JP2003095911A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation having good skin bleaching and/or whitening and beautifying effects and high storage stability. SOLUTION: This skin care preparation contains the extract of a plant belonging to the genus Phymatosorus, family Polypodiaceae, order Filicales.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the genus Phymatus (Polypodiaceae, hereinafter, the Latin notation indicating the family is omitted).
Osorus (hereinafter, Latin notation indicating the genus is omitted) contains an extract obtained from a plant belonging to the genus, to prevent and improve pigmentation, and improve the transparency of the skin. The present invention relates to a skin external preparation having an excellent skin beautifying effect.

[0002]

2. Description of the Related Art Conventionally, skin external preparations such as emulsions, creams, lotions, beauty essences, packs, detergents, dispersions, ointments, liquids, aerosols, patches, poultices and liniments have been used. Various drugs have been added for the purpose of imparting predetermined drug effects to these. For example, whitening agents such as ascorbic acid, placenta extract, glutathione and hydroquinone have been added to prevent or ameliorate skin darkening caused by sunburn etc., spots caused by pigmentation, freckles and the like.

[0003]

However, with these whitening agents, the desired whitening effect may not be obtained due to insufficient whitening effect, or deterioration in the formulation, and the improvement thereof may not be achieved. Was wanted.

An object of the present invention is to provide an external preparation for skin which has good whitening and / or skin beautifying effect and has good storage stability.

[0005]

Means for Solving the Problems The present inventors have conducted various studies on natural ingredients which have an excellent whitening effect and can be used as medicinally effective ingredients for external preparations for the skin, and as a result, have been found to belong to the genus Fimatosolus of the family Fernaceae. It was found that the extract obtained from the fern plant to which it belongs has a high melanin production inhibitory action. Then, it was found that this extract can be blended with a skin external preparation as a whitening and / or skin beautifying component, and by combining with other medicinal components, a further excellent effect as a skin external preparation can be obtained, and the present invention has been completed. Came to do.

That is, the present invention provides a skin external preparation containing an extract obtained from a plant belonging to the genus Fimatosolus of the family Fernaceae of the order Fern.

As a preferred embodiment of the present invention, the above-mentioned external preparation for skin containing the extract as a whitening and / or skin beautifying component; (A) an extract obtained from a plant belonging to the genus Fimatosols of the family Fernaceae of the order Fern. B) The above external preparation for skin, which comprises one or more kinds of medicinal agents selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activating agent, and an anti-UV agent. From another viewpoint, the present invention provides a skin external preparation containing the above plant extract as a melanin production inhibitor.

In the present specification, the term "beautiful skin" is used in the broadest sense including, for example, suppression of pigmentation, dull skin, darkening of the skin due to sunburn, prevention and improvement of spots and freckles. It needs to be interpreted and it should be understood that "whitening" falls within that range.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The external preparation for skin of the present invention is an extract of a plant belonging to the genus Fimatosols of the family Fernaceae of the order Fern (hereinafter sometimes referred to simply as "fern plant") (hereinafter simply referred to as "fern plant extract"). In some cases)). Examples of the fern plant used in the present invention include, for example, Phymatotorus diversifoli.
us), Fimatosols Nigresense (Phyma)
tosorus nigrescens), Fimatosolus Scoropendria
scorpopendria), Phymatothorus longississ
imus), Phymatosorus novae-zelan
diae), Fimatosols Parksii (Phyma)
tomatos parksii) Physmatorus scans
ens) and the like. Among these, Phymatothorus
diversifolia) is preferably used.

The fern plant extract used in the present invention is not particularly limited in its extraction site, and may be an extract of any part of the fern plant such as roots, stems, stems, leaves and spores. In addition, the external preparation for skin of the present invention may be used by mixing an extract obtained from two or more parts of the fern plant, or an extract extracted from two or more parts with different solvents. You may mix and use 2 or more types.

The fern plant extract is a root of a fern plant,
It can be obtained by extracting one or more sites such as stems, trunks, leaves and spores with a suitable solvent. These portions may be subjected to an appropriate treatment such as drying, shredding, squeezing or fermentation, and then subjected to an extraction treatment. The extraction can be carried out by immersing the fern plant in a solvent for a predetermined time at low temperature or while heating. The extraction solvent is not particularly limited, and examples thereof include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; ketones such as acetone; ethyl ether. Or the like; ethers such as ethyl acetate; esters such as ethyl acetate; and the like.

The fern plant extract may be blended as it is into an external preparation for the skin, or may be left as it is for a suitable period of time and aged and then used. If necessary, it can be used after being subjected to purification treatment such as filtration, deodorization and decolorization with an ion exchange resin, etc. within a range that does not affect the effect. It is also possible to use only a highly active fraction by using a separation means such as liquid chromatography.

As an example of a preferable method for extracting the fern plant, the fern plant is used at room temperature or by heating with ethyl alcohol, 1,3-butylene glycol or water having a water content of 0 to 100% by volume. After extracting for ~ 5 days,
Examples include a method in which the obtained filtrate is filtered, and the obtained filtrate is left for about 1 week to be aged, and then filtered again. However, the extraction method is not limited to this.

The fern plant extract may be contained in the external preparation for skin in any form such as liquid, paste or gel. After the liquid extract is dried and solidified,
Alternatively, it may be contained in an external preparation for skin after being dried by spray drying or the like to give a powder.

The content of the fern plant extract (dry solid) in the external preparation for skin of the present invention is preferably 0.00.
001 to 5 mass% (hereinafter simply indicated as "%"), and more preferably 0.001 to 0.5%. Within this range, the fern plant extract can be stably blended, and a high whitening and / or skin beautifying effect can be exhibited. When the extract is used as the solution, the concentration of the extract solution is not limited as long as the content of the dry solid matter as the solute is within the above range.

The external preparation for skin of the present invention can be prepared by blending the fern plant extract with various forms of bases and formulating it according to a conventional method. In particular, it is preferable to add the fern plant extract as a whitening and / or skin beautifying component. Furthermore, by blending the fern plant extract in combination with one or more other medicinal agents, it is possible to prepare a skin external preparation having a more effective whitening and / or skin beautifying effect.

As a preferred embodiment of the present invention, (A)
With one or more of the fern plant extract as a component,
Examples of the component (B) include an external preparation for skin containing one or more medicinal effect agents selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator and an anti-UV agent. The medicinal agent used as the component (B) in the present embodiment is selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator and an ultraviolet ray inhibitor, and specific medicinal agents include:
Examples are shown below. In the following specific examples, the “derivative” includes a salt that can be formed. In addition, compounds having two or more drug efficacy are duplicated as specific examples of each drug efficacy.

(Whitening agent) As a whitening agent, vitamin C and its derivatives (L-ascorbyl dipalmitate, L-ascorbyl alkyl ester such as L-ascorbyl tetraisopalmitate, L-ascorbyl phosphate, L -Ascorbic acid sulfate, etc.), placenta extract, glabridin, glabrene, liquiritin, isoliquiritin, and licorice extract containing these, quinoline (pearl barley) extract, Scutellaria baicalensis (spleen)
Extracts, seaweed extracts (brown algae such as kelp, mackerel, seaweed, hijiki, hibamata, shimeji, torocombu, kajime, tsurarame, chigaiso, hondarawawa, giant kelp; agar beetle, okirinsai, giraffe, tsunomata, sugi nori, ausakunosari, ausuginosa, Red algae such as pine, pine tree, Japanese pine tree, Japanese pine tree, Funori tree, Japanese gonorrhoeae, Kamensou, squid, and egonori; Chlorella, Aonori, Donariera, Chlorococcus, Anahosa, Kawanori, Marimo, Shiogusa, Prunus algae, Azusa, Amaranthaceae, Amaranthaceae, Astragalus vulgaris, Astragalus japonicum, Astragalus vulgaris Cyanobacteria, etc.), juniper japonica extract, Sempukuka extract,
Grape extract, wheat extract, tomato extract, carotenoid (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharide, neo-agarobiose,
Hydroquinone and its derivatives, cysteine and its derivatives, asparagus extract, acerola extract, ibukitrano extract, Neubara (Ageitsu) extract, eleuthero extract, pea extract, chamomile extract, camu camu extract, causticus extract Thing, orange extract, raspberry extract, kiwi extract, Clara (kujin) extract,
Coffee extract, sesame oil, sesame oil, gokahi extract, rice extract, rice bran extract, cabbage extract, hawthorn extract, sunpens extract (pepper peony), peony extract, white lily extract, mulberry extract , Touki extract, Beech extract, Beech sprout extract,
Blackcurrant extract, hop extract, Maikai (Maikai, Hermanus) extract, Mokka (Bokeh) extract, Yukinoshita extract, Tea extract (Oolong tea, black tea, green tea, etc.), Reishi extract, Microbial fermentation metabolite , Soybean extract,
Examples include molasses extract and Rakan fruit extract. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Among these whitening agents, particularly preferred are vitamin C and its derivatives, placenta extract, licorice extract, adlay (Yokuinin) extract, wheat extract, juniper extract, seaweed extract, tea. An extract is mentioned.

(Antioxidant) As an antioxidant, vitamin E and its derivative (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl)
-Α-tocopherol, linoleic acid-dl-α-tocopherol, tocopherols such as dl-α-tocopherol succinate and its derivatives, ubiquinones, etc., vitamin A and its derivatives (retinol palmitate, retinol acetate, and the like) Derivatives, retinals such as dehydroretinal and their derivatives), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate) , Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), vitamin C and its derivatives (L-ascorbyl dipalmitate, Toraiso palmitate L- ascorbyl etc. L- ascorbic acid alkyl ester, L-
Ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), Vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal, etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine , Catechin and its derivatives, glabridin, glabrene, liquiritin, isoliquiritin and licorice extract containing them, glutathione and its derivatives,
Gallic acid and its derivatives, Cholesterol and its derivatives, Superoxide dismutase, Mannitol, Cucumber extract, Caixet extract, Gentian (Gentian) extract, Gentian ginger extract, Hawthorn extract, Peony extract, Ginkgo biloba extract, Scutellaria baicalensis ( Cucumber extract, carrot extract, squid (Maikai, Hermanus) extract, Sampens (Kawara-Ketsumei) extract, Tormentilla extract, parsley extract,
Grape extract, Botanpi extract, Mokka (bokeh) extract, Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannen wax) extract, Lettuce extract, Tea extract (Oolong tea) , Tea,
Green tea, etc.), microbial fermentation metabolites, seaweed extracts, ganoderma lucidum extracts, eggshell membrane extracts, placenta extracts, Rakan fruit extracts and the like. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Of these antioxidants, particularly preferred are vitamin E and its derivatives, vitamin C and its derivatives, rutin and its derivatives, yashajitsu extract, yukinoshita extract, mite squid extract, superoxide dismutase, Examples include ginkgo biloba extract, glutathione and its derivatives, histidine, mannitol and carotenoids.

(Anti-inflammatory agent) As the anti-inflammatory agent, glycyrrhizic acid and its derivative, glycyrrhetinic acid and its derivative, vitamin B and its derivative (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine diacid) Octanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), aloe extract, ashitaba extract, altea extract, arnica extract, sulfur and its Derivatives, nettle extract, Chinese mackerel extract, turmeric extract, yellowfin extract, St. John's wort extract, chamomile extract, comfrey extract, honeysuckle extract, watercress extract , S Via (sage) extract, burnet (Jiyu) extract, lithospermum (purple) extract,
Perilla extract, birch extract, elderberry extract, cattail (Phoutaceae) extract, mukuroji extract, eucalyptus extract,
Examples include mugwort extract, astragalus extract, chondroitin sulfate and its derivatives, zinc oxide and the like. In the specific examples of the extract, the names in parentheses are plant aliases, crude drug names, and the like.

Among these anti-inflammatory agents, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and their derivatives are particularly preferable.

(Cell activating agent) Cell activating agents include carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin A and its derivatives (retinol palmitate, retinol acetate, etc. and its derivatives;
Retinal such as dehydroretinal and its derivative), vitamin C and its derivative (dipalmitic acid L-
Ascorbyl, L-ascorbic acid alkyl ester such as L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, etc., Vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin) Riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), ribonucleic acid and salts thereof,
Deoxyribonucleic acid and salts thereof, α- and γ-linolenic acid, xanthine and derivatives thereof (caffeine etc.), amino acids and derivatives thereof (serine, glutamic acid, theanine, hydroxyproline, pyrrolidonecarboxylic acid etc.),
Docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, citric acid, lactic acid, malic acid, succinic acid, almond extract, asparagus extract, apricot extract, ginkgo extract, yellowfin extract , Barley extract, kiwi extract, cucumber extract, shiitake extract, horsetail extract,
Assemblage extract, soybean extract, jujube extract, Centella asiatica extract, Capsicum extract, Calendula officinalis extract, tomato extract, garlic extract, carrot extract, hinokitiol, bud extract, grape seed oil, Beech extract, beech sprout extract, peach extract,
Eucalyptus extract, lily extract, lettuce extract, lemon extract, rosemary (mannen wax) extract, malt root extract, animal-derived extract (mollusk extract such as squid, shell extract, shell meat extract, Fish meat extract, poultry extract, royal jelly, silk protein and its degradation products, placenta extract, serum deproteinization extract, lactoferrin or its degradation product, yeast extract, microbial fermentation metabolites (lactic acid bacteria, bifidobacteria, etc.) ), Reishi extract and the like. In the specific example of the extract, parentheses are aliases of plants,
Indicates the name of crude drug.

Of these cell activating agents, particularly preferred are vitamin A and its derivatives, and vitamin C.
And derivatives thereof, vitamin B and derivatives thereof, lactic acid, citric acid, malic acid, pyrrolidonecarboxylic acid, chicken cob extract, serum deproteinization extract, yeast extract, microbial fermentation metabolite (derived from lactic acid bacteria, bifidobacteria, etc.), Examples include extracts selected from Reishi extract.

(Ultraviolet Preventing Agent) As an ultraviolet preventing agent,
2-Ethylhexyl paramethoxycinnamate, 4-te
rt-Butyl-4′-methoxydibenzoylmethane, oxybenzone and its derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4
-Sodium methoxybenzophenone-5-sulfonate, etc.), titanium oxide, zinc oxide and the like. Further, if the fine particles of inorganic powder such as titanium oxide and zinc oxide are used, a higher effect is exhibited.

Among these UV inhibitors, particularly preferable are 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide and zinc oxide.

The amount of the above-mentioned component (B), which is a medicinal agent, in the external whitening skin preparation of the present invention is preferably mixed in the following range, although it varies depending on the kind of the medicinal agent. Within this range, when it is combined with an extract obtained from a fern plant belonging to the fermented order Fimatosolus of the fern of the component (A), the formulation and the stability of the component (A) in the formulation over time are affected. It is possible to exhibit higher whitening and / or skin beautifying effect.

That is, the content of the whitening agent in the external preparation for skin of the present invention is preferably 0.00001 to 5%, more preferably 0.0001 to 3%.
When the extract is used as a solution, the dry solid content may be within this range. Within this range, a skin external preparation that exhibits a more excellent whitening and / or skin beautifying effect and has a good feeling in use can be obtained.

The content of the antioxidant in the external preparation for skin of the present invention is preferably in the range of 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as a solution, the dry solid content may be within this range. Within this range, a superior anti-oxidant effect can be seen, and an external preparation for skin that exhibits an excellent whitening and / or skin beautifying effect can be obtained.

The compounding amount of the anti-inflammatory agent in the external preparation for skin of the present invention is preferably in the range of 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as a solution, the dry solid content may be within this range. Within this range, an external preparation for skin that exhibits an excellent anti-inflammatory effect and exhibits an excellent whitening and / or skin beautifying effect can be obtained.

The content of the cell activating agent in the external preparation for skin of the present invention is preferably 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as a solution, the dry solid content may be within this range. Within this range, a skin external preparation exhibiting a more excellent effect of improving rough skin and exhibiting an excellent whitening and / or skin beautifying effect can be obtained.

The compounding amount of the ultraviolet protective agent in the external preparation for skin of the present invention is preferably 0.001 to 20%, more preferably 0.01 to 10%. Within this range, a skin external preparation that exhibits a more excellent anti-ultraviolet effect and exhibits an excellent whitening and / or skin beautifying effect can be obtained.

These whitening agents, antioxidants, anti-inflammatory agents, cell activators and UV inhibitors can be used alone or in combination of two or more.

Examples of the compounding form of the external preparation for skin are not particularly limited, and include, for example, emulsions, creams, lotions, beauty essences, packs, detergents, makeup cosmetics, dispersions, ointments, solutions, aerosols, The cosmetic may be in any form such as a patch, a poultice and a liniment, or may be an external drug.

Further, the external preparation for skin of the present invention includes the above-mentioned (A)
In addition to the component (B), components (water such as purified water, hot spring water, deep water, etc.) that are usually used for the preparation of cosmetics, quasi drugs, external medicines, etc. within a range that does not impair the effects of the present invention. ), Oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters , Cooling agents, extracts derived from plants / animals / microorganisms, active oxygen removers, blood circulation promoters, astringents, antiseborrheic agents, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins, etc. It can be added as needed. Specific examples of these are shown below.

As the oil agent, whether it is a natural oil or a synthetic oil, as long as it is used in ordinary cosmetics for improving the constitutional components or usability and feeling of use of the base, is it a natural oil or a synthetic oil? Or, regardless of properties such as solid, semi-solid, liquid, for example, hydrocarbons such as squalane, petrolatum,
Olive oil, castor oil, jojoba oil, mink oil, macadamian nut oil, apricot kernel oil, persic oil, safflower oil,
Sunflower oil, avocado oil, medu home oil, camellia oil,
Oils of plant or animal origin such as almond oil, perilla oil, sesame oil, borage oil, cocoa butter, shea butter, beeswax, carnauba wax, candelilla wax, waxes such as geiro,
Fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils and the like can be used.

The surfactant is used for emulsification and solubilization of oils and the like, and anionic, cationic, nonionic and amphoteric surfactants can be used.

The powder is mainly used for various purposes such as coloring in makeup cosmetics, hiding the skin, or improving the feeling of use, and if it is used in ordinary cosmetics, its shape (spherical, Any of them can be used regardless of their shape (needle shape, plate shape, etc.), particle size (fume, fine particles, pigment grade, etc.) and particle structure (porous, non-porous, etc.).
For example, examples of the inorganic powder include talc, mica, mica, kaolin, sericite, silicic acid anhydride, ceramics powder, boron nitride, and the like, and examples of the organic powder include polyethylene powder, nylon powder, and the like. Examples of pigments include inorganic pigments such as iron oxide, carbon black, chromium oxide, navy blue, and ultramarine blue, tar-based pigments and lakes of natural pigments, and the like.Pearl pigments include mica, talc, and mica. Examples thereof include those coated with titanium oxide and the like, bismuth oxychloride, fish scale foil, and other tar pigments and natural pigments such as carminic acid. These powders may be compounded or surface-treated with an oil agent, silicone, a fluorine compound or the like.

Examples of alcohols include monohydric lower alcohols and various polyhydric alcohols such as polyethylene glycol.

The water-soluble polymer is used for stabilizing the system, improving the usability and the feeling of use, and also for obtaining a moisturizing effect. Plant-based polymers such as carrageenan and agar; microbial-based polymers such as xanthan gum; animal-based polymers such as casein and gelatin; starch-based polymers such as starch; cellulosic polymers such as ethyl cellulose and carboxymethyl cellulose; sodium alginate, etc. Alginic acid-based polymer; vinyl-based polymer such as carboxyvinyl polymer; polyoxyethylene-based polymer; acrylic polymer such as sodium polyacrylate;
In addition, a film forming agent such as polyvinyl alcohol or polyvinylpyrrolidone is also included in this.

Examples of the antibacterial agent include benzoic acid, sodium benzoate, paraoxybenzoic acid ester, parachlorometacresol, benzalkonium chloride, phenoxyethanol and isopropylmethylphenol.

The active oxygen scavengers include superoxide dismutase, quercetin, catechin and its derivatives, thiamines (thiamine hydrochloride, thiamine sulfate),
Riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), vitamin Bs such as nicotinic acids (nicotinamide, benzyl nicotinate, etc.), dibutylhydroxytoluene, butylhydroxyanisole, etc. Is mentioned.

Examples of moisturizers include glycerin, 1,3-butylene glycol, proteins or their derivatives or hydrolysates and their salts (collagen, elastin, keratin, etc.), mucopolysaccharides and their derivatives (hyaluronic acid, chondroitin sulfate, etc.). ), Amino acids and their derivatives (histidine, serine, glycine, theanine, aspartic acid, arginine, pyrrolidonecarboxylic acid, etc.), sugars (sorbitol, erythritol, trehalose, inositol, glucose, xylitol, sucrose and its derivatives, dextrin and its derivatives, Honey, etc.),
D-panthenol and its derivatives, glycolipids, ceramides,
Hot spring water, armature extract, almond extract, ashitaba extract, avocado extract, althea extract, arnica extract, aloe extract, usvenia mallow extract, Scutellaria baicalensis extract, Coptis vulgaris extract, Hypericum perforatum extract, Odorikosou extract, Ononisu extract, chamomile extract, oat extract, glabridin, glabrene, liquiritin, isoliquiritin and licorice extract containing these, raspberry extract, honeysuckle (Kinginka) extract, quince seed (quince) extract , Clara extract, Gardenia extract, Kumazasa extract, Grapefruit extract, Watercress extract,
Gentiana (gentian) extract, ginkgo biloba extract, burdock extract, sesame extract, wheat extract, comfrey (composite) extract, sausage extract, cactus extract, savanna extract, salvia (sage) extract, Hawthorn extract, diorhea extract, perilla extract, spirea extract, peony extract, ginger extract, ginger extract, birch extract, peppermint (peppermint,
(Midori mint, spearmint, etc.) extract, mallow (Musca serrata) extract, senkyu extract, mulberry (sakuhakuhi) extract, pearl millet (thyme)
Extract, camellia extract, Touki extract, Astragalus extract, corn extract, Dokudami extract, Tormentilla extract, parsley extract, adlay (Yokuinin) extract, Hamamelis (witch hazel) extract,
Rose extract, cypress extract, sunflower extract, coltsfoot extract, butchers bloom extract, grape extract, prune (plum) extract, loofah extract, bodhiju extract, peony extract, hop extract , Jojoba oil, macadamia nut oil, olive oil, apricot kernel oil, persic oil, safflower oil, sunflower oil, avocado oil, medhu home oil, camellia oil, almond oil, perilla oil, sesame oil, borage oil, cacao butter, shea Fat, pine extract, horse chestnut extract, mukuroji extract,
Mucin, Purple (Sikon) extract, Melissa extract,
Cornflower extract, Yukinoshita extract, lily extract,
Lime extract, lavender extract, apple extract, gentian (ryutan) extract, phospholipids (derived from soybean, egg yolk, etc.), astragalus extract, waremoko (juyu) extract,
Tea (oolong tea, green tea, black tea, etc.) extract, urea, Rakan fruit extract, seaweed extract (kelp, mackerel, wakame, hijiki,
Brown algae such as hibamatata, shimeji, trollocombu, swordfish, tsurame, chigaiso, hondarawa, giant kelp and the like; Green algae such as Chlorella, Aonori, Donariera, Chlorococcus, Anahaosa, Kawanori, Marimo, Shiogusa, Kasanori, Futojuzumo, Tamajumo, Aegusa, Aomidoro; and cyanobacteria such as Spirulina).

Examples of the blood circulation promoter include vitamin E and its derivatives, as well as γ-oryzanol, and examples of the enzyme include lipase and papain.

[0046]

The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples.

(Example 1: Production of fern plant extract) Phymatotos (Phymatos) belonging to the genus Fimatosols of the family Fernaceae of the order Fern, shown in Table 1.
orus diversifolius) leaves and stem mixture 500g, purified water, 50% by volume hydrous ethyl alcohol, 3 L separately added to each,
After extraction at room temperature or by heating for 1 day, the mixture is filtered, the solvent of the obtained filtrate is evaporated to dryness, and the purified water extract of each fern plant which is a solid content, 50% by volume ethyl acetate An alcohol extract and an ethyl alcohol extract were obtained.

(Example 2: Production of Yokuinin extract) To 10 g of Yokuinin (JP), 100 mL of 70% by volume hydrous ethyl alcohol was added, and extraction was carried out at room temperature for 3 days.
The Yokuinin extract was obtained by filtration. At this time, the dry solid content of Yokuinin extract was 0.8%.

Example 3: Suppression of melanin production (whitening rate) and cell viability test by cell culture B derived from mouse
Using 16 melanoma cultured cells, using the purified water extract of each fern plant obtained in Example 1 as a sample, the melanin production inhibitory effect and cell viability were examined. Specifically, an appropriate amount of 10% FBS-containing MEM medium is placed in two 6-well petri dishes, and B
16 melanoma cells were seeded and left to stand at 37 ° C. in a carbon dioxide concentration of 5%. The next day, the purified water extract of each fern plant obtained in Example 1 was dissolved in purified water to give a final concentration of 0.
(Control), 30 and 100 μg / mL of the sample preparation solution was added and mixed. Change the medium on the 5th day of culture,
The sample preparation solution was added again. On the next day, the medium was removed, and one dish was washed with phosphate buffer and then collected, and the whiteness of B16 melanoma cultured cells was evaluated according to the following criteria. Further, as a comparative example, the same test was carried out for Yokuinin extract known to have a melanin production inhibitory action, but the final concentration, 300, 500 and 1000 μg / mL was also checked for confirming the effect.

(Judgment criteria) ++: Very white with respect to the control. +: Clearly white with respect to the control. ±: slightly whiter than the control. -: The same black color as the control.

With respect to the remaining one petri dish, the cells were fixed with formalin and then added to 1% crystal violet solution for staining. The viable cell rate for each sample concentration was measured with a monoserator (Olympus). The results are shown in Table 1.

[0052]

[Table 1]

As is clear from the results shown in Table 1, Phymatotos (Phymatotos) belonging to the genus Fimatosols of the family Fernidae of the present invention
It was confirmed that the extract obtained from Orus diversifolius) had a higher melanin production-inhibiting ability at a lower concentration than the Yokuinin extract and had low toxicity to B16 melanoma cultured cells. Therefore, the external preparation for skin of the present invention containing the fern plant extract exerts an extremely excellent melanin production-inhibiting effect by applying it to the skin, and blackening of the skin due to sunburn, stains, freckles, etc. It can be effectively suppressed to obtain a whitening effect and a beautiful skin effect.

(Example 4: Cream) Creams having the compositions shown in Table 2 below were prepared by the following methods. First, Table 2
The components (1) to (6) and (9) shown in (1) were mixed, heated and maintained at 70 ° C. To this mixture, a part of the component (11) heated and maintained at 70 ° C. was added to emulsify, and (7) to (8) and (10) dissolved in the rest of (11) were mixed. . Then, it cooled and each cream was obtained.

With respect to each of the creams thus obtained, the whitening effect and the skin beautifying effect were evaluated by the following test methods. A panel consisting of 15 women aged 27 to 54 per test cream was applied twice daily in the morning and evening, after washing the face for 12 weeks, and applied an appropriate amount of the test cream on the face. Was evaluated according to the following criteria. The results are shown in Table 2. The number in the evaluation column in the table indicates the number of people. <Evaluation><Contents> Effectiveness The dullness of the skin became inconspicuous. Somewhat effective The dullness of the skin became less noticeable. Ineffective No change from before use.

[0056]

[Table 2]

From the results shown in Table 2, the product of the present invention containing the fern plant extract of the present invention can be applied to the skin to prevent and improve "dullness" of the skin, It became clear that the skin was beautiful.

(Example 5: Cream) A cream having the composition shown in Table 3 below was prepared by the following method. First, component (1)
~ (6), (10), (13) and (14) are mixed,
Heated and maintained at 70 ° C. Add the ingredients (1
A part of 6) was heated and maintained at 70 ° C. to be mixed and emulsified, and the mixture was further added with components (7) to (8).
Then, (9), (11) and (12) dissolved in the rest of the component (16) and (15) were mixed and then cooled to obtain a cream.

Each of the obtained creams (Phymatosorus divius, which belongs to the genus Phimatosolus of the family Fernaceae)
The whitening and skin beautifying effects of the purified water extract obtained from rsifoliaus) and a cream containing a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an anti-UV agent were evaluated by the following test methods. 27 to 5 per cream for test
A panel of 15 4-year-old women, twice daily in the morning and at night, 1
After washing the face for 2 weeks, an appropriate amount of the test cream was applied to the face, and the whitening effect and the skin beautifying effect of the application were evaluated according to the following criteria. The evaluation results are shown in Table 3. The number in the evaluation column in the table indicates the number of people. <Evaluation><Contents> Effectiveness The dullness of the skin became inconspicuous. Somewhat effective The dullness of the skin became less noticeable. Ineffective No change from before use.

[0060]

[Table 3]

Fimatosolus diversifolius (Phym) belonging to the genus Fimatosolus of the family Fernidae
The cream of the product 1 of the present invention containing a purified water extract of Atosome diversifolius) can prevent and improve "dullness" and the like of the skin by applying these to the skin, and it is clear that beautiful skin is obtained. However, as shown in the results of Table 3, in addition to the purified water extract of the fern plant, a whitening agent, an antioxidant, an anti-inflammatory agent,
By applying to the skin the creams of the products 5 to 10 of the present invention, which were formulated in combination with a cell activator and an ultraviolet protective agent, the creams containing the purified water extract obtained from the fern plant alone were applied. It was clarified that, compared with the case, the effect of preventing and improving the "dullness" of the skin and the like was more excellent, and the skin was transparent and beautiful.

(Example 6: Lotion) The following component (3),
A solution obtained by mixing and dissolving (4), (6) and (7) and a solution obtained by mixing and dissolving components (1), (2), (5) and (8) are mixed to make uniform, and a lotion is applied. Obtained. (Prescription) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) sorbitan monolaurate 1.2 (4) Ethyl alcohol 8 0.0 (5) Purified water extract of Phymatosorus diversifolius * 1 0.001 (6) Preservative proper amount (7) Perfume proper amount (8) Purified water residual amount * 1 Produced with Example 1

(Example 7: Emulsion) The following components (11) and (1)
The mixture of 3) heated and mixed and maintained at 70 ° C. was added to the mixture of the following components (1) to (6) and (9) heated and mixed and maintained at 70 ° C., and emulsified. After cooling, (7),
(8), (10), (12) and (14) were added and uniformly mixed to obtain an emulsion. (Prescription) (%) (1) Polyoxyethylene (10 EO) sorbitan monostearate 1.0 (2) Polyoxyethylene (60 EO) sorbit tetraoleate 0.5 (3) Glyceryl monostearate Rate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) 50% by volume ethyl alcohol extract of Phymatosorus diversifolius (Phymatosorus diversifolius) * 10 .05 (8) Placenta extract * 2 5.0 (9) Preservative Suitable amount (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Purified water Remaining amount (14) Perfume Proper amount * 1 Made in Example 1 * 2 Nichirei

Both the lotion prepared in Example 6 and the emulsion prepared in Example 7 are excellent in stability over time, and when applied to the skin, "dullness" of the skin due to sunburn, spots and freckles are prevented, and a transparent feeling is obtained. It was a lotion and a lotion that gave beautiful skin.

(Example 8: Ointment) A part of the following components (3), (4) and (9) was heated and mixed, and the mixture maintained at 75 ° C. was used to prepare the following components (1), (2) and (7). ) And (8) were heated and mixed, and gradually added to the mixture maintained at 75 ° C., and while cooling this, (5) and (6) dissolved in the rest of the component (9) were added to obtain an ointment. (Prescription) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Phymatosorus diversifolius (Phymatosorus diversifolius) Ethanol extract * 1 1.0 (6) Dipotassium glycyrrhizinate * 2 0.5 (7) Acetic acid dl-α-tocopherol * 3 0.2 (8) Preservative appropriate amount (9) Purified water balance * 1 Example 1 * 2 Made by Nippon Roche * 3 Made by Eisai

The ointment prepared in Example 8 has excellent stability over time,
When applied to the skin, it was an ointment that prevented skin "dullness", spots and freckles, and made the skin beautiful and transparent.

(Example 9: Pack) The following component (1),
Mix (3), (4) and (8) and heat to 70 ° C.
A mixture was obtained by stirring. The mixture obtained by mixing the components (2) and (6) was mixed with this mixture, and after cooling,
(5) and (7) were uniformly mixed to obtain a pack. (Prescription) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Purification of Phymatosorus diversifolius Water extract * 1 0.0001 (6) Preservative Suitable amount (7) Perfume Suitable amount (8) Purified water Remainder * 1 Produced in Example 1

The pack prepared in Example 9 was excellent in stability over time, and when applied to the skin, it was a pack which prevented "dullness" and stains on the skin and making the skin beautiful and transparent.

(Example 10: Liquid foundation) The following components (11) to (16) were added to a solution prepared by mixing and dissolving the following components (1) to (6) and (20), and the mixture was uniformly mixed and heated to 70 ° C. Maintained. Into this solution, components (7) to (1
0) was uniformly dissolved, and a solution maintained at 70 ° C. was added to uniformly emulsify. After cooling the emulsion, the following components (17) to (19) were added to obtain a liquid foundation. (Prescription) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 3.0 -2- Ethylhexyl (6) Sorbitan sesquioleate 0.5 (7) Glycerin 5.0 (8) Triethanolamine 1.0 (9) Carboxymethylcellulose 0.7 (10) Purified water Remaining amount (11) Titanium oxide 8.0 (12) Fine Titanium Oxide 2.0 (13) Zinc Oxide 4.0 (14) Mica 1.0 (15) Talc 4.0 (16) Coloring Pigment 3.0 (17) Phymatosorus diversifolius ) Of 50% by volume hydrous ethyl alcohol extract * 1 0.05 (18) Yokuinin extract * 2 0.5 (19) Perfume proper amount (20) Preservative proper amount * 1 Produced in Example 1 Those produced in the ones * 2 Example 2

The liquid foundation prepared in Example 10 was excellent in stability over time, and when applied to the skin, the liquid foundation was a liquid foundation which prevented blackening of the skin due to sunburn or the like and stains or freckles.

[0071]

As described above, the external preparation for skin containing the fern plant extract of the present invention has an excellent melanin production inhibitory effect and exerts a high inhibitory effect on pigmentation,
It is effective in preventing and improving the darkening of the skin, darkening of the skin due to sunburn, etc., and the prevention of spots and freckles.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Misako Kobayashi             Kose Co., Ltd. 48-18 Sakaemachi, Kita-ku, Tokyo             -In Research Division (72) Inventor Masatake Yoshida             11-7 Nihonbashi Tomizawa-cho, Chuo-ku, Tokyo             Inside the medicinal industry (72) Inventor Masayo Fujimoto             11-7 Nihonbashi Tomizawa-cho, Chuo-ku, Tokyo             Inside the medicinal industry (72) Inventor Taketsugu Kodaira             11-7 Nihonbashi Tomizawa-cho, Chuo-ku, Tokyo             Inside the medicinal industry F-term (reference) 4C083 AA072 AA082 AA111 AA112                       AA122 AB032 AB212 AB242                       AB432 AB442 AC022 AC072                       AC102 AC122 AC172 AC242                       AC302 AC422 AC442 AC542                       AD092 AD112 AD512 AD532                       AD642 AD662 BB46 BB47                       BB51 CC04 CC05 CC07 DD22                       DD31 EE01 EE16

Claims (4)

[Claims] 1. A Polypodi family of the order Fern
aceae) Phymatosor
external preparation for skin comprising an extract of a plant belonging to (us). 2. The external preparation for skin according to claim 1, which contains the extract as a whitening and / or skin beautifying component. 3. A whitening agent, an antioxidant, an anti-inflammatory agent,
The external preparation for skin according to claim 1 or 2, which contains one or more kinds of medicinal agents selected from a cell activator and an ultraviolet protective agent. 4. The plant is Phymatosorus divers.
The external preparation for skin according to any one of claims 1 to 3, which is ifolius).