JP2002539762A5 - - Google Patents
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- Publication number
- JP2002539762A5 JP2002539762A5 JP2000581189A JP2000581189A JP2002539762A5 JP 2002539762 A5 JP2002539762 A5 JP 2002539762A5 JP 2000581189 A JP2000581189 A JP 2000581189A JP 2000581189 A JP2000581189 A JP 2000581189A JP 2002539762 A5 JP2002539762 A5 JP 2002539762A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- pge
- pge synthase
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 37
- 108090000765 processed proteins & peptides Proteins 0.000 description 37
- 102000004196 processed proteins & peptides Human genes 0.000 description 37
- 238000000034 method Methods 0.000 description 27
- 230000000694 effects Effects 0.000 description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 16
- 238000012360 testing method Methods 0.000 description 13
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 239000000126 substance Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 7
- 125000004122 cyclic group Chemical group 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 108010024636 Glutathione Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 238000003556 assay Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 238000011534 incubation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10768798P | 1998-11-09 | 1998-11-09 | |
| US60/107,687 | 1998-11-09 | ||
| PCT/EP1999/008363 WO2000028022A1 (en) | 1998-11-09 | 1999-11-02 | Pge synthase and methods and means for modulating its activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010011053A Division JP2010115205A (ja) | 1998-11-09 | 2010-01-21 | Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539762A JP2002539762A (ja) | 2002-11-26 |
| JP2002539762A5 true JP2002539762A5 (enExample) | 2006-12-14 |
| JP4503849B2 JP4503849B2 (ja) | 2010-07-14 |
Family
ID=22317930
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000581189A Expired - Lifetime JP4503849B2 (ja) | 1998-11-09 | 1999-11-02 | Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 |
| JP2010011053A Pending JP2010115205A (ja) | 1998-11-09 | 2010-01-21 | Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010011053A Pending JP2010115205A (ja) | 1998-11-09 | 2010-01-21 | Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6395502B1 (enExample) |
| EP (1) | EP1129188B1 (enExample) |
| JP (2) | JP4503849B2 (enExample) |
| AT (1) | ATE305040T1 (enExample) |
| AU (1) | AU770307B2 (enExample) |
| CA (1) | CA2349529C (enExample) |
| DE (1) | DE69927400T2 (enExample) |
| ES (1) | ES2249042T3 (enExample) |
| WO (1) | WO2000028022A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69927400T2 (de) * | 1998-11-09 | 2006-06-29 | Karolinska Innovations Ab | Pge synthase und verfahren und mitteln zur modulation deren aktivität |
| WO2001057225A1 (fr) * | 2000-02-03 | 2001-08-09 | Chugai Seiyaku Kabushiki Kaisha | Proteine regissant l'activite de la pge2 synthase et son utilisation |
| AU2002323358A1 (en) * | 2001-08-24 | 2003-03-10 | Karoliska Innovations Ab | Methods for preparing purified prostaglandin e synthase |
| IL161831A0 (en) * | 2001-11-30 | 2005-11-20 | Pfizer Prod Inc | Disruption of the prostaglandin e synthase 2 gene |
| EP1575498A2 (en) * | 2002-09-25 | 2005-09-21 | Pharmacia Corporation | Antisense modulation of microsomal prostaglandin e2 synthase expression |
| WO2004067766A1 (en) * | 2003-01-27 | 2004-08-12 | Pfizer Products Inc. | Novel methods involving the determination of activity of enzymes that use or produce prostaglandin endoperoxide h2 |
| WO2005024059A2 (en) * | 2003-09-09 | 2005-03-17 | Karolinska Innovations Ab | Methods for identifying compounds for inhibiting fever |
| US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
| CA2639412A1 (en) * | 2007-09-11 | 2009-03-11 | Universite Laval | Prostaglandin e2 modulation and uses thereof |
| CN117323320B (zh) * | 2023-11-20 | 2025-10-31 | 复旦大学附属中山医院 | 长链脂肪酸12-hht在睡眠呼吸暂停合并高血压中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US914356A (en) * | 1901-11-30 | 1909-03-02 | Harry Ward Leonard | Electric-circuit controller. |
| EP1015624A2 (en) * | 1997-09-17 | 2000-07-05 | The Johns Hopkins University | P53-induced apoptosis |
| DE69927400T2 (de) * | 1998-11-09 | 2006-06-29 | Karolinska Innovations Ab | Pge synthase und verfahren und mitteln zur modulation deren aktivität |
-
1999
- 1999-11-02 DE DE69927400T patent/DE69927400T2/de not_active Expired - Lifetime
- 1999-11-02 ES ES99957275T patent/ES2249042T3/es not_active Expired - Lifetime
- 1999-11-02 CA CA002349529A patent/CA2349529C/en not_active Expired - Lifetime
- 1999-11-02 JP JP2000581189A patent/JP4503849B2/ja not_active Expired - Lifetime
- 1999-11-02 AT AT99957275T patent/ATE305040T1/de not_active IP Right Cessation
- 1999-11-02 EP EP99957275A patent/EP1129188B1/en not_active Expired - Lifetime
- 1999-11-02 AU AU15041/00A patent/AU770307B2/en not_active Expired
- 1999-11-02 WO PCT/EP1999/008363 patent/WO2000028022A1/en not_active Ceased
- 1999-11-04 US US09/433,466 patent/US6395502B1/en not_active Expired - Lifetime
-
2002
- 2002-03-28 US US10/109,438 patent/US7067296B2/en not_active Expired - Lifetime
-
2004
- 2004-10-07 US US10/962,155 patent/US7192733B2/en not_active Expired - Lifetime
-
2007
- 2007-02-27 US US11/679,585 patent/US7645601B2/en not_active Expired - Lifetime
-
2010
- 2010-01-21 JP JP2010011053A patent/JP2010115205A/ja active Pending
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