JP2003146873A - Iron absorption promoter - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an iron absorption promoter that includes vinegar so that the absorption of iron into blood may be increased. SOLUTION: The iron absorption promoter includes vinegar. The vinegars is at least one selected from the group consisting of fruit vinegar, black vinegar, rice vinegar, alcohol vinegar and cereal vinegars. The acidity of the vinegar is 0.3-1.3 w/v%. In another embodiment, this iron absorption promoter may includes prune vinegar of 0.3-1.3 w/v% acidity.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an iron absorption promoter that promotes iron absorption and improves iron deficiency.

[0002]

2. Description of the Related Art Iron is one of the essential micronutrients essential for sustaining life and is a major component of hemoglobin in red blood cells that carry oxygen, as well as myoglobin in muscle and oxidation in the body. It is an important component of the enzyme involved in the reduction and is an essential factor for the blood increasing action in the living body.

Iron deficiency is caused by bleeding, ureteral bleeding, pregnancy, intake of iron-deficient diet, abnormal absorption of iron from the intestine, and the like, which persists leading to iron deficiency anemia.

Conventionally, when deficiency of iron, iron citrate,
Ingestion of non-heme iron such as iron lactate, ferric chloride and iron sulfate and heme iron contained in meat, liver, etc., vitamin C,
It is recommended to eat foods that contain many components that promote iron absorption, such as cysteine, and it is desirable to avoid foods that contain a large amount of phytic acid, phosphoric acid, tannic acid, etc. that decrease iron absorption. .

Although vinegar has been widely used as a seasoning for a long time, not only seasoning but also other functions such as antibacterial have been utilized. In particular, it is empirically known that taking vinegar is good for health, and it is also used with the expectation that it will be used as a folk medicine.

Vinegar is said to be effective in promoting secretion of gastric juice, recovery from fatigue, protection of fatty liver, prevention of high blood pressure, reduction of lipid peroxide, reduction of cholesterol, reduction of blood alcohol.

[0007]

Iron is a trace element that is difficult to be absorbed in blood, and iron absorbed from the intestinal tract is 10%.
It is known to be degree. Therefore, even if a large amount of iron is orally ingested, most of the ingested iron is excreted out of the body as it is, and thus a material that promotes absorption of iron from the intestinal tract is desired.

However, vinegar has not yet been specifically defined as promoting the absorption of iron.

The present invention provides an iron absorption enhancer containing vinegar which improves the absorption rate of iron which is difficult to be absorbed in blood.

[0010]

Means for Solving the Problems The inventors of the present invention have made extensive studies on the above problems, and as a result, found that the ingestion of iron is promoted by ingesting vinegar and iron at the same time. It came to completion.

That is, the iron absorption promoter of the present invention is an iron absorption promoter containing vinegar. In a preferred embodiment of the present invention, the vinegar comprises at least one of fruit vinegar, black vinegar, rice vinegar, alcohol vinegar, and grain vinegar, and the vinegar has an acetic acid equivalent acidity of 0.
The content is 3 w / v% or more and 1.3 w / v% or less. In addition, prune vinegar has an acidity of acetic acid equivalent of 0.3 w /
The content is v% or more and 1.3 w / v% or less.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The iron absorption promoter of the present invention is an iron absorption promoter containing vinegar.

In the present invention, the vinegar may be brewed vinegar or synthetic vinegar. Here, in brewed vinegar, alcohol-containing mash becomes edible vinegar by oxidative fermentation of acetic acid bacteria, and there are various types of raw materials. Specifically, fruit vinegar (prune vinegar, blueberry vinegar, apple vinegar, grape vinegar) , Persimmon vinegar, peach vinegar, strawberry vinegar, etc.), black vinegar (brown rice vinegar,
Vinegar vinegar, etc.), rice vinegar (pure rice vinegar, etc.), sake vinegar (alcohol vinegar, etc.), grain vinegar (malt vinegar, lees vinegar, corn vinegar, wheat vinegar, pigeon vinegar, rye vinegar, wheat germ vinegar, buckwheat vinegar, Amaranth vinegar, etc.), and brewed vinegar other than grain vinegar and fruit vinegar (onion vinegar, tomato vinegar, plum vinegar, shiso vinegar, herb vinegar, seaweed vinegar, etc.). Synthetic vinegar uses 4 parts of brewed vinegar in glacial acetic acid or dilute acetic acid.
It is a mixture of 0% or more.

In the present invention, from the viewpoint of promoting the absorption of iron, vinegar includes fruit vinegar, black vinegar, rice vinegar, alcohol vinegar,
It is preferably composed of one or more of grain vinegar,
The vinegar preferably contains 0.3 w / v% or more and 1.3 w / v% or less in terms of acidity in terms of acetic acid.

The black vinegar referred to in the present invention includes all that are generally called black vinegar, and is not limited to the natural vinegar production method.

In the present invention, prune vinegar is made from prune juice. In the case of containing prune vinegar, it is preferable that the prune vinegar is contained in an acidity of 0.3 w / v% or more and 1.3 w / v% or less in terms of acetic acid.

The iron absorption promoter of the present invention is a mixture of vitamin C and other iron absorption and metabolism promoters, iron compounds, etc., as long as the effects of the present invention are not impaired.
For example, various substances such as nutrients and trace elements can be mixed.

The iron absorption promoter of the present invention can be used not only as it is, but also by being dried by freeze-drying or spray-drying, or by purifying necessary components.

The iron absorption enhancer of the present invention can be provided in the form of medicines, quasi drugs, foods and drinks having an iron absorption promoting effect, and foods.

In the case of a pharmaceutical product, for example, an excipient, binder, disintegrating agent, lubricant, diluent, flavoring agent or the like known in the field of formulation technology, which are commonly used in the formulation, are appropriately used. , Orally or parenterally administered as a liquid, tablet, powder, granule, dragee, capsule, enteric agent, suppository,
It may be in any dosage form such as an ointment, an inhalant, a syrup, a troche, and an injection.

In the case of quasi-drugs, for example, beverages, tablets, capsules, troches (candy), granules, etc. that can be easily ingested on a daily basis and have a sufficient iron absorption effect on the living body. To

When the food or drink has an iron absorption promoting effect, for example, food materials (including fruits and jellies),
Milk components, carbonic acid, excipients (including granulating agents), diluents,
Mixing one or more selected from various proteins such as sweeteners, flavors, flour, starch, sugar, fats and oils, sugar raw materials, vitamins, minerals, canned beverages, bottled beverages, solid foods, sports, etc. Beverages, fruit drinks, milk drinks, dairy drinks, jellies, jelly drinks, carbonated drinks and other food and drink.

In the case of a food having an effect of promoting iron absorption, for example, sugars, fats, trace elements, vitamins,
Blended with emulsifiers, flavors, etc. to make natural liquid food, semi-digestible nutrition food, ingredient nutrition food, solid, liquid food, seasoning, luxury food, agricultural food, fermented food, livestock food, seafood, etc. To

[0024]

[Examples] (Example 1) Iron absorption-promoting effect in iron-deficient rats The absorption rate of iron into blood when iron is ingested is dependent on the state of iron sufficiency in the body, and absorption is promoted in the iron-deficient state. It is supposed to be done. Therefore, it was investigated whether or not iron absorption and absorption by vinegar were promoted in iron-deficient rats.

Prune vinegar made from prune juice
The acidity was adjusted with distilled water so that the acidity in terms of acetic acid was 1.25 w / v% to obtain an iron absorption promoter 1a according to the present invention.

Separately, 10 6-week-old male Wistar rats were fed a low iron diet for 6 days and then fasted overnight.

Rats fasted overnight were divided into two groups of 5 animals each. The first group was orally administered with a solution obtained by mixing the iron absorption enhancer 1a and 2.25 mg of Sunactive Iron (manufactured by Taiyo Kagaku Co., Ltd.) as iron content per 1 kg of rat body weight. The second group contained distilled water and a rat body weight of 1
A solution in which 2.25 mg of iron content per kg of Sunactive Iron (manufactured by Taiyo Kagaku Co., Ltd.) was orally administered and used as a control.

1.5 hours after oral administration, blood was collected from each rat and centrifuged to measure the iron concentration in the obtained serum.

As a result, when the average iron concentration in the serum of the second group to which distilled water was administered was 1, the average iron concentration in the serum of the first group to which the iron absorption promoter 1a was administered was 1.25. became. From this, it was proved that the iron absorption promoter of the present invention exerts an excellent iron absorption promoting effect in the iron deficiency state.

Example 2 Iron Absorption Properties of Iron Absorption Promoters Prune vinegar made from prune juice was used as acetic acid equivalent acidity of 0.3 w / v% and 0.6 w / v, respectively.
%, 1.25 w / v%, 2.5 w / v%,
Iron absorption promoter 2 which is the present invention by adjusting the acidity with distilled water
a, 2b, 2c and 2d were obtained.

Separately, 30 6-week-old male Wistar rats preliminarily bred for 1 week were fasted overnight.

Rats fasted overnight were divided into 5 groups of 6 animals each. The first group was orally administered with a solution in which the iron absorption promoter 2a and Sunactive Iron were mixed. In the second group,
A solution in which the iron absorption promoter 2b and Sunactive Iron were mixed was orally administered. The third group was orally administered with a solution of the iron absorption enhancer 2c and Sunactive iron. A solution obtained by mixing the iron absorption enhancer 2d and Sunactive Iron was orally administered to the fourth group. A solution obtained by mixing distilled water and Sunactive Iron was orally administered to the fifth group, which served as a control. Here, the sun active iron is manufactured by Taiyo Kagaku Co., Ltd., and the mixing amount is 1 kg of rat body weight.
Therefore, the iron content was adjusted to 2.25 mg.

1.5 hours after oral administration, blood was collected from the rat and centrifuged to measure the iron concentration in the obtained serum.

As a result, assuming that the average iron concentration in the serum of the fifth group administered with distilled water is 1, the iron absorption promoters 2a to 2c
The average iron concentration in the serum of the first to fourth groups administered with was 1.02, 1.07, 1.13, and 0.87, respectively. From this, the iron absorption promoter of the present invention is 0.3 w /
It was confirmed that v%, 0.6 w / v%, and 1.25 w / v% had a high iron absorption promoting effect.

[0035]

The iron absorption enhancer of the present invention accelerates the absorption of iron in the intestinal tract, and therefore, it can treat and prevent various diseases caused by iron deficiency, and can further reduce the latent iron deficiency observed in young women. Effective for improvement.

The iron absorption enhancer of the present invention is highly safe, can be continuously ingested, can be supplied in a large amount, and can be easily added to foods. It is a big contribution to.

The iron absorption promoter of the present invention is a symptom caused by insufficient utilization of iron, such as anemia, headache, tinnitus, shortness of breath, dizziness, dyskinesia, malaise and the like, after blood donation, after surgery, Application to postpartum iron deficiency is expected.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Mino Sueda             Tamanoi 100 Nishimachi, Yamatokoriyama City, Nara Prefecture             Vinegar Co., Ltd. Central Research Institute (72) Inventor Satoshi Ujiie             Tamanoi 100 Nishimachi, Yamatokoriyama City, Nara Prefecture             Vinegar Co., Ltd. Central Research Institute F-term (reference) 4C206 AA01 AA02 DA02 MA01 MA72                       NA14 ZA55 ZC75 ZC80

Claims (4)

[Claims] 1. An iron absorption enhancer comprising vinegar. 2. The iron absorption enhancer according to claim 1, wherein the vinegar comprises at least one of fruit vinegar, black vinegar, rice vinegar, alcohol vinegar and grain vinegar. 3. Vinegar has an acidity of acetic acid equivalent of 0.3.
The iron absorption promoter according to claim 1 or 2, wherein the iron absorption promoter is contained in a content of w / v% or more and 1.3 w / v% or less. 4. Pruned vinegar having an acidity of acetic acid equivalent,
An iron absorption promoter containing 0.3 w / v% or more and 1.3 w / v% or less.