JP2002543114A5 - - Google Patents
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- Publication number
- JP2002543114A5 JP2002543114A5 JP2000614980A JP2000614980A JP2002543114A5 JP 2002543114 A5 JP2002543114 A5 JP 2002543114A5 JP 2000614980 A JP2000614980 A JP 2000614980A JP 2000614980 A JP2000614980 A JP 2000614980A JP 2002543114 A5 JP2002543114 A5 JP 2002543114A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- use according
- compound
- ring
- hydrocarbyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001183 hydrocarbyl group Chemical group 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 7
- 150000001923 cyclic compounds Chemical class 0.000 description 7
- -1 polycyclic compound Chemical class 0.000 description 7
- 230000022131 cell cycle Effects 0.000 description 6
- 210000004940 Nucleus Anatomy 0.000 description 5
- 230000003637 steroidlike Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- ABLZXFCXXLZCGV-UHFFFAOYSA-L CHEBI:8154 Chemical group [O-]P([O-])=O ABLZXFCXXLZCGV-UHFFFAOYSA-L 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 230000035521 G2 Phase Effects 0.000 description 1
- 230000010337 G2 phase Effects 0.000 description 1
- 230000035779 M Phase Effects 0.000 description 1
- 230000027311 M phase Effects 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9910166.9A GB9910166D0 (en) | 1999-04-30 | 1999-04-30 | Use |
GB9910166.9 | 1999-04-30 | ||
US13952099P | 1999-06-16 | 1999-06-16 | |
US60/139,520 | 1999-06-16 | ||
GB60/139,520 | 2000-01-28 | ||
GB0002113.9 | 2000-01-28 | ||
GB0002113A GB0002113D0 (en) | 2000-01-28 | 2000-01-28 | Use |
PCT/GB2000/001661 WO2000066095A2 (en) | 1999-04-30 | 2000-04-28 | Use of estrone derivatives as antitumour agents |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002543114A JP2002543114A (ja) | 2002-12-17 |
JP2002543114A5 true JP2002543114A5 (US07794700-20100914-C00152.png) | 2007-04-26 |
JP5042411B2 JP5042411B2 (ja) | 2012-10-03 |
Family
ID=27255503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000614980A Expired - Fee Related JP5042411B2 (ja) | 1999-04-30 | 2000-04-28 | 抗腫瘍剤としてのエストロン誘導体の使用 |
Country Status (7)
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
US20020106348A1 (en) * | 2000-07-12 | 2002-08-08 | Peng Huang | Cancer therapeutics involving the administration of 2-methoxyestradiol and an agent that increases intracellular superoxide anion |
GB0020498D0 (en) * | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
WO2002042319A2 (en) * | 2000-11-27 | 2002-05-30 | Entremed, Inc. | 2-substituted estrogens as antiangiogenic agents |
GB0113920D0 (en) * | 2001-06-07 | 2001-08-01 | Sterix Ltd | Composition |
DE10139494A1 (de) * | 2001-08-13 | 2003-03-06 | Jenapharm Gmbh | Antitumor wirksame 2-Alkoxyestradiolsulfamate |
US8026229B2 (en) | 2001-08-13 | 2011-09-27 | Sterix Limited | Antitumor-active 2-alkoxyestradiol sulfamates |
PT1456224E (pt) * | 2001-12-21 | 2006-06-30 | Schering Ag | Processo industrialmente aplicavel para a sulfamoilacao de alcoois e fenois |
GB0306717D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
CA2520142C (en) | 2003-03-24 | 2011-01-04 | Sterix Limited | Oestrogen derivatives as inhibitors of steroid sulphatase |
JP2007529426A (ja) | 2004-03-12 | 2007-10-25 | エントレメッド インコーポレイテッド | 抗血管新生薬 |
GB0421106D0 (en) * | 2004-09-22 | 2004-10-27 | Sterix Ltd | Compound |
AU2007227256B2 (en) | 2006-03-20 | 2012-10-04 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
WO2023105303A1 (en) * | 2021-12-06 | 2023-06-15 | Kashiv Biosciences, Llc | Compounds for the treatment of cancer |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9003939D0 (en) | 1990-02-21 | 1990-04-18 | Imperial College | Sulphatase inhibitors |
GB9603325D0 (en) | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
GB9118465D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
ATE286038T1 (de) | 1996-03-05 | 2005-01-15 | Sterix Ltd | Verbindungen mit sulfonsäure-amidgruppe |
US6087347A (en) | 1996-09-12 | 2000-07-11 | Teikoku Hormone Mfg. Co., Ltd. | 3-substituted-D-homo-1,3,5(10)-estratriene derivatives |
US5763492A (en) | 1996-10-01 | 1998-06-09 | Duguesne University Of The Holy Ghost | Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors |
US5880115A (en) | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
GB2331987B (en) * | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
GB2331988B (en) * | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
DE69939171D1 (de) * | 1998-06-10 | 2008-09-04 | Sterix Ltd | Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern |
GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
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2000
- 2000-04-28 NZ NZ515061A patent/NZ515061A/en not_active IP Right Cessation
- 2000-04-28 EP EP00929660A patent/EP1173182A2/en not_active Withdrawn
- 2000-04-28 JP JP2000614980A patent/JP5042411B2/ja not_active Expired - Fee Related
- 2000-04-28 IL IL14599500A patent/IL145995A0/xx unknown
- 2000-04-28 WO PCT/GB2000/001661 patent/WO2000066095A2/en active IP Right Grant
- 2000-04-28 AU AU47668/00A patent/AU783910B2/en not_active Ceased
-
2001
- 2001-10-17 IL IL145995A patent/IL145995A/en not_active IP Right Cessation
-
2005
- 2005-10-05 US US11/244,416 patent/US8207152B2/en not_active Expired - Fee Related