JP2002531138A - 酸化代謝に対する感受性に関して候補化合物をスクリーニングする方法 - Google Patents
酸化代謝に対する感受性に関して候補化合物をスクリーニングする方法Info
- Publication number
- JP2002531138A JP2002531138A JP2000586939A JP2000586939A JP2002531138A JP 2002531138 A JP2002531138 A JP 2002531138A JP 2000586939 A JP2000586939 A JP 2000586939A JP 2000586939 A JP2000586939 A JP 2000586939A JP 2002531138 A JP2002531138 A JP 2002531138A
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- metabolism
- testosterone
- dcf
- formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/205,762 US6312917B1 (en) | 1998-12-04 | 1998-12-04 | Method of screening candidate compounds for susceptibility to oxidative metabolism |
| US09/205,762 | 1998-12-04 | ||
| PCT/US1999/027130 WO2000034506A2 (en) | 1998-12-04 | 1999-11-15 | Method of screening candidate compounds for susceptibility to oxidative metabolism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531138A true JP2002531138A (ja) | 2002-09-24 |
| JP2002531138A5 JP2002531138A5 (https=) | 2006-09-14 |
Family
ID=22763550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586939A Pending JP2002531138A (ja) | 1998-12-04 | 1999-11-15 | 酸化代謝に対する感受性に関して候補化合物をスクリーニングする方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6312917B1 (https=) |
| EP (1) | EP1135521B1 (https=) |
| JP (1) | JP2002531138A (https=) |
| KR (1) | KR20010093140A (https=) |
| AT (1) | ATE317914T1 (https=) |
| AU (1) | AU774229B2 (https=) |
| BR (1) | BR9916458A (https=) |
| CA (1) | CA2352523A1 (https=) |
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| MX (1) | MXPA01005528A (https=) |
| NZ (1) | NZ512217A (https=) |
| WO (1) | WO2000034506A2 (https=) |
Cited By (1)
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|---|---|---|---|---|
| JP2007531538A (ja) * | 2004-04-05 | 2007-11-08 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 活性酸素種に基づいたチトクロームｐ４５０阻害ハイスループット測定法 |
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| US6632630B2 (en) * | 2000-03-29 | 2003-10-14 | Aclara Biosciences, Inc. | Monooxygenase assays |
| US20050159901A1 (en) * | 2001-04-02 | 2005-07-21 | Astex Technology Limited | Crystal structure of cytochrome P450 |
| US20050032119A1 (en) * | 2001-04-02 | 2005-02-10 | Astex Technology Ltd. | Crystal structure of cytochrome P450 |
| US7148046B2 (en) * | 2001-04-02 | 2006-12-12 | Astex Therapeutics Limited | Crystal structure of cytochrome P450 |
| US20070179716A1 (en) * | 2001-04-02 | 2007-08-02 | Astex Therapeutics Limited | Crystal structure of cytochrome P450 3A4 and uses thereof |
| AU2002365070A1 (en) * | 2001-08-03 | 2003-06-30 | Diversa Corporation | P450 enzymes, nucleic acids encoding them and methods of making and using them |
| DE60214869T2 (de) * | 2001-10-25 | 2007-04-12 | Astex Technology Ltd., Cambridge | Cytochrome p450 2c9 kristalle, strukturen und dessen verwendung |
| US20040053383A1 (en) * | 2001-10-25 | 2004-03-18 | Astex Technology Ltd. | Crystals of cytochrome P450 2C9, structures thereof and their use |
| US20040096874A1 (en) * | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
| US20050164341A1 (en) * | 2002-05-30 | 2005-07-28 | Jose Cosme | Methods of purification of cytochrome p450 proteins and of their crystallizing |
| GB0216203D0 (en) * | 2002-07-12 | 2002-08-21 | Imp Cancer Res Tech | Mondulation of cytochrome P450 reductase activity |
| EP1546162B1 (en) | 2002-09-20 | 2011-06-22 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
| WO2004038015A1 (en) * | 2002-10-25 | 2004-05-06 | Astex Technology Limited | Crystal structure of cytochrome p450 3a4 and its use |
| US20040219602A1 (en) * | 2003-03-01 | 2004-11-04 | Symyx Technologies, Inc. | Evaluating effects of exposure conditions on drug samples over time |
| US20060046278A1 (en) * | 2004-08-26 | 2006-03-02 | Qualyst, Inc. | Methods and kits for determining metabolic stability of compounds |
| US20060223135A1 (en) * | 2005-04-05 | 2006-10-05 | The University Of North Carolina At Chapel Hill | High throughput reactive oxygen species-based cytochrome P450 inhibition assay |
| EP2272972A1 (en) | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| US20090318561A1 (en) * | 2008-06-23 | 2009-12-24 | Mutual Pharmaceutical Company, Inc. | Colchicine products, method of manufacture, and methods of use |
| US8288559B2 (en) | 2008-08-18 | 2012-10-16 | Promega Corporation | Luminogenic compounds and methods to detect cytochrome P450 3A enzymes |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| WO2018118897A1 (en) * | 2016-12-19 | 2018-06-28 | Dice Molecules Sv, Llc | Methods of estimating metabolic stability of tagged combinatorial library compounds |
| WO2024223797A1 (en) | 2023-04-28 | 2024-10-31 | Institut National de la Santé et de la Recherche Médicale | Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections |
Family Cites Families (6)
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| US4341868A (en) * | 1978-08-18 | 1982-07-27 | Kyowa Hakko Kogyo Co., Ltd. | Method and test composition for the determination of the substrate for xanthine oxidase |
| WO1980000454A1 (fr) | 1978-08-18 | 1980-03-20 | Kyowa Hakko Kogyo Kk | Methode de mesure d'un substrat de xanthine oxydase et composition pour sa determination |
| JP2515551B2 (ja) * | 1987-06-08 | 1996-07-10 | 和光純薬工業株式会社 | 新規な過酸化水素の定量方法 |
| US5413915A (en) | 1988-07-12 | 1995-05-09 | Resource Technologies Group, Inc. | Method and sensor for detecting toxic chemical exposure effects and metabolic activation of carcinogenic chemical agents |
| AU1970897A (en) | 1996-04-15 | 1997-11-07 | Fox Chase Cancer Center | Assays for detection of purine metabolites |
| GB9821932D0 (en) | 1998-10-09 | 1998-12-02 | Univ Leicester | Cytochrome P450 electrochemical system |
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- 1999-11-15 CA CA002352523A patent/CA2352523A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007531538A (ja) * | 2004-04-05 | 2007-11-08 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 活性酸素種に基づいたチトクロームｐ４５０阻害ハイスループット測定法 |
Also Published As
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| EP1135521A2 (en) | 2001-09-26 |
| ATE317914T1 (de) | 2006-03-15 |
| EP1135521B1 (en) | 2006-02-15 |
| WO2000034506A3 (en) | 2000-11-23 |
| KR20010093140A (ko) | 2001-10-27 |
| WO2000034506A2 (en) | 2000-06-15 |
| NZ512217A (en) | 2002-03-28 |
| AU1525000A (en) | 2000-06-26 |
| AU774229B2 (en) | 2004-06-17 |
| MXPA01005528A (es) | 2002-04-24 |
| DE69929900T2 (de) | 2006-08-17 |
| US6312917B1 (en) | 2001-11-06 |
| BR9916458A (pt) | 2001-09-04 |
| US20020058295A1 (en) | 2002-05-16 |
| DE69929900D1 (de) | 2006-04-20 |
| CA2352523A1 (en) | 2000-06-15 |
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