JP2003093497A - Bone supplementing material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a bone supplementing material superior in bone regeneration performance or the like. SOLUTION: The bone supplementing material is a fluid having viscosity and it contains a thickener, a dispersion medium and calcium phosphate granules with porosity of 10-90%. The calcium phosphate granules are dispersed in the dispersion medium. The thickener is dissolved in the dispersion medium. In the bone supplementing material, viscosity of liquid with insoluble components removed from the bone supplementing material when 72 hours have passed after producing the bone supplementing material becomes 20-50% of viscosity of liquid with the thickener dissolved in the dispersion medium at a quantity rate of the thickener and the dispersion medium when producing the bone supplementing material.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bone substitute material mainly used for medical and dental purposes.

[0002]

2. Description of the Related Art In the fields of medicine and dentistry, calcium phosphate is used as an artificial bone or a bone filling material. For example, if a bone defect occurs due to a bone fracture or bone tumor,
A bone defect material made of calcium phosphate is used to compensate for a bone defect.

Block-shaped and granular-shaped bone filling materials made of calcium phosphate are known. However, the block-shaped one is troublesome because it is necessary to shape the bone filling material into the shape of the bone defect portion at the operating site. Especially, in the case of urgent surgery, its use is difficult.

On the other hand, since the granular bone filling material has fluidity, the bone defect portion can be filled only by filling it. Therefore, surgery can be performed smoothly and quickly. However, when the bone filling material is composed only of calcium phosphate granules, there is a drawback in that the handleability in the surgical field becomes poor. For example, in the case of filling a bone defect material with a granular bone filling material, the granule may spill out and may be scattered to a portion other than the bone defect portion. Further, even after the surgery, the granules filled in the bone defect part may be scattered outside the bone defect part.

In order to solve such a drawback, a bone substitute material has been developed in which a polymer material is mixed with calcium phosphate granules to improve the handling property during surgery (Japanese Patent Nos. 2984112 and 2902452, and Japanese Patent No. 2902452). JP-A-60-256460). Such a bone prosthetic material has high operability, and the bone prosthetic material can be filled into the bone defect portion easily and quickly. Moreover, it is possible to suitably prevent the bone filling material from being dissipated from the bone defect portion in the body after the operation.

[0006] However, these bone prosthetic materials cannot be said to have sufficient action to promote postoperative bone regeneration, and there is room for improvement. At present, there is a demand for the development of a bone filling material that promotes bone regeneration after bone filling.

[0007]

SUMMARY OF THE INVENTION An object of the present invention is to provide a bone substitute material which has good operability and is excellent in bone reproducibility and the like.

[0008]

The above object is achieved by the present invention described below.

(1) A bone prosthetic material containing granules of calcium phosphate having a porosity of 10 to 90%, a binder and a dispersion medium in which the granules of calcium phosphate are dispersed, and aged for 72 hours after the production of the bone prosthetic material. At this time, the viscosity of the liquid obtained by removing the insoluble component from the bone filling material is 20 to 20% of the viscosity of the liquid in which the binder is dissolved in the dispersion medium in the amount ratio of the binder and the dispersion medium at the time of forming the bone filling material. 50%
A bone prosthesis material having the following property.

(2) In a solution in which a binder is dissolved,
A bone prosthetic material having a porosity of 10 to 90% of calcium phosphate granules dispersed therein, and the viscosity of a liquid obtained by removing insoluble components from the bone prosthetic material when aged for 72 hours after the production of the bone prosthetic material, A bone prosthesis material having a property of 20 to 50% of the viscosity of the solution. This makes it possible to obtain a bone prosthetic material which has good operability and is excellent in bone reproducibility.

(3) The above-mentioned (1) or (2), wherein the content of the calcium phosphate granules is 10 to 90 wt%.
The bone substitute material described in. This facilitates adjustment of the amount of binder adsorption by calcium phosphate so as to be in a state suitable for bone regeneration.

(4) The calcium phosphate granules are
The bone substitute material according to any one of (1) to (3) above, which is fired. This makes it possible to control the adsorption force of the binder of calcium phosphate.

(5) The bone filling material according to any one of (1) to (4) above, wherein the calcium phosphate is hydroxyapatite. Hydroxyapatite is excellent in terms of binder adsorption.

(6) The content of the binder is 0.
The bone substitute material according to any one of (1) to (5) above, which is 1 to 20 wt%. As a result, the amount of the binder adsorbed on the calcium phosphate tends to be more suitable for bone regeneration.

(7) When it is aged for 72 hours after the bone filling material is formed, 0.1 to 30% of the binder has a property of adsorbing to the calcium phosphate granules.
The bone substitute material according to any one of (1) to (6). This further improves the reproducibility of bone.

(8) The bone filling material according to any one of (1) to (7) above, wherein the binder is composed of a polysaccharide. Polysaccharides are excellent in shapeability and biocompatibility.

(9) The bone filling material according to the above (8), wherein the binder is composed of a non-human-derived polysaccharide. This can reduce the risk of infection.

(10) The bone filling material according to the above (9), wherein the binder is a chitin. Chitins excel in the function of inducing osteoblasts and activating bone regeneration.

(11) The bone filling material according to any one of the above (1) to (10), which is produced by mixing a solution in which the binder is dissolved and the calcium phosphate granules. According to this method, it is easy to obtain a homogeneous bone prosthetic material with no unevenness in viscosity, distribution of calcium phosphate granules, and the like.

(12) The bone filling material as described in (11) above, wherein the viscosity of the solution in which the binder is dissolved is 100 to 1,000,000 cps at room temperature. This facilitates manufacturing of the bone substitute material.

(13) The bone substitute material according to any one of the above (1) to (12), which is used by being placed in a liquid guide. This makes it easier to fill the bone defect portion with the bone filling material.

[0022]

BEST MODE FOR CARRYING OUT THE INVENTION In the present specification, the term "bone" is used to include not only normal bone but also teeth. Hereinafter, the bone prosthesis (biological filler) of the present invention will be described in detail.

The bone filling material of the present invention is a fluid having a viscosity at least immediately before use, and contains calcium phosphate granules, a binder and a dispersion medium. The calcium phosphate granules are dispersed in, for example, a dispersion medium. The binder is, for example, dissolved in the dispersion medium (that is, the dispersion medium functions as a solvent for the binder). When the bone filling material of the present invention is aged for 72 hours after the bone filling material is formed, the viscosity of the liquid obtained by removing the insoluble component from the bone filling material is the amount ratio of the binder and the dispersion medium at the time of forming the bone filling material. It has the property of being 20 to 50% of the viscosity of the liquid in which the binder is dissolved in the dispersion medium.

For example, when calcium phosphate granules and a binder are added to a dispersion medium and the mixture is kneaded (kneaded) to obtain a bone prosthetic material (a manufacturing method will be described in detail later), the amount of the binder at the time of addition and The liquid prepared by dissolving the binder in the dispersion medium in the same amount ratio as the amount of the dispersion medium is the "liquid in which the binder is dissolved in the dispersion medium in the amount ratio of the binder and the dispersion medium at the time of forming the bone filling material". .

When a binder solution and calcium phosphate granules are mixed and the solution is kneaded (kneaded) to obtain a bone filling material, the original binder solution is prepared as follows: "Binder and dispersion medium at the time of forming the bone filling material. A liquid in which a binder is dissolved in a dispersion medium at a ratio of

Further, in the present invention, for example, the supernatant obtained by allowing the bone prosthetic material to stand or centrifuging it can be used as a "liquid in which insoluble components have been removed from the bone prosthetic material".
The insoluble component is usually composed of calcium phosphate granules.

In the present invention, the elapsed time of the bone substitute material is 37
It can be stored at 0 ° C. and in a state of being shielded from the air and aged, which can be used as an index.

A major feature of the bone filling material of the present invention is that the viscosity of a liquid obtained by removing insoluble components from the bone filling material (hereinafter, simply referred to as "liquid component") when the bone filling material is aged for 72 hours. , "Viscosity of the liquid in which the binder is dissolved in the dispersion medium in the amount ratio of the binder and the dispersion medium at the time of forming the bone filling material"
That is, it has a property of 50%.

As a result of earnest studies, the present inventor has found that a bone substitute material having such properties is excellent in operability during surgery and also excellent in bone regeneration in a bone defect portion (affected area of a patient). I found it.

That is, the bone filling material of the present invention contains calcium phosphate granules and a binder, has a viscosity when the bone filling material is formed (initial state), and is 7 after the bone filling material is formed.
When aged for 2 hours (after a predetermined time), the calcium phosphate granules adsorb a part of the binder,
Viscosity is reduced.

Since such a bone filling material has a relatively high viscosity at the time of producing the bone filling material, the calcium phosphate granules and the binder can be mixed uniformly, and the bone filling material (injection device) such as a syringe can be easily mixed. ) Can be used to fill the bone defect. On the other hand, when 72 hours have passed since the bone filling material was produced, its viscosity decreases, so that body fluid, bone cells, etc. easily enter the bone filling material filled in the bone defect portion, and bone formation is promoted. .

By the way, when calcium phosphate adsorbs the binder in the liquid component, the viscosity of the liquid component decreases. The amount of decrease in viscosity of the liquid component corresponds to the amount of adsorption of the binder to calcium phosphate. In addition, the viscosity of the liquid component greatly affects the ease with which body fluid and bone cells (somatic cells) enter the bone prosthetic material. When the viscosity of the liquid component is low, body fluid, bone cells (somatic cells), etc., easily enter the bone prosthetic material. From this point of view, the viscosity of the liquid component is suitable from the viewpoint of the relationship with the easiness of bone formation.

It is to be noted that such a bone filling material usually has a change (decrease) in its viscosity within about 2 days after the bone filling material is produced, although it depends on the kind of calcium phosphate and the like in a stationary state. And become stable. From this point of view, with a margin for this period, 3 days, that is, 72 hours, was set as a period for aging to see a change in viscosity. In addition, since it is preferable to perform the measurement in an environment closer to the human body, the measurement was performed at 37 ° C. in the state of being shielded from the air, and was used as an index.

As a result of repeated experiments and research by the present inventor based on such a policy, the viscosity of the liquid component when 72 hours passed after the bone filling material was formed was found to be the binder and the dispersion medium at the time of forming the bone filling material. A bone prosthesis material having a property of being 20 to 50% (more preferably 25 to 45%, further preferably 30 to 40%) of the viscosity of a liquid in which a binder is dissolved in a dispersion medium in a ratio of , And found that it is excellent in bone formation. Therefore, for example, if the bone defect portion is filled with the bone filling material having such a property, the bone is regenerated faster.

From the viewpoint of obtaining such an effect more effectively, when the bone filling material is allowed to stand for 72 hours after being formed, about 0.1 to 30% of the binder in the bone filling material is calcium phosphate granules. It is preferable to have a property of adsorbing to (more preferably 1 to 20%). This further improves the bone regeneration property of the bone substitute material.

In addition to the effects described above, the bone filling material of the present invention has an advantage that it is excellent in operability and handleability. Since the bone prosthesis material of the present invention has fluidity with an appropriate viscosity, the user can easily insert the bone prosthesis material into the bone defect portion and a simple operation associated therewith to easily perform bone replacement. The defective portion can be filled. Moreover, since the bone filling material of the present invention has fluidity, the bone filling material is filled in the bone defect portion while deforming following the shape of the bone defect portion. For this reason,
The bone substitute material of the present invention can be applied to various shapes of bone defect portions. Therefore, by using the bone substitute material of the present invention, it is possible to easily and quickly perform surgery for filling a bone defect. Hereinafter, the bone filling material of the present invention will be described for each component.

[Calcium Phosphate Granules] The calcium phosphate granules in the present invention mean, for example, calcium phosphate granules or powders.

The calcium phosphate (calcium phosphate-based compound) used is not particularly limited, but one having a Ca / P ratio of 1.0 to 2.0 is preferable.

Specific examples of such calcium phosphate include hydroxyapatite, fluoroapatite,
Apatites such as carbonate apatite, calcium hydrogen phosphate (anhydrous or dihydrate), tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, etc.
Examples thereof include one kind or a mixture of two or more kinds.

Among them, hydroxyapatite is preferable as the calcium phosphate used in the present invention. Hydroxyapatite is excellent in binder adsorption capacity.

Calcium phosphate granules have a porosity of 1
The content is 0 to 90%, preferably about 12 to 50%.

When the porosity of the calcium phosphate granules is less than the lower limit value described above, the calcium phosphate granules do not sufficiently adsorb the binder, and a proper viscosity reduction of the bone prosthetic material is achieved even after 72 hours have elapsed after the bone prosthetic material was produced. Can not.
Therefore, invasion of bone cells into the bone prosthetic material is inhibited, and the effect of promoting bone formation by bone cells cannot be expected.

On the other hand, when the porosity of the calcium phosphate granules exceeds the above-mentioned upper limit value, the calcium phosphate granules excessively adsorb the binder and the viscosity of the bone filling material is lowered too much. Becomes worse. For this reason,
For example, the operability of the bone prosthetic material decreases during surgery or the like. Further, in the calcium phosphate granules having such a porosity, it is not possible to secure the mechanical strength of the calcium phosphate granules themselves, which is necessary when filling the bone defect portion.

The average particle size of the calcium phosphate granules is not particularly limited, but is preferably about 10 μm to 4 mm, more preferably about 20 μm to 2 mm. This improves the handleability of the bone filling material.

The particle size distribution of the calcium phosphate granules is such that at least 60% of all granules have an average particle size of ± 120 μm.
It is preferable that the average particle size is ± 10
More preferably, it is included in 0 μm. When the particle size distribution is within this range, the handling property of the bone prosthetic material is
Further improve.

Such calcium phosphate granules are preferably calcined. Thereby, the amount of the calcium phosphate granules adsorbing the binder can be adjusted (controlled). In addition, the mechanical strength of the calcium phosphate granules itself, which is necessary when the bone filling material is filled in the bone defect portion, is further improved. Further, it becomes easy to prevent impurities, foreign substances, and the like from mixing into the calcium phosphate granules. The firing conditions may be, for example, 1100 to 1550 ° C. × 0.5 to 24 hours in the air or under a reduced pressure atmosphere.

The bone filling material varies slightly depending on the content and type of the binder, but it is preferable that the calcium phosphate granules are contained in an amount of 10 to 90 wt%, more preferably 30 to 60 wt%. preferable.
This facilitates adjustment of the amount of binder adsorption by calcium phosphate so as to be in a state suitable for bone regeneration.

[Binder] The binder (thickener) is
By adjusting the viscosity of the bone filling material, the flowability and shapeability of the bone filling material
Keep balance with shape retention.

Examples of the binder include monosaccharides such as glucose and fructose, oligosaccharides such as saccharose, maltose and lactose, and carboxymethyl (CM).
Polysaccharides such as chitin, CM cellulose, starch, glycogen, pectin, chitin, chitosan, etc., water-soluble (or hydrophilic) polymers such as glycerin, sugar alcohols (sorbitol, mannitol, xylitol), gelatin, polyvinyl alcohol, maleic anhydride, etc. Materials include.

Among them, polysaccharides are particularly preferable as the binder. Polysaccharides are excellent in shapeability and biocompatibility. Further, among them, it is more preferable to use a non-human-derived polysaccharide such as CM chitin, CM cellulose, starch, pectin, chitin, and chitosan as the binder. Non-human-derived binders are obtained from non-human sources. This reduces the risk of infection. Moreover, the rate of decomposition of such substances in the body is neither too fast nor too slow, and is suitable for bone regeneration. The term “non-human origin” can be generally used as an index that the source of collection of the raw material is other than human.

Among these, chitins such as chitin and chitin derivatives (chitosan, carboxymethyl chitin, etc.) are particularly preferable as the binder. Chitins are particularly excellent in the function of inducing osteoblasts and activating bone regeneration.

The bone filling material varies slightly depending on the kind of binder and the content of calcium phosphate, but it is preferable to contain such a binder in an amount of 0.1 to 20 wt%, and 0.3 to 15 wt%. It is more preferable that the content is about%. As a result, the amount of binder adsorbed on calcium phosphate tends to be in a state more suitable for bone regeneration. In addition, as a result, the bone prosthesis material has an appropriate viscosity and the handleability during surgery is improved.

[Dispersion medium] The dispersion medium has a function of dispersing the calcium phosphate granules. Moreover, this dispersion medium also functions as a solvent for the binder.

Examples of such a dispersion medium include water and physiological saline, and among them, water is preferably used. The bone filling material described above includes a pH adjusting agent, a hardening accelerator,
It may contain an antibacterial agent, an X-ray contrast agent, various drugs and the like.

[Manufacture of Bone Filling Material] An example of a method for manufacturing a bone filling material will be described below.

<1> First, a solution in which a binder is dissolved in a dispersion medium (hereinafter referred to as “binder solution”) is prepared. The concentration of the binder in the binder solution is not particularly limited, but it is preferably about 0.1 to 20 wt%.

The binder solution preferably has a viscosity of 100 to 1,000,000 cps at room temperature (for example, 20 ° C.).
It is better to adjust the level to about 300 to 100,000 cps. This facilitates kneading in successive steps. In addition, the shapeability of the obtained bone substitute material is improved.

The pH of the binder solution is not particularly limited, but it is preferably about 3-10 and 4-8.
It is more preferable to adjust the degree. When the bone prosthetic material is manufactured in this manner, the binder solution corresponds to the liquid component. Before performing the next step, the binder solution may be subjected to heat treatment (eg, autoclave) or the like to adjust the viscosity of the binder solution.

<2> Next, the binder solution and the calcium phosphate granules are mixed. Mixing ratio (mass ratio) of calcium phosphate granules and binder solution (liquid component) at this time
Is not particularly limited, but is preferably about 1: 0.2 to 1:10.

<3> Thereafter, this solution is preferably
For example, the mixture is kneaded (kneaded) in the air at room temperature. Thereby, a bone substitute material is obtained.

When the bone substitute material is manufactured in this manner, there is no variation in viscosity, distribution of calcium phosphate granules, etc.
A homogeneous bone substitute material is obtained. The bone filling material may be produced, for example, by mixing the calcium phosphate granules and the binder and then adding the dispersion medium to the mixture. Also,
For example, after adding calcium phosphate granules to the dispersion medium,
A binder may be added to this to produce a bone substitute material. In the case of producing a bone prosthetic material in this way, the viscosity of the liquid in which the binder is dissolved in the dispersion medium in the amount ratio of the binder and the dispersion medium at the time of producing the bone prosthetic material is described in the description of the above step <1>. It can be treated as being equivalent to the viscosity.

When the bone filling material of the present invention is used by being put in a liquid guide (injection device) such as a syringe (a syringe) or a catheter, for example, the operation of surgery becomes easy. For example, if the bone filling material is put into a syringe, and the pusher of the syringe is pushed to be discharged from the tip of the syringe and injected into the bone defect portion, the bone defect portion can be easily filled with a simple operation. You can

As described above, the viscosity of the liquid component of the bone prosthetic material, which has been aged for 72 hours after the production (that is, after the bone prosthetic material has been produced), is determined by the amount ratio of the binder to the dispersion medium at the time of producing the bone prosthetic material. 20 to 50 of the viscosity of the liquid in which is dissolved in the dispersion medium (the viscosity of the solution prepared in step <1> in the above manufacturing method).
% (More preferably 25 to 45%, even more preferably 3
0 to 40%), the bone regeneration property is
It will be excellent.

The viscosity at room temperature of the liquid component of the bone filling material which has been aged for 72 hours after formation of the bone filling material is not particularly limited, but is preferably about 10 to 500,000 cps.

[0065]

[Example] (Example 1) 1. Preparation of calcium phosphate granules Hydroxyapatite (Ca / P ratio = 1.
67) Granules were prepared. The hydroxyapatite granules were fired in the air at 1200 ° C. for 1 hour.

Average particle size: about 200 μm Particle size distribution: 150-250 μm (at least 60 of the granules
% Is included in the range of particle size 150 to 250 μm. Hereinafter, the term “particle size distribution” has the same meaning. ) Porosity: 20%

2. Preparation of CM-chitin aqueous solution CM-chitin (binder) was dissolved in distilled water to prepare a solution of 0.
A 5 wt% CM-chitin aqueous solution was obtained.

The viscosity of this CM-chitin aqueous solution at 20 ° C. was 400 cps. Also, the pH of this aqueous solution
Was 7.2.

3. Mixing and kneading the granules and the aqueous solution The hydroxyapatite granules obtained as described above and the CM-chitin aqueous solution were mixed in a mass ratio of 1: 2.

Next, this was kneaded in the air at room temperature using a rod. ☆ Thereby, a bone substitute material was obtained. The CM-chitin concentration in this bone substitute material was 0.35 wt%. Also,
The content of hydroxyapatite granules in this bone filling material was 33 wt%.

Then, a part of the bone filling material was put in a glass container up to the upper end. Then, the container was capped so that the back surface of the cap was in close contact with the bone filling material, and the inside of the container was completely sealed. Then, this bone substitute material is used at 37 ° C. for 7 hours.
It was aged for 2 hours.

After 72 hours, the bone filling material in the container was filtered to remove insoluble components (hydroxyapatite granules adsorbing CM-chitin). Then, the viscosity of the obtained filtrate was measured at 20 ° C. and found to be 125 cps.
This is the same as step 2. This corresponds to 31% of the viscosity of the aqueous solution prepared in (that is, the liquid obtained by removing the insoluble component from the bone filling material).

Furthermore, based on the nitrogen determination method (general test method 31) described in the 13th revised Japanese Pharmacopoeia, CM- in the filtrate was
Chitin concentration was calculated. When the amount of CM-chitin adsorbed on the hydroxyapatite granules was calculated based on this concentration, 17% of CM-chitin in the CM-chitin aqueous solution (aqueous solution prepared in the above step 2) was converted to hydroxyapatite granules. It was confirmed that it was adsorbed.

(Example 2) 1. Preparation of Calcium Phosphate Granules The same hydroxyapatite granules as in Example 1 were prepared except that the porosity was 12%.

2. Preparation of CM-chitin aqueous solution The same procedure as in Example 1 was performed.

3. Mixing and kneading granules and aqueous solution The same procedure as in Example 1 was performed.

After 72 hours, the bone filling material in the container was filtered to remove insoluble components. The viscosity of the obtained filtrate was measured at 20 ° C., and it was 160 cps. This is the same as step 2. It corresponds to 40% of the viscosity of the aqueous solution prepared in.

It was also confirmed that 10% of CM-chitin in the CM-chitin aqueous solution was adsorbed on the hydroxyapatite granules.

Comparative Example 1. Preparation of Calcium Phosphate Granules Hydroxyapatite granules similar to those in Example 1 were prepared except that they were dense (porosity less than 1%).

2. Preparation of CM-chitin aqueous solution The same procedure as in Example 1 was performed.

3. Mixing and kneading granules and aqueous solution The same procedure as in Example 1 was performed.

After 72 hours, the bone filling material in the container was filtered to remove insoluble components. Then, the viscosity of the obtained filtrate was measured at 20 ° C., and it was 330 cps. This is the same as step 2. 82.5 of the viscosity of the aqueous solution prepared in
Equivalent to%.

It was also confirmed that 0.5% of CM-chitin in the CM-chitin aqueous solution was adsorbed on the hydroxyapatite granules.

(Evaluation) In Examples 1 and 2 and Comparative Example, the above step 3. The bone substitutes obtained after the kneading in step (the bone substitutes obtained at the stage marked with a star) were respectively
An attempt was made to fill a hole made in the parietal bone of a rabbit (same solid). This operation was performed by injecting each bone substitute material into three holes opened in the parietal bone of a rabbit from a syringe.

Each of the bone substitute materials of the respective examples was easily discharged from the syringe. Moreover, the bone substitute materials of all the examples had excellent shapeability and shape retention.

Four weeks after the operation, the rabbits were sacrificed, the surgical site was extracted together with the surrounding tissues, and these were fixed with formalin. Next, this was decalcified, resin-embedded, and stained to prepare a sample.

Then, each specimen was observed with a microscope. As a result, the following points were confirmed.

In the rabbit specimens using the bone filling material obtained in each Example, the number of osteoblasts in the bone filling portion was the same as that in the rabbit specimen using the bone filling material obtained in Comparative Example. It was much higher than the number of osteoblasts in the bone filling part. -In the rabbit samples using the bone substitute material obtained in each example, more new bones were confirmed than in the comparative example.

From the above results, it was confirmed that the use of the bone filling material of the present invention promotes the formation of new bone.

[0090]

As described above, according to the present invention, it is possible to obtain a bone prosthetic material having excellent bone reproducibility and the like. Moreover, the bone substitute material of the present invention is excellent in handleability during surgery and the like.

Therefore, for example, when the bone filling material of the present invention is used for filling a bone defect portion, the operation is facilitated and the bone regeneration is promoted after the operation.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Masahiko Nakasu             2-36 Maeno-cho, Itabashi-ku, Tokyo Asahikou             Gaku Kogyo Co., Ltd. (72) Inventor Takahiro Fukuhara             Katakura Chi, 5551 Namiki, Tsuchiura City, Ibaraki Prefecture             Kukarin Co., Ltd. Tsukuba Research Institute F-term (reference) 4C081 AB03 AB04 AB06 BB08 BC02                       CD012 CD092 CF011 CF031                       DA13 DA14 DB05 DC13                 4C089 AA06 BA16 BE14 CA03 CA06

Claims (13)

[Claims] 1. A bone prosthetic material containing calcium phosphate granules having a porosity of 10 to 90%, a binder, and a dispersion medium in which the calcium phosphate granules are dispersed, wherein the bone prosthetic material is aged for 72 hours after formation. The viscosity of the liquid obtained by removing the insoluble component from the bone filling material is 20 to 50 of the viscosity of the liquid in which the binder is dissolved in the dispersion medium in the amount ratio of the binder and the dispersion medium at the time of forming the bone filling material. A bone filling material characterized by having a property of becoming%. 2. A bone prosthetic material obtained by dispersing granules of calcium phosphate having a porosity of 10 to 90% in a solution in which a binder is dissolved, wherein the bone prosthetic material is aged for 72 hours after the production of the bone prosthetic material. A bone filling material characterized in that the viscosity of a liquid obtained by removing insoluble components from the filling material is 20 to 50% of the viscosity of the solution. 3. The bone prosthesis material according to claim 1, wherein the content of the calcium phosphate granules is 10 to 90 wt%. 4. The bone prosthesis material according to claim 1, wherein the calcium phosphate granules are calcined. 5. The bone substitute material according to claim 1, wherein the calcium phosphate is hydroxyapatite. 6. The content of the binder is 0.1 to 2
The bone filling material according to any one of claims 1 to 5, which is 0 wt%. 7. The bone according to claim 1, wherein 0.1 to 30% of the binder has a property of being adsorbed to the calcium phosphate granules when it is aged for 72 hours after the bone substitute material is formed. Supplementary material. 8. The bone substitute material according to claim 1, wherein the binder is composed of a polysaccharide. 9. The bone substitute material according to claim 8, wherein the binder is composed of a non-human-derived polysaccharide. 10. The bone substitute material according to claim 9, wherein the binder is a chitin. 11. The bone prosthesis material according to claim 1, which is produced by mixing a solution in which the binder is dissolved and the calcium phosphate granules. 12. The bone prosthesis material according to claim 11, wherein the viscosity of the solution in which the binder is dissolved is 100 to 1,000,000 cps at room temperature. 13. The bone substitute material according to claim 1, which is used by being put in a liquid guide.