JP2002525327A5 - - Google Patents
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- Publication number
- JP2002525327A5 JP2002525327A5 JP2000571923A JP2000571923A JP2002525327A5 JP 2002525327 A5 JP2002525327 A5 JP 2002525327A5 JP 2000571923 A JP2000571923 A JP 2000571923A JP 2000571923 A JP2000571923 A JP 2000571923A JP 2002525327 A5 JP2002525327 A5 JP 2002525327A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- receptor antagonist
- antagonist
- use according
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 239000002464 receptor antagonist Substances 0.000 description 8
- 229940044551 receptor antagonist Drugs 0.000 description 8
- 239000002876 beta blocker Substances 0.000 description 4
- 229940097320 beta blocking agent Drugs 0.000 description 4
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical group C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 4
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 208000018238 Primary Headache disease Diseases 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical group C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 2
- 229960004704 dihydroergotamine Drugs 0.000 description 2
- 125000002250 eicosanoid group Chemical group 0.000 description 2
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical group C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 description 2
- 229960005417 ketanserin Drugs 0.000 description 2
- 229960005254 naratriptan Drugs 0.000 description 2
- UNHGSHHVDNGCFN-UHFFFAOYSA-N naratriptan Chemical compound C=12[CH]C(CCS(=O)(=O)NC)=CC=C2N=CC=1C1CCN(C)CC1 UNHGSHHVDNGCFN-UHFFFAOYSA-N 0.000 description 2
- 229960003712 propranolol Drugs 0.000 description 2
- 229940127293 prostanoid Drugs 0.000 description 2
- 239000004003 serotonin 1D agonist Substances 0.000 description 2
- 229960003708 sumatriptan Drugs 0.000 description 2
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical group CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 229960001360 zolmitriptan Drugs 0.000 description 2
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- -1 ergot derivatives Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9720270.9A GB9720270D0 (en) | 1997-09-25 | 1997-09-25 | Medicaments for the treatment of migraine |
| PCT/GB1998/002895 WO2000018405A1 (en) | 1997-09-25 | 1998-09-25 | Use of prostanoid antagonists for the treatment of primary headache disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009235310A Division JP2010047583A (ja) | 2009-10-09 | 2009-10-09 | 原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002525327A JP2002525327A (ja) | 2002-08-13 |
| JP2002525327A5 true JP2002525327A5 (https=) | 2006-01-05 |
Family
ID=26312305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000571923A Pending JP2002525327A (ja) | 1997-09-25 | 1998-09-25 | 原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8513027B2 (https=) |
| EP (1) | EP1115404B1 (https=) |
| JP (1) | JP2002525327A (https=) |
| AT (1) | ATE257707T1 (https=) |
| AU (1) | AU757265B2 (https=) |
| CA (1) | CA2345248C (https=) |
| DE (1) | DE69821142T2 (https=) |
| DK (1) | DK1115404T3 (https=) |
| ES (1) | ES2213914T3 (https=) |
| GB (2) | GB9720270D0 (https=) |
| PT (1) | PT1115404E (https=) |
| WO (1) | WO2000018405A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720270D0 (en) | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
| AU3445100A (en) * | 2000-03-24 | 2001-10-08 | Pharmagene Lab Ltd | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
| US20050059742A1 (en) * | 2001-10-31 | 2005-03-17 | Jabbour Henry Nicolas | Antagonists of prostaglandin receptors ep2 and/or ep4 for the treatment of dysmenorrhea and menorphagia |
| WO2003072138A1 (en) * | 2002-02-26 | 2003-09-04 | Ortho-Mcneil Pharmaceutical Inc. | Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| EP2846793A1 (en) | 2012-05-09 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2028805B (en) | 1978-07-11 | 1982-11-03 | Glaxo Group Ltd | Prostanoid compounds |
| JPS5718671A (en) | 1980-04-30 | 1982-01-30 | Glaxo Group Ltd | Aminocyclopentane alkenoic acid and esters thereof,manufacture and drug composition |
| US4839384A (en) | 1988-10-07 | 1989-06-13 | E. R. Squibb & Sons, Inc. | Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist |
| ES2133324T3 (es) | 1991-05-03 | 1999-09-16 | Searle & Co | Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso. |
| US5182272A (en) | 1991-05-03 | 1993-01-26 | G. D. Searle & Co. | 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain |
| US5212169A (en) | 1991-10-31 | 1993-05-18 | G. D. Searle & Co. | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain |
| CA2118688A1 (en) | 1991-11-05 | 1993-05-13 | Timothy J. Hagen | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| WO1993013082A1 (en) | 1991-12-20 | 1993-07-08 | G.D. Searle & Co. | Substituted dibenzoxazepines or dibenzothiazepines and their use as prostaglandin e2 antagonists |
| US5266571A (en) | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| US5395932A (en) | 1993-04-30 | 1995-03-07 | G. D. Searle & Co. | 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| US5344991A (en) | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
| US5488046A (en) | 1993-11-03 | 1996-01-30 | G. D. Searle & Co. | Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| CA2179399A1 (en) | 1993-12-20 | 1995-06-29 | Kiyoshi Taniguchi | 4,5-diaryloxazole derivatives |
| WO1995024393A1 (en) | 1994-03-10 | 1995-09-14 | Fujisawa Pharmaceutical Co., Ltd. | Naphthalene derivatives as prostaglandin i2 agonists |
| TW401408B (en) | 1995-07-21 | 2000-08-11 | Fujisawa Pharmaceutical Co | Heterocyclic compounds having prostaglandin I2 agonism |
| AUPO713297A0 (en) | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| US20030158240A1 (en) | 1998-09-25 | 2003-08-21 | Pharmagene Laboratories Limited | Methods for the treatment of primary headache disorders using prostanoid EP4 receptor antagonists, and assays for agents for such treatment |
| GB9720270D0 (en) | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
| EP1071648A2 (en) | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| AU1444200A (en) | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
| DE60012751T2 (de) | 1999-08-10 | 2005-01-20 | Glaxo Group Ltd., Greenford | Verwendung von EP 4 Rezeptorliganden zur Behandlung von neuropathischem Schmerz |
| EP1742662A2 (en) | 2004-05-03 | 2007-01-17 | Astellas Pharma Inc. | Combination of prostaglandin e2 receptor antagonists and renin-angiotensin system inhibitors for treating renal diseases |
-
1997
- 1997-09-25 GB GBGB9720270.9A patent/GB9720270D0/en not_active Ceased
-
1998
- 1998-09-25 ES ES98944111T patent/ES2213914T3/es not_active Expired - Lifetime
- 1998-09-25 AT AT98944111T patent/ATE257707T1/de active
- 1998-09-25 DK DK98944111T patent/DK1115404T3/da active
- 1998-09-25 PT PT98944111T patent/PT1115404E/pt unknown
- 1998-09-25 WO PCT/GB1998/002895 patent/WO2000018405A1/en not_active Ceased
- 1998-09-25 EP EP98944111A patent/EP1115404B1/en not_active Expired - Lifetime
- 1998-09-25 GB GB9820936A patent/GB2341799B/en not_active Expired - Fee Related
- 1998-09-25 DE DE69821142T patent/DE69821142T2/de not_active Expired - Lifetime
- 1998-09-25 CA CA002345248A patent/CA2345248C/en not_active Expired - Fee Related
- 1998-09-25 JP JP2000571923A patent/JP2002525327A/ja active Pending
- 1998-09-25 AU AU91776/98A patent/AU757265B2/en not_active Ceased
-
2007
- 2007-10-30 US US11/976,945 patent/US8513027B2/en not_active Expired - Fee Related
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