JP2003126017A5 - - Google Patents
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- JP2003126017A5 JP2003126017A5 JP2001327987A JP2001327987A JP2003126017A5 JP 2003126017 A5 JP2003126017 A5 JP 2003126017A5 JP 2001327987 A JP2001327987 A JP 2001327987A JP 2001327987 A JP2001327987 A JP 2001327987A JP 2003126017 A5 JP2003126017 A5 JP 2003126017A5
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Description
【０００８】
【課題を解決するための手段】
本発明の請求項１は、手術部位の顕微鏡画像を得る手術用顕微鏡と、少なくとも生体組織の蛍光像を得る内視鏡装置と、この内視鏡装置で得た蛍光像を画像処理し蛍光画像を得る画像処理手段と、前記内視鏡装置の観察位置と前記手術部位との相対位置を検出する検出手段とを有する手術用顕微鏡システムにおいて、前記手術用顕微鏡で得た顕微鏡画像の倍率変更に応じて、前記画像処理手段で得た少なくとも生体組織の蛍光画像を変倍する変倍手段と、前記検出手段で検出される前記内視鏡装置の観察位置と前記手術部位との相対位置に基づき、前記顕微鏡画像に対して前記変倍手段で変倍する蛍光画像の範囲を演算する範囲演算手段と、前記範囲演算手段の結果に基づき、前記内視鏡装置の観察位置に応じて前記顕微鏡画像に前記蛍光画像を重畳する画像重畳手段と、を具備したことを特徴としている。
また、本発明の請求項２は、請求項１の手術用顕微鏡システムにおいて、前記画像処理手段は、前記内視鏡装置で得た複数の蛍光像を画像処理した後、合成する合成手段を有し、前記範囲演算手段は、前記検出手段で検出される前記内視鏡装置の観察位置と前記手術部位との相対位置に基づき、前記顕微鏡画像に対して前記合成手段で得た蛍光合成画像の範囲を演算し、前記画像重畳手段は、前記範囲演算手段の結果に基づき、前記内視鏡装置の観察位置に応じて前記顕微鏡画像に前記蛍光合成画像を重畳することを特徴としている。
また、本発明の請求項３は前記内視鏡装置は前記生態組織の処置前光学像を得、前記画像処理手段は前記内視鏡装置で得た処置前光学像を画像処理して処置前画像を得、前記画像重畳手段は前記処置前画像を前記顕微鏡画像に重畳することを特徴としている。
この構成により、残存腫瘍の発見をアシストし、確実な全摘が可能な手術用顕微鏡システムを実現する。
[0008]
[Means for Solving the Problems]
According to a first aspect of the present invention, there is provided an operation microscope for obtaining a microscope image of a surgical site, an endoscope apparatus for obtaining at least a fluorescence image of a living tissue, and a fluorescence image obtained by processing the fluorescence image obtained by the endoscope apparatus. In a microscope system for operation having an image processing means for obtaining the position, and a detection means for detecting the relative position between the observation position of the endoscope apparatus and the surgical site, the magnification change of the microscope image obtained by the operation microscope Accordingly, based on the relative position between the observation position of the endoscope apparatus detected by the detection unit and the surgical site, the magnification change unit configured to change the magnification of the fluorescence image of at least the living tissue obtained by the image processing unit. The microscope image according to the observation position of the endoscope apparatus based on the range calculation means for calculating the range of the fluorescence image to be scaled by the magnification change means with respect to the microscope image and the result of the range calculation means Said fluorescent picture It is characterized by comprising and an image superimposing means for superimposing a.
According to a second aspect of the present invention, in the microscope system for operation according to the first aspect, the image processing means has a combining means for performing image processing on a plurality of fluorescent images obtained by the endoscope apparatus. The range calculation means is a fluorescence synthesis image obtained by the synthesis means with respect to the microscope image based on the relative position between the observation position of the endoscope apparatus detected by the detection means and the surgical site. A range is calculated, and the image superposition means is characterized in that the fluorescence composite image is superimposed on the microscope image according to the observation position of the endoscope apparatus based on the result of the range calculation means.
Further, according to claim 3 of the present invention, the endoscope apparatus obtains a pre-treatment optical image of the biological tissue, and the image processing means processes the pre-treatment optical image obtained by the endoscope apparatus to perform pre-treatment An image is obtained, and the image superimposing means superimposes the pre-treatment image on the microscope image .
With this configuration, a surgical microscope system that assists in finding a residual tumor and can be completely resected is realized.
尚、顕微鏡像は、図５に示すようにオーバーレイモニタによって蛍光画像と処置前光学画像との２つを同時に表示されるように構成しても良い。
図５は本実施の形態の変形例である手術用顕微鏡の顕微鏡像を示す。
The microscopic image may be configured to simultaneously display the fluorescence image and the pre- treatment optical image by the overlay monitor as shown in FIG.
FIG. 5 shows a microscopic image of a surgical microscope which is a modification of the present embodiment.
図５に示すように顕微鏡像５１は、図示しないオーバーレイモニタによって蛍光画像５２と処置前光学画像５３とが同時に表示されるようになっている。
このことにより、術部３及び切除部分５５を観察する場合、顕微鏡画像５１は、腫瘍組織の処置前光学画像５３及び蛍光画像５２を同時に表示することで、腫瘍の切除部分５５及び残存組織５６にある残存腫瘍５７を同時に観察することができ、腫瘍の取り残し部分の表示が可能となる。
As shown in FIG. 5, in the microscope image 51, the fluorescence image 52 and the pre- treatment optical image 53 are simultaneously displayed by an overlay monitor (not shown).
By this, when the operation part 3 and the excision part 55 are observed, the microscope image 51 is displayed on the excision part 55 of the tumor and the residual tissue 56 by simultaneously displaying the pre- treatment optical image 53 and the fluorescence image 52 of the tumor tissue. A certain residual tumor 57 can be observed at the same time, and it becomes possible to display the remaining part of the tumor.
この結果、本変形例は、処置前光学画像と蛍光画像とを重ね合わせることで、腫瘍部の取り残しの確認や、処置前診断画像では発見できなかった腫瘍の広がり、転移を処置前光学画像と対比させて観察することができ、１つの画面（顕微鏡画像）の中で摘出範囲の判断が容易に行える。これにより、本変形例は、手術時間を短縮し、患者への負担を軽減することが可能である。 As a result, in this modification, by overlapping the pre- treatment optical image and the fluorescence image, it is confirmed that the tumor part is left behind, the spread of the tumor which can not be found in the pre- treatment diagnostic image, and the metastasis are taken as the pre- treatment optical image. The contrast can be observed, and the extraction range can be easily determined in one screen (microscopic image). Thereby, this modification can shorten the operation time and reduce the burden on the patient.
この結果、本第２の実施の形態は、上記第１の実施の形態と同様な効果を得る上に、更に広範囲に亘って腫瘍の位置確認を１つの画面の中で行うことが可能である。また、本第２の実施の形態は、蛍光プローブ４に加え、プローブ６２を併用することで、腫瘍範囲１０４の位置を正確に検出することが可能となる。尚、この顕微鏡視野（顕微鏡画像１０５）は、図５で説明したようにオーバーレイモニタによって蛍光画像と処置前光学画像との２つを同時に表示されるように構成しても良い。 As a result, in the second embodiment, in addition to obtaining the same effect as that of the first embodiment, it is possible to perform the localization of the tumor in one screen over a wider range. . Further, in the second embodiment, by using the probe 62 in combination with the fluorescent probe 4, the position of the tumor range 104 can be accurately detected. The microscope visual field (microscopic image 105) may be configured to simultaneously display the fluorescence image and the pre- treatment optical image by the overlay monitor as described in FIG.
［付記］
（付記項１） 手術部位の顕微鏡画像を得る手術用顕微鏡と、少なくとも生体組織の蛍光像を得る内視鏡装置と、この内視鏡装置で得た蛍光像を画像処理し蛍光画像を得る画像処理手段と、前記内視鏡装置の観察位置と前記手術部位との相対位置を検出する検出手段とを有する手術用顕微鏡システムにおいて、
前記手術用顕微鏡で得た顕微鏡画像の倍率変更に応じて、前記画像処理手段で得た少なくとも生体組織の蛍光画像を変倍する変倍手段と、
前記検出手段で検出される前記内視鏡装置の観察位置と前記手術部位との相対位置に基づき、前記顕微鏡画像に対して前記変倍手段で変倍する蛍光画像の範囲を演算する範囲演算手段と、
前記範囲演算手段の結果に基づき、前記内視鏡装置の観察位置に応じて前記顕微鏡画像に前記蛍光画像を重畳する画像重畳手段と、
を具備したことを特徴とする手術用顕微鏡システム。
[Supplementary note]
(Appendix 1) An operating microscope for obtaining a microscopic image of a surgical site, an endoscope apparatus for obtaining at least a fluorescent image of a living tissue, and an image for processing a fluorescent image obtained by this endoscopic apparatus to obtain a fluorescent image A surgical microscope system comprising processing means, and detection means for detecting a relative position between an observation position of the endoscope apparatus and the surgical site,
Scaling means for scaling a fluorescence image of at least a living tissue obtained by the image processing means according to a change in magnification of a microscope image obtained by the surgical microscope;
Range calculation means for calculating the range of a fluorescence image to be scaled by the magnification changing means with respect to the microscope image based on the relative position between the observation position of the endoscope apparatus detected by the detection means and the surgical site When,
An image superimposing means for superimposing the fluorescence image on the microscope image according to the observation position of the endoscope apparatus based on the result of the range calculation means;
A surgical microscope system characterized by comprising:
（付記項３） 前記内視鏡装置は前記生体組織の処置前光学像を得、
前記画像処理手段は前記内視鏡装置で得た処置前光学像を画像処理して処置前画像を得、
前記画像重畳手段は前記処置前画像を前記顕微鏡画像に重畳することを特徴とする付記項１記載の手術用顕微鏡システム。
(Additional Item 3) The endoscope apparatus obtains a pre-treatment optical image of the living tissue,
The image processing means performs image processing on the pre-treatment optical image obtained by the endoscopic device to obtain a pre-treatment image,
The surgical microscope system according to claim 1, wherein the image superimposing means superimposes the pre-treatment image on the microscope image.
Claims (3)
前記手術用顕微鏡で得た顕微鏡画像の倍率変更に応じて、前記画像処理手段で得た少なくとも生体組織の蛍光画像を変倍する変倍手段と、
前記検出手段で検出される前記内視鏡装置の観察位置と前記手術部位との相対位置に基づき、前記顕微鏡画像に対して前記変倍手段で変倍する蛍光画像の範囲を演算する範囲演算手段と、
前記範囲演算手段の結果に基づき、前記内視鏡装置の観察位置に応じて前記顕微鏡画像に前記蛍光画像を重畳する画像重畳手段と、
を具備したことを特徴とする手術用顕微鏡システム。A surgical microscope for obtaining a microscopic image of a surgical site; an endoscope apparatus for obtaining at least a fluorescent image of a living tissue; an image processing means for processing the fluorescent image obtained by the endoscopic apparatus to obtain a fluorescent image; In a surgical microscope system having detection means for detecting a relative position between an observation position of an endoscope apparatus and the surgical site,
Scaling means for scaling a fluorescence image of at least a living tissue obtained by the image processing means according to a change in magnification of a microscope image obtained by the surgical microscope;
Range calculation means for calculating the range of a fluorescence image to be scaled by the magnification changing means with respect to the microscope image based on the relative position between the observation position of the endoscope apparatus detected by the detection means and the surgical site When,
An image superimposing means for superimposing the fluorescence image on the microscope image according to the observation position of the endoscope apparatus based on the result of the range calculation means;
A surgical microscope system characterized by comprising:
前記範囲演算手段は、前記検出手段で検出される前記内視鏡装置の観察位置と前記手術部位との相対位置に基づき、前記顕微鏡画像に対して前記合成手段で得た蛍光合成画像の範囲を演算し、
前記画像重畳手段は、前記範囲演算手段の結果に基づき、前記内視鏡装置の観察位置に応じて前記顕微鏡画像に前記蛍光合成画像を重畳することを特徴とする請求項１に記載の手術用顕微鏡システム。The image processing means includes a combining means for performing image processing on a plurality of fluorescent images obtained by the endoscope apparatus,
The range computing means is configured to compare the range of the fluorescence synthesis image obtained by the synthesizing means with respect to the microscope image based on the relative position between the observation position of the endoscope apparatus detected by the detecting means and the surgical site. Calculate
The said image superimposition means superimposes the said fluorescence synthetic | combination image on the said microscope image according to the observation position of the said endoscope apparatus based on the result of the said range calculating means. Microscope system.
前記画像処理手段は前記内視鏡装置で得た処置前光学像を画像処理して処置前画像を得、The image processing means performs image processing on the pre-treatment optical image obtained by the endoscopic device to obtain a pre-treatment image,
前記画像重畳手段は前記処置前画像を前記顕微鏡画像に重畳することを特徴とする請求項１記載の手術用顕微鏡システム。The surgical microscope system according to claim 1, wherein the image superimposing means superimposes the pre-treatment image on the microscope image.
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| JP2001327987A JP2003126017A (en) | 2001-10-25 | 2001-10-25 | Surgical microscope system |
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| JP2001327987A JP2003126017A (en) | 2001-10-25 | 2001-10-25 | Surgical microscope system |
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| JP2003126017A JP2003126017A (en) | 2003-05-07 |
| JP2003126017A5 true JP2003126017A5 (en) | 2005-06-09 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005005984B4 (en) * | 2005-02-09 | 2019-10-24 | Leica Instruments (Singapore) Pte. Ltd. | Fluorescence / infrared device for surgical microscopes |
| JP4794928B2 (en) * | 2005-07-13 | 2011-10-19 | オリンパスメディカルシステムズ株式会社 | Image processing device |
| JP2007244746A (en) * | 2006-03-17 | 2007-09-27 | Olympus Medical Systems Corp | Observation system |
| JP5191333B2 (en) * | 2008-09-26 | 2013-05-08 | オリンパス株式会社 | Microscope system, program, and method |
| WO2010035414A1 (en) | 2008-09-26 | 2010-04-01 | オリンパス株式会社 | Microscope system, storage medium in which control program therefor is stored, and control method therefor |
| JP5580758B2 (en) * | 2011-02-22 | 2014-08-27 | オリンパス株式会社 | Fluorescence observation equipment |
| DE102015202605B4 (en) * | 2015-02-12 | 2017-03-09 | Carl Zeiss Meditec Ag | visualization system |
| JP7239363B2 (en) * | 2019-03-22 | 2023-03-14 | ソニー・オリンパスメディカルソリューションズ株式会社 | Medical image processing device, medical observation device, medical observation system, operating method of medical image processing device, and medical image processing program |
| CN114948205B (en) * | 2021-10-30 | 2023-01-31 | 河北医科大学第二医院 | Intraoperative fluorescence navigation microscope for surgery |
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2001
- 2001-10-25 JP JP2001327987A patent/JP2003126017A/en active Pending
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