JP2002542794A5 - - Google Patents
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- Publication number
- JP2002542794A5 JP2002542794A5 JP2000614433A JP2000614433A JP2002542794A5 JP 2002542794 A5 JP2002542794 A5 JP 2002542794A5 JP 2000614433 A JP2000614433 A JP 2000614433A JP 2000614433 A JP2000614433 A JP 2000614433A JP 2002542794 A5 JP2002542794 A5 JP 2002542794A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- mediator
- target nucleic
- self
- assembled monolayer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108020004707 nucleic acids Proteins 0.000 description 43
- 102000039446 nucleic acids Human genes 0.000 description 43
- 150000007523 nucleic acids Chemical class 0.000 description 43
- 239000002094 self assembled monolayer Substances 0.000 description 26
- 239000013545 self-assembled monolayer Substances 0.000 description 26
- 239000000523 sample Substances 0.000 description 23
- 238000006479 redox reaction Methods 0.000 description 20
- 238000000034 method Methods 0.000 description 19
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 16
- 239000002751 oligonucleotide probe Substances 0.000 description 16
- 229910052723 transition metal Inorganic materials 0.000 description 14
- 150000003624 transition metals Chemical class 0.000 description 14
- 230000003197 catalytic effect Effects 0.000 description 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 8
- 239000002356 single layer Substances 0.000 description 8
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000008929 regeneration Effects 0.000 description 6
- 238000011069 regeneration method Methods 0.000 description 6
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 5
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 4
- -1 carboxyalkyl phosphonate Chemical compound 0.000 description 4
- 239000007822 coupling agent Substances 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000001172 regenerating effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- BUKGQBGCJBXIKV-UHFFFAOYSA-N 12-phosphonododecanoic acid Chemical group OC(=O)CCCCCCCCCCCP(O)(O)=O BUKGQBGCJBXIKV-UHFFFAOYSA-N 0.000 description 2
- UBKVUFQGVWHZIR-UHFFFAOYSA-N 8-oxoguanine Chemical group O=C1NC(N)=NC2=NC(=O)N=C21 UBKVUFQGVWHZIR-UHFFFAOYSA-N 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/296,929 | 1999-04-22 | ||
| US09/296,929 US6127127A (en) | 1995-06-27 | 1999-04-22 | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
| PCT/US2000/002976 WO2000065099A1 (en) | 1999-04-22 | 2000-02-04 | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542794A JP2002542794A (ja) | 2002-12-17 |
| JP2002542794A5 true JP2002542794A5 (https=) | 2006-01-05 |
Family
ID=23144136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000614433A Withdrawn JP2002542794A (ja) | 1999-04-22 | 2000-02-04 | 標識担持標的を検出するための単層および電極ならびにその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6127127A (https=) |
| EP (1) | EP1185692B1 (https=) |
| JP (1) | JP2002542794A (https=) |
| KR (1) | KR20020008157A (https=) |
| CN (1) | CN1347460A (https=) |
| AT (1) | ATE312200T1 (https=) |
| AU (1) | AU781085B2 (https=) |
| CA (1) | CA2367594A1 (https=) |
| DE (1) | DE60024618D1 (https=) |
| HK (1) | HK1045178B (https=) |
| NO (1) | NO20014882L (https=) |
| NZ (1) | NZ514682A (https=) |
| WO (1) | WO2000065099A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207369B1 (en) * | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6346387B1 (en) | 1995-06-27 | 2002-02-12 | Xanthon, Inc. | Detection of binding reactions using labels detected by mediated catalytic electrochemistry |
| US7815963B2 (en) * | 1996-10-17 | 2010-10-19 | The Trustees Of Princeton University | Enhanced bonding layers on titanium materials |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US6833267B1 (en) * | 1998-12-30 | 2004-12-21 | Clinical Micro Sensors, Inc. | Tissue collection devices containing biosensors |
| US20020177135A1 (en) * | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US7348183B2 (en) * | 2000-10-16 | 2008-03-25 | Board Of Trustees Of The University Of Arkansas | Self-contained microelectrochemical bioassay platforms and methods |
| WO2002047266A2 (en) * | 2000-10-20 | 2002-06-13 | The Board Of Trustees Of The Leland Stanford Junior University | Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample |
| US6632536B2 (en) * | 2000-12-28 | 2003-10-14 | International Business Machines Corporation | Self-assembled monolayer etch barrier for indium-tin-oxide useful in manufacturing thin film transistor-liquid crystal displays |
| DE10126798A1 (de) * | 2001-06-01 | 2002-12-19 | Nanotype Gmbh | Verfahren zur Bestimmung einer Probe |
| US20020182606A1 (en) * | 2001-06-04 | 2002-12-05 | Xanthon, Inc. | Detection of single nucleotide polymorphisms |
| CA2450109A1 (en) * | 2001-06-11 | 2003-05-22 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| US6824974B2 (en) * | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| WO2003001889A2 (en) | 2001-06-29 | 2003-01-09 | Meso Scale Technologies, Llc. | Assay plates reader systems and methods for luminescence test measurements |
| AU2002365115A1 (en) * | 2001-07-20 | 2003-09-02 | North Carolina State University | Light addressable electrochemical detection of duplex structures |
| JP4262426B2 (ja) * | 2001-09-03 | 2009-05-13 | 富士フイルム株式会社 | 核酸断片固定電極及びその利用 |
| US20050014151A1 (en) * | 2001-09-12 | 2005-01-20 | Marcus Textor | Device with chemical surface patterns |
| US7202028B2 (en) * | 2001-09-24 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods for the electrochemical detection of multiple target compounds |
| AU2004201425B2 (en) * | 2001-09-24 | 2007-06-28 | University Of North Carolina At Chapel Hill | Methods for the electrochemical detection of multiple target compounds |
| AU2002367807B2 (en) * | 2001-09-24 | 2007-06-28 | University Of North Carolina At Chapel Hill | Methods for the electrochemical detection of multiple target compounds |
| EP1478783A4 (en) * | 2002-02-06 | 2006-12-27 | Ge Healthcare Bio Sciences Ab | COMPOSITIONS AND METHODS OF ROLLING CIRCLE AMPLIFICATION |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| GB0211449D0 (en) * | 2002-05-17 | 2002-06-26 | Oxford Biosensors Ltd | Analyte measurement |
| WO2004057027A1 (fr) * | 2002-12-11 | 2004-07-08 | Centre National De La Recherche Scientifique | Procede de detection electronique d'au moins une interaction specifique entre des molecules sondes et des biomolecules cibles. |
| US20040180369A1 (en) * | 2003-01-16 | 2004-09-16 | North Carolina State University | Photothermal detection of nucleic acid hybridization |
| US7138121B2 (en) * | 2003-01-23 | 2006-11-21 | Spangler Brenda D | Biosensors utilizing dendrimer-immobilized ligands and there use thereof |
| KR100547015B1 (ko) * | 2003-05-23 | 2006-01-26 | 주식회사 올메디쿠스 | 일정한 크기 이상의 분석물질을 정량 분석하기 위한바이오센서 및 그 제조방법 |
| US20100000881A1 (en) * | 2003-10-30 | 2010-01-07 | North Carolina State University | Electrochemical detection of nucleic acid hybridization |
| WO2005042783A1 (en) * | 2003-10-30 | 2005-05-12 | North Carolina State University | Temperature-jump enhanced electrochemical detection of nucleic acid hybridization |
| US7981362B2 (en) * | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
| US8048377B1 (en) | 2004-03-08 | 2011-11-01 | Hewlett-Packard Development Company, L.P. | Immobilizing chemical or biological sensing molecules on semi-conducting nanowires |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
| US20060094024A1 (en) * | 2004-11-01 | 2006-05-04 | Pirrung Michael C | Electrochemical arrays |
| US20090203547A1 (en) * | 2005-02-18 | 2009-08-13 | Albert Banes | Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions |
| US20070235346A1 (en) * | 2006-04-11 | 2007-10-11 | Popovich Natasha D | System and methods for providing corrected analyte concentration measurements |
| US7909983B2 (en) * | 2006-05-04 | 2011-03-22 | Nipro Diagnostics, Inc. | System and methods for automatically recognizing a control solution |
| US8465926B2 (en) * | 2006-08-11 | 2013-06-18 | The Hong Kong University Of Science And Technology | Method and system for real time quantification and monitoring of nucleic acid amplification using electroconductive or electrochemically active labels |
| US20080131709A1 (en) * | 2006-09-28 | 2008-06-05 | Aculon Inc. | Composite structure with organophosphonate adherent layer and method of preparing |
| US9688718B2 (en) | 2008-01-11 | 2017-06-27 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising hydrogenases and related products, methods and systems |
| WO2009100201A2 (en) * | 2008-02-07 | 2009-08-13 | Lawrence Livermore National Security, Llc | Functionalized platform for arrays configured for optical detection of targets and related arrays, methods and systems |
| US9303273B2 (en) | 2008-05-09 | 2016-04-05 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems |
| US20110195862A1 (en) | 2010-02-08 | 2011-08-11 | Pett-Ridge Jennifer | Devices, methods and systems for target detection |
| US9731297B2 (en) | 2011-01-06 | 2017-08-15 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| US9644038B2 (en) | 2011-12-21 | 2017-05-09 | The Regents Of The University Of California | Apolipoprotein nanodiscs with telodendrimer |
| WO2016049061A1 (en) | 2014-09-22 | 2016-03-31 | Lawrence Livermore National Security, Llc | Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems |
| US12226529B2 (en) | 2015-08-25 | 2025-02-18 | Lawrence Livermore National Security, Llc | Stable nanolipoprotein particles and related compositions methods and systems |
| WO2017044899A1 (en) | 2015-09-11 | 2017-03-16 | Lawrence Livermore National Security, Llc | Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation |
| KR101862198B1 (ko) * | 2016-09-30 | 2018-05-30 | (주)스파크바이오파마 | 2차원 겔 전기영동에서의 열 안정성 변화-기반 형광 차이를 이용한 표적 단백질의 규명 방법 |
| US11207422B2 (en) | 2017-05-02 | 2021-12-28 | Lawrence Livermore National Security, Llc | MOMP telonanoparticles, and related compositions, methods and systems |
| WO2018204495A1 (en) | 2017-05-02 | 2018-11-08 | Synthetic Genomics, Inc. | Nanolipoprotein particles and related compositions methods and systems for loading rna |
| JP7287956B2 (ja) | 2017-10-11 | 2023-06-06 | マイクロベンション インコーポレイテッド | ホスホネート及びその使用 |
| CN116242814B (zh) * | 2023-04-14 | 2025-10-03 | 中国农业大学 | 一种联吡啶类化合物的荧光检测方法 |
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| DE3278334D1 (en) * | 1981-10-23 | 1988-05-19 | Genetics Int Inc | Sensor for components of a liquid mixture |
| WO1985002627A1 (en) * | 1983-12-16 | 1985-06-20 | Genetics International, Inc. | Assay for nucleic acids |
| US4883579A (en) * | 1984-04-27 | 1989-11-28 | Molecular Devices Corporation | Photoresponsive redox detection and discrimination |
| US4704353A (en) * | 1984-04-27 | 1987-11-03 | Molecular Devices Corporation | Photoresponsive redox detection and discrimination |
| GB8417301D0 (en) * | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
| US5157032A (en) * | 1985-01-18 | 1992-10-20 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents and probes to DNA |
| US5112974A (en) * | 1985-01-18 | 1992-05-12 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents to DNA |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
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-
1999
- 1999-04-22 US US09/296,929 patent/US6127127A/en not_active Expired - Lifetime
-
2000
- 2000-02-04 AU AU34830/00A patent/AU781085B2/en not_active Ceased
- 2000-02-04 DE DE60024618T patent/DE60024618D1/de not_active Expired - Lifetime
- 2000-02-04 HK HK02106722.0A patent/HK1045178B/en not_active IP Right Cessation
- 2000-02-04 JP JP2000614433A patent/JP2002542794A/ja not_active Withdrawn
- 2000-02-04 WO PCT/US2000/002976 patent/WO2000065099A1/en not_active Ceased
- 2000-02-04 CA CA002367594A patent/CA2367594A1/en not_active Abandoned
- 2000-02-04 KR KR1020017013429A patent/KR20020008157A/ko not_active Ceased
- 2000-02-04 AT AT00913366T patent/ATE312200T1/de not_active IP Right Cessation
- 2000-02-04 EP EP00913366A patent/EP1185692B1/en not_active Expired - Lifetime
- 2000-02-04 CN CN00806497A patent/CN1347460A/zh active Pending
- 2000-02-04 NZ NZ514682A patent/NZ514682A/en unknown
-
2001
- 2001-10-08 NO NO20014882A patent/NO20014882L/no unknown
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