JP2003139751A - 精度管理用物質 - Google Patents
精度管理用物質Info
- Publication number
- JP2003139751A JP2003139751A JP2001374980A JP2001374980A JP2003139751A JP 2003139751 A JP2003139751 A JP 2003139751A JP 2001374980 A JP2001374980 A JP 2001374980A JP 2001374980 A JP2001374980 A JP 2001374980A JP 2003139751 A JP2003139751 A JP 2003139751A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- serum albumin
- human serum
- molecular weight
- kda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 title claims abstract description 90
- 238000003908 quality control method Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 28
- 102000009027 Albumins Human genes 0.000 claims abstract description 17
- 108010088751 Albumins Proteins 0.000 claims abstract description 17
- 210000002966 serum Anatomy 0.000 claims description 34
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 27
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 3
- 238000011002 quantification Methods 0.000 claims description 2
- 238000010998 test method Methods 0.000 claims description 2
- 238000000691 measurement method Methods 0.000 abstract description 5
- 238000005259 measurement Methods 0.000 abstract description 4
- 239000012634 fragment Substances 0.000 abstract description 2
- 229920000642 polymer Polymers 0.000 abstract description 2
- 230000002485 urinary effect Effects 0.000 abstract 1
- 238000001641 gel filtration chromatography Methods 0.000 description 10
- 238000002523 gelfiltration Methods 0.000 description 10
- 230000007717 exclusion Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000007853 buffer solution Substances 0.000 description 8
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 210000000540 fraction c Anatomy 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 210000000585 glomerular basement membrane Anatomy 0.000 description 4
- 201000001474 proteinuria Diseases 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000012521 purified sample Substances 0.000 description 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 2
- 206010027525 Microalbuminuria Diseases 0.000 description 2
- 102000007562 Serum Albumin Human genes 0.000 description 2
- 108010071390 Serum Albumin Proteins 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 208000033679 diabetic kidney disease Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 210000002196 fr. b Anatomy 0.000 description 2
- 210000003918 fraction a Anatomy 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- HKJKONMZMPUGHJ-UHFFFAOYSA-N 4-amino-5-hydroxy-3-[(4-nitrophenyl)diazenyl]-6-phenyldiazenylnaphthalene-2,7-disulfonic acid Chemical compound OS(=O)(=O)C1=CC2=CC(S(O)(=O)=O)=C(N=NC=3C=CC=CC=3)C(O)=C2C(N)=C1N=NC1=CC=C([N+]([O-])=O)C=C1 HKJKONMZMPUGHJ-UHFFFAOYSA-N 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001374980A JP2003139751A (ja) | 2001-11-02 | 2001-11-02 | 精度管理用物質 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001374980A JP2003139751A (ja) | 2001-11-02 | 2001-11-02 | 精度管理用物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003139751A true JP2003139751A (ja) | 2003-05-14 |
| JP2003139751A5 JP2003139751A5 (https=) | 2005-07-07 |
Family
ID=19183440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001374980A Pending JP2003139751A (ja) | 2001-11-02 | 2001-11-02 | 精度管理用物質 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2003139751A (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013679A1 (ja) * | 2005-07-27 | 2007-02-01 | Ajinomoto Co., Inc. | 試料溶液中のアルブミンの分析方法 |
-
2001
- 2001-11-02 JP JP2001374980A patent/JP2003139751A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013679A1 (ja) * | 2005-07-27 | 2007-02-01 | Ajinomoto Co., Inc. | 試料溶液中のアルブミンの分析方法 |
| US7833798B2 (en) | 2005-07-27 | 2010-11-16 | Ajinomoto Co., Inc. | Method for analysis of albumin in sample solution |
| JP5024044B2 (ja) * | 2005-07-27 | 2012-09-12 | 味の素株式会社 | 試料溶液中のアルブミンの分析方法 |
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