JP2003212740A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair growth inhibitor capable of inhibiting growth or elongation of the hair and having high safety, and to provide a preparation for external use, such as a pharmaceutical, quasi-drug product, and cosmetic, containing the inhibitor. <P>SOLUTION: This hair growth inhibitor contains one or more methyl isopropyl phenols, such as thymol(5-methyl-2-isopropylphenol), carvacrol(2- methyl-5-isopropylphenol), and biosol (3-methyl-4-isopropylphenol), as active ingredients. Various compositions used for the preparation for external use, such as the cosmetic, are prepared by mixing the active ingredients with aqueous-phase components and oil-phase components through ordinary procedures. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair growth inhibitor, such as a hair growth inhibitor, which contains a specific phenol derivative as an active ingredient, and an external composition for cosmetics, quasi drugs or external preparations for skin containing the same. And especially cosmetics.

[0002]

2. Description of the Related Art The hair or hair of a human body is originally biologically intended to protect important organs such as the head, chest and limbs, but protective means such as clothes and protective equipment appears. However, as human beings utilize and develop them, the function of body hair to protect organs is becoming less important.

Further, while it is generally desired that the hair is rich, in recent years, there is an increasing tendency that it is preferable that the body hair, especially on the limbs, not have an aesthetic appearance. Has been developed and used.
Specifically, a mechanical removal method using a shaver, an epilator, etc., a method of removing body hair from a hair root using a depilatory, a method of removing body hair by its chemical action using a depilatory agent, etc. .

[0004]

However, these hair removal methods are accompanied by physical or chemical irritation to the skin, and although there are some differences depending on the hair removal methods, the hair removal effect is There is a limit to sustainability.
Therefore, the hair removal process must be performed again after a certain period of time, and it is desired to reduce the work of the hair removal process.

As described above, it is desired to develop a technique for suppressing the growth of body hair or removing the hair, which is less irritating to the skin and further reduces the burden of the hair removal operation. Under such circumstances, the present inventor diligently researched the hair growth-inhibiting ability of various substances, found that a specific phenol derivative has a hair growth-inhibiting ability, and succeeded in the development of the invention. And a composition for external use such as a hair growth inhibitor and a cosmetic containing the same.

Accordingly, the present invention provides a hair growth inhibitor capable of effectively suppressing the growth or development of body hair and reducing the number of hair removal treatments, and a composition for external use such as cosmetics containing the same. This is the problem to be solved by the invention, that is, the object. In particular, the invention relates to certain phenol derivatives,
Specifically, it has been found that methylisopropylphenol directly acts on hair mother cells and hair papilla cells to show an excellent hair growth inhibitory effect, and is highly safe for a long period of time. The present invention provides a hair growth inhibitor and a composition for external use such as a cosmetic containing the same.

[0007]

SUMMARY OF THE INVENTION The present invention, which was developed under such circumstances, is an invention of a hair growth inhibitor and a composition for external use, particularly a cosmetic as described above. Contains methyl isopropylphenol as an active ingredient, and a composition for external use such as cosmetics contains the hair growth inhibitor.

The hair growth inhibitor of the present invention containing methylisopropylphenol as an active ingredient has excellent hair growth inhibitory ability and is safe since it has been used for many years as a home remedy for the human body. It is highly effective and can be used by being mixed with various compositions applied to the outer skin of pharmaceuticals, quasi drugs, cosmetics and the like, and these compositions can exhibit excellent hair growth inhibitory ability. In particular, when blended with a cosmetic, it has an excellent hair growth inhibitory ability and can provide a highly safe cosmetic. More specifically, it is possible to provide a cosmetic that has less irritation to the skin and can further reduce the burden of hair removal processing work.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION As described above, the hair growth inhibitor of the present invention contains methylisopropylphenol as an active ingredient, and the methylisopropylphenol is thymol (5-methyl-2-isopropylphenol). , Carvacrol (2-methyl-5-isopropylphenol), and biozole (3-methyl-4-isopropylphenol).

When the above-mentioned methyl isopropylphenol is used as an active ingredient of a hair growth inhibitor, it is preferably added in an amount of 0.00001 to 5% by weight, preferably 0.0001 to 10% by weight based on the total amount of the external preparation such as cosmetics. It is preferable to add 1% by weight, more preferably 0.001 to 0.5% by weight.

When the above-mentioned methyl isopropyl phenol is used as an active ingredient having a hair growth inhibiting property in an external composition such as cosmetics, in addition to the methyl isopropyl phenol, within a range that does not impair the effects of the present invention,
Various other ingredients usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as oils, humectants, ultraviolet absorbers, antioxidants, surfactants, preservatives, moisturizers, fragrances, water, alcohols, thickeners Agents and the like can be appropriately blended as necessary.

Examples of the ultraviolet absorber include 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4.
-Sodium methoxybenzophenone-5-sulfonate, sodium benzotriazolylbutylphenolsulfonate, benzophenone derivatives such as methylenebis-benzotriazoyltetramethylbutylphenol, octyl paramethoxycinnamate, diparamethoxycinnamic acid mono-
Glyceryl 2-ethylhexanoate, methoxycinnamic acid derivatives such as isopentyltrimethoxycinnamic acid trisiloxane, urocanic acid, 4-tert-4′-methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazine, ethylhexyltriazone,
Phenylbenzimidazole sulfonic acid and the like can be appropriately blended if necessary.

In addition to the above-mentioned other components used in the external preparation for skin, the composition for external use of the present invention can be blended with disodium edetate, trisodium edetate, sodium citrate, Sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid or its derivatives, licorice extract, glabridin, various herbal medicines, tocopherol acetate, glycyrrhizic acid, its derivatives or their salts Such as drugs, vitamin C,
Magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, resorcinol, ellagic acid, other whitening agents such as chamomile extract, or saccharides such as glucose, fructose, mannose, sucrose, trehalose, etc. are also appropriately blended. be able to.

The hair growth inhibitor containing methylisopropylphenol as an active ingredient of the present invention can be used by being blended with cosmetics, pharmaceuticals, quasi-drugs, etc. applied to the outer skin, and especially for cosmetics. It can be widely and suitably used, and its dosage form may be any as long as it can be applied to the skin.Solution system, solubilization system, emulsion system, powder dispersion system, water-oil bilayer system, water. -Oil-powder three-layer system, ointment, gel, aerosol, or any other dosage form can be adopted.

The product form (use form) of the composition for external use containing the hair growth inhibitor containing methylisopropylphenol as an active ingredient of the present invention is arbitrary. For example, in the case of cosmetics, a lotion, In addition to facial cosmetics and foundations such as emulsions, creams, and packs, make-up cosmetics, aromatic cosmetics, bath agents and the like can be used.

The product form of the cosmetic containing the hair growth inhibitor is not particularly limited as described above, but it is preferable to use a cosmetic related to hair removal, depilation or shaving. As such a cosmetic, specifically, a paste-shaped, cream-shaped, aerosol-shaped dehairing agent, a wax-shaped, gel-shaped, sheet-shaped dehairing agent, a lotion used for dehairing or post-hair removal treatment, Post-treatment such as cream, deodorant lotion, deodorant powder, deodorant spray, anti-perspirant cosmetics such as deodorant stick, shaving pre-treatment such as pre-shave lotion,
Examples include shaving cream and other shaving agents, and after-shave lotion and other shaving and post-shaving agents.

Regarding the dosage forms, product forms and specific products of external compositions such as cosmetics containing the hair growth inhibitor containing methylisopropylphenol as an active ingredient of the present invention, the specific agents mentioned above are used. It goes without saying that the type, product form and product are not limited.

[0018]

[Examples] The following is an example of a hair growth inhibitory performance evaluation test of methylisopropylphenol, which is an active ingredient of the hair growth inhibitor of the present invention, and various dosage forms and various product forms containing the hair growth inhibitor. The present invention will be described in more detail, but the present invention is not limited by these evaluation tests and examples, and is specified by the description of the claims.

[Hair Growth Inhibition Evaluation Test 1] In order to evaluate the hair growth suppression effect, an evaluation test using immortalized human outer root sheath cells was performed. The details of the evaluation test are shown below. The immortalized human outer root sheath cell proliferation is described in JP-A-2000-89.
The cells described in the publication were used.

[Immortalized Human Outer Hair Root Sheath Cell Growth Inhibition Test] The evaluation test was carried out according to the following procedure. Using immortalized outer hair root sheath cells (IORS), K-GM (Clonetics)
A cell suspension was prepared at a cell density of 50,000 cells / ml. 100 μl each of this, collagen type I
-Coated 96-well plate (Iwaki Glass)
(5,000 cells / well) at 37 ° C, 5%
Pre-incubation was performed for 24 hours in CO ₂ to attach the cells.

[Preparation of test sample] For thymol, carvacrol and biozole, 0.04% solution was prepared with ethanol and further diluted with K-GM medium. Next, K-BM (Clonetics) of basal medium containing no PBS or growth factors
After washing in, the medium was replaced with K-GM containing the substance to be tested (200 μl). KG as control medium
M was used, and basal medium K-BM was added as a growth inhibition control in an amount of 200 μl as a test medium in order to further confirm cytotoxicity. 4 wells for each concentration of control, growth suppression control and each test sample
The average value of each relative cell number was determined.

[Evaluation of cell growth] After culturing the control, the growth suppression control and each test sample for 48 hours,
20 μl of Alamar Blue (Bio Source Internationa
l) was added to each well and reacted at 37 ° C for 6 hours, then 570 nm and 600 nm with a microplate reader.
The absorbance of was measured. According to the attached instruction manual, the reduction rate of alamar blue was obtained from the measurement result of the absorbance.
Since this reduction rate correlates with the number of viable cells, the relative number of cells in each control and test substance addition system can be determined.

[Determination of Effect] Two days after the medium replacement, IORS proliferated about 2-fold in the KGM medium as the control medium. The growth inhibition rate was calculated based on the following formula. Cell growth inhibition rate (%) = (A−C) / (A−B) × 10
0 A: control cell growth B: growth suppression control cell growth C: cell growth in sample addition system The cell growth in the growth suppression control medium was 0%, and the growth rate in the control medium was 100%. %
The cell growth inhibition rate at the time of adding the sample was calculated.

[Criteria] The following criteria were used to judge the effect. Proliferation suppression 20% or more Strong suppressive effect ◎ Proliferation suppression 10% or more but less than 20% Suppressive effect ○ Proliferation suppression less than 10% Weak suppressive effect △ Proliferation suppression -5% or less Promoting effect × In addition, cells in sample addition When the growth was below the growth suppression control, it was judged to be cytotoxic and excluded from the evaluation.

The hair growth inhibition evaluation test was conducted at various concentrations using thymol, carvacrol, and biozole, which are the active ingredients of the hair growth inhibitor of the present invention, which are methylisopropylphenol, as test samples. The results are shown in Table 1. The results show that thymol, carvacrol, and biozole have a hair growth inhibitory effect even at an extremely low concentration, and have a very excellent hair growth inhibitory effect.

[0026]

[Table 1]

[Hair Growth Inhibition Evaluation Test 2] In order to evaluate the hair growth inhibition effect, an evaluation test by the following C3H mouse hair growth inhibition test was also performed. [C3H Mouse Hair Suppression Test] C from 8 to 10 weeks of age
The back hair of 3 groups of 3H mice 1 × 4 with an electric clipper
After cutting the hair over cm ^{2, the} hair was removed using a hair removal cream (Shiseido: Debene). A test sample was applied to the hair removal site once a day in 100 μl aliquots for 18 days. The test sample was dissolved in a solvent (100% ethanol). Only the solvent was applied to the control group.

[Evaluation of hair growth inhibitory effect] 10 days after application and 1
After 8 days, hair regrowth at the hair removal site was scored based on the following evaluation criteria. Regarding the hair growth suppressing effect, the score after 10 days of application is compared with that of the control group, and the one having a lower point than the control group is evaluated as "present" regarding the hair growth suppressing effect. For the elongation inhibitory effect, the difference between the scores 10 and 18 days after application is calculated,
Those having a difference smaller than that of the control group are evaluated as the elongation inhibitory effect.

[Evaluation Criteria] Point Hair regeneration state 0 No hair growth 1 Black skin of hair removal part 2 Hair tips are visible 3 Hair of about half the length of non-hair removal part is observed 4 Non-removal It is covered with hair of the same length as the hair. For the evaluation, hair regrowth was carried out in 0.5 point steps for each mouse.

[Judgment Criteria] The hair growth suppression effect and the elongation suppression effect were evaluated according to the following judgment criteria based on the scores. [Hair growth suppression effect] Yes: "Hair regrowth point" on day 10 is "solvent (EtOH)"
Lower than [Elongation inhibitory effect] ⊚: Strong (the difference in score between 10 and 18 days after application is less than 2) ○: The difference in score between 10 and 18 days after application is 2 or more 2.
Less than 5 △: Weak (Score difference between 10 and 18 days after application is less than 3)

A hair growth inhibitory evaluation test was conducted at various concentrations using thymol, carvacrol, and biozole, which are the methyl isopropylphenol active ingredients of the hair growth inhibitor of the present invention, as test samples. The results are shown in Table 2. The results show that thymol, carvacrol, and biozole have a hair growth inhibitory effect at a low concentration and have an excellent hair growth inhibitory effect. The concentration at which the effect was recognized was higher than that of the evaluation method using the cells performed in the evaluation test 1. This is because in Evaluation Test 1, the active ingredient directly contacts the cells in the culture medium, whereas in Evaluation Test 2, a higher concentration is required for the active ingredient to penetrate the hair root due to the barrier function of the mouse skin. It is considered to indicate that

[0032]

[Table 2]

With respect to various external preparations containing the hair growth inhibitor of the present invention, examples of various dosage forms and product forms will be described below.
This will be described as an example. In addition, the total amount of the weight% of all compounding ingredients in each of the following examples is 100%, and therefore, the "remainder" in the column of "(weight%)" is 100%.
Is obtained by subtracting the weight% of all other components excluding the component.

[0034]   (Example 1) Vanishing cream       (Composition component) (% by weight)   (1) Stearic acid 6.0   (2) Sorbitan monostearate 2.0   (3) Polyoxyethylene (20 mol)           Sorbitan monostearate 1.5   (4) Arbutin 7.0   (5) Sodium hydrogen sulfite 0.03   (6) Propylene glycol 7.0   (7) Glycerin 3.0   (8) Timol 1.0   (9) Ethyl paraben 0.1 (10) Butylparaben 0.1 (11) Thiotaurine 0.01 (12) Perfume 0.1 (13) Residual ion exchange water

(Production method) In (13), (4), (6),
(7) was added and heated to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (3), (5), (8) to (12)
Were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase for preliminary emulsification, and the mixture was uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring to obtain a vanishing cream.

[0036]   (Example 2) Neutral cream       (Composition component) (% by weight)   (1) Stearyl alcohol 5.0   (2) Stearic acid 2.0   (3) Hydrogenated lanolin 2.0   (4) 2-hydroxy-4-methoxybenzophenone 2.0   (5) Squalane 5.0   (6) 2-octylde deserial call 6.0   (7) Polyoxyethylene (25 mol)           Cetyl alcohol ether 3.0   (8) Glycerin monostearate 2.0   (9) Placenta extract 0.1 (10) Propylene glycol 2.0 (11) 1,3 butylene glycol 3.0 (12) Timor 5.0 (13) Perfume 0.2 (14) 1.2-Pentadiol 0.5 (15) Butyl paraben 0.1 (16) Hypotaurine 0.01 (17) Residual ion-exchanged water

(Production method) (17) to (9) to (11),
(16) was added and heated to prepare an aqueous phase maintained at 70 ° C. On the other hand, (1) to (8) and (12) to (15) were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase for preliminary emulsification, and the mixture was uniformly emulsified with a homomixer and then cooled to 30 ° C. with thorough stirring to obtain a neutral cream.

[0038]   (Example 3) Cold cream       (Composition component) (% by weight)   (1) Solid paraffin 5.0   (2) Beeswax 5.0   (3) Vaseline 5.0   (4) Liquid paraffin 20.0   (5) Squalane 10.0   (6) Glycerin monostearate 2.0   (7) Polyoxyethylene (20 mol)           Sorbitan monolaurate 2.0   (8) Kojic acid 2.0   (9) 2-hydroxy-4-methoxybenzophenone           -5-sodium sulfonate 3.5 (10) Soap powder 0.1 (11) Borax 0.2 (12) Thymol 0.1 (13) Residual ion exchange water (14) Perfume 0.2 (15) Ethyl paraben 0.2 (16) Butylparaben 0.1 (17) Butyl hydroxytoluene 0.05

(Production method) (13) to (8), (10),
(11) was added and dissolved by heating to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (7), (9), (12),
(14) to (17) were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase while stirring, and the reaction was carried out. After completion of the reaction, the mixture was uniformly emulsified with a homomixer, and after emulsification, the mixture was cooled to 30 ° C. with thorough stirring to obtain a cold cream.

[0040] (Example 4) Nutrition cream       (Composition component) (% by weight)   (1) Dimethyl distearyl chloride           Ammonium-treated hectorite 2.0   (2) Polyoxyethylene / methylpolysiloxane polymer 0.1   (3) Liquid paraffin 10.0   (4) Vaseline 5.0   (5) Cetyl octanoate 20.0   (6) L-Glutamate 0.01   (7) Dipropylene glycol 5.0   (8) Methylparaben 0.2   (9) Sodium hyaluronate 0.05 (10) Vitamin E acetate 0.02 (11) Biozol 5.0 (12) Residual ion-exchanged water

(Manufacturing method) (2), (3) and (5) at 50 ° C.
After heating to (4), (10) and (11), (1) was added to the completely dissolved oil phase parts and uniformly dispersed, and then to (12) (6), The water phase parts in which (7) and (8) are dissolved are heated to 50 ° C. and added, and HM is added.
After uniform dispersion in, cooled to room temperature to obtain a water-in-oil emulsion composition.

[0042]   (Example 5) Emulsion       (Composition component) (% by weight)   (1) Polyoxyethylene (10 mol)           Monooleate 2.0   (2) Octyl paramethoxycinnamate 3.5   (3) Liquid paraffin 2.0   (4) Cyclopentadimethylsiloxane 1.0   (5) Squalane 3.0   (6) 1,3-butylene glycol 5.0   (7) Arbutin 2.0   (8) Sodium hydrogen sulfite 0.03   (9) Glycerin 2.0 (10) Ethanol 5.0 (11) Carboxyvinyl polymer 0.3 (12) Hydroxypropyl cellulose 0.1 (13) Potassium hydroxide 0.15 (14) Ethyl paraben 0.1 (15) 1.2-Pentanediol 1.0 (16) Carvacrol 0.01 (17) Residual ion-exchanged water (18) Fragrance 0.3

(Production method) (7) was dissolved in a mixed solution of (17) and (10) by heating, and (6), (8), (9),
(11) to (13) were dissolved to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (5), (14), (1
5), (16) and (18) are mixed, heated and melted to 70
An oil phase maintained at 0 ° C was prepared. The oil phase was added to the aqueous phase, preliminarily emulsified, homogeneously emulsified with a homomixer, and after emulsification, cooled to 30 ° C. with thorough stirring to obtain an emulsion.

[0044]   (Example 6) Emulsion       (Composition component) (% by weight)   (1) Polyoxyethylene (20 mol) polyoxy           Propylene (2 mol) cetyl alcohol 1.0   (2) Octyl-p-methoxycinnamate 3.5   (3) "Silicone KF 96" (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0   (4) Liquid paraffin (medium viscosity) 3.0   (5) 4-tert-butylmethoxydibenzoylmethane 0.3   (6) Glyceryl tri-2-ethylhexanoate 1.0   (7) Arbutin 2.0   (8) Sodium hydrogen sulfite 0.03   (9) Glycerin 2.0 (10) Ethanol 3.0 (11) Carboxyvinyl polymer 0.3 (12) Hydroxypropyl cellulose 0.1 (13) Potassium hydroxide 0.1 (14) 1.2-Pentanediol 2.0 (15) Phenoxyethanol 0.2 (16) Thymol 0.01 (17) Residual ion-exchanged water

(Production method) (17) and (10) were dissolved by heating (7), and then (6), (8), (9) and (11).
(13) and (15) were dissolved to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (5), (14) and (1
6) were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase, preliminarily emulsified, homogeneously emulsified with a homomixer, and after emulsification, cooled to 30 ° C. with thorough stirring to obtain an emulsion.

[0046]   (Example 7) Emulsion       (Composition component) (% by weight)   (1) Polyoxyethylene (20 mol) polyoxy           Propylene (2 mol) cetyl alcohol 1.0   (2) Paramethoxycinnamic acid mono-2           -Glyceryl ethylhexanoate 2.0   (3) "Silicone KF 96" (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0   (4) Squalane 3.0   (5) 1,3-butylene glycol 5.0   (6) Ascorbic acid-2-glucoside 3.0   (7) Polyethylene glycol 400 3.0   (8) Glycerin 2.0   (9) Ethanol 5.0 (10) Carboxyvinyl polymer 0.3 (11) Hydroxypropyl cellulose 0.1 (12) Potassium hydroxide 0.1 (13) Butyl paraben 0.1 (14) Phenoxyethanol 0.4 (15) Thiotaurine 0.02 (16) thymol 0.001 (17) Residual ion-exchanged water (18) Perfume 0.1

(Production Method) (15) and (6) are dissolved in (17) and (9), and (5), (7), (8),
(10) to (12) and (14) were dissolved to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (4) and (1
3), (16) and (18) were mixed, heated and melted to 70
An oil phase maintained at 0 ° C was prepared. The oil phase was added to the aqueous phase, preliminarily emulsified, homogeneously emulsified with a homomixer, and after emulsification, cooled to 30 ° C. with thorough stirring to obtain an emulsion.

[0048]   (Example 8) Emulsion       (Composition component) (% by weight)   (1) Polyoxyethylene (20 mol) polyoxy           Propylene (2 mol) cetyl alcohol 1.0   (2) "Silicone KF 96" (20cs) (Shin-Etsu Chemical Co., Ltd.) 2.0   (3) Liquid paraffin (medium viscosity) 3.0   (4) Methylenebis-benzotriazolyl           Tetramethylbutylphenol 1.0   (5) 1,3-butylene glycol 5.0   (6) Glycerin 2.0   (7) Ethanol 4.0   (8) Carboxyvinyl polymer 0.3   (9) Hydroxypropyl cellulose 0.1 (10) Potassium hydroxide 0.05 (11) 1.2-Pentanediol 1.0 (12) Butyl paraben 0.1 (13) Kojic acid 3.0 (14) Timor 3.0 (15) Residual ion-exchanged water

(Manufacturing method) (13) was dissolved in (15) by heating, and (5) to (10) were further dissolved to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (4), (11),
(12) and (14) were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase, preliminarily emulsified, uniformly emulsified with a homomixer, and after emulsification, cooled to 30 ° C. with thorough stirring to obtain an emulsion.

[0050]   (Example 9) Emulsion       (Composition component) (% by weight)   (1) Stearic acid 1.5   (2) Cetyl alcohol 0.5   (3) Beeswax 2.0   (4) Polyoxyethylene (20 mol)           Monooleate 1.0   (5) Glycerin monostearate 1.0   (6) Ethanol 3.0   (7) Arbutin 10.0   (8) Sodium hydrogen sulfite 0.03   (9) 1,3-butylene glycol 5.0 (10) Polyethylene glycol 400 2.0 (11) Biozol 1.0 (12) Residual ion-exchanged water (13) Perfume 0.15 (14) Methylparaben 0.3 (15) Butylparaben 0.2 (16) Thiotaurine 0.1

(Production method) (12) to (7), (9), (1
0) and (16) were added and dissolved by heating to prepare an aqueous phase kept at 70 ° C. Further, (11) was added to (6) and dissolved to prepare an alcohol phase. Furthermore, (1) to (5),
(8) (13), (14) and (15) were mixed, heated and melted to prepare an oil phase kept at 70 ° C. The oil phase was added to the aqueous phase for preliminary emulsification, and the mixture was homogenized with a homomixer. The alcohol phase was added while stirring. Then, the mixture was cooled to 30 ° C. with stirring to obtain an emulsion.

[0052]   (Example 10) Emulsion       (Composition component) (% by weight)   (1) Microcrystalline wax 1.0   (2) Beeswax 1.0   (3) Vaseline 2.0   (4) Liquid paraffin 10.0   (5) Squalane 5.0   (6) Jojoba oil 5.0   (7) Sorbitan sesquioleate 4.0   (8) Polyoxyethylene (20 mol)           Sorbitan monooleate 1.0   (9) Arbutin 5.0 (10) Sodium hydrogen sulfite 0.03 (11) Tranexamic acid 5.0 (12) 1,3-butylene glycol 5.0 (13) Sorbitol 2.0 (14) Carvacrol 0.01 (15) Bis-ethylhexyloxyphenol           Methoxyphenyltriazine 1.5 (16) Residual ion-exchanged water (17) Fragrance 0.2 (18) Ethyl paraben 0.1 (19) Butylparaben 0.1 (20) Dibutylhydroxytoluene 0.05

(Production method) (16) to (9), (11)
(13) was added and heated to prepare an aqueous phase maintained at 70 ° C. On the other hand, (1) to (8), (10), (14), (1
5), (17) to (20) are mixed, heated and dissolved to 70
An oil phase maintained at 0 ° C was prepared. While stirring the oil phase, the aqueous phase was gradually added to this oil phase, and the mixture was uniformly emulsified with a homomixer. After emulsification, cool to 30 ℃ while stirring well,
An emulsion was obtained.

[0054] (Example 11) Emulsion       (Composition component) (% by weight)   (1) Isopropyl alcohol 10.0   (2) Diglyceryl diisostearate 0.5   (3) POE-modified dimethylpolysiloxane 1.0   (4) Octamethylcyclotetrasiloxane 25.0   (5) Decamethylcyclopentasiloxane 15.0   (6) Trimethylsiloxysilicic acid 5.0   (7) Eucalyptus oil 3.0   (8) Perfume 0.05   (9) Timol 0.5 (10) Dipropylene glycol 2.0 (11) Arbutin 7.0 (12) Sodium hydrogen sulfite 0.03 (13) Methylparaben 0.1 (14) Trisodium edetate 0.1 (15) Residual ion-exchanged water (16) Potassium chloride 0.5

(Production Method) (1) to (8) were dissolved to prepare an oil phase, (9) to (16) were dissolved to prepare an aqueous phase, the aqueous phase was added to the oil phase and emulsified, An emulsion was obtained.

[0056] (Example 11) Emulsion       (Composition component) (% by weight) A. Oil phase   Dimethyl polysiloxane 0.5   Decamethylcyclopentasiloxane 1.0   Jojoba oil 0.5   Thymol 0.0001 B. Water phase   Arbutin 1.0   Alkyl-modified carboxyvinyl polymer 0.05   Carboxy vinyl polymer 0.3   Gum arabic 0.05   Ethyl alcohol 8.0   Trisodium edetate 0.1   Methylparaben 0.1   Phenoxyethanol 0.2   Ion-exchanged water residue C. Neutralization     KOH 0.15

(Production Method) The dissolved (A) phase was added to the dissolved (B) phase, and after emulsification, the (C) phase was neutralized to obtain an emulsion.

[0058]   (Example 12) jelly       (Composition component) (% by weight)   (1) 95% ethanol 10.0   (2) Dipropylene glycol 10.0   (3) Glycerin 5.0   (4) Polyoxyethylene (15 mol)           Oleyl alcohol ale 2.0   (5) Arbutin 0.5   (6) Sodium hydrogen sulfite 0.03   (7) Ascorbic acid distearate 0.5   (8) Carboxy vinyl polymer (“Carbopol 941”) 1.0   (9) Caustic potash 0.15 (10) L-arginine 0.1 (11) Timor 2.0 (12) Perfume 0.1 (13) Phenoxyethanol 0.4 (14) Ion-exchanged water residue

(Production method) An aqueous phase was prepared by uniformly dissolving (5), (3) and (8) in (14). On the other hand, (1)
(2), (4), (6), (7), (11) to (1
3) was dissolved and this was added to the aqueous phase. Then (9),
It was neutralized with (10) and thickened to obtain jelly.

[0060]   (Example 13) Peel-off type pack       (Composition component) (% by weight) (Alcohol phase)   95% ethanol 10.0   Polyoxyethylene (15 mol)     Oleyl alcohol ether 2.0   Ethylhexyltriazone 1.0   Methylparaben 0.3   Phenoxyethanol 0.3   Biosol 0.5   Fragrance 0.2 (Water phase)   Arbutin 1.0   Sodium hydrogen sulfite 0.03   Polyvinyl alcohol 12.0   Glycerin 3.0   Polyethylene glycol 1500 1.0   Ion-exchanged water residue

(Manufacturing method) A water phase was prepared at 80 ° C.
Cooled to. Then, the alcohol phase prepared at room temperature is added, mixed uniformly and allowed to cool.

[0062]   (Example 14) Pack containing powder       (Composition component) (% by weight) (Alcohol phase)   95% ethanol 5.0   Methylparaben 0.1   1,2-Pentanediol 2.0   Fragrance 0.3   Ascorbic acid diolate 1.0   Carvacrol 0.01 (Water phase)   Arbutin 1.0   Dipropylene glycol 3.0   Polyethylene glycol 1500 0.5   Zinc flower 15.0   Kaolin 8.0   Ion-exchanged water residue

(Production Method) An aqueous phase was uniformly prepared at room temperature.
The alcohol phase prepared at room temperature was added thereto and mixed uniformly to obtain a powder-containing pack.

[0064]   (Example 14) Water absorption ointment       (Composition component) (% by weight)   (1) Vaseline 40.0   (2) Stearyl alcohol 18.0   (3) Mokuro 20.0   (4) Polyoxyethylene (10 mol)           Monooleate 0.25   (5) Glycerin monostearate 0.25   (6) Placenta extract 0.5   (7) Carvacrol 0.0001   (8) Residual ion-exchanged water

(Production method) (6) was added to (8) to prepare an aqueous phase kept at 70 ° C. On the other hand, (1) to (5), (7)
Was mixed and dissolved at 70 ° C. to prepare an oil phase. The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain a water absorbing ointment.

[0066]   (Example 15) Lotion       (Composition component) (% by weight) (Water phase)   Ion-exchanged water residue   Glycerin 5.0   1,3-butylene glycol 2.0   Ascorbic acid-2-glucoside 1.0   Brilliant blue 0.0002   Edetate 0.1   Caustic potash 0.2   Sodium citrate 0.15   Citric acid 0.03 (Alcohol phase)   Ethanol (95%) 7.0   Polyoxyethylene (60 mol) hydrogenated castor oil ether 0.3   Vitamin E acetate 0.1   Thymol 1.0   Fragrance 0.05   Methylparaben 0.15   Phenoxyethanol 0.3

(Production Method) After the aqueous phase component and the alcohol phase component were uniformly dissolved, the alcohol phase was added to the aqueous phase and mixed uniformly.

[0068]   (Example 16) Lotion       (Composition component) (% by weight) (Water phase)   Ion-exchanged water residue   Glycerin 5.0   Polyethylene glycol 400 2.0   Xylitol 0.5   Ascorbic acid-2-glucoside 1.0   First green 0.0003   Metaphosphoric acid 0.1   Xanthan gum 0.1   Sodium alginate 0.1   Hyaluronic acid 0.1   Trimethylglycine 3.0   Caustic potash 0.4   Sodium lactate 0.1   Lactic acid 0.03 (Alcohol phase)   Ethanol (95%) 7.0   POE oleyl alcohol ether 0.3   Vitamin E acetate 0.1   Carvacrol 1.0   Fragrance 0.05   Methylparaben 0.15   Phenoxyethanol 0.3

(Production Method) After the aqueous phase component and the alcohol phase component were uniformly dissolved, the alcohol phase was added to the aqueous phase and mixed uniformly.

The cosmetics containing the hair growth-suppressing agents of the above Examples all showed excellent effects in the hair growth-suppressing effect test.

[0071]

Industrial Applicability As described in detail above, the hair growth inhibitor of the present invention containing methylisopropylphenol as an active ingredient has excellent hair growth inhibitory ability, and has been used as a home remedy on the human body for many years. It is highly safe and can be used in combination with various compositions applied to the outer skin of medicines, quasi-drugs, cosmetics, etc., and these compositions have an excellent ability to suppress hair growth. Can be expressed. In particular, when blended with a cosmetic, it has an excellent hair growth inhibitory ability and can provide a highly safe cosmetic.
More specifically, it is possible to provide a cosmetic that has less irritation to the skin and can further reduce the burden of hair removal processing work.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Tomoko Yokoyama             2-12-1, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa               Shiseido Research Center Co., Ltd. (Kanazawa             (Hakkei) F-term (reference) 4C083 AA072 AA082 AA122 AB012                       AB032 AB152 AB212 AB282                       AB332 AB352 AB442 AC012                       AC022 AC072 AC092 AC102                       AC112 AC122 AC132 AC172                       AC182 AC212 AC242 AC302                       AC352 AC402 AC422 AC432                       AC442 AC471 AC472 AC482                       AC532 AC552 AC582 AC622                       AC692 AC742 AC792 AC842                       AC852 AD042 AD092 AD112                       AD152 AD162 AD172 AD282                       AD302 AD332 AD352 AD392                       AD512 AD642 AD662 CC04                       CC05 CC07 CC18 DD22 DD23                       DD27 DD31 DD32 DD41 EE21                       EE28 FF05                 4C206 AA01 AA02 CA17 KA01 MA01                       MA04 MA83 NA14 ZA92 ZB21

Claims (5)

[Claims] 1. A hair growth inhibitor containing methylisopropylphenol as an active ingredient. 2. The methylisopropylphenol is thymol (5-methyl-2-isopropylphenol), carvacrol (2-methyl-5-isopropylphenol) and / or biozole (3-methyl-4-isopropylphenol). The hair growth inhibitor according to claim 1. 3. A composition for external use, which comprises the hair growth inhibitor according to claim 1 or 2. 4. A cosmetic containing the hair growth inhibitor according to claim 1. 5. The product form is a depilatory agent, depilatory agent, shaving agent,
The cosmetic composition according to claim 4, which is selected from the group consisting of a pre-shaving agent, a post-shaving agent, a post-shaving agent and a post-shaving agent.