phosphor foils can be added. And various vitamins. The present invention will be described below in detail with reference to examples. [Example 1] "Card run" using a mixer with a jacket
10 parts by weight were dispersed in 90 parts by weight of water, and the mixture was heated to about 50 ° C. with slow stirring. Get a gel. This gel is formed into a film at a temperature of 60 ° C. or less to produce two films. During this time, a royal jelly in the form of a paste previously emulsified and dispersed in soybean oil is filled according to a conventional method, and a rugby ball type non-heated gel having a content of 250 mg is filled. A resistant capsule was made. The rugby ball type capsule produced as described above was placed in a tumbler-type heating and drying machine, heated at 85 ° C. for 1 hour while slowly rotating so as not to be deformed, and allowed to cool at room temperature to obtain a temperature-resistant capsule. As a result of a 1-minute heating test using a 500 W household microwave oven, no deformation, melting, or elution occurred. Example 2 A shark liver oil capsule having a content of 200 mg was prepared by using the same contents as in Example 1 except that shark liver oil was used. EXAMPLE 3 Curdlan prepared according to Example 1
50% by weight of a 5% gel of
50% by weight of a prepared gel composed of 3% by weight of sorbitol, 3% by weight of sorbitol, 3% by weight of glycerol and 74% by weight of water.
A 50 mg wheat germ oil capsule was made. This was further dried at 85 ° C. using a tamper-type heating dryer, and allowed to cool at room temperature to obtain a product. This capsule is temperature resistant,
No deformation was observed in the heat resistance test at 90 ° C. for 30 minutes. EXAMPLE 4 Microorganism Agrobacterium is added to glucose.
“3-O- (β-D-glucopyranosyl) -β-D- obtained by the action of Viova (Agrobacterium biovar) 1
10 parts by weight of a crude fermented polysaccharide containing a molecular structure unit of "glucopyranos" is mixed with 90 parts by weight of a prepared gel comprising 45% by weight of gelatin, 12.5% by weight of glycerin, and 42.5% by weight of water produced by a conventional method. And the content is 30
Omg spherical olive oil capsules were made. This was superior in temperature resistance as compared with a normal gelatin capsule.

Claims (1)

Claims: 1. In producing a capsule, "3-O- (β-D-glucopyranosyl) -β-D-glucopyranos" ([3-O- (Β-D
-Glucopyranosyl) -β-D-Glucopyranose]) A method for producing a capsule, characterized by using a compound having a structural unit: