JP2002536449A - Ｇａｂａレセプターに対するリガンドとしてのトリアゾロ−ピリダジン誘導体 - Google Patents

Ｇａｂａレセプターに対するリガンドとしてのトリアゾロ−ピリダジン誘導体

Info

Publication number
JP2002536449A
JP2002536449A JP2000598502A JP2000598502A JP2002536449A JP 2002536449 A JP2002536449 A JP 2002536449A JP 2000598502 A JP2000598502 A JP 2000598502A JP 2000598502 A JP2000598502 A JP 2000598502A JP 2002536449 A JP2002536449 A JP 2002536449A
Authority
JP
Japan
Prior art keywords
triazolo
methyl
triazol
formula
pyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000598502A
Other languages
English (en)
Japanese (ja)
Inventor
カーリング，ウイリアム・ロバート
ミツチンソン，アンドリユー
ラツセル，マイケル・ジエフリイ・ニール
ストリート，レズリー・ジヨージフ
Original Assignee
メルク シャープ エンド ドーム リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク シャープ エンド ドーム リミテッド filed Critical メルク シャープ エンド ドーム リミテッド
Publication of JP2002536449A publication Critical patent/JP2002536449A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2000598502A 1999-02-11 2000-02-02 Ｇａｂａレセプターに対するリガンドとしてのトリアゾロ−ピリダジン誘導体 Withdrawn JP2002536449A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9903119.7 1999-02-11
GBGB9903119.7A GB9903119D0 (en) 1999-02-11 1999-02-11 Therapeutic agents
PCT/GB2000/000308 WO2000047582A1 (fr) 1999-02-11 2000-02-02 Derives de la triazolo-pyridazine, liants des recepteurs du gaba

Publications (1)

Publication Number Publication Date
JP2002536449A true JP2002536449A (ja) 2002-10-29

Family

ID=10847573

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000598502A Withdrawn JP2002536449A (ja) 1999-02-11 2000-02-02 Ｇａｂａレセプターに対するリガンドとしてのトリアゾロ−ピリダジン誘導体

Country Status (6)

Country Link
EP (1) EP1150983A1 (fr)
JP (1) JP2002536449A (fr)
AU (1) AU2306500A (fr)
CA (1) CA2362400A1 (fr)
GB (1) GB9903119D0 (fr)
WO (1) WO2000047582A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002251266A1 (en) 2001-04-10 2002-10-28 Merck Sharp And Dohme Limited Inhibitors of akt activity
WO2002083140A1 (fr) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibiteurs de l'activite d'akt
WO2002083139A1 (fr) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibiteurs de l'activite d'akt
GB0122696D0 (en) * 2001-09-20 2001-11-14 Merck Sharp & Dohme Therapeutic agents
CA2542682A1 (fr) * 2003-10-18 2005-05-06 Bayer Healthcare Ag Derives de 2-(phenylmethyl)thio-4-phenyl-4h-1,2,4-triazole substitues en 5 et composes associes utilises en tant que gaba-agonistes dans le traitement de l'incontinence urinaire et des maladies associees
PT1753748E (pt) 2004-05-12 2009-08-28 Pfizer Prod Inc Derivados de prolina e a sua utilização como inibidores de dipeptidil peptidase iv
UA108596C2 (xx) 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
SG11201806393QA (en) 2016-01-27 2018-08-30 Univ Zuerich Use of gabaa receptor modulators for treatment of itch

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK9399A3 (en) * 1996-07-25 2000-04-10 Merck Sharp & Dohme Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
WO2000047582A1 (fr) 2000-08-17
GB9903119D0 (en) 1999-04-07
AU2306500A (en) 2000-08-29
EP1150983A1 (fr) 2001-11-07
CA2362400A1 (fr) 2000-08-17

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Legal Events

Date Code Title Description
A300 Withdrawal of application because of no request for examination

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20070403