JP2003073250A - Sheetlike bleaching cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a bleaching cosmetic from which an excellent bleaching effect of tropolone compound is drawn out to the fullest extent, controls fugitivity and photo-bleaching of the compound and continuously exhibits bleaching effect. SOLUTION: This sheetlike bleaching cosmetic comprises a sheetlike material containing a tropolone compound.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a sheet whitening cosmetic containing a tropolone compound as an active ingredient. More specifically, the present invention relates to a sheet-like cosmetic composition in which the excellent whitening effect of the tropolone compound is maximized, and the escape and photo-denaturation of the compound are suppressed, and the whitening effect is exhibited with good sustainability.

[0002]

2. Description of the Related Art With regard to pigmentation disorders such as spots and freckles caused by an abnormal increase in melanin in the epidermis, it has been pointed out that ultraviolet rays, female hormones, genetic factors, etc. are involved, but details are unknown. It is a situation.
Therefore, as a symptomatic treatment, measures that focus on the suppression of melanin production are often taken. It is known that by the action of the oxidative enzyme tyrosinase in pigment cells (melanocytes), tyrosine, which is a type of amino acid, is oxidatively polymerized to produce black melanin. Based on this principle,
Various cosmetics have been devised for the purpose of suppressing the production of melanin by incorporating a component that inhibits the activity of tyrosinase.

It is already known that tropolone compounds have an excellent function of inhibiting the activity of tyrosinase,
Cosmetics containing it are also known. For example, JP-A-56-8309 can be cited. The publication exemplifies various liquid cosmetics. However, as a result of the experiments by the present inventors, in order to maximize the excellent tyrosinase activity inhibitory effect (whitening effect) of the compound, it is extremely important to keep the skin moisturized when the compound acts. It has been found that such a method of simply applying a liquid cosmetic containing a compound to the skin does not have such a moisturizing effect and it is difficult to obtain the whitening effect of the compound. Further, since the tropolone compound has a subliming property, the method of simply applying a liquid cosmetic containing the compound to the skin has a big problem that the tropolone compound escapes due to the sublimation and the whitening effect is difficult to obtain. . Further, the tropolone compound is unstable to light, and when the compounded composition is exposed to light, it undergoes denaturation in a relatively short time and the effect is reduced or discoloration occurs. Since the method of simply applying to the skin is often exposed to light during use,
Such photo-denaturation was also a serious problem.

As described above, the tropolone compound is a compound useful as a whitening agent, but on the other hand, it has the problems that it is essential to keep the skin moisturized at the time of action, and that it has sublimation properties and is susceptible to photodenaturation. There were problems such as not being able to obtain the excellent effects of, and many restrictions on use, and there was a strong demand for the creation of effective measures.

[0005]

The present invention maximizes the excellent whitening effect of tropolone compounds,
Moreover, it is an object of the present invention to provide a whitening cosmetic composition in which the escaping property and the photo-denaturation of the compound are suppressed and the whitening effect is exhibited with good sustainability.

[0006]

Means for Solving the Problems As a result of intensive studies for solving the above-mentioned problems, the present inventors have found that a tropolone compound is contained in a sheet-like material, and the compound is contacted with the skin by a method of whitening the compound. It was found that the effect is efficiently and sustainably exhibited. Further, they have found that the use of a tropolone compound in the form of a metal complex, a salt, an acyl derivative, or a glycoside has even better durability and photostability, and completed the present invention.

That is, the present invention is as follows. 1. A sheet whitening cosmetic comprising a sheet containing a tropolone compound. 2. The sheet-like material is one or more selected from non-woven fabric, woven fabric, paper, and film. The sheet-shaped whitening cosmetic described. 3. 1. The tropolone compound is in the form of any one of a metal complex, a salt, an acyl derivative and a glycoside. Or 2. The sheet-shaped whitening cosmetic described. 4. 1. The tropolone compound is hinokitiol, To 3. The sheet-shaped whitening cosmetic composition according to any one of 1. 5. 1. A tropolone compound is included in cyclodextrin. To 4. The sheet-shaped whitening cosmetic composition according to any one of 1.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be specifically described below. It is an essential requirement of the present invention that the sheet-shaped material contains a tropolone compound. As a result of the experiments by the present inventors, when a sheet-shaped material containing a tropolone compound is adhered to the skin, compared to a case where a liquid cosmetic containing the compound is simply applied to the skin, it is more efficient, namely,
It was found that a higher whitening effect can be obtained at a lower concentration.
On the other hand, it has been confirmed by the experiments of the present inventors that the moisturizing effect on the skin is an important factor for the whitening effect of the compound, and the moisturizing effect on the skin can be enhanced by using a sheet form. It is speculated that it is closely related to the excellent whitening effect of the present invention.

There are no particular restrictions on the material and form of the sheet material that constitutes the sheet whitening cosmetic composition of the present invention, as long as it can stably contain the tropolone compound. For example, sheets, such as woven fabrics, nonwoven fabrics, and papers, are impregnated with cosmetics such as lotion, gel, emulsion, and cream containing the tropolone compound, and sheets, such as woven fabrics, nonwoven fabrics, and papers, are coated with tropolone. Examples thereof include a form in which a gelled or non-gelled polymer containing a compound is applied. Alternatively, a single-layer or multi-layer gel polymer containing a tropolone compound may be used in the form of a sheet. Examples of the gel-like polymer include (meth) acrylic acid (and its salt), t-butylacrylamide sulfonic acid (and its salt), N, N′-dimethylacrylamide, dimethylaminopropylmethacrylamide, and the like. Acrylamide derivative, vinylpyrrolidone, N, N '
-Methylenebisacrylamide, N, N'-methylenebismethacrylamide, N, N'-ethylenebisacrylamide, N, N'-ethylenebismethacrylamide, 1,2-diacrylamideethyleneglycol,
Examples include polyvinyl alcohol and the like.
Preferred as the sheet-like material of the present invention is cellulose,
The tropolone compound is contained in a non-woven fabric composed of one or more selected from materials such as polyamide, polyester, polyethylene and polypropylene.
Most preferred is a non-woven fabric containing cellulose having high hydrophilicity as a main constituent and containing a tropolone compound.

The shape of the sheet whitening cosmetic composition of the present invention is not particularly limited as long as it is a shape that can be easily applied to the face. For example, in addition to a shape such as a circle, an ellipse, and a quadrangle, a shape in which a cut, a punch, or the like is made in the eye, nose, or mouth according to the shape of the face can be used. The tropolone compound content in the sheet-shaped whitening cosmetic composition of the present invention is preferably 0.001 to 5 wt% from the viewpoint of substantial whitening effect and economical efficiency. A more preferable content is 0.01 to 4% by weight.

The sheet-shaped whitening cosmetic composition of the present invention has a thickness of 10 μm to 1.0 cm from the viewpoint of easy handling. More preferably, it is 100 μm to 0.5 cm. The moisture content of the sheet-shaped whitening cosmetic composition of the present invention is preferably 1 to 90 wt% from the viewpoint of maintaining the skin moisturizing effect and handling. In the present invention, there is no limitation on the timing of incorporating the tropolone compound into the sheet. For example, a sheet-like material containing a tropolone compound is stored in a closed container in advance, and in addition to a form in which it is opened at the time of use, a liquid containing a tropolone compound immediately before use (lotion, gel, emulsion, cream) Etc.), a sheet-like material such as a non-woven fabric is immersed in the compound to contain the compound.

The tropolone compound as referred to in the present invention includes a compound (formula (1)) having a free oxygen functional group,
Metal complexes and metal salts (formula (2)), acyl compounds (formula (3)), glycosides (formula (4)), ammonium salts, organic amine salts such as triethanolamine and triethylamine, and the like are included.

[0013]

[Chemical 1]

However, R ₁ , R ₂ and R ₃ represent hydrogen or a linear or branched alkyl group, an alkenyl group, an alkynyl group or a cycloalkyl group, which may be linear or branched. It may also contain an unsaturated bond. In addition, a hetero atom such as oxygen, silicon or halogen may be contained. R ₁ , R ₂ and R ₃ may be the same or different.

Examples of the alkyl group include methyl, ethyl, n-propyl, isopropyl, n-butyl and sec.
-Butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,
1-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, n-hexyl, n-octyl, n-nonyl, n-decyl, n- Undecyl, n-
Dodecyl, 2-propenyl, 2-methyl-2-propenyl, 2-butenyl, 3-butenyl, 2-hexenyl, 5
-Hexenyl and the like.

The alkenyl group has the general formula --CH = CR
₆ R ₇ and is represented by the general formula —CH═C as the alkynyl group.
Represented by -R _6. R ₆ and R ₇ may be the same or different and each is hydrogen or a hydrocarbon group, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, n-hexyl, Examples thereof include n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-hexenyl, 5-hexenyl and the like.

Examples of the cycloalkyl group include cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopenten-1-yl, 2-cyclopenten-1-yl,
Cyclopentadienyl, cyclohexyl, 1-cyclohexen-1-yl, 2-cyclohexen-1-yl, 3
-Cyclohexen-1-yl, 1,3-cyclohexadiene-1-yl, 2,4-cyclohexadiene-1-yl, cycloheptyl, 1-cyclohepten-1-yl,
2-cyclohepten-1-yl, 3-cycloheptene-
1-yl, 4-cyclohepten-1-yl, cyclooctyl, 1-cycloocten-1-yl, 2-cycloocten-1-yl, cyclononyl, cyclodecyl and the like can be mentioned.

Examples of those containing oxygen include those having a substituent represented by the general formula —OR ₈ or general formula —COOR ₉ in the groups described above. R ₈ and R ₉ may be the same or different and each is hydrogen or a hydrocarbon group, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, n-pentyl. , 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1
-Methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, n-hexyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-hexenyl, 5
-Hexenyl and the like. Further, the groups described so far may contain halogens such as silicon, fluorine, chlorine, bromine and iodine.

Among the tropolones represented by the above formula (1), 4-isopropyltropolone having an isopropyl group at the 4-position (β-tsuyaprisin, also known as hinokitiol),
Β-drabulin having an isopropenyl group at the 4-position, 3
Α-tsuyapurisin having an isopropyl group at position 5 is a natural product contained in essential oils of Aomori Hiba and Taiwan cypress, and tropolone used in the present invention is highly safe. Is preferred as Most preferred is 4-isopropyltropolone (hinokitiol).

Hinokitiol (4-isopropyltropolone) is a natural product contained in the essential oils of Japanese cypress and Aomori Hiba, as described above, and has not only pest repellent and insecticidal activity but also a wide variety of fungal species. It is an extremely useful crystalline substance having excellent antibacterial and antifungal properties. As used in the present invention, hinokitiol may be a natural product or a chemically synthesized product.

[0021]

[Chemical 2]

However, in the formula, M represents a metal element, for example, Na, K, Mg, Ca, Zn, Ni, Cu, Al, Ag.
And so on. In the formula, n represents the valence of the metal.

[0023]

[Chemical 3]

However, R ₄ represents a substituted or unsubstituted alkyl group.

[0025]

[Chemical 4]

However, R ₅ OH represents a saccharide. The tropolone compound used in the present invention may be a natural extract or a chemically synthesized product. The method for producing the tropolone compound in the form of a metal complex and a salt is not particularly limited and may be synthesized by a known method. For example, a sodium salt, potassium salt, ammonium salt, or organic amine salt can be synthesized by reacting a tropolone compound having a free oxygen functional group with sodium hydroxide, potassium hydroxide, ammonia, or an organic amine. Reaction of tropolone compound with free functional group or tropolone compound in the form of sodium salt or potassium salt with inorganic salts such as copper chloride, zinc chloride and calcium chloride, and organic salts such as copper stearate, zinc stearate and calcium stearate. If so, a tropolone compound in the form of a metal complex can be synthesized.

The tropolone compound in the form of an acyl may be produced by a general method, for example, a method of reacting an acid chloride or ester of a carboxylic acid such as a fatty acid with a tropolone compound having an oxygen functional group free, Examples include a method of reacting (esterifying) a carboxylic acid such as a fatty acid with a tropolone compound having a free oxygen functional group in the presence of an enzyme. For example, butyric acid, valeric acid, caproic acid,
Octanoic acid, capric acid, lauric acid, myristic acid,
A method of reacting a tropolone compound having a free oxygen functional group with a salt such as a saturated fatty acid such as palmitic acid or stearic acid or an unsaturated fatty acid such as oleic acid or linoleic acid, or a method in which those acids and an oxygen functional group are free Examples include a method of esterifying a tropolone compound in the presence of an enzyme such as lipase or esterase.

The tropolone compound in the form of a glycoside has a hydroxyl group and a sugar (R
It can be produced by dehydration condensation of the hydroxyl group of ( ₅ OH) to form an ether bond, and a general method therefor may be adopted. The saccharide (R ₅ OH) is not particularly limited and may be a common one, for example, hexoses such as glucose, fructose, mannose and galactose, monosaccharides such as xylose and pentoses such as arabinose, primeverose, gentiobiose, Disaccharides such as rutinose, strophantobiose, cellobiose, and other polysaccharides or their derivatives can be used.

In the sheet-shaped whitening cosmetic composition of the present invention,
The tropolone compound may be contained in the form of inclusion in cyclodextrin. The cyclodextrin (CD) used in that case is not particularly limited, and for example, α-CD,
β-CD, γ-CD, branched CD (eg, glucosyl-C
D, maltosyl-CD, etc.), hydroxypropylated-
CD, monochlorotriazino-CD, methylated-CD,
Examples thereof include acetylated-CD, triacetylated-CD, and mixtures thereof.

Although the tropolone compound is an essential component in the sheet-shaped whitening cosmetic composition of the present invention, one or more selected from the following components may be appropriately mixed together. Arbutin,
Kojic acid, ellagic acid, ascorbic acid and its derivatives such as magnesium ascorbate phosphate, glutathione, licorice extract, clove extract, tea extract, astaxanthin, bovine placenta extract, tocopherol and its derivatives, tranexamic acid and its salts, azulene, Whitening components such as γ-hydroxybutyric acid; N-long-chain acylamino acids having a fatty acid residue having one or more unsaturated bonds or salts thereof, which are whitening components (here, as fatty acids having one or more unsaturated bonds, , Palmitoleic acid, oleic acid,
Examples thereof include linoleic acid and linolenic acid, and the amino acid of the N-long chain acylamino acid may be any of acidic, neutral, and basic amino acids, but glutamic acid or glutamic acid may be used because it is close to the skin pH and has less skin irritation. Acidic amino acids such as aspartic acid are preferred. );

Powder components such as calcium carbonate, talc, mica, lauroyl lysine, titanium dioxide and zinc dioxide;
Jojoba oil, macadamia nut oil, avocado oil, evening primrose oil, mink oil, rapeseed oil, castor oil, sunflower oil, corn oil, cacao oil, palm oil, rice bran oil, olive oil, almond oil, sesame oil, safflower oil, soybean oil, Camellia oil, Persic oil, castor oil, mink oil, cottonseed oil, mokuro, palm oil, palm kernel oil, egg yolk oil, lanolin, squalene and other natural animal and vegetable oils, synthetic triglycerides;
Hydrocarbons such as squalane, liquid paraffin, petrolatum, ceresin, microcrystalline wax, and isoparaffin;

Carnauba wax, paraffin wax, whale wax, beeswax, candelilla wax, lanolin and other waxes, cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol, Higher alcohols such as octyldodecanol, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, oleic acid, linolenic acid,
Higher fatty acids such as linoleic acid, oxystearic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, and soft lanolin fatty acid;

Cholesteryl-octyldodecyl-behenyl and other cholesterols and their derivatives; Isopropyl myristic acid, isopropyl palmitic acid, isopropyl stearic acid, glycerol 2-ethylhexanoate, butyl stearic acid and other esters; Diethylene glycol monopropyl ether, polyoxyethylene Polar oil such as polyoxypropylene pentaerythritol ether, polyoxypropylene butyl ether, ethyl linoleate,

Amino-modified silicone, epoxy-modified silicone, carboxyl-modified silicone, carbinol-modified silicone, methacryl-modified silicone, mercapto-modified silicone, phenol-modified silicone, one-terminal reactive silicone, different functional group-modified silicone, polyether-modified silicone, methyl Styryl modified silicone,
Alkyl-modified silicone, higher fatty acid ester-modified silicone, hydrophilic special modified silicone, higher alkoxy-modified silicone, higher fatty acid-containing silicone, fluorine-modified silicone, and more specifically, silicone resin, methylphenyl polysiloxane, methyl polysiloxane, octamethyl Cyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, methylcyclopolysiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, polyoxyethylene / methylpolysiloxane copolymer, polyoxypropylene / methylpolysiloxane copolymer Combined, poly (oxyethylene / oxypropylene) methyl polysiloxane copolymer, methyl hydrogen polysiloxane, tetrahydrotetrame Rucyclotetrasiloxane, stearoxymethylpolysiloxane, setoxymethylpolysiloxane, methylpolysiloxane emulsion, highly polymerized methylpolysiloxane (1) and (2), trimethylsiloxysilicic acid, crosslinked methylpolysiloxane, crosslinked methylphenyl Silicones containing various derivatives such as polysiloxane and cross-linked methylphenylpolysiloxane (2);

Paraaminobenzoic acid and its derivatives, homomethyl-7N-acetylallantoylanilate, butylmethoxybenzoylmethane, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate, paramethoxysilicic acid such as octylcinnamate. Skin acid derivatives, salicylic acid derivatives such as amyl salicylate, benzophenone derivatives such as 2,4-dihydroxybenzophenone, dimethoxybenzylidene dioxoimidazoline propionate ethylhexyl propionate, acetic acid liquid lanolin, Scutellaria baicalensis root extract, trianilino-p-carboethylhexyloxy-triazine, etc. UV absorber; fermented rice extract;

Polyhydric alcohols such as maltitol, sorbitol, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol and glycol, organic acids such as sodium pyrrolidone carboxylic acid, sodium lactate and sodium citrate, and salts thereof, hyaluronic acid. Hyaluronic acid and its salts such as soda, yeast and yeast extract hydrolysates, yeast cultures, fermentation metabolites such as lactic acid bacteria cultures, water-soluble proteins such as collagen, elastin, keratin and sericin, collagen hydrolysates, casein hydrolysates Degradation products, silk hydrolysates, peptides and salts thereof such as sodium polyaspartate, trehalose, xylobiose, maltose, sucrose, glucose, saccharides and polysaccharides such as plant mucilage polysaccharides and their derivatives, water-soluble chitin, Chitosan, Baek Emissions, glycosaminoglycans and salts thereof such as chondroitin sulfate and its salts, glycine, serine, threonine, alanine, aspartic acid,
Tyrosine, valine, leucine, arginine, glutamine, amino acids such as prophosphate, sugar amino acid compounds such as aminocarbonyl reaction products, aloe, plant extracts such as horse chestnut, trimethylglycine, urea, uric acid, ammonia, lecithin, lanolin, squalane, Moisturizers for nucleic acid-related substances such as squalene, glucosamine, creatinine, DNA and RNA;

Carboxymethyl cellulose, hydroxyethyl cellulose hydroxypropyl trimethyl ammonium chloride ether, ethyl cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, soluble starch, carboxymethyl starch,
Methyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinylpyrrolidone,
Polyvinyl methyl ether, carboxyvinyl polymer, polyacrylic acid, methyl cellulose, hydroxyethyl cellulose, gum arabic, xanthan gum, guar gum, locust bingham, quince seed, carrageenan, galactan, pectin, mannan, starch,
Dextran, succinoglucan, curdlan, hyaluronic acid, gelatin, casein, albumin, collagen, methoxyethylene maleic anhydride copolymer, amphoteric methacrylic acid ester copolymer, polychlorinated dimethylmethylene piperidinium, polyacrylic acid ester Polymer,
Polyvinyl acetate, nitrocellulose, silicone resin, polyethylene glycol fatty acid ester, polyoxyethylene fatty acid ester such as polyethylene glycol distearate, polyoxyethylene fatty acid ester methyl glycoside such as polyoxyethylene dioleic acid methyl glucoside, tetradecene sulfonic acid, etc. Thickening agents such as α-olefin sulfonic acid;

Ethylenediaminetetraacetic acid and salts thereof,
Hydroxylethylenediamine triacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates and other sequestering agents; organic solvents such as ethanol, propylene glycol, 1,3-butyle glycol , Butylhydroxytoluene, tocopherol, phytic acid, and other antioxidants; benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, paraoxybenzoic acid alkyl esters (ethylparaben, butylparaben, etc.) and its salts, dehydro Acetic acid and its salts, parachlorometacresol, hexachlorophene, boric acid, resorcin, tribromsalan, orthophenylphenol, chlorhexidine gluconate, thiram, photosensitizer 201, phenoxyethanol, cetylpi chloride. Jiniumu, benzalkonium chloride,
Antibacterial and antiseptic agents such as benzethonium chloride, halocarban, chlorhexidine chloride, trichlorocarbanide, tocopherol acetate, zinc pyrithione, phenol, isopropylmethylphenol, 2,4,4-trichloro-2-hydroxyphenol and hexachlorophene;

Organic acids such as citric acid, malic acid, tartaric acid, lactic acid, adipic acid, glutamic acid, aspartic acid and maleic acid; vitamin A and its derivatives; vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ Vitamin Bs such as dioctanoate, vitamin B ₂ and its derivatives; Vitamin Cs such as ascorbic acid, ascorbic acid sulfate, and ascorbic acid phosphate,
Vitamin Es such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamins D, vitamin H, vitamins such as pantothenic acid, nicotinic acid amide,
Benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt) glycyrrhetinic acid and its derivatives, muscidin, bisabolol, eucalyptol, thymol inositol, saponins (Quillayasaponin, azuxaponin, hemimasaponin, etc.) Tranexamic acid, pantotel Ethyl ether, ethinyl estradiol, cepharanzin, placenta extract, assembly extract, cepharanthin, vitamin E and its derivatives,
Blood circulation promoters such as gamma-oryzanol,

Topical stimulants such as Capsicum tincture, Ginseng tincture, Cantharis tincture, nicotinic acid benzyl ester, various vitamins and amino acids such as vitamin A, vitamin B group, vitamin D group, vitamin E, pantothenic acid, vitamin H Nutrients such as, glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, anti-inflammatory agents such as hydrocortisone, zinc oxide, zinc sulfate, allantoin hydroxyaluminium, aluminum chloride, zinc sulfocarbonate, astringents such as tannic acid, Cooling agents such as menthol and camphor, antihistamines, polymeric silicones, silicone-based substances such as cyclic silicones, tocopherols, BHA,
Various agents such as antioxidants such as BHT, gallic acid and NDGA;

Yeasts such as Saccharomyces, filamentous fungi, bacteria, bovine placenta, human placenta, human umbilical cord, yeast, bovine collagen, milk-derived protein, wheat, soybean, bovine blood, porcine blood, poultry, chamomile, cucumber, rice, shii Avatar, birch, tea, tomato, garlic, hamamelis, roses, loofah, hops, peaches, apricots, lemons, kiwi, dokudami, capsicum, clara, crepe, koufone, sage, saw grass, mallow, senkyu, senburi,
Thyme, Touki, Spruce, Birch, Horsetail, Loofah, Horse chestnut, Yukinoshita, Arnica, Lily, Mugwort, Peony, Aloe, Aloe vera, Ougon, Oataku, Cucumber, Safflower, Sanshin, Shikon, Taiso, Chimp,
Natural extracts obtained by extracting or hydrolyzing animal or plant / microorganisms such as carrots, yokinin, adlay, gardenia, and sawara with organic solvents, alcohols, polyhydric alcohols, water, aqueous alcohols, etc .; pigments;

Sorbitan monolaurate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monooleate, sorbitan monostearate, sorbitan tristearate, sorbitan monoisostearate, sorbitan fatty acid esters, polyoxyethylene sorbitan monolaurate, mono Stearic acid POE
(Polyoxymethylene is abbreviated as POE hereinafter) Sorbitan, POE sorbitan tristearate, POE sorbitan monostearate, POE sorbitan monoisostearate, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol monooleate, polyethylene glycol monolauric acid, polyethylene glycol Polyethylene glycol fatty acid esters such as monostearic acid, polyethylene glycol monooleic acid, polyethylene glycol distearic acid, polyethylene glycol dioleic acid, polyethylene glycol diisostearic acid, POE lauryl ether, POE cetyl ether, POE stearyl ether, POE oleyl ether, POE behenyl Polyoxyethylene alkyl ether such as ether , Diglyceryl monostearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl monoisostearate, tetraglyceryl monostearate, tetraglyceryl tristearate, tetraglyceryl pentastearate, hexaglyceryl monolaurate, monomyristic acid Hexaglyceryl, decaglyceryl distearate, polyglycerin fatty acid ester such as deisoglyceryl diisostearate, polyglycol diester, coconut oil fatty acid monoethanolamide, lauroyl monoethanolamide,
Myristoyl monoethanolamide, lauroyl diethanol amide, coconut oil fatty acid diethanol amide,
Lauroyl isopropanol amide, myristoyl isopropanol amide, fatty acid alkanol amide such as coconut oil fatty acid isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, sugar ester and other sugar derivatives, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor Oil, propylene glycol monostearate, propylene glycol fatty acid ester such as self-emulsifying propylene glycol monostearate, glyceryl monostearate, glycerin fatty acid ester such as self-emulsifying glyceryl monostearate, polyoxy ester such as POE glyceryl monostearate Ethylene glycerin fatty acid ester, hexastearic acid POE sorbit, tetrastearic acid POE Rubitto, tetra oleic acid POE
Polyoxyethylene sorbit fatty acid ester such as sorbit, POE sorbit monolaurate, nonionic surfactant such as POE octylphenol ether, POE nonylphenol ether, POE chlorophenol ether, polyethylene glycol, etc.

Lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, tallow alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, dioctyldimethylammonium chloride, distearyldimethylammonium chloride, coconut oil alkyltrimethylammonium bromide, stearyltrimethylammonium chloride. Alkylammonium salts such as bromide, lanolin-derived quaternary ammonium salts, benzalkonium chloride, stearyldimethylbenzylammonium chloride, laurylamine oxide,
Cationic surfactants such as coconut oil alkyl amine oxide, stearic acid diethylaminoethylamide;

Sodium laurate, sodium myristate, coconut oil fatty acid sodium, palm kernel oil fatty acid sodium, lysine laurate, lysine myristate, coconut oil fatty acid lysine, palm kernel oil fatty acid lysine, arginine laurate, arginine myristate, palm Oil fatty acid arginine, palm kernel oil fatty acid arginine, potassium laurate, potassium myristate, palm oil fatty acid potassium, palm kernel oil fatty acid potassium, triethanolamine myristate, triethanolamine myristate, palm oil fatty acid triethanolamine, palm kernel Fatty acids such as oil fatty acid triethanolamine, ammonium laurate, ammonium myristate, coconut oil fatty acid ammonium, palm kernel oil fatty acid ammonium and salts thereof, lauryl sulfate sodium salt Alkyl sulfates and salts thereof such as potassium lauryl sulfate, sodium myristyl sulfate and potassium myristyl sulfate, alkyl phosphoric acid salts such as sodium lauryl phosphate and sodium myristyl phosphate and salts thereof, lauryl sulfate triethanolamine ether, myristyl phosphate Alkyl sulfate triethanolamine ethers such as triethanolamine ether and coconut oil fatty acid alkyl sulfate triethanolamine ether and salts thereof, alkyl sulfonic acids such as sodium lauryl sulfonate, sodium myristyl sulfonate, coconut oil alkyl sulfonates and salts thereof , Alkyl lauric acid such as sodium lauryl phosphate, sodium myristyl phosphate, coconut oil fatty acid sodium phosphate and its salts, dodecene sulfonic acid Α-olefin sulfonic acids and salts thereof such as thorium, sodium tetradecene sulfonate, potassium dodecene sulfonate and potassium tetradecene sulfonate, linear and branched chain alkyl benzene sulphates and salts thereof such as linear dodecyl benzene sulphate and its salts, Linear and branched chain alkylbenzene sulfonic acid and its salts such as linear dodecyl benzene sulfonic acid and its salts, sodium lauroyl methyl taurine, sodium myristoyl methyl taurine, sodium coconut oil fatty acid acyl methyl taurine,
Acylmethyl taurine and its salts such as lauroyl methyl taurine potassium, myristoyl methyl taurine potassium, coconut oil fatty acid acylmethyl taurine potassium, lauroyl methyl taurine triethanolamine, myristoyl methyl taurine triethanolamine, coconut oil fatty acid acylmethyl taurine triethanolamine and the like, Lauroylmethyl-β-alanine sodium, myristoylmethyl-β-alanine sodium, coconut oil fatty acid acylmethyl-β-alanine sodium, lauroylmethyl-β-alanine potassium, myristoylmethyl-β-alanine potassium, coconut oil fatty acid acylmethyl-β-alanine Potassium, lauroylmethyl-β-alaninetriethanolamine, myristoylmethyl-β-alaninetriethanolamine, Seed oil fatty acid acylmethyl-β-
Acylmethyl-β such as alanine triethanolamine
-Alanine and its salts, sodium N-lauroyl glutamate, sodium N-myristoyl glutamate, sodium N-coconut oil fatty acid acylglutamate,
N-hardened tallow fatty acid sodium acylglutamate, N
-Tallow / coconut oil mixed fatty acid acylglutamate sodium, N-lauroylglutamate potassium, N-myristoylglutamate potassium, N-coconut oil fatty acid acylglutamate potassium, N-hardened beef tallow fatty acid acylglutamate potassium, N-beef tallow / coconut oil mixed fatty acid acyl Potassium glutamate, N-lauroyl glutamate triethanolamine, N-myristoyl glutamate triethanolamine, N-coconut oil fatty acid acyl glutamate triethanolamine, N-hardened tallow fatty acid acyl glutamate triethanolamine, N-beef / coconut oil mixed fatty acid acyl Glutamic acid N-acyl glutamic acid such as triethanolamine and salts thereof, sodium lauroyl sarcosine, myristoyl sarcosine, palmitoyl sarcosine N-acyl sarcosine such as oleoyl sarcosine and its salts, N-acyl amino acid and its salts, polyoxyethylene such as sodium polyoxyethylene lauryl ether sulfate, sodium polyoxyethylene cetyl ether sulfate, and sodium polyoxyethylene oleyl ether sulfate. Alkyl ether sulfuric acid and its salts, sodium polyoxyethylene lauryl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, sodium polyoxyethylene oleyl ether phosphate, etc., polyoxyethylene alkyl ether phosphoric acid and its salts, carboxylated polyoxy Ether carboxylic acids such as ethylene tridecyl ether sodium salt, and salts thereof, lauroyl isethionate, myristoyl isethionate, coconut oil and fat Anionic surface active agents such as acid acyl isethionate;

Betaines such as betaine lauryldimethylaminoacetate, coconut oil fatty acid amidopropyldimethylaminoacetate, etc., alkylcarboxymethylhydroxyethyl imidazolinium betaines, imidazolinium betaines such as alkylsodium carboxymethylcarboxyethyl imidazolinium betaines , Coconut oil alkyl betaine, alkyl betaines such as lauryl betaine, amphoteric surfactants such as bis (stearyl hydroxyethyl imidazoline) chloroacetic acid complex, natural surfactants such as lecithin, lanolin, cholesterol, saponin, sodium alginate, starch derivatives, Polymeric surfactants such as tragacanth rubber;

Mg, Ca, Zn, Ni, Cu, Al, A
Inorganic or organic substance containing metal such as g {oxide, hydroxide, chloride, sulfate, sulfite, nitrate, nitrite, carbonate, chlorate, perchlorate, bromide, iodide, phosphoric acid Salts, diphosphates, ammonium salts, formates containing the above metals, acetates, fatty acid salts (butyric acid, valeric acid, caproic acid, octanoic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, etc. Saturated fatty acids, salts of unsaturated fatty acids such as oleic acid and linoleic acid), citrates, 4-cyclohexylbutyrate, gluconates, naphthenates, thiocyanates, nicotinates, picolinates, the metals mentioned above. And a compound with picolinic acid amide, a compound with nicotinic acid amide, chlorophyll,
Compounds with (mono-, di- or tri) ethanolamine, compounds with amino acids and peptides}; fennel, oyster, chamomile, cinnamon, safflower, peony, ginger,
Irises, senkyu, touki, chimpi, sojutsu, valerian, juniper, toushi, light load, bukuro, carrot,
Herbal medicine such as peach leaves;

Next, the present invention will be described in more detail with reference to Examples and the like, but the present invention is not limited thereto. All parts and percentages in the blending amount and the like are based on mass. The test methods and evaluation methods in the examples of the present invention were according to the following methods. <Evaluation of pigmentation inhibitory effect using guinea pig> (1) Animal species, strain Animal species: brown guinea pig (SPF) Strain: Kwl: A-1 (2) Quarantine and acclimation Obtained animals have a quarantine period of 5 days, After that, a habituation period of 2 days or more was provided. During this period, body weight measurement was performed three times or more and observation of the general condition was performed every day for quarantine and acclimation, and animals in which there were no abnormalities in weight transition or general condition were used for distribution.

(3) Distributing method For the measurement of the minimum amount of erythema, two young animals with acclimated animal numbers were used. In this experiment, the remaining animals were sorted according to the acclimated animal number. The distribution was performed on the day before irradiation, and on the distribution day, the back of the guinea pig was shaved. (4) Individual identification method Animals were identified by marking the ear with a quarantine / acclimatized animal number with an oil-based ink on the day of acquisition. After the sorting, the hair dyeing method using an oil-based ink was used for identification. Each cage has a quarantine
During the acclimation period, the test number, date of acquisition, sex, quarantine / acclimatized animal number is entered on the label.
A label with gender and animal number was attached.

(5) Environmental conditions and breeding room temperature 20 to 26 ° C., humidity 40 to 70%, light and dark for 12 hours each (lighting: 6:00 am to 6:00 pm), ventilation frequency 12 times / hour (sterilized by a filter) Fresh air and circulating air)
The animals were bred in the breeding room set to. During the quarantine period, a stainless steel hanging cage (W: 262 × D: 38) in the quarantine room
(0 × H: 200 mm) was used for group breeding, and during the acclimation period and after sorting, individual breeding was performed in a breeding room using a stainless steel 5-strip cage (W: 755 × D: 210 × H: 170 mm). During the quarantine period, water bottles and saucers were changed at least twice a week, and cages and feeders were changed at least once a week. The animal room was cleaned and disinfected daily.

(6) Measurement of minimum erythema dose (minimum irradiation time required for skin reaction to appear) The guinea pig was fixed in the abdominal position using a fixing plate. A irradiating center of the back of the guinea pig was placed symmetrically to form a square of 2 cm x 2 cm, and three irradiation sites were provided (3 cm in total) (2 cm.
A light-shielding paper obtained by cutting out a 6 × 2 cm square was attached to the back of the guinea pig). SE lamp (wavelength 250
Ultraviolet ray (UVB) irradiation was performed from a distance of 40 cm using 5 pieces (-350 nm). The irradiation time was set to 4, 6, 8, 10, 12, and 14 minutes for one animal (one irradiation site was shielded from light each time a predetermined time elapsed). The next day, the skin reaction at the irradiated site was observed. As a result, erythema was observed at an irradiation time of 14 minutes or longer. Next, using another animal (eight irradiation sites were provided), at the interval of 15 seconds between the minimum time when skin reaction was observed and the maximum time when skin reaction was not observed in the above experiment. Break, 12 minutes 15 seconds,
12 minutes 30 seconds, 12 minutes 45 seconds, 13 minutes, 13 minutes 15 seconds,
At 13 minutes and 30 seconds, 13 minutes and 45 seconds, and 14 minutes, the skin reaction was similarly observed and the minimum erythema level was measured. As a result, the minimum amount of erythema was 12 minutes and 15 seconds.

(7) Method of UV irradiation The guinea pig was fixed in the abdominal position using a fixing plate. The UV irradiation sites were two symmetrical 2 cm x 2 cm squares (2 cm x 2 c) across the midline of the back of the guinea pig.
A piece of light-blocking paper cut out from the square m was attached to the back of the guinea pig). SE lamp (wavelength 250-35
UV rays (UV) from a distance of 40 cm using 5
B) was irradiated. Ultraviolet irradiation was performed three times in total, starting from the day when the sample was applied (this day is 0 day) and thereafter 2 and 4 days after the sample was applied. The irradiation time was the minimum erythema dose.

(8) Application of Specimen (8-1) When a Sheet-like Material is Applied To the right and left sides of the dorsal skin of each animal, a sample cut into a size of 2 cm × 2 cm and a control are applied and occluded for 22 hours. The application operation of removing the sample and the control for 2 hours, then applying a new sample and the control and closing the sample for 22 hours was repeated every day for 14 days. The ultraviolet irradiation day was applied after the ultraviolet irradiation, and the pigmentation determination day was applied after the determination. (8-2) When applying a liquid substance A sample and a control were applied to the right and left sides of the back skin of each animal. The application frequency was once a day (overcoating at the same place at 9 am), and the application period was 14 days. The ultraviolet irradiation day was applied after the ultraviolet irradiation, and the pigmentation determination day was applied after the determination.

(9) Judgment Method of Pigmentation L value (brightness) of the irradiation site was measured using a color difference meter (CR-300, Minolta Camera Co., Ltd.) before the irradiation on the sample application start day and 14 days after the application start. Then, the ΔL value (L value on the observation day-L value before irradiation) is calculated, and the Δ (ΔL) value (specimen ΔL value-control Δ
The L value) was used to determine the effect of suppressing pigmentation as follows. In addition, as ΔL, an average value of values obtained from 6 guinea pigs was used. × when the Δ (ΔL) value is less than 0.5,
The case of 0.5 or more and less than 1.0 was judged as Δ, the case of 1.0 or more and less than 2.0 was judged as ◯, and the case of 2.0 or more was judged as ⊚.

[0054]

Examples 1-10, Comparative Examples 1-3 0.24 ml of a 1 wt% solution of various tropolone compounds (70% ethanol)
2 cm × 2 cm cellulose nonwoven fabric (Asahi Kasei Co., Ltd., Benliese TS-100) was impregnated with the sample to the back skin of guinea pig to evaluate the pigmentation suppressing effect. A non-woven fabric made of the same cellulose impregnated with 0.24 ml of 70% ethanol was used as a control. The results are shown in Table 1.

[0055]

Comparative Example 4 100 μL of a 1 wt% solution of hinokitiol (70% ethanol) was applied to the dorsal skin of guinea pigs to evaluate the effect of suppressing pigmentation. In addition, 70% ethanol was applied as a control. The results are shown in Table 1.

[0056]

Comparative Example 5 100 μL of a 1 wt% solution of tropolone (70% ethanol) was applied to the dorsal skin of guinea pigs to evaluate the effect of suppressing pigmentation. In addition, 70% ethanol was applied as a control. The results are shown in Table 1.

[0057]

Example 11 Polyacrylic acid (weight average molecular weight of about 50
200,000 parts by mass, sodium polyacrylate (molecular weight about 300,000) 6.0 parts by mass, copper complex of hinokitiol 1.0
Parts by mass, 1,3-butylene glycol (moisturizer) 10.
After 0 parts by mass and 81 parts by mass of purified water were mixed at 50 ° C. for about 30 minutes to homogenize, 1.3 parts by mass of synthetic aluminum silicate was added and mixed at 60 ° C. for 10 minutes to homogenize. The copper complex of hinokitiol was dissolved in 1,3-butylene glycol in advance and blended. This was uniformly spread on a 100 μm polypropylene sheet with a thickness of 1.0 mm. This was left at room temperature for about 2 hours to form a polymer gel sheet. This sample was cut into a piece of 2 cm × 2 cm and attached to the back skin of a guinea pig to evaluate the pigmentation suppressing effect. A polymer gel sheet control was prepared in the same manner except that it did not contain a copper complex of hinokitiol. The results are shown in Table 1.

[0058]

Comparative Example 6 A polymer gel sheet prepared in the same manner as in Example 11 except that ellagic acid was blended in place of the copper complex of hinokitiol was evaluated for pigmentation inhibiting effect in the same manner as in Example 11. Since Examples 1 to 11 contain the tropolone compound which is an essential component of the present invention and apply the sheet-like material, the pigmentation suppressing effect is better than that of Comparative Examples 1 to 6.

[0059]

[Table 1]

[0060]

The present invention provides a whitening cosmetic composition in which the excellent whitening effect of the tropolone compound is maximized, and the escape and photo-denaturation of the compound are suppressed, and the whitening effect is exhibited in a long-lasting manner. It becomes possible to provide.

Claims (5)

[Claims] 1. A sheet-shaped whitening cosmetic comprising a sheet-shaped product containing a tropolone compound. 2. The sheet whitening cosmetic composition according to claim 1, wherein the sheet material is one or more selected from a non-woven fabric, a woven fabric, paper and a film. 3. The sheet-shaped whitening cosmetic composition according to claim 1, wherein the tropolone compound is in the form of a metal complex, a salt, an acyl derivative or a glycoside. 4. The sheet whitening cosmetic composition according to claim 1, wherein the tropolone compound is hinokitiol. 5. The tropolone compound is included in cyclodextrin, which is characterized in that:
The sheet-shaped whitening cosmetic composition according to any one of 1.