JP2003070903A - Blood filtration equipment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide blood filtration equipment requiring a liquid flow control before blood is filtered by a filter and making stable filtration performance while reducing the burden of a filtration implementing patient. SOLUTION: This blood filtration equipment has liquid flow control means (7 and 7') of the blood at manifolds (5 and 6) for connecting a storage section (2) and recovering section (3) of the blood and leucocytes removing filter (4). The liquid flow control means (7 and 7') release automatically the liquid flow control of the blood in accordance with the signal from signal generating means (8).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hemofiltration device used for removing leukocytes from blood using a leukocyte removal filter. More specifically, the present invention relates to a hemofiltration device having means for automatically controlling the passage of blood passing through a leukocyte removal filter.

[0002]

2. Description of the Related Art A large amount of leukocytes are mixed in blood for transfusion, and these mixed leukocytes have relatively minor side effects such as headache, nausea, chills, non-hemolytic fever reaction, and serious effects on recipients. It has become clear that it causes serious side effects such as alloantigen sensitization, viral infection, and post-transfusion GVHD. Therefore, a filter that removes white blood cells mixed in blood is widely used in clinical practice.

Opportunities for removing leukocytes using a leukocyte removal filter are roughly classified into cases where they are removed from whole blood and cases where they are removed after each blood component preparation is prepared. The latter requires a filter for each blood component preparation, whereas the former removes leukocytes from whole blood with one filter and then centrifuges to prepare multiple types of blood component preparations with leukocytes removed. It is considered to be the more preferable method because it is possible. In particular, recently, a so-called closed system has been attracting attention, in which a bag for whole blood, a filter, a bag for each blood component preparation prepared after centrifugation, and the like are integrated, and a blood component preparation from which leukocytes have been removed aseptically can be prepared. , Used in blood centers and the like (JP-A-1-320064).

[0004] Usually, a method of preparing leukocyte-removed blood using a filter at a blood center or the like is a method in which a bag containing blood containing a large amount of leukocytes, a filter and a bag for collecting blood filtered by the filter are vinyl chloride. Etc. using a system connected via a soft tube. Specifically, hang a bag containing blood without leukocyte removal on a rack with hooks, hang it at a drop of 0.5 to 2 m, mix well with blood without leukocyte removal, and then clamp or break the tube. Manually release the seal,
It is carried out by a method in which the blood from which white blood cells have been removed through a filter is collected in a collection bag.

The inventors of the present invention have conducted extensive studies on a method for further enhancing leukocyte-removing ability in such a hemofiltration method. As a result, by allowing the blood reservoir to stand for a predetermined period of time, a blood cell concentration gradient was intentionally formed in the blood in the reservoir, and after a heterogeneous state, the concentration of erythrocytes and granulocytes with a large specific gravity It was found that the leukocyte-removing ability was significantly improved when blood was filtered from a high blood content with a filter. Furthermore, at this time, it was surprisingly found that filtering the non-homogenized blood using a filter having a platelet recovery function markedly improves the platelet recovery rate (Japanese Patent Application No. 2001-129177. Hereinafter, this method). Is referred to as a "blood cell concentration gradient filtration method"). Furthermore, the present inventors have also found that the platelet recovery rate is significantly improved by controlling the passage of blood for a predetermined time while the filter having a platelet recovery function is filled with blood, and then filtering (Patent Application 2001). No. 129176. Hereinafter, this method is referred to as a "filtration method after blood filling".

In order to perform blood filtration by the above-described blood cell concentration gradient filtration method or blood filling and filtration method using a conventional rack, the blood bag is hung by the rack and left standing for a predetermined time in order to form a blood cell concentration gradient. Alternatively, it is necessary to fill the filter with blood and control the passage of blood for a predetermined time, and then the filter operator must manually release the clamp or breakable seal to start the filtration. In such an operation, the standing or liquid passage control for a predetermined time before the start of filtration,
Although it will be left to the filtering person, if the filtering person is in a very busy environment such as having to process a large amount of blood in one day, etc. There is a risk that it will fall. As a result, there arises a problem that filtration performance such as leukocyte removal rate of filtered blood is not stable. In particular, blood is filtered after forming a concentration gradient so that the degree of blood cell separation (the ratio of the plasma component, the platelet component, and the lymphocytes with a low specific gravity to the total blood volume) is appropriate. In such a case, it is necessary to frequently check the blood cell separation degree at regular intervals, which further restricts the filter operator. In addition, since blood itself has individual differences (for example, differences in blood cell concentration, etc.), the standing time until an appropriate degree of separation differs depending on the individual blood. Therefore, it is necessary for the person who carries out the filtration to check the blood cell separation degree of all the blood, which significantly increases the burden on the person who carries out the filtration.

As described above, when performing "blood cell concentration gradient filtration" or "filtration after blood filling" using a conventional rack, there is a problem that the burden on the person performing the filtration becomes large, and the filter performance is impaired due to an erroneous operation. There are inherent risks such as stabilization.

On the other hand, in recent years, stricter quality control of blood products has been required more than ever, and in order to meet this demand, the hemofiltration process is automated, and filtration data of individual blood (filtration time, temperature, An automated hemofiltration device capable of recording the flow velocity etc. by a computer has been developed (Vox Sanguinis Vol. 78 (Sup).
plement 1), 2000, P517). Such an automated device is an excellent device because it can automate simultaneous simultaneous filtration of as many as 40 blood filters and can automatically record filtration data and the like. However, the device introduced here is a device that performs filtration while mechanically automatically mixing blood not only before filtration but also during filtration, and is referred to as “blood cell gradient filtration” or “blood filling” in the present invention. It is not a device that can be applied to "post-filtration".

Further, US Pat. No. 4,350,585 discloses a device for separating blood components separated into a plurality of phases by centrifugation. This is, for example, an apparatus that detects the interface of blood components formed in a blood bag after centrifugation with an optical sensor and automatically separates a plasma phase and a red blood cell phase. Specifically, the plasma phase of the upper phase of the blood bag is transferred to another bag, and the blood component is separated by closing the circuit when the red blood cell phase is detected by the sensor. It is not an apparatus for separating blood components that uses a removal filter, and does not require fluid control for a predetermined time as in the present invention.

Further, in JP-A-7-313588, blood collected from a donor is introduced into a centrifuge called a centrifuge bowl and then centrifuged to detect the interface of blood components with an optical sensor. A blood component separation device that controls the operation of a pump or the like based on a signal is disclosed. However, this device also does not use a filter, and only the components necessary for blood transfusion are collected, and the other components are devices that are suitably used for component blood collection to be returned to the donor, such as the present invention. However, it is essentially different from a hemofilter for removing leukocytes.

Further, Japanese Unexamined Patent Publication (Kokai) No. 10-212237 discloses an apparatus for automatically filtering blood using a pump while ensuring a constant flow rate. Such a device
While monitoring the pressure near the inlet of the filter, the controller controls the operation of the pump according to the pressure fluctuation and maintains an appropriate blood filtration flow rate. However,
Unlike the present invention, it is not a device that automatically starts filtration after a predetermined time or a predetermined blood cell concentration gradient in order to improve the performance of the filter.

[0012]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above problems in the hemofiltration means, and more specifically, "blood cell gradient filtration" and "filtration after blood filling". It is an object of the present invention to provide a device capable of automatically performing a hemofiltration method that requires fluid control for a predetermined time before actually starting hemofiltration with a filter. The present invention also imposes a burden on a filter performer such as "hemocyte concentration gradient filtration" and "filtration after blood filling", which requires fluid control until blood filtration is started by the filter. An object of the present invention is to provide a hemofiltration device for reducing and reducing the filtration performance of a stable filter.

[0013]

Means for Solving the Problems As a result of intensive studies on the above problems, the present inventors have provided a hemofiltration device capable of automatically releasing blood flow control means and automatically starting hemofiltration. It was found that the above problems can be achieved by doing so.

That is, the present invention provides (1) a reservoir for retaining blood, a retainer for retaining the reservoir, a leukocyte removal filter, a collector for collecting blood filtered by the filter, and a reservoir. First to connect the leukocyte removal filter with
A blood filtering device having a connecting pipe and a second connecting pipe connecting a leukocyte removal filter and a recovery unit, wherein the first connecting pipe and / or the second connecting pipe is provided.
Liquid passage control means for controlling the passage of blood through the connecting pipe, signal generating means for interlocking the liquid passage controlling means, and operation for automatically releasing the liquid passage controlling means based on the signal from the signal generating means. A blood filtering device, characterized in that
(2) The blood filtering device according to (1) above, wherein the signal generating means is a timer, (3) the blood filtering device according to (1) above, wherein the signal generating means is an optical sensor, and (4) fluid flow control. The blood filtering device according to any one of (1) to (3) above, wherein the means is means for stopping the passage of blood or maintaining it at a low speed.

Furthermore, according to the present invention, in the hemofilter as described in (1) above, (a) a signal is output from the signal generating means after the blood reservoir is left standing by the holder for 5 minutes or more and less than 300 minutes. A device that emits a signal, (b) a device that emits a signal from the signal generating means after filling the filter with blood for 1 minute or more, and (c) a blood separation degree of 5% or more and less than 40% The invention also relates to a device in which a signal is emitted from the signal generating means.

In the hemofiltration apparatus of the present invention, the filtration can be automatically started by automatically releasing the liquid flow control means based on the signal from the signal generating means.
It is possible to reduce the burden on the person who carries out filtration and to exhibit stable filtration performance.

[0017]

BEST MODE FOR CARRYING OUT THE INVENTION The blood filtering device of the present invention will be described below in detail with reference to the accompanying drawings. However, the hemofiltration device of the present invention is not limited to only the specific examples shown in the accompanying drawings. 1 and 2 are schematic diagrams showing the configuration of the blood filtering device of the present invention, FIG. 3 is a block diagram showing a control system of the blood filtering device shown in FIG. 1 or 2, and FIGS. 3 is a schematic diagram showing an example in which an optical sensor is used as a signal generating means in FIG.

As shown in FIGS. 1 and 2, the blood filtering device (1) of the present invention has a blood reservoir (2) represented by a blood bag and a blood reservoir (2) represented by a hook. The holding part (11) for holding the blood, the recovery part (3), and the filter (4) having the blood inlet and outlet are connected by a hollow tubular connecting pipe (5, 6), The liquid flow control means (7, 7 ') is a device which is automatically released by the actuating means (10) based on the signal from the signal generating means (8, 9).

In the hemofiltration apparatus (1) of the present invention, before the blood is actually filtered by the filter (4), the first connecting pipe (5) and / or the second connecting pipe (6) is connected. The fluid control means (7, 7 ') is set so that the fluid passage is maintained at a low speed or stopped so that the blood passage cannot be substantially performed for a predetermined time. The actuating means (10) recognizes the signal emitted from the signal generating means (8, 9) described later, and thereafter the signal from the actuating means (10) is sent to the liquid flow control means (7, 7 '). By this, the blood flow control is automatically released, and the filtration is started. That is, in the blood filtering device (1) of the present invention, the liquid flow control means (7, 7 '), the signal generating means (8, 9) and the operating means (10) need to be linked. Here, "being interlocked" means that the signal from the signal generating means (8, 9) is automatically passed through the actuating means (10) to the liquid passage control means (7, 9).
7 ') is in a state where it can be transmitted to the liquid flow control means (7, 7'), the signal generating means (8, 9) and the operating means (10) are electrically connected. Say.
The actuating means (10) may be a device integrated with the signal generating means (8, 9) and / or the liquid flow control means (7, 7 ′) or may be an independent device. good.

The signal generating means means the operating means (1) after a predetermined time or after the blood reaches a predetermined blood cell separation state.
It is a device having a function of transmitting a signal to. An example of the signal generating means (8) in FIG. 1 is a timer that releases the liquid flow control means (7, 7 ′) after a predetermined time.
As a preferable example of the signal generating means (9), an optical sensor capable of detecting the blood cell separation degree of the blood storing part (2) and being linked with the liquid flow control means (7, 7 ′) can be mentioned.

The timer can be used for both the "blood cell gradient filtration" and the "filtration after blood filling". In FIG. 1, when a timer is used as the signal generating means (8), the storage part (2) is held by the holding part (11) and allowed to stand still, or the blood is passed through after the filter (4) is filled with blood. After controlling the liquid, set so that the signal will be emitted from the timer when the predetermined time has elapsed,
This signal passes through the operating means (10) and the liquid flow control means (7,
7 '), the liquid flow control means (7, 7') is automatically released, and filtration is started.

The optical sensor is a signal generating means that can be particularly preferably used when performing "blood cell concentration gradient filtration" in which whole blood preparations are filtered out of blood. When performing "blood cell concentration gradient filtration" using the optical sensor as the signal generating means (9) in the blood filtration device as shown in Fig. 2, the storage part (2) should be held by the holding part (11). Causes the sensor to generate a blood cell concentration gradient, and when the optical sensor detects that the predetermined blood cell separation degree has been reached, a signal is emitted from the sensor, and this signal is passed through the operating means (10) and the liquid flow control means (7, 7 '), and automatic release of the fluid flow control is performed.

As an optical sensor, as shown in FIG. 4, a blood interface when a blood cell concentration gradient is formed (for example, plasma, platelets, a phase containing many lymphocytes with low specific gravity and red blood cells, granules with high specific gravity) A sensor for optically detecting the position of a sphere or an interface with a phase containing a lot of monocytes) can be mentioned. This sensor is a sensor having a light emitting element and a light receiving element, in which light emitted from the light emitting element is reflected by blood and the reflected light is received. When blood cell separation progresses and the blood interface reaches the position where the sensor is installed, the intensity of reflected light changes. Taking advantage of this,
A sensor is installed at a position that provides an appropriate degree of blood cell separation, a signal is emitted from the sensor when the intensity of reflected light changes, and the liquid flow control means (7, 7 ') is automatically released to filter blood. Is started.

As another optical sensor, as shown in FIG. 5, there is a form in which a sensor having a light emitting element and a sensor having a light receiving element are attached to both sides so as to sandwich the blood reservoir (2). This sensor is a sensor that detects the intensity of transmitted light, and a signal is emitted from the sensor at the time when the blood interface reaches the position of the sensor, that is, when the transmitted light intensity increases, and the liquid passage canceling means (7,
7 ') will be automatically released.

Alternatively, as shown in FIG. 6, the sensors are attached to the upper and lower parts of the blood reservoir, and when the difference in the intensity of the reflected light or the transmitted light between the upper part and the lower part becomes a constant value, the signal is output. A sensor that emits and automatically releases the liquid passage releasing means (7, 7 ') can also be used in the present invention.

The blood referred to in the present invention includes not only whole blood products but also platelet rich plasma products, concentrated platelet products and the like. The whole blood preparation here means a preparation that has been artificially processed by adding an appropriate amount of an anticoagulant to whole blood collected from a healthy person. More specifically, it contains an anticoagulant such as ACD (acid citrate dextrose) or CPD (cytolate phosphate dextrose) and is within 3 days, preferably within 1 day, more preferably 8 after blood collection. A blood product within a period of time. Moreover, it is preferable that the whole blood preparation is stored at a temperature of 4 ° C. or higher and lower than 30 ° C., preferably 15 ° C. or higher and lower than 25 ° C. after blood collection and before filtration with the filter (4). Further, the platelet-rich plasma preparation and the concentrated platelet preparation are blood preparations prepared by centrifuging a collected whole blood preparation or prepared by component blood collection, preferably within 3 days after blood collection, and at 20 ° C or higher. Those stored at room temperature below 25 ° C. are preferred.

When the blood filtering device of the present invention automatically releases the liquid flow control means (7, 7 ') by the timer, all the blood listed here can be filtered.
Among them, the whole blood preparation is the most suitable blood to be filtered. When the liquid flow control means (7, 7 ′) is automatically released by the optical sensor, the whole blood preparation is a suitable blood to be filtered.

The blood flow control in the present invention means an extremely slow average of blood flow exceeding 0 cm / min to 0.2 cm / min, preferably above 0 cm / min to 0.1 cm / min. Controlling (holding) at the linear velocity or stopping the passage of liquid completely. Here, the “average linear velocity” is a value obtained by dividing the blood flow velocity (mL / min) by the effective filtration cross-sectional area (cm ² ) of the filter through which the blood flows, which is perpendicular to the blood flow direction. Depending on the shape of the filter, a plurality of filter materials having different effective filtration cross-sectional areas may be included. In that case, the average value of the effective filtration cross-sectional areas of each filter material is used.

Further, the liquid flow control means (7, 7 ') has such a function and operates in conjunction with the signal generating means (8, 9) such as the timer or the optical sensor described above, and the signal generating means (8, 7'). There is no particular limitation as long as the liquid flow control can be automatically canceled by the signal from 9). For example, a clamp, a valve, a pump, etc. can be illustrated. Here, the release of the fluid flow control means (7, 7 ′) means, for example, when the fluid flow control is performed by compressing the fluid connection pipe with a clamp or a valve, the compression is released to allow the blood flow. To increase the opening diameter of. Alternatively, when the liquid flow is controlled by the pump, it means to start the liquid flow by operating the pump or increase the capacity of the pump to increase the liquid flow amount.

In FIGS. 1 and 2, the liquid flow control means (7, 7 ′) is connected to the blood reservoir (2) and the filter (4) by the first connecting pipe (5) and the filter (4). ) And the second connecting pipe (6) for connecting the blood collecting part (3) to each other. However, the liquid flow control means includes the blood storing part (2) and the filter (4). )
It is also possible to equip either one of the first connecting pipe (5) for connecting the filter and the second connecting pipe (6) for connecting the filter (4) and the blood collecting part (3).

The storage part (2) and the recovery part (3) for storing blood of the present invention are containers that can store or collect and store blood, and can activate blood cells or significantly adsorb or denature plasma proteins. Any material can be used without particular limitation as long as it does not cause the above. More specifically, examples thereof include blood bags made of soft polyvinyl chloride and polyolefin, which are widely and commonly used for blood collection and storage, and syringes made of polypropylene, polyethylene, polystyrene and the like. Further, the recovery unit (3) may include at least one or more containers for recovering the filtered blood for each component by centrifugation.

When a soft blood bag is used as the blood reservoir (2), the bag may be deformed and the interface detection by the optical sensor may become unstable. For the purpose of solving such a problem and improving the accuracy of the sensor, a holder for keeping the shape of the blood bag constant may be provided.

As the holding part (11) for holding the blood reservoir (2) of the present invention, any device can be used as long as it has a function of holding the reservoir in a predetermined position. Those that can be left still without being given are particularly preferable. More specifically, a hook or the like that hooks the storage portion and can be hung so as to have a desired drop can be cited.

The leukocyte removal filter (4) preferably used in the present invention captures leukocytes mixed in blood,
It is a filter filled with a removable filter material, and any known leukocyte removal filter can be used. More specifically, when the logarithmic value of the value obtained by dividing the residual leukocyte concentration after filtration by the leukocyte concentration before filtration (-Log (leukocyte concentration after filtration / leukocyte concentration before filtration)) is defined as the leukocyte removal capacity, , Its value is 2.30 or more, preferably 3.
A filter having a value of 00 or more.

Examples of the filter material include a fibrous medium and a sponge medium. Also, as long as it does not adversely affect blood, the surface of the filter material is chemically treated by coating with a hydrophilic polymer or by radiation graft polymerization for the purpose of making the filter material easily wet with blood. It may be modified, or the surface of the filter material may be physically modified by irradiation with radiation. When imparting a platelet passage function to the leukocyte removal filter, a low platelet adhesion material may be introduced on the surface of the filter material. As a low-adhesive material for platelets, JP-B-6-51060 and JP-A-1-
Polymers having a hydrophilic group and a chargeable group such as an amino group or a carboxyl group as described in Japanese Patent No. 249063, and polyurethane can be cited as suitable materials.

The storage part (2) and the recovery part (3) and the leukocyte removal filter (4) are connected by a hollow tubular connecting pipe (5, 6). The connection of the connecting pipes (5, 6) may be performed using a sterile connection device (SCD). The connecting pipes (5, 6) here are not particularly limited as long as they do not damage blood cells. Among them, organic materials such as vinyl chloride, silicon, polysulfone, polyamide, polyester, urethane, polyethylene and polypropylene are preferable because they are excellent in processability.

The blood filtering device (1) of the present invention comprises a signal generating means ((8, 9)) such as a timer or an optical sensor.
Then, the liquid flow control means (7, 7 ') is automatically released, and 0.
Blood may be filtered at an appropriate drop of about 5 to 2 m, or blood may be filtered by a pump that is linked with the signal generating means (8, 9), and the form of filtration is not particularly limited. Further, from the whole blood preparation, the hemofiltration device of the present invention (1)
It is also possible to prepare a blood component preparation from which white blood cells have been removed by a known centrifugation method after obtaining a whole blood product from which white blood cells have been removed using.

Next, examples will be given to describe the operating method and preferable conditions when blood is filtered using the blood filtering device of the present invention.

[Embodiment 1] When performing "blood cell concentration gradient filtration" using a timer as a signal generating means (8) in a blood filtering device as shown in Fig. 1, first, the liquid flow controlling means (7, 7 ') is closed. Then, the blood reservoir (2) filled with blood is hooked. After hooking the blood reservoir (2) on the hook, set the timer. When the time preset in the timer has elapsed, the actuating means (10) is activated based on the signal from the timer.
As a result, the liquid flow control means (7, 7 ') is released, the blood automatically starts liquid flow, and the blood from which the white blood cells have been removed by passing through the leukocyte removal filter (4) is collected in the blood collecting part (3). Will be collected. Liquid passing control means (7,
The time until 7 ') is automatically released is preferably 5 minutes or more and less than 300 minutes after the blood reservoir is hung on a hook or the like, and 1
It is more preferable that it is 0 minutes or more and less than 180 minutes, and further 30 minutes or more and less than 120 minutes. If it is less than 5 minutes, a sufficient concentration gradient of blood cells (separation of blood cells) may be difficult to be formed, and if it is 300 minutes or more, it is difficult to filter a large amount of blood, which is not preferable.

[0039]

[Embodiment 2] In the blood filtering device as shown in FIG. 1, when performing "filtration after blood filling" using a timer as a signal generating means (8), the blood reservoir (2) filled with blood is hooked. Hang on. Next, open the liquid flow control means (7, 7 '),
Fill the leukocyte removal filter (4) with blood. When the white blood cell removal filter (4) is filled with blood, the liquid passage control means (7 ') is closed and the timer is set. When the time set in advance in the timer has elapsed, the liquid flow control means (7 ') is released by the operating means (10) based on the signal from the timer, and blood automatically starts liquid flow,
The blood from which the white blood cells have been removed by passing through the white blood cell removing filter (4) is collected in the blood collecting unit (3). The time for filling the filter with blood and controlling the subsequent liquid passage is preferably 1 minute or longer, preferably 5 minutes or longer but less than 300 minutes, 10 minutes or longer 18
It is preferably less than 0 minutes, more preferably 30 minutes or more and less than 120 minutes. If the fluid flow control time is less than 1 minute, the effect of filling the filter with blood may not be obtained, and the platelet recovery may not be improved, which is not preferable.

[0040]

[Embodiment 3] When "blood cell concentration gradient filtration" using an optical sensor as a signal generating means (9) is performed in a blood filtering device as shown in FIG. With the liquid control means (7, 7 ') closed, the blood reservoir (2) is hooked. When the sensor detects the preset degree of separation of blood cells, the liquid flow control means (7, 7 ′) is automatically released by the operating means (10) based on the signal from the sensor, and the blood The blood flow is started, and the blood from which the white blood cells have been removed by passing through the white blood cell removal filter (4) is collected in the blood collection unit (3). The blood cell separation ratio is the ratio of the amount of the phase, which is substantially free of erythrocytes and mainly composed of lymphocytes having a low specific gravity to plasma and platelets, to the total blood volume, and the value is 5% or more. %Less than,
Further, it is preferably 10% or more and less than 30%.
When the blood cell separation degree is less than 5%, the blood cell concentration gradient formation is insufficient and the filter performance is not improved. When it is 40% or more, the hematocrit (volume ratio of red blood cells in the blood) in the lower part of the reservoir is This is because the temperature may become too high and hemolysis due to extension of filtration time or increase of pressure loss, or decrease of liquid permeability may be induced.

[0041]

As described above, according to the blood filtering device of the present invention, there is a predetermined period of time before actually filtering blood with a filter, such as "blood cell gradient filtration" and "filtration after blood filling". This device is suitable when liquid control or liquid flow control until formation of a predetermined blood cell concentration gradient is required. In the blood filtering device of the present invention, the liquid flow control means is automatically released, so that the burden on the person who carries out the filtration can be reduced. Also,
Since the filtration is automatically performed after a predetermined time or after a predetermined blood cell separation state occurs, the filter performance is high,
And can be stabilized.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing an embodiment of a blood filtration device of the present invention.

FIG. 2 is a schematic view showing another embodiment of the hemofiltration device of the present invention.

FIG. 3 is a block diagram showing a control system of the blood filtration device shown in FIGS. 1 and 2.

FIG. 4 is a partial side view showing an embodiment of a sensor and a blood reservoir when an optical sensor is used as a signal generating means.

FIG. 5 is a partial side view showing another embodiment of the sensor and the blood reservoir when the optical sensor is used as the signal generating means.

FIG. 6 is a partial side view showing still another embodiment of the sensor and the blood reservoir when the optical sensor is used as the signal generating means.

[Explanation of symbols]

1 blood filter 2 Blood reservoir Collection part of 3 blood 4 Leukocyte removal filter 5 First connecting pipe 6 Second connecting pipe 7, 7'liquid flow control means 8, 9 Signal generation means 10 Actuating means 11 Storage part holding part

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Claims (4)

[Claims] 1. A storage part for storing blood, a holding part for holding the storage part, a leukocyte removal filter, a recovery part for collecting blood filtered by the filter, and a storage part and a leukocyte removal filter. And a second connecting pipe connecting the leukocyte removal filter and the recovery unit.
In a hemofiltration device for removing leukocytes contained in blood, a liquid flow control means for controlling the liquid flow through the first connecting pipe and / or the second connecting pipe, and a signal generating means interlocking the liquid flowing control means. And based on the signal from the signal generating means,
A blood filtering device, comprising: an actuating unit that automatically releases the liquid flow control unit. 2. The signal generating means is a timer.
The hemofilter described. 3. The blood filtering device according to claim 1, wherein the signal generating means is an optical sensor. 4. The blood filtering device according to claim 1, wherein the liquid flow control means is means for stopping the passage of blood or maintaining it at a low speed.